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2025-05-09 17:13:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001261829 4872 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens MYC induced nuclear antigen (MINA), transcript variant
4, mRNA.
ACCESSION NM_001261829
VERSION NM_001261829.1 GI:387849374
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4872)
AUTHORS Chen,Y., Yang,X., Huang,Y., Liu,E. and Wang,L.
TITLE Associations of the single-nucleotide polymorphisms of the Mina
gene with the development of asthma in Chinese Han children: a
case-control study
JOURNAL Genet Test Mol Biomarkers 15 (7-8), 531-536 (2011)
PUBMED 21631300
REMARK GeneRIF: The single nucleotide polymorphism of the Mina gene is
associated with the development of asthma in Chinese Han children.
REFERENCE 2 (bases 1 to 4872)
AUTHORS Komiya,K., Sueoka-Aragane,N., Sato,A., Hisatomi,T., Sakuragi,T.,
Mitsuoka,M., Sato,T., Hayashi,S., Izumi,H., Tsuneoka,M. and
Sueoka,E.
TITLE Expression of Mina53, a novel c-Myc target gene, is a favorable
prognostic marker in early stage lung cancer
JOURNAL Lung Cancer 69 (2), 232-238 (2010)
PUBMED 19914733
REMARK GeneRIF: favorable prognostic marker in early stage lung cancer
REFERENCE 3 (bases 1 to 4872)
AUTHORS Komiya,K., Sueoka-Aragane,N., Sato,A., Hisatomi,T., Sakuragi,T.,
Mitsuoka,M., Sato,T., Hayashi,S., Izumi,H., Tsuneoka,M. and
Sueoka,E.
TITLE Mina53, a novel c-Myc target gene, is frequently expressed in lung
cancers and exerts oncogenic property in NIH/3T3 cells
JOURNAL J. Cancer Res. Clin. Oncol. 136 (3), 465-473 (2010)
PUBMED 19756735
REMARK GeneRIF: Mina53 plays an important role in carcinogenesis and may
be a target for cancer prevention.
REFERENCE 4 (bases 1 to 4872)
AUTHORS Lu,Y., Chang,Q., Zhang,Y., Beezhold,K., Rojanasakul,Y., Zhao,H.,
Castranova,V., Shi,X. and Chen,F.
TITLE Lung cancer-associated JmjC domain protein mdig suppresses
formation of tri-methyl lysine 9 of histone H3
JOURNAL Cell Cycle 8 (13), 2101-2109 (2009)
PUBMED 19502796
REMARK GeneRIF: The MINA protein alters histone H3 methylation contributes
to the initiation or development of the human lung cancer.
REFERENCE 5 (bases 1 to 4872)
AUTHORS Zhang,Q., Hu,C.M., Yuan,Y.S., He,C.H., Zhao,Q. and Liu,N.Z.
TITLE Expression of Mina53 and its significance in gastric carcinoma
JOURNAL Int. J. Biol. Markers 23 (2), 83-88 (2008)
PUBMED 18629780
REMARK GeneRIF: Mina53 was overexpressed in gastric carcinoma and
associated with tumor proliferation and antioncogene inactivation.
REFERENCE 6 (bases 1 to 4872)
AUTHORS Eilbracht,J., Kneissel,S., Hofmann,A. and Schmidt-Zachmann,M.S.
TITLE Protein NO52--a constitutive nucleolar component sharing high
sequence homologies to protein NO66
JOURNAL Eur. J. Cell Biol. 84 (2-3), 279-294 (2005)
PUBMED 15819408
REMARK GeneRIF: Data suggests NO52 protein (MYC induced nuclear antigen)
is directly involved in ribosome biogenesis, most likely during the
assembly process of preribosomal particles.
REFERENCE 7 (bases 1 to 4872)
AUTHORS Tsuneoka,M., Fujita,H., Arima,N., Teye,K., Okamura,T., Inutsuka,H.,
Koda,Y., Shirouzu,K. and Kimura,H.
TITLE Mina53 as a potential prognostic factor for esophageal squamous
cell carcinoma
JOURNAL Clin. Cancer Res. 10 (21), 7347-7356 (2004)
PUBMED 15534111
REMARK GeneRIF: Mina53 may have a role in progression of esophageal
squamous cell carcinoma
REFERENCE 8 (bases 1 to 4872)
AUTHORS Eilbracht,J., Reichenzeller,M., Hergt,M., Schnolzer,M., Heid,H.,
Stohr,M., Franke,W.W. and Schmidt-Zachmann,M.S.
