GGRNA | NM_001252634.1

LOCUS       NM_001252634            7651 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens thyroid hormone receptor, beta (THRB), transcript
            variant 4, mRNA.
ACCESSION   NM_001252634
VERSION     NM_001252634.1  GI:358001056
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7651)
  AUTHORS   Kim,W.G., Zhu,X., Kim,D.W., Zhang,L., Kebebew,E. and Cheng,S.Y.
  TITLE     Reactivation of the silenced thyroid hormone receptor beta gene
            expression delays thyroid tumor progression
  JOURNAL   Endocrinology 154 (1), 25-35 (2013)
   PUBMED   23183175
  REMARK    GeneRIF: THRB mRNA expression in DTC was 90% lower than in normal
            controls, and this decrease was associated with a higher
            tumor/lymph node staging.
REFERENCE   2  (bases 1 to 7651)
  AUTHORS   Yuan,C., Nguyen,P., Baxter,J.D. and Webb,P.
  TITLE     Distinct ligand-dependent and independent modes of thyroid hormone
            receptor (TR)/PGC-1alpha interaction
  JOURNAL   J. Steroid Biochem. Mol. Biol. 133, 58-65 (2013)
   PUBMED   22974658
  REMARK    GeneRIF: TRbeta1 binds PGC-1alpha in a second ligand and LxxLL
            motif independent mode and show this interaction requires the
            TRbeta1 N-terminal domain and the PGC-1alpha N-terminal activation
            domain at amino acids 1-130.
REFERENCE   3  (bases 1 to 7651)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   4  (bases 1 to 7651)
  AUTHORS   Liu,Y.Y., Kogai,T., Schultz,J.J., Mody,K. and Brent,G.A.
  TITLE     Thyroid hormone receptor isoform-specific modification by small
            ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent
            gene regulation
  JOURNAL   J. Biol. Chem. 287 (43), 36499-36508 (2012)
   PUBMED   22930759
  REMARK    GeneRIF: conjugation of SUMO to TR has a TR-isoform preference and
            is important for T3-dependent gene induction and repression.
REFERENCE   5  (bases 1 to 7651)
  AUTHORS   Miki,I., Nakamura,T., Kuwahara,A., Yamamori,M., Nishiguchi,K.,
            Tamura,T., Okuno,T., Omatsu,H., Mizuno,S., Hirai,M., Azuma,T. and
            Sakaeda,T.
  TITLE     THRB genetic polymorphisms can predict severe myelotoxicity after
            definitive chemoradiotherapy in patients with esophageal squamous
            cell carcinoma
  JOURNAL   Int J Med Sci 9 (9), 748-756 (2012)
   PUBMED   23136537
  REMARK    GeneRIF: THRB intronic SNPs can provide useful information on
            chemoradiotherapy-related severe myelotoxicity in patients with
            esophageal squamous cell carcinoma
REFERENCE   6  (bases 1 to 7651)
  AUTHORS   Falcone,M., Miyamoto,T., Fierro-Renoy,F., Macchia,E. and
            DeGroot,L.J.
  TITLE     Antipeptide polyclonal antibodies specifically recognize each human
            thyroid hormone receptor isoform
  JOURNAL   Endocrinology 131 (5), 2419-2429 (1992)
   PUBMED   1425440
REFERENCE   7  (bases 1 to 7651)
  AUTHORS   Behr,M. and Loos,U.
  TITLE     A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA
            beta thyroid hormone receptor gene in a family with generalized
            thyroid hormone resistance
  JOURNAL   Mol. Endocrinol. 6 (7), 1119-1126 (1992)
   PUBMED   1324420
REFERENCE   8  (bases 1 to 7651)
  AUTHORS   Cugini,C.D. Jr., Leidy,J.W. Jr., Chertow,B.S., Berard,J.,
            Bradley,W.E., Menke,J.B., Hao,E.H. and Usala,S.J.
  TITLE     An arginine to histidine mutation in codon 315 of the c-erbA beta
            thyroid hormone receptor in a kindred with generalized resistance
            to thyroid hormones results in a receptor with significant
            3,5,3'-triiodothyronine binding activity
  JOURNAL   J. Clin. Endocrinol. Metab. 74 (5), 1164-1170 (1992)
   PUBMED   1314846
REFERENCE   9  (bases 1 to 7651)
  AUTHORS   Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
            Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
            Wiersinga,W.M. and Koornneef,L.
