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2025-05-09 17:21:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001184 8258 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens ataxia telangiectasia and Rad3 related (ATR), mRNA.
ACCESSION NM_001184 XM_940761
VERSION NM_001184.3 GI:157266316
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8258)
AUTHORS Somyajit,K., Basavaraju,S., Scully,R. and Nagaraju,G.
TITLE ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA
double-strand break-induced checkpoint activation and repair
JOURNAL Mol. Cell. Biol. 33 (9), 1830-1844 (2013)
PUBMED 23438602
REMARK GeneRIF: hXRCC3 S225 phosphorylation is mediated by ATR via an
ATM-dependent signaling pathway.
REFERENCE 2 (bases 1 to 8258)
AUTHORS Ding,G., Liu,H.D., Liang,H.X., Ni,R.F., Ding,Z.Y., Ni,G.Y.,
Hua,H.W. and Xu,W.G.
TITLE HIF1-regulated ATRIP expression is required for hypoxia induced ATR
activation
JOURNAL FEBS Lett. 587 (7), 930-935 (2013)
PUBMED 23454212
REMARK GeneRIF: indicate that ATRIP is a direct target gene of HIF-1, and
the increased ATRIP then activates the ATR signaling pathway under
hypoxia.
REFERENCE 3 (bases 1 to 8258)
AUTHORS Liu,S., Ho,C.K., Ouyang,J. and Zou,L.
TITLE Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient
DNA damage signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (6), 2175-2180 (2013)
PUBMED 23345434
REMARK GeneRIF: as an ATR-associated kinase, Nek1 enhances the stability
and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for
a robust DNA damage response
REFERENCE 4 (bases 1 to 8258)
AUTHORS Xie,L., Gazin,C., Park,S.M., Zhu,L.J., Debily,M.A., Kittler,E.L.,
Zapp,M.L., Lapointe,D., Gobeil,S., Virbasius,C.M. and Green,M.R.
TITLE A synthetic interaction screen identifies factors selectively
required for proliferation and TERT transcription in p53-deficient
human cancer cells
JOURNAL PLoS Genet. 8 (12), E1003151 (2012)
PUBMED 23284306
REMARK GeneRIF: Our collective results identify a regulatory pathway
involving ETV1, ATR, and TERT that is preferentially important for
proliferation of diverse p53- cancer cells
REFERENCE 5 (bases 1 to 8258)
AUTHORS Chiu,Y.T., Liu,J., Tang,K., Wong,Y.C., Khanna,K.K. and Ling,M.T.
TITLE Inactivation of ATM/ATR DNA damage checkpoint promotes androgen
induced chromosomal instability in prostate epithelial cells
JOURNAL PLoS ONE 7 (12), E51108 (2012)
PUBMED 23272087
REMARK GeneRIF: ATM/ATR inactivation is a crucial step in promoting
androgen-induced genomic instability and prostate carcinogenesis
REFERENCE 6 (bases 1 to 8258)
AUTHORS Wright,J.A., Keegan,K.S., Herendeen,D.R., Bentley,N.J., Carr,A.M.,
Hoekstra,M.F. and Concannon,P.
TITLE Protein kinase mutants of human ATR increase sensitivity to UV and
ionizing radiation and abrogate cell cycle checkpoint control
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (13), 7445-7450 (1998)
PUBMED 9636169
REFERENCE 7 (bases 1 to 8258)
AUTHORS Cliby,W.A., Roberts,C.J., Cimprich,K.A., Stringer,C.M., Lamb,J.R.,
Schreiber,S.L. and Friend,S.H.
TITLE Overexpression of a kinase-inactive ATR protein causes sensitivity
to DNA-damaging agents and defects in cell cycle checkpoints
JOURNAL EMBO J. 17 (1), 159-169 (1998)
PUBMED 9427750
REFERENCE 8 (bases 1 to 8258)
AUTHORS Bentley,N.J., Holtzman,D.A., Flaggs,G., Keegan,K.S., DeMaggio,A.,
Ford,J.C., Hoekstra,M. and Carr,A.M.
TITLE The Schizosaccharomyces pombe rad3 checkpoint gene
JOURNAL EMBO J. 15 (23), 6641-6651 (1996)
PUBMED 8978690
REFERENCE 9 (bases 1 to 8258)
AUTHORS Keegan,K.S., Holtzman,D.A., Plug,A.W., Christenson,E.R.,
Brainerd,E.E., Flaggs,G., Bentley,N.J., Taylor,E.M., Meyn,M.S.,
Moss,S.B., Carr,A.M., Ashley,T. and Hoekstra,M.F.
TITLE The Atr and Atm protein kinases associate with different sites
along meiotically pairing chromosomes
JOURNAL Genes Dev. 10 (19), 2423-2437 (1996)
PUBMED 8843195
REFERENCE 10 (bases 1 to 8258)
AUTHORS Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L.
TITLE cDNA cloning and gene mapping of a candidate human cell cycle
checkpoint protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (7), 2850-2855 (1996)
PUBMED 8610130
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC346860.1, U49844.1, U76308.1
and BE859077.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 14, 2007 this sequence version replaced gi:20143978.
Summary: The protein encoded by this gene belongs the
PI3/PI4-kinase family, and is most closely related to ATM, a
protein kinase encoded by the gene mutated in ataxia
telangiectasia. This protein and ATM share similarity with
Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene
required for cell cycle arrest and DNA damage repair in response to
DNA damage. This kinase has been shown to phosphorylate checkpoint
kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor
suppressor protein BRCA1. Mutations of this gene are associated
with Seckel syndrome. An alternatively spliced transcript variant
of this gene has been reported, however, its full length nature is
not known. Transcript variants utilizing alternative polyA sites
exist. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U76308.1, Y09077.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-17 DC346860.1 2-18
18-4342 U49844.1 1-4325
4343-7996 U76308.1 4300-7953
7997-8258 BE859077.1 1-262 c
FEATURES Location/Qualifiers
source 1..8258
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q23"
gene 1..8258
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="ataxia telangiectasia and Rad3 related"
/db_xref="GeneID:545"
/db_xref="HGNC:882"
/db_xref="MIM:601215"
exon 1..181
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
misc_feature 99..101
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="upstream in-frame stop codon"
CDS 123..8057
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/EC_number="2.7.11.1"
/note="MEC1, mitosis entry checkpoint 1, homolog; Rad3
related protein; FRAP-related protein-1; protein kinase
ATR; FRAP-related protein 1; ataxia telangiectasia and
Rad3-related protein"
/codon_start=1
/product="serine/threonine-protein kinase ATR"
/protein_id="NP_001175.2"
/db_xref="GI:157266317"
/db_xref="CCDS:CCDS3124.1"
/db_xref="GeneID:545"
/db_xref="HGNC:882"
/db_xref="MIM:601215"
/translation="
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM
"
misc_feature 1404..1406
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13535.3); phosphorylation site"
misc_feature 2517..2627
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13535.3);
Region: HEAT 1"
misc_feature 3477..3794
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="Domain in UVSB PI-3 kinase, MEI-41 and ESR-1;
Region: UME; smart00802"
/db_xref="CDD:129038"
misc_feature 4107..4217
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13535.3);
Region: HEAT 2"
misc_feature 5433..6398
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="FAT domain; Region: FAT; pfam02259"
/db_xref="CDD:202179"
misc_feature 6087..6089
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q13535.3); phosphorylation site"
misc_feature 6999..7823
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="ATR (Ataxia telangiectasia and Rad3-related),
catalytic domain; The ATR catalytic domain subfamily is
part of a larger superfamily that includes the catalytic
domains of other kinases such as the typical