TITLE NO66, a highly conserved dual location protein in the nucleolus and
in a special type of synchronously replicating chromatin
JOURNAL Mol. Biol. Cell 15 (4), 1816-1832 (2004)
PUBMED 14742713
REFERENCE 9 (bases 1 to 4872)
AUTHORS Teye,K., Tsuneoka,M., Arima,N., Koda,Y., Nakamura,Y., Ueta,Y.,
Shirouzu,K. and Kimura,H.
TITLE Increased expression of a Myc target gene Mina53 in human colon
cancer
JOURNAL Am. J. Pathol. 164 (1), 205-216 (2004)
PUBMED 14695334
REMARK GeneRIF: the elevated expression of Mina53 is a characteristic
feature in colon cancer
REFERENCE 10 (bases 1 to 4872)
AUTHORS Tsuneoka,M., Koda,Y., Soejima,M., Teye,K. and Kimura,H.
TITLE A novel myc target gene, mina53, that is involved in cell
proliferation
JOURNAL J. Biol. Chem. 277 (38), 35450-35459 (2002)
PUBMED 12091391
REMARK GeneRIF: role in cell division
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA310030.1, AK027299.1, AC026100.19 and AC110491.5.
Summary: MINA is a c-Myc (MYC; MIM 190080) target gene that may
play a role in cell proliferation or regulation of cell growth.
(Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005
[PubMed 15897898]).[supplied by OMIM, May 2008].
Transcript Variant: This variant (4) uses alternate splice sites in
the 5' UTR and 3' coding region, compared to variant 1, and encodes
a shorter protein (isoform B), compared to isoform A. Variants 3
and 4 encode the same protein (isoform B).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK027299.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-50 DA310030.1 7-56
51-584 AK027299.1 1-534
585-585 AC026100.19 95339-95339
586-862 AK027299.1 536-812
863-863 AC026100.19 102581-102581
864-1262 AK027299.1 814-1212
1263-1263 AC026100.19 111124-111124
1264-1651 AK027299.1 1214-1601
1652-4872 AC110491.5 67-3287
FEATURES Location/Qualifiers
source 1..4872
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q11.2"
gene 1..4872
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/note="MYC induced nuclear antigen"
/db_xref="GeneID:84864"
/db_xref="HGNC:19441"
/db_xref="MIM:612049"
exon 1..71
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 72..542
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
CDS 111..1505
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/note="isoform b is encoded by transcript variant 4;
myc-induced nuclear antigen, 53 kDa; mineral dust induced
gene protein; nucleolar protein 52; mineral dust-induced
gene protein; ribosomal oxygenase MINA; histone lysine
demethylase MINA; 60S ribosomal protein L27a histidine
hydroxylase; bifunctional lysine-specific demethylase and
histidyl-hydroxylase MINA"
/codon_start=1
/product="bifunctional lysine-specific demethylase and
histidyl-hydroxylase MINA isoform b"
/protein_id="NP_001248758.1"
/db_xref="GI:387849375"
/db_xref="CCDS:CCDS2929.1"
/db_xref="GeneID:84864"
/db_xref="HGNC:19441"
/db_xref="MIM:612049"
/translation="
MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV
"
misc_feature 264..1199
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/note="Cupin superfamily protein; Region: Cupin_4;
pfam08007"
/db_xref="CDD:191926"
misc_feature <465..836
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/note="JmjC domain, hydroxylase; Region: JmjC; cl15814"
/db_xref="CDD:210214"
misc_feature 1032..1034
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IUF8.1); phosphorylation site"
STS 117..264
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/standard_name="D3S4225"
/db_xref="UniSTS:3610"
variation 159
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/replace="c"
/replace="g"
/db_xref="dbSNP:35391656"
STS 305..441
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/standard_name="SHGC-77141"
/db_xref="UniSTS:28655"
variation 389
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/replace="a"
/replace="g"
/db_xref="dbSNP:34097037"
exon 543..662
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 663..791
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 792..895
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 896..998
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 999..1167
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 1168..1256
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 1257..1346
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
exon 1347..4872
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/inference="alignment:Splign:1.39.8"
STS 1805..1958
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/standard_name="D3S2782E"
/db_xref="UniSTS:33564"
STS 4569..4721
/gene="MINA"
/gene_synonym="MDIG; MINA53; NO52; ROX"
/standard_name="SHGC-77136"
/db_xref="UniSTS:35373"
ORIGIN
acgctgccccgcctccagccgctgcgccgcaacgcagtgggctcgcggccgcgagcaacaggccgtgccgggtttgcatttccttactgctttgtcttgaagacagaacgatgccaaagaaagcaaagcctacagggagtgggaaggaagaggggccggctccctgtaagcagatgaagttagaagcagctggggggccttcagctttaaactttgacagtcccagtagtctctttgaaagtttaatctcgcccatcaagacagagacttttttcaaggaattctgggagcagaagccccttctcattcagagagatgaccctgcactggccacatactatgggtccctgttcaagctaacagatctgaagagtctgtgcagccgggggatgtactatggaagagatgtgaatgtctgccggtgtgtcaatgggaagaagaaggttttaaataaagatggcaaagcacactttcttcagctgagaaaagattttgatcagaaaagggcaacgattcagtttcaccaacctcagagatttaaggatgagctttggaggatccaggagaagctggaatgttactttggctccttggttggctcgaatgtgtacataactcccgcaggatctcagggcctgccgccccattatgatgatgtcgaggttttcatcctgcagctggagggagagaaacactggcgcctctaccaccccactgtgcccctggcacgagagtacagcgtggaggccgaggaaaggatcggcaggccggtgcatgagtttatgctgaagccgggtgatttgttgtactttcccagaggaaccattcatcaagcggacactcctgcggggctggcccactctactcacgtgaccatcagcacctaccagaacaattcatggggagatttccttttggataccatctcggggcttgtatttgatactgcaaaggaagacgtggagttacggaccggcataccccggcagctgctcctggtggaatccacaactgttgctacaagacgattaagtggcttcctgaggacacttgcagaccggctggagggcaccaaagaactgctttcctcagacatgaagaaggattttattatgcacagactccccccttactctgcgggagatggggcagagctgtcaacaccaggtggaaagttaccgaggctggacagtgtagtgagactgcagtttaaagaccacattgtcctcacagtactgccggatcaagatcaatctgatgaagctcaagaaaagatggtgtacatctatcattccttaaagaatagtagagagacacacatgatgggaaatgaggaggaaacagagtttcatggacttcgcttccctttgtcacatttggatgcactgaagcaaatttggaatagtccagctatttctgtcaaggacctgaaacttactacagatgaggaaaaggaaagcctggtattatccctctggacagaatgtttaattcaagtagtctagtgcctttgcagaatcaaatgcctactattttatatgcatatattaaaagaaaagcaaagacctgagccgaggagaggatgaattcaagtttccttacctgcgtatctactaacaaacatgagacctccctgttacaggtggtcagttggccaaatgtactaacgggcacatgaaagaaagaacagcaaattaccaagtgtctcagaaaatgacaaaaccatattttgacaagtttatttaatccagtgtggtagaaaaggcacaattccaatgtatcatttagaattgaatgtcattaacctggctttgttctttggaagaaacaacttctttaaagagcttctttggctctagaaaaatttcaaacaattaaaataagaaaaaattttaaactggttttttataatgaaaatatacatacctttgtgtatagacaagcccatgcccattaaaataaagttatcctgtaacataaattttattaaataatacttccccacagatgagaggcacgcaacacctatggacaaaagggagttacagaggctgcttaaaagatggagaaaagcctgagattgaaggaggaaaaaaacccagtatttaaagtctataaaaaatactcaaaatagtgggtcttcgagtttaaaatagtcattgttattttacattctaaagtgcatgtaggttgatattttttaaaatatcattggagaatttaatctttctttataaaaatagagcatttttctgctttctggcaaaagttggggataaaaggaaaaaaagttgtcaaaatgtaattttcagtccaattcaccaggaaaacatgcttgtgaattgtgcagtaaaaggtggtaatgactactggaagctaagtcaaaggtgatttcctacctgattttacttacttaaataaaagttacttacaatgggagtgaaaaactgaggtttctgttatttagtagagaaatcaactccacgtttacttaaagagatggtaaggtcaaggttcaaatgctactgtgttttaatttggatatttgaaatttctcttgaggcaaaaaaaaaaaaaaattgatgcctctccttaaatctaggatgaagtgtcaacatggagacaggtaaccactgttatagagtcttgtcacctaaagggatgtcttggttaacacgtaacagtgcaagtttggccataggttatttatttgtacttttttagtttgaaggactgaggaaacaatagctacagaaaatacttcttgtgccttattcctaacaaagctgaggtccctgcctggggttagttacaagtataaatacttaacgaggtgcgttcattataaaagcctcagtatagaaaccttaaagtttatctaggaaagtttagtatattttcaggtgttgctaaaaaattactcatctgtttgcaaaagtatgacttgacctatagaaatctgtttctttatgctttgtactcatacaagcatctaggtaggatattaataaataatacaggataatagcatcaccagtgtccaataacgggccatcaggaacaggattcacgtttggtggatatgagagaaaataaacacttcaggaaacttgctcaccacagctggagatcaggaatagaacctttccaagatatcataatattttctttataggaacactgagtaatggcaagaatattttgagcttttccatggttaagagcgatagtctcagaggctggagaaaatgttcattctgctcagtgatccaggagtgtgaggacagtagcttcctttccacgtccacaagacaatgacagatgtgtttccttctttgctctttctagggatctttctagggatgttgattctctcacaatatttcaatgtcccatttctgtgtttcttctccctccaggggctgatttacaattacatgagtcttgtcacaataatttcctcctaaaatagaaattccaaaagaaaagattatttgttcaggcaggtgcttagcaatttcacaattttcacaagcttctgttcagctcaccatttcggtggatgaatgtgtcatttacaaagaagtctgaaatgggaagctgagtttgaacaggcttagccattattcacctcaaattggaccttattatgactcaaattgaaatactaaaaggtataatacatgattgtataagtggcgtgccttaatgtgattctttagaacaaagtgctcttgagagaactctggctgaatgtcaggtactgtgtttttgtttctacaccaacaaaactgtgactaacccaattaaagcaacagccatgaataatattggccctgaccttgctgaattcaaaaacaaggttaattgatacctaccataaattctacctgagggtttttaaggaccatggcaattcctggcaaaaagctagagatgtttctaagaaacagatgacattcatttcatggtttatggtgcttgaaatttagaactgttctgagttcacgtagcaaatgaaagttttacaactgtactaatgaacaaaaaccctaagctttgttgtttggctttttctgctaattgttttgtttgtaaaactgcctatcttaattttcttcaagcataattttaaatgacttaacatttctcttatacataaggatgtcctttacccaaaatgaggagatttggaactgaaactaatatccagggacacaacattgggtatcatcaaaggcccacctttaacatcaaggacaagttgatcactgagataagagctgatagttccatttttattcagtctccacttctgcctgaattgcccatgttcagtccatagagctactttagctccaggtgtgtcccggccaccaatcacatcaagacatgtatcactggcctaaaagggttaagaaatgattaattggcagtagtatgtttgctaaagtaagttgaattaggtcccttttatcttaggtaaacaagtcatagacatgaagtgtgtgtgtgtcttatctaaaaaaatactatatagtataatttcagtaagccttttttaatgtcttctttacggctgtgggtaggagatggtacagaaataaaccaactgaaatagaggtacttgtttttaataggatgtctacatctgacaacagatgttcaataaagatttggtgaattggaattaaatgttaaatccctgtttgcttaaaacgtattatgttgagcttggttttcttatgaaaacattgcatgatgggctaaagatatccagacaataattacttttaaaagtttttcatttttgaagcatgagaaaaagtagataatccattggtgatacaataaaacacagtttgaatgttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84864 -> Molecular function: GO:0001191 [RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription] evidence: IEA
GeneID:84864 -> Molecular function: GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] evidence: IEA
GeneID:84864 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:84864 -> Biological process: GO:0042254 [ribosome biogenesis] evidence: IEA
GeneID:84864 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:84864 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:84864 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:84864 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:84864 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
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