  TITLE     Distribution of the nuclear thyroid-hormone receptor in extraocular
            and skeletal muscles
  JOURNAL   J. Endocrinol. 133 (1), 67-74 (1992)
   PUBMED   1517709
REFERENCE   10 (bases 1 to 7651)
  AUTHORS   Adams,M., Nagaya,T., Tone,Y., Jameson,J.L. and Chatterjee,V.K.
  TITLE     Functional properties of a novel mutant thyroid hormone receptor in
            a family with generalized thyroid hormone resistance syndrome
  JOURNAL   Clin. Endocrinol. (Oxf) 36 (3), 281-289 (1992)
   PUBMED   1563081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012087.10, AK096628.1,
            GQ869477.1, AC098971.2 and AW449568.1.
            
            Summary: The protein encoded by this gene is a nuclear hormone
            receptor for triiodothyronine. It is one of the several receptors
            for thyroid hormone, and has been shown to mediate the biological
            activities of thyroid hormone. Knockout studies in mice suggest
            that the different receptors, while having certain extent of
            redundancy, may mediate different functions of thyroid hormone.
            Mutations in this gene are known to be a cause of generalized
            thyroid hormone resistance (GTHR), a syndrome characterized by
            goiter and high levels of circulating thyroid hormone (T3-T4), with
            normal or slightly elevated thyroid stimulating hormone (TSH).
            Several alternatively spliced transcript variants encoding the same
            protein have been observed for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096628.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC012087.10        124172-124182
            12-2012             AK096628.1         1-2001
            2013-6576           GQ869477.1         107-4670
            6577-7401           AC098971.2         142059-142883       c
            7402-7651           AW449568.1         1-250               c
FEATURES             Location/Qualifiers
     source          1..7651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..7651
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="thyroid hormone receptor, beta"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:11799"
                     /db_xref="MIM:190160"
     exon            1..171
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            172..243
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            244..380
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            381..478
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            479..542
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    515..517
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="upstream in-frame stop codon"
     CDS             521..1906
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="oncogene ERBA2; thyroid hormone nuclear receptor
                     beta variant 1; nuclear receptor subfamily 1 group A
                     member 2; thyroid hormone receptor, beta (erythroblastic
                     leukemia viral (v-erb-a) oncogene homolog 2, avian)"
                     /codon_start=1
                     /product="thyroid hormone receptor beta"
                     /protein_id="NP_001239563.1"
                     /db_xref="GI:358001057"
                     /db_xref="CCDS:CCDS2641.1"
                     /db_xref="GeneID:7068"
                     /db_xref="HGNC:11799"
                     /db_xref="MIM:190160"
                     /translation="

MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED

"
     misc_feature    521..838
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P10828.2);
                     Region: Modulating"
     misc_feature    836..1081
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="DNA-binding domain of thyroid hormone receptors