serine/threonine/tyrosine protein kinases (PKs); Region:
PIKKc_ATR; cd00892"
/db_xref="CDD:119418"
misc_feature order(7029..7031,7035..7043,7047..7049,7095..7097,
7101..7103,7110..7112,7215..7217,7251..7262,7275..7277,
7560..7562,7566..7568,7599..7604)
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:119418"
misc_feature 7092..7823
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="Phosphoinositide 3-kinase, catalytic domain;
Region: PI3Kc; smart00146"
/db_xref="CDD:197542"
misc_feature 7536..7562
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="catalytic loop [active]"
/db_xref="CDD:119418"
misc_feature 7602..7670
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:119418"
misc_feature 7956..8054
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/note="FATC domain; Region: FATC; pfam02260"
/db_xref="CDD:202180"
exon 182..273
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 274..414
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 390
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:28897763"
exon 415..1292
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 754
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2227928"
variation 938
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34685245"
variation 1013
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2229033"
variation 1068
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897764"
exon 1293..1471
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 1448
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28897765"
exon 1472..1663
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 1664..1854
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 1855..2007
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 1898
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2227930"
variation 1937
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2227929"
exon 2008..2200
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 2072
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28910270"
exon 2201..2463
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 2464..2654
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 2655..2755
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 2756..2927
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 2928..3098
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 2997
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28910271"
exon 3099..3293
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 3242
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:28910272"
exon 3294..3479
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 3480..3572
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 3573..3703
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 3704..3847
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 3848..3941
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 3942..4067
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4068..4274
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4275..4388
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4389..4504
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4505..4625
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4626..4763
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4764..4974
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 4975..5153
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 5154..5318
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 5319..5410
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 5330
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2227931"
exon 5411..5502
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 5503..5680
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 5582
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2227932"
exon 5681..5860
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 5861..6020
