GGRNA | NM_001258289.1

LOCUS       NM_001258289            1977 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens selenium binding protein 1 (SELENBP1), transcript
            variant 3, mRNA.
ACCESSION   NM_001258289
VERSION     NM_001258289.1  GI:385137129
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Jerome-Morais,A., Wright,M.E., Liu,R., Yang,W., Jackson,M.I.,
            Combs,G.F. Jr. and Diamond,A.M.
  TITLE     Inverse association between glutathione peroxidase activity and
            both selenium-binding protein 1 levels and Gleason score in human
            prostate tissue
  JOURNAL   Prostate 72 (9), 1006-1012 (2012)
   PUBMED   22072582
  REMARK    GeneRIF: Glutathione peroxidase (GPx)-1 enzyme activity is
            inversely correlated with selenium binding protein (SBP)-1 levels
            in prostate tissue, based on the Gleason score.
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Xia,Y.J., Ma,Y.Y., He,X.J., Wang,H.J., Ye,Z.Y. and Tao,H.Q.
  TITLE     Suppression of selenium-binding protein 1 in gastric cancer is
            associated with poor survival
  JOURNAL   Hum. Pathol. 42 (11), 1620-1628 (2011)
   PUBMED   21497372
  REMARK    GeneRIF: The 3-year survival rate of gastric cancer patients with
            high expression of selenium-binding protein 1 was significantly
            higher than that of patients with low expression
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Raucci,R., Colonna,G., Guerriero,E., Capone,F., Accardo,M.,
            Castello,G. and Costantini,S.
  TITLE     Structural and functional studies of the human selenium binding
            protein-1 and its involvement in hepatocellular carcinoma
  JOURNAL   Biochim. Biophys. Acta 1814 (4), 513-522 (2011)
   PUBMED   21338716
  REMARK    GeneRIF: A reduced SELENBP1 expression by immunohistochemistry in
            liver tissues of patients with hepatocarcinoma (HCC), is reported.
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Johnatty,S.E., Beesley,J., Chen,X., Macgregor,S., Duffy,D.L.,
            Spurdle,A.B., deFazio,A., Gava,N., Webb,P.M., Rossing,M.A.,
            Doherty,J.A., Goodman,M.T., Lurie,G., Thompson,P.J., Wilkens,L.R.,
            Ness,R.B., Moysich,K.B., Chang-Claude,J., Wang-Gohrke,S.,
            Cramer,D.W., Terry,K.L., Hankinson,S.E., Tworoger,S.S.,
            Garcia-Closas,M., Yang,H., Lissowska,J., Chanock,S.J.,
            Pharoah,P.D., Song,H., Whitemore,A.S., Pearce,C.L., Stram,D.O.,
            Wu,A.H., Pike,M.C., Gayther,S.A., Ramus,S.J., Menon,U.,
            Gentry-Maharaj,A., Anton-Culver,H., Ziogas,A., Hogdall,E.,
            Kjaer,S.K., Hogdall,C., Berchuck,A., Schildkraut,J.M.,
            Iversen,E.S., Moorman,P.G., Phelan,C.M., Sellers,T.A.,
            Cunningham,J.M., Vierkant,R.A., Rider,D.N., Goode,E.L., Haviv,I.
            and Chenevix-Trench,G.
  CONSRTM   Ovarian Cancer Association Consortium; Australian Ovarian Cancer
            Study Group; Australian Cancer Study (Ovarian Cancer)
  TITLE     Evaluation of candidate stromal epithelial cross-talk genes
            identifies association between risk of serous ovarian cancer and
            TERT, a cancer susceptibility 'hot-spot'
  JOURNAL   PLoS Genet. 6 (7), E1001016 (2010)
   PUBMED   20628624
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Zhang,P., Zhang,C., Wang,X., Liu,F., Sung,C.J., Quddus,M.R. and
            Lawrence,W.D.
  TITLE     The expression of selenium-binding protein 1 is decreased in
            uterine leiomyoma
  JOURNAL   Diagn Pathol 5, 80 (2010)
   PUBMED   21143902
  REMARK    GeneRIF: Decreased expression of selenium-binding protein 1 in
            uterine leiomyoma may indicate a role of the protein in
            tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Porat,A., Sagiv,Y. and Elazar,Z.
  TITLE     A 56-kDa selenium-binding protein participates in intra-Golgi
            protein transport
  JOURNAL   J. Biol. Chem. 275 (19), 14457-14465 (2000)
   PUBMED   10799528
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Chang,P.W., Tsui,S.K., Liew,C., Lee,C.C., Waye,M.M. and Fung,K.P.
  TITLE     Isolation, characterization, and chromosomal mapping of a novel
            cDNA clone encoding human selenium binding protein
  JOURNAL   J. Cell. Biochem. 64 (2), 217-224 (1997)
   PUBMED   9027582
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Czar,M.J., Owens-Grillo,J.K., Dittmar,K.D., Hutchison,K.A.,
            Zacharek,A.M., Leach,K.L., Deibel,M.R. Jr. and Pratt,W.B.
  TITLE     Characterization of the protein-protein interactions determining
            the heat shock protein (hsp90.hsp70.hsp56) heterocomplex
  JOURNAL   J. Biol. Chem. 269 (15), 11155-11161 (1994)
   PUBMED   8157642
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Lanfear,J., Fleming,J., Walker,M. and Harrison,P.
  TITLE     Different patterns of regulation of the genes encoding the closely
            related 56 kDa selenium- and acetaminophen-binding proteins in
            normal tissues and during carcinogenesis
  JOURNAL   Carcinogenesis 14 (3), 335-340 (1993)
   PUBMED   8453708
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Bartolone,J.B., Birge,R.B., Bulera,S.J., Bruno,M.K.,
            Nishanian,E.V., Cohen,S.D. and Khairallah,E.A.
  TITLE     Purification, antibody production, and partial amino acid sequence
            of the 58-kDa acetaminophen-binding liver proteins
  JOURNAL   Toxicol. Appl. Pharmacol. 113 (1), 19-29 (1992)
   PUBMED   1553752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB288439.1, AK296661.1,
            CR456852.1 and BQ045424.1.
            
            Summary: This gene encodes a member of the selenium-binding protein
            family. Selenium is an essential nutrient that exhibits potent
            anticarcinogenic properties, and deficiency of selenium may cause
            certain neurologic diseases. The effects of selenium in preventing
            cancer and neurologic diseases may be mediated by selenium-binding
            proteins, and decreased expression of this gene may be associated
            with several types of cancer. The encoded protein may play a
            selenium-dependent role in ubiquitination/deubiquitination-mediated
            protein degradation. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' region and initiates translation at an alternate start
            codon, compared to variant 1. The encoded isoform (3) is longer and
            has a distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB288439.1         1-31
            32-1134             AK296661.1         1-1103
            1135-1719           CR456852.1         833-1417
            1720-1977           BQ045424.1         1-258               c
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1977
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /note="selenium binding protein 1"
                     /db_xref="GeneID:8991"
                     /db_xref="HGNC:10719"
                     /db_xref="MIM:604188"
     exon            1..97
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    3..5
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /note="upstream in-frame stop codon"
     exon            98..363
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     CDS             177..1721
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /note="isoform 3 is encoded by transcript variant 3; 56
                     kDa selenium-binding protein"
                     /codon_start=1
                     /product="selenium-binding protein 1 isoform 3"
                     /protein_id="NP_001245218.1"
                     /db_xref="GI:385137130"
                     /db_xref="GeneID:8991"
                     /db_xref="HGNC:10719"
                     /db_xref="MIM:604188"
                     /translation="