                     (TRs) is composed of two C4-type zinc fingers; Region:
                     NR_DBD_TR; cd06961"
                     /db_xref="CDD:143519"
     misc_feature    order(839..841,848..850,890..892,899..901,953..955,
                     971..973,1001..1003,1010..1012)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:143519"
     misc_feature    order(869..877,893..898,902..904,908..910,914..919,
                     926..928,992..997,1004..1006,1013..1015,1052..1060,
                     1073..1075)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143519"
     misc_feature    order(869..871,878..880,1043..1045,1049..1054)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="heterodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:143519"
     misc_feature    1166..1894
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="The ligand binding domain of thyroid hormone
                     receptor, a members of a superfamily of nuclear receptors;
                     Region: NR_LBD_TR; cd06935"
                     /db_xref="CDD:132733"
     misc_feature    1250..1903
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P10828.2);
                     Region: Interaction with NR2F6"
     misc_feature    1250..1903
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P10828.2);
                     Region: Ligand-binding"
     misc_feature    order(1325..1327,1334..1339,1343..1348,1355..1357,
                     1364..1366,1448..1450,1457..1459,1469..1471,1505..1513,
                     1541..1543,1550..1552,1556..1558,1577..1579,1823..1825,
                     1844..1846,1883..1885)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:132733"
     misc_feature    order(1361..1363,1370..1372,1382..1384,1412..1414,
                     1424..1426,1433..1435,1877..1882,1889..1891)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="coactivator recognition site [polypeptide binding];
                     other site"
                     /db_xref="CDD:132733"
     misc_feature    order(1562..1564,1697..1699,1787..1789,1796..1801,
                     1808..1810,1817..1822,1826..1831)
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:132733"
     exon            543..803
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            804..904
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            905..1052
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            1053..1258
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     variation       1255
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3752874"
     exon            1259..1405
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     exon            1406..1664
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     variation       1510
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:267607113"
     variation       1530
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1054624"
     exon            1665..7637
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /inference="alignment:Splign:1.39.8"
     STS             1744..1906
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /standard_name="SHGC-76783"
                     /db_xref="UniSTS:76713"
     variation       3260
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:844107"
     variation       4567
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201503958"
     variation       6894
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1349265"
     variation       7273
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2167116"
     polyA_signal    7617..7622
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
     polyA_site      7637
                     /gene="THRB"
                     /gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
                     PRTH; THR1; THRB1; THRB2"