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 6021..6200
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 6201..6343
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 6344..6441
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 6442..6674
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 6516
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:28910273"
exon 6675..6809
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 6810..7019
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7020..7163
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7164..7314
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7315..7471
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 7396
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229032"
variation 7422
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:33972295"
exon 7472..7625
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7626..7777
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7778..7883
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
exon 7884..8251
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/inference="alignment:Splign:1.39.8"
variation 7997
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1802904"
variation 8023
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804758"
STS 8100..8183
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
/standard_name="STS-U76308"
/db_xref="UniSTS:71733"
polyA_signal 8230..8235
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
polyA_site 8251
/gene="ATR"
/gene_synonym="FCTCS; FRP1; MEC1; SCKL; SCKL1"
ORIGIN
ttccgggaggagttttggcctccacacggctccgtcgggcgccgcgctcttccggcagcggtagctttggagacgccgggaacccgcgttggcgtggttgactagtgcctcgcagcctcagcatgggggaacatggcctggagctggcttccatgatccccgccctgcgggagctgggcagtgccacaccagaggaatataatacagttgtacagaagccaagacaaattctgtgtcaattcattgaccggatacttacagatgtaaatgttgttgctgtagaacttgtaaagaaaactgactctcagccaacctccgtgatgttgcttgatttcatccagcatatcatgaaatcctccccacttatgtttgtaaatgtgagtggaagccatgaggccaaaggcagttgtattgaattcagtaattggatcataacgagacttctgcggattgcagcaactccctcctgtcatttgttacacaagaaaatctgtgaagtcatctgttcattattatttctttttaaaagcaagagtcctgctatttttggggtactcacaaaagaattattacaactttttgaagacttggtttacctccatagaagaaatgtgatgggtcatgctgtggaatggccagtggtcatgagccgatttttaagtcaattagatgaacacatgggatatttacaatcagctcctttgcagttgatgagtatgcaaaatttagaatttattgaagtcactttattaatggttcttactcgtattattgcaattgtgttttttagaaggcaagaactcttactttggcagataggttgtgttctgctagagtatggtagtccaaaaattaaatccctagcaattagctttttaacagaactttttcagcttggaggactaccagcacaaccagctagcacttttttcagctcatttttggaattattaaaacaccttgtagaaatggatactgaccaattgaaactctatgaagagccattatcaaagctgataaagacactatttccctttgaagcagaagcttatagaaatattgaacctgtctatttaaatatgctgctggaaaaactctgtgtcatgtttgaagacggtgtgctcatgcggcttaagtctgatttgctaaaagcagctttgtgccatttactgcagtatttccttaaatttgtgccagctgggtatgaatctgctttacaagtcaggaaggtctatgtgagaaatatttgtaaagctcttttggatgtgcttggaattgaggtagatgcagagtacttgttgggcccactttatgcagctttgaaaatggaaagtatggaaatcattgaggagattcaatgccaaactcaacaggaaaacctcagcagtaatagtgatggaatatcacccaaaaggcgtcgtctcagctcgtctctaaacccttctaaaagagcaccaaaacagactgaggaaattaaacatgtggacatgaaccaaaagagcatattatggagtgcactgaaacagaaagctgaatcccttcagatttcccttgaatacagtggcctaaagaatcctgttattgagatgttagaaggaattgctgttgtcttacaactgactgctctgtgtactgttcattgttctcatcaaaacatgaactgccgtactttcaaggactgtcaacataaatccaagaagaaaccttctgtagtgataacttggatgtcattggatttttacacaaaagtgcttaagagctgtagaagtttgttagaatctgttcagaaactggacctggaggcaaccattgataaggtggtgaaaatttatgatgctttgatttatatgcaagtaaacagttcatttgaagatcatatcctggaagatttatgtggtatgctctcacttccatggatttattcccattctgatgatggctgtttaaagttgaccacatttgccgctaatcttctaacattaagctgtaggatttcagatagctattcaccacaggcacaatcacgatgtgtgtttcttctgactctgtttccaagaagaatattccttgagtggagaacagcagtttacaactgggccctgcagagctcccatgaagtaatccgggctagttgtgttagtggattttttatcttattgcagcagcagaattcttgtaacagagttcccaagattcttatagataaagtcaaagatgattctgacattgtcaagaaagaatttgcttctatacttggtcaacttgtctgtactcttcacggcatgttttatctgacaagttctttaacagaacctttctctgaacacggacatgtggacctcttctgtaggaacttgaaagccacttctcaacatgaatgttcatcttctcaactaaaagcttctgtctgcaagccattccttttcctactgaaaaaaaaaatacctagtccagtaaaacttgctttcatagataatctacatcatctttgtaagcatcttgattttagagaagatgaaacagatgtaaaagcagttcttggaactttattaaatttaatggaagatccagacaaagatgttagagtggcttttagtggaaatatcaagcacatattggaatccttggactctgaagatggatttataaaggagctttttgtcttaagaatgaaggaagcatatacacatgcccaaatatcaagaaataatgagctgaaggataccttgattcttacaacaggggatattggaagggccgcaaaaggagatttggtaccatttgcactcttacacttattgcattgtttgttatccaagtcagcatctgtctctggagcagcatacacagaaattagagctctggttgcagctaaaagtgttaaactgcaaagttttttcagccagtataagaaacccatctgtcagtttttggtagaatcccttcactctagtcagatgacagcacttccgaatactccatgccagaatgctgacgtgcgaaaacaagatgtggctcaccagagagaaatggctttaaatacgttgtctgaaattgccaacgttttcgactttcctgatcttaatcgttttcttactaggacattacaagttctactacctgatcttgctgccaaagcaagccctgcagcttctgctctcattcgaactttaggaaaacaattaaatgtcaatcgtagagagattttaataaacaacttcaaatatattttttctcatttggtctgttcttgttccaaagatgaattagaacgtgcccttcattatctgaagaatgaaacagaaattgaactggggagcctgttgagacaagatttccaaggattgcataatgaattattgctgcgtattggagaacactatcaacaggtttttaatggtttgtcaatacttgcctcatttgcatccagtgatgatccatatcagggcccgagagatatcatatcacctgaactgatggctgattatttacaacccaaattgttgggcattttggctttttttaacatgcagttactgagctctagtgttggcattgaagataagaaaatggccttgaacagtttgatgtctttgatgaagttaatgggacccaaacatgtcagttctgtgagggtgaagatgatgaccacactgagaactggccttcgattcaaggatgattttcctgaattgtgttgcagagcttgggactgctttgttcgctgcctggatcatgcttgtctgggctcccttctcagtcatgtaatagtagctttgttacctcttatacacatccagcctaaagaaactgcagctatcttccactacctcataattgaaaacagggatgctgtgcaagattttcttcatgaaatatattttttacctgatcatccagaattaaaaaagataaaagccgttctccaggaatacagaaaggagacctctgagagcactgatcttcagacaactcttcagctctctatgaaggccattcaacatgaaaatgtcgatgttcgtattcatgctcttacaagcttgaaggaaaccttgtataaaaatcaggaaaaactgataaagtatgcaacagacagtgaaacagtagaacctattatctcacagttggtgacagtgcttttgaaaggttgccaagatgcaaactctcaagctcggttgctctgtggggaatgtttaggggaattgggggcgatagatccaggtcgattagatttctcaacaactgaaactcaaggaaaagattttacatttgtgactggagtagaagattcaagctttgcctatggattattgatggagctaacaagagcttaccttgcgtatgctgataatagccgagctcaagattcagctgcctatgccattcaggagttgctttctatttatgactgtagagagatggagaccaacggcccaggtcaccaattgtggaggagatttcctgagcatgttcgggaaatactagaacctcatctaaataccagatacaagagttctcagaagtcaaccgattggtctggagtaaagaagccaatttacttaagtaaattgggtagtaactttgcagaatggtcagcatcttgggcaggttatcttattacaaaggttcgacatgatcttgccagtaaaattttcacctgctgtagcattatgatgaagcatgatttcaaagtgaccatctatcttcttccacatattctggtgtatgtcttactgggttgtaatcaagaagatcagcaggaggtttatgcagaaattatggcagttctaaagcatgacgatcagcataccataaatacccaagacattgcatctgatctgtgtcaactcagtacacagactgtgttctccatgcttgaccatctcacacagtgggcaaggcacaaatttcaggcactgaaagctgagaaatgtccacacagcaaatcaaacagaaataaggtagactcaatggtatctactgtggattatgaagactatcagagtgtaacccgttttctagacctcataccccaggatactctggcagtagcttcctttcgctccaaagcatacacacgagctgtaatgcactttgaatcatttattacagaaaagaagcaaaatattcaggaacatcttggatttttacagaaattgtatgctgctatgcatgaacctgatggagtggccggagtcagtgcaattagaaaggcagaaccatctctaaaagaacagatccttgaacatgaaagccttggcttgctgagggatgccactgcttgttatgacagggctattcagctagaaccagaccagatcattcattatcatggtgtagtaaagtccatgttaggtcttggtcagctgtctactgttatcactcaggtgaatggagtgcatgctaacaggtccgagtggacagatgaattaaacacgtacagagtggaagcagcttggaaattgtcacagtgggatttggtggaaaactatttggcagcagatggaaaatctacaacatggagtgtcagactgggacagctattattatcagccaaaaaaagagatatcacagctttttatgactcactgaaactagtgagagcagaacaaattgtacctctttcagctgcaagctttgaaagaggctcctaccaacgaggatatgaatatattgtgagattgcacatgttatgtgagttggagcatagcatcaaaccacttttccagcattctccaggtgacagttctcaagaagattctctaaactgggtagctcgactagaaatgacccagaattcctacagagccaaggagcctatcctggctctccggagggctttactaagcctcaacaaaagaccagattacaatgaaatggttggagaatgctggctgcagagtgccagggtagctagaaaggctggtcaccaccagacagcctacaatgctctccttaatgcaggggaatcacgactcgctgaactgtacgtggaaagggcaaagtggctctggtccaagggtgatgttcaccaggcactaattgttcttcaaaaaggtgttgaattatgttttcctgaaaatgaaaccccacctgagggtaagaacatgttaatccatggtcgagctatgctactagtgggccgatttatggaagaaacagctaactttgaaagcaatgcaattatgaaaaaatataaggatgtgaccgcgtgcctgccagaatgggaggatgggcatttttaccttgccaagtactatgacaaattgatgcccatggtcacagacaacaaaatggaaaagcaaggtgatctcatccggtatatagttcttcattttggcagatctctacaatatggaaatcagttcatatatcagtcaatgccacgaatgttaactctatggcttgattatggtacaaaggcatatgaatgggaaaaagctggccgctccgatcgtgtacaaatgaggaatgatttgggtaaaataaacaaggttatcacagagcatacaaactatttagctccatatcaatttttgactgctttttcacaattgatctctcgaatttgtcattctcacgatgaagtttttgttgtcttgatggaaataatagccaaagtatttctagcctatcctcaacaagcaatgtggatgatgacagctgtgtcaaagtcatcttatcccatgcgtgtgaacagatgcaaggaaatcctcaataaagctattcatatgaaaaaatccttagagaagtttgttggagatgcaactcgcctaacagataagcttctagaattgtgcaataaaccggttgatggaagtagttccacattaagcatgagcactcattttaaaatgcttaaaaagctggtagaagaagcaacatttagtgaaatcctcattcctctacaatcagtcatgatacctacacttccatcaattctgggtacccatgctaaccatgctagccatgaaccatttcctggacattgggcctatattgcagggtttgatgatatggtggaaattcttgcttctcttcagaaaccaaagaagatttctttaaaaggctcagatggaaagttctacatcatgatgtgtaagccaaaagatgacctgagaaaggattgtagactaatggaattcaattccttgattaataagtgcttaagaaaagatgcagagtctcgtagaagagaacttcatattcgaacatatgcagttattccactaaatgatgaatgtgggattattgaatgggtgaacaacactgctggtttgagacctattctgaccaaactatataaagaaaagggagtgtatatgacaggaaaagaacttcgccagtgtatgctaccaaagtcagcagctttatctgaaaaactcaaagtattccgagaatttctcctgcccaggcatcctcctatttttcatgagtggtttctgagaacattccctgatcctacatcatggtacagtagtagatcagcttactgccgttccactgcagtaatgtcaatggttggttatattctggggcttggagaccgtcatggtgaaaatattctctttgattctttgactggtgaatgcgtacatgtagatttcaattgtcttttcaataagggagaaacctttgaagttccagaaattgtgccatttcgcctgactcataatatggttaatggaatgggtcctatgggaacagagggtctttttcgaagagcatgtgaagttacaatgaggctgatgcgtgatcagcgagagcctttaatgagtgtcttaaagacttttctacatgatcctcttgtggaatggagtaaaccagtgaaagggcattccaaagcgccactgaatgaaactggagaagttgtcaatgaaaaggccaagacccatgttcttgacattgagcagcgactacaaggtgtaatcaagactcgaaatagagtgacaggactgccgttatctattgaaggacatgtgcattaccttatacaggaagctactgatgaaaacttactatgccagatgtatcttggttggactccatatatgtgaaatgaaattatgtaaaagaatatgttaataatctaaaagtaatgcatttggtatgaatctgtggttgtatctgttcaattctaaagtacaacataaatttacgttctcagcaactgttatttctctctgatcattaattatatgtaaaataatatacattcagttattaagaaataaactgctttcttaatacaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:545 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:545 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:545 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:545 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:545 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:545 -> Molecular function: GO:0032405 [MutLalpha complex binding] evidence: IDA
GeneID:545 -> Molecular function: GO:0032407 [MutSalpha complex binding] evidence: IDA
GeneID:545 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IDA
GeneID:545 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:545 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:545 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: TAS
GeneID:545 -> Biological process: GO:0007049 [cell cycle] evidence: TAS
GeneID:545 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
GeneID:545 -> Biological process: GO:0008156 [negative regulation of DNA replication] evidence: IMP
GeneID:545 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:545 -> Biological process: GO:0034644 [cellular response to UV] evidence: IMP
GeneID:545 -> Biological process: GO:0043393 [regulation of protein binding] evidence: IEA
GeneID:545 -> Biological process: GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] evidence: IMP
GeneID:545 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:545 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IDA
GeneID:545 -> Biological process: GO:0090399 [replicative senescence] evidence: IMP
GeneID:545 -> Cellular component: GO:0001741 [XY body] evidence: IEA
GeneID:545 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:545 -> Cellular component: GO:0005694 [chromosome] evidence: ISS
GeneID:545 -> Cellular component: GO:0016605 [PML body] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001175 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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