MRLEWGPRPAALPWPAGMCAAERAEGAFTLQSVAQPMRPIASTATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI

"
     misc_feature    324..1718
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /note="56kDa selenium binding protein (SBP56); Region:
                     SBP56; pfam05694"
                     /db_xref="CDD:147702"
     exon            364..476
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     exon            477..662
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     variation       541
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1043849"
     variation       634
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11539467"
     exon            663..783
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     variation       666
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35396382"
     variation       706
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1043857"
     exon            784..966
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     exon            967..1145
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     variation       1086
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1043860"
     variation       1094
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043861"
     exon            1146..1224
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     exon            1225..1346
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     exon            1347..1439
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     STS             1365..1640
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="ECD09001"
                     /db_xref="UniSTS:290047"
     exon            1440..1558
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     exon            1559..1962
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /inference="alignment:Splign:1.39.8"
     variation       1571
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1127513"
     STS             1610..1863
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="WI-20043"
                     /db_xref="UniSTS:70113"
     STS             1631..1893
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="REN33842"
                     /db_xref="UniSTS:358642"
     STS             1697..1877
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="A002D26"
                     /db_xref="UniSTS:65169"
     STS             1697..1877
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="G19959"
                     /db_xref="UniSTS:65168"
     STS             1733..1899
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
                     /standard_name="SHGC-2948"
                     /db_xref="UniSTS:16359"
     polyA_signal    1936..1941
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
     polyA_site      1962
                     /gene="SELENBP1"
                     /gene_synonym="hSBP; LPSB; SBP56; SP56"
ORIGIN

tataaattccctcccttcgctccttccccggaacagcggcctctgacaccagcacagcaaacccgccgggatcaaagtgtaccagtcggcagcatgggtcatgtgtctccagctcttcccagcacaacctcaccctcctcagggctctgagggggcggagaggacaggccagagcgatgaggctggagtggggacctaggccagccgcactgccgtggcccgctgggatgtgtgctgcagaacgtgcggagggagccttcaccctccagagcgtggcccagccaatgcgccccattgcttccacagctacgaaatgtgggaattgtggacccggctactccacccctctggaggccatgaaaggacccagggaagagatcgtctacctgccctgcatttaccgaaacacaggcactgaggccccagattatctggccactgtggatgttgaccccaagtctccccagtattgccaggtcatccaccggctgcccatgcccaacctgaaggacgagctgcatcactcaggatggaacacctgcagcagctgcttcggtgatagcaccaagtcgcgcaccaagctggtgctgcccagtctcatctcctctcgcatctatgtggtggacgtgggctctgagccccgggccccaaagctgcacaaggtcattgagcccaaggacatccatgccaagtgcgaactggcctttctccacaccagccactgcctggccagcggggaagtgatgatcagctccctgggagacgtcaagggcaatggcaaagggggttttgtgctgctggatggggagacgttcgaggtgaaggggacatgggagagacctgggggtgctgcaccgttgggctatgacttctggtaccagcctcgacacaatgtcatgatcagcactgagtgggcagctcccaatgtcttacgagatggcttcaaccccgctgatgtggaggctggactgtacgggagccacttatatgtatgggactggcagcgccatgagattgtgcagaccctgtctctaaaagatgggcttattcccttggagatccgcttcctgcacaacccagacgctgcccaaggctttgtgggctgcgcactcagctccaccatccagcgcttctacaagaacgagggaggtacatggtcagtggagaaggtgatccaggtgccccccaagaaagtgaagggctggctgctgcccgaaatgccaggcctgatcaccgacatcctgctctccctggacgaccgcttcctctacttcagcaactggctgcatggggacctgaggcagtatgacatctctgacccacagagaccccgcctcacaggacagctcttcctcggaggcagcattgttaagggaggccctgtgcaagtgctggaggacgaggaactaaagtcccagccagagcccctagtggtcaagggaaaacgggtggctggaggccctcagatgatccagctcagcctggatgggaagcgcctctacatcaccacgtcgctgtacagtgcctgggacaagcagttttaccctgatctcatcagggaaggctctgtgatgctgcaggttgatgtagacacagtaaaaggagggctgaagttgaaccccaacttcctggtggacttcgggaaggagccccttggcccagcccttgcccatgagctccgctaccctgggggcgattgtagctctgacatctggatttgaactccaccctcatcacccacactccctattttgggccctcacttccttggggacctggcttcattctgctctctcttggcacccgacccttggcagcatgtaccacacagccaagctgagactgtggcaatgtgttgagtcatatacatttactgaccactgttgcttgttgctcactgtgctgcttttccatgagctcttggaggcaccaagaaataaactcgtaaccctgtccttcagaaaaaaaaaaaaaaaa

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