ORIGIN

cggcggggattaactttgcatgaataatgtgagtgcgcttggaaaagagacctcctgctccgcgggctcggggcaagagcccgcaggctaccttccccgggcaggggcgctcaacccaaccggctccagggcactggtaatttggctagaggaccgcgcggaggcagcgggatctgcgatttccttctggttggctgtcctgcgtgggtgccaagttccacacatgatttaatgaataagaagggggcttggaggctcatagcaaaggtccttgaagagagcaagaaaaagtcttcccaggaaaagtggacacctgagtgagtgttacaacgagaaggggggcatcccaggcaaggcagctaccaagcacaggtgtgaagtgacttcactgtaggaagaggaaatgcagaaaaacaaacgtcttgaagactgaaagcctgttattcaaagaggttagcagtagactgttggaagtaaggagatgtcagtgaaaaaagggatccagaatgattactaacctatgactcccaacagtatgacagaaaatggccttacagcctgggacaaaccgaagcactgtccagaccgagaacacgactggaagctagtaggaatgtctgaagcctgcctacataggaagagccattcagagaggcgcagcacgttgaaaaatgaacagtcgtcgccacatctcatccagaccacttggactagctcaatattccatctggaccatgatgatgtgaacgaccagagtgtctcaagtgcccagaccttccaaacggaggagaagaaatgtaaagggtacatccccagttacttagacaaggacgagctctgtgtagtgtgtggtgacaaagccaccgggtatcactaccgctgtatcacgtgtgaaggctgcaagggtttctttagaagaaccattcagaaaaatctccatccatcctattcctgtaaatatgaaggaaaatgtgtcatagacaaagtcacgcgaaatcagtgccaggaatgtcgctttaagaaatgcatctatgttggcatggcaacagatttggtgctggatgacagcaagaggctggccaagaggaagctgatagaggagaaccgggagaaaagacggcgggaagagctgcagaagtccatcgggcacaagccagagcccacagacgaggaatgggagctcatcaaaactgtcaccgaagcccatgtggcgaccaacgcccaaggcagccactggaagcaaaaacggaaattcctgccagaagacattggacaagcaccaatagtcaatgccccagaaggtggaaaggttgacttggaagccttcagccattttacaaaaatcatcacaccagcaattaccagagtggtggattttgccaaaaagttgcctatgttttgtgagctgccatgtgaagaccagatcatcctcctcaaaggctgctgcatggagatcatgtcccttcgcgctgctgtgcgctatgacccagaaagtgagactttaaccttgaatggggaaatggcagtgacacggggccagctgaaaaatgggggtcttggggtggtgtcagacgccatctttgacctgggcatgtctctgtcttctttcaacctggatgacactgaagtagccctccttcaggccgtcctgctgatgtcttcagatcgcccggggcttgcctgtgttgagagaatagaaaagtaccaagatagtttcctgctggcctttgaacactatatcaattaccgaaaacaccacgtgacacacttttggccaaaactcctgatgaaggtgacagatctgcggatgataggagcctgccatgccagccgcttcctgcacatgaaggtggaatgccccacagaactcttcccccctttgttcttggaagtgttcgaggattagactgactggattcattctcataattcctacagcactactgggtgtcatttcattccattgcctagctcttttttgtttgtttctttgtgttgggagggattatttgggagggaaaagggaagtagtccttggcatagacatggatgaaattgccccttgaatgcgggtacttgaaactattgcatttcgttctccggtcctgtgatgtgaatgctctgaaggttttatggttgtggaggtggggtgggggacaatcattaactcaccagcaccaagcatcaccagctcccacccgtccctggtccaagacttgagtcagcaaaatggcgccacaggacactaaagaagccttaaaaccaagataatacgaccacctccacccaatcctgatgttcgcagggctgaagttaacagagcacagaccacctttagttagatgtggctttcagccttttagggaaagactcgaacaaattttcatctattcaagagcatgctgtttgcagcactctttatggtctcctaggagcataacttggaatgtacaggaatatttgtgtcctaaaaaaatcagctgcccttccaatatcatttttataacgttatggtttaattcaagttatacaaaggtgtgactcaaggatgtgcaggtattgactgatggaggccaacaaggaaaatattttttttcagtgagcccagagaaattagaaatcttcaccaatgtcagtgactgcatggtttccaaaaattcacatagtattacctcacagtaggaaggcttctttcccatttaggctcagagaacacttttacagaaatcaaacctatttacagggtggcaccccttttctgtggcatctgatctgtcatctcccaagctcctgaagttctttatccaggttgtatctttgctgagctgacaacagatttctctatggatcaaatattctaatcaaggaaagatacggtgaaacttcagtcttcttctggagaaatgctgaggcgagattagtgcagctacattctgagttgaaggaaatgcagtgttctgagggcccctttgtgtcctgatggctggaggacgcttcctcctggttagatcctcaagctccttgcctcattgacaaatgtctcctagtcccctttttccctctgactctgaggaactaaatagcttgactatctctaaacagagactggccctgccactgaccctcctgtccctctcatagcataccctgacagatactcaatagaaaacacctgcagaccatgtgcacacttaactttcctgcccaacctgcctccccaacggcccatgctagaatagcttgtgcccagaaaacaaacagtgacacttcatctcttcagcgtcagaaaatgggcatagaatgtacccatgcaattgaatgtatctcattctccactggcatagtagatataaactattcctttgcctaccttttactgccttatcctggaaatattggggaaaataagccatatcagtgagatttacctaaaaacaaaggaaggaaagtcactatggaaaccaagtagatgctttttgtaagtttggtggagcataactggcccagaagtctgggtgcctgagttctagttcgtgctctgtcaactggtagatttgtaattctaggtcttggttttcttacctggtgaataagtcatgatctctaaaacccttcctgcccttaatattgtctgaatttcaaggggaaaaaaaaaatctggttcctttaattatttttttttaacacttaaattcctaactttattagacaagaagtatggcccacttaacagttaaggaacgtaaatttgttattggctcgaaataataatttgacacaatactagtcaaccatttagaggccttggaaaaagaagaggaacagcactgaaaattccaagtatgattggaaattatctgggagcggggaattaaatattcaatgcatgaaagcaattgtactggcttctgggaaaaaggaaacaagaacattgctatggaacttgttacccagagaaaggaagtgaaaagatttacaattataagcacgaaattcattggcagattacctgctttatctacagacagattgttttggggtttggttttgtctaggcagcctctggccaggctccttaattgcttgctctgctaatatttcagcttcctctcttgactccttgaggaaccaaccgctctttggaagacaaacacttagccacctctgtgctccagggtaaccctgagaagctctgctgtctggggcaagctttctttccaaagggaatgagaggaaggcaagcaggcagggtcctgcagcgtcaggccttctggggaaagtttcctcattttgtttgacagggtcctcagtacatcagacacccagatttgaatataagttcagagcctgatctcaagctaaatcagaatgctttggggactaaccatgatcgagaattggccaaatagtatggcatataaacagccatccagccagccgcaagtaaaggaacgtttgatccttggcaccttaaatgattgattgccttcaataggcaaactgctggtctggaaatctcgttgaaggctgaatacttcatgcggagtaggacaagccttagcccaccttcaggttgaaaggaaaggccataggactcaaaagataatgactctgaaactaaactccttccttctgaagctgacagaggtacttagtgcatctcaagactccatctcataaaactcatttgtgagggatttgctctagatttttctaaacattttttcatctattgtccagacttgcaaatccagtgtggacctgatggagatacccttcacacctgcgctcccaccccctcggcagggagacgtctcagtagaggagaacacacccattatgctgggatttgtatttataaatcacttcccttttagggatgagcggtgtggggcgtgtgtgcgtgtgagtgtatgcgcgtgcgtgtgtgaccctcaagtgtactttgctcaatttagacgtgcagtatttccagaaacaatgaaaaaagtaagatgttttcttctttatgattctgctcaaaacaccacgtgccgcctcagagctttttctagagcctcggtcctcaatgacgcgcttgacctgttgatgcctcagcccagcgaagcccctcacctgtgccccgggcgacagctcttcagtgtgcagtgcaggcctggggtggactgccaggccttcgctctgtgccagcaacgccgttcttgttgctcctccatgaacaggggtacaagccctggcccctcctcgacactaagccccccacagactcagcctccaaggaaccgctgagcacccttgaagcatgtcattgtcagtgatacctttttattctatggaactctaacctattcgtgtcatattgaccttttgctgcatgagtcataaattatgaaatcagtcttacagtttttgaaatgtagccagcatttgtaaggctaaacctttttcatgaactgaatttaagtgaataaccaagccacagttcctcctcaaatggagagtgatgatcgacatttgaatctctttgccctttccaacggctatggcatcaggttctaaaataagctcgtaatttttcctgttattttaataatatggaaatattagcatagtgtttcttttgatagtgatagactataatccatatttaaattttatagagaagaaattttattgtactgtgatgtagatatttattatccaggtaaggatttgcccggtgtgtattttttacaattgagacattttactttaatctttaaaaaaaatgcattaaaaacacactcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaccagactgggggaaaaaaggtttggccttatcacagaatttttactgtgctgtataaatgtttgcaaatgcgaaaagtgtgcatttatagtgtgtttccacattaattaatgccgccttcaagagcaatattgtgcaggtaaaacgctgtttgtggctttctgttgcacagttaaagctgacccaccctatgcacaagacaatcaaatataaatctgtcctcctcaggatgcagataatactcatgtaaattatggagcacaatgtaagacaaaaggagacactttacatatgtattgttgatacagaaattatcagggcatgaatgagctgatgtgacattatgccacttctttcttttggttctcccttattaacttggcatttttaatttgaccatagagccaaattagttctccatgctttcttcgtagaaaatccttttttttcccataatgttttcatgccctgagaatcagaaaaatactacagaatagaaaaagatttacagtcattggaagatttgtgttttgcaaacagtgttaagtgatattgctagatggtgatatttttttcagcctaaaactctgttgaaatctgtgatcaaaatgttttaaactatccaaaaaaaatttgtatatttgggaaaaatggatttttacatagcttttgtatgcagatataaaactgtaattatgaatatagtgggcgtagataaactcataagcttaaattctaaaaaagaaaaagcttataacagatatattttcctgtctctttctttaaatattattattttctacataggcaaagagttgcctgctcttctcacttcagctgctgccaaaagacggaaccacggatgtaaggacatttatttcataaataaacatctactagaataagcaaatttacttgagaagaaactatggagggagagaagaaactaagtaaaatgctgatggggggttacctctttggaaggggccacaaagatgaagggaggagagaggtgaagttttgcagctcaaggacaacattcatcttctcatctcaaattattcaggaatattactaatggaattatgttaacatcagctgccaacatatatctcaatctctgttgccctgaacacatgttaattgagattctttctatgacaagtaacaaaaagctaactcaaactggcttaagcagaaagctaattattgactttaatatctgggatctagggtattgcataccaaagcttcaggcatggctggatctgggtgcacttactcagtattctcaggaagctcctttttttgtcattcatgtagacttaacattcacatggcctttcaccttacggtggcctccaatagctccaggatgagctttacagctccaaatatagtgaaaggagaatttcttttctccaacaattctaatgaaaattctggcctaattctcactggcccaagttcagtcatgtgcccattcctgagccaatcactgtggtgaggaaaacagatgcataaccaaccttatcctcaggaatcctggaactgggtgaggggaaagagggacagtcagcttcatctaaactatggactgagagttgaggcaagatgattcctgaaagaaaattctaagtcttgctgctataagtggaagagaatggtgggcaagcaaaagcaaccagtgcccacaccaaaggtaaatctaaaacaacatcccatttcagtacagcaagcggttctccttcacacagaggaagctcatctccaagtttttatttggccaggacatgaaccaaataaacaccttccaaagaaaaaaaaaaaaaaaaa

//

Annotations: