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2025-05-09 17:04:17, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001160230 3485 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens adenosine deaminase, RNA-specific, B1 (ADARB1),
transcript variant 7, mRNA.
ACCESSION NM_001160230
VERSION NM_001160230.1 GI:237681090
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3485)
AUTHORS Galeano,F., Rossetti,C., Tomaselli,S., Cifaldi,L., Lezzerini,M.,
Pezzullo,M., Boldrini,R., Massimi,L., Di Rocco,C.M., Locatelli,F.
and Gallo,A.
TITLE ADAR2-editing activity inhibits glioblastoma growth through the
modulation of the CDC14B/Skp2/p21/p27 axis
JOURNAL Oncogene 32 (8), 998-1009 (2013)
PUBMED 22525274
REMARK GeneRIF: Findings demonstrate that post-transcriptional A-to-I RNA
editing might be crucial for glioblastoma pathogenesis, identify
ADAR2-editing enzyme as a candidate tumor suppressor gene and
provide proof that ADAR2 may represent a suitable target.
REFERENCE 2 (bases 1 to 3485)
AUTHORS Yamashita,T., Hideyama,T., Teramoto,S. and Kwak,S.
TITLE The abnormal processing of TDP-43 is not an upstream event of
reduced ADAR2 activity in ALS motor neurons
JOURNAL Neurosci. Res. 73 (2), 153-160 (2012)
PUBMED 22414730
REMARK GeneRIF: ADAR2 activity does not consistently change due to the
overexpression or knockdown of TDP-43 or the expression of abnormal
TDP-43 in amyotrophic lateral sclerosis (ALS) motor neurons.
REFERENCE 3 (bases 1 to 3485)
AUTHORS Kawahara,Y., Ito,K., Ito,M., Tsuji,S. and Kwak,S.
TITLE Novel splice variants of human ADAR2 mRNA: skipping of the exon
encoding the dsRNA-binding domains, and multiple C-terminal splice
sites
JOURNAL Gene 363, 193-201 (2005)
PUBMED 16297572
REFERENCE 4 (bases 1 to 3485)
AUTHORS Slavov,D. and Gardiner,K.
TITLE Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2
genes and transcripts: conservation and diversity in editing site
sequence and alternative splicing patterns
JOURNAL Gene 299 (1-2), 83-94 (2002)
PUBMED 12459255
REFERENCE 5 (bases 1 to 3485)
AUTHORS Gerber,A., O'Connell,M.A. and Keller,W.
TITLE Two forms of human double-stranded RNA-specific editase 1 (hRED1)
generated by the insertion of an Alu cassette
JOURNAL RNA 3 (5), 453-463 (1997)
PUBMED 9149227
REFERENCE 6 (bases 1 to 3485)
AUTHORS Lai,F., Chen,C.X., Carter,K.C. and Nishikura,K.
TITLE Editing of glutamate receptor B subunit ion channel RNAs by four
alternatively spliced DRADA2 double-stranded RNA adenosine
deaminases
JOURNAL Mol. Cell. Biol. 17 (5), 2413-2424 (1997)
PUBMED 9111310
REFERENCE 7 (bases 1 to 3485)
AUTHORS Yang,J.H., Sklar,P., Axel,R. and Maniatis,T.
TITLE Purification and characterization of a human RNA adenosine
deaminase for glutamate receptor B pre-mRNA editing
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (9), 4354-4359 (1997)
PUBMED 9113993
REFERENCE 8 (bases 1 to 3485)
AUTHORS Mittaz,L., Scott,H.S., Rossier,C., Seeburg,P.H., Higuchi,M. and
Antonarakis,S.E.
TITLE Cloning of a human RNA editing deaminase (ADARB1) of glutamate
receptors that maps to chromosome 21q22.3
JOURNAL Genomics 41 (2), 210-217 (1997)
PUBMED 9143496
REFERENCE 9 (bases 1 to 3485)
AUTHORS O'Connell,M.A., Gerber,A. and Keller,W.
TITLE Purification of human double-stranded RNA-specific editase 1
(hRED1) involved in editing of brain glutamate receptor B pre-mRNA
JOURNAL J. Biol. Chem. 272 (1), 473-478 (1997)
PUBMED 8995285
REFERENCE 10 (bases 1 to 3485)
AUTHORS Melcher,T., Maas,S., Herb,A., Sprengel,R., Seeburg,P.H. and
Higuchi,M.
TITLE A mammalian RNA editing enzyme
JOURNAL Nature 379 (6564), 460-464 (1996)
PUBMED 8559253
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC030663.1, AB194373.1 and BU726292.1.
Summary: This gene encodes the enzyme responsible for pre-mRNA
editing of the glutamate receptor subunit B by site-specific
deamination of adenosines. Studies in rat found that this enzyme
acted on its own pre-mRNA molecules to convert an AA dinucleotide
to an AI dinucleotide which resulted in a new splice site.
Alternative splicing of this gene results in several transcript
variants, some of which have been characterized by the presence or
absence of an ALU cassette insert and a short or long C-terminal
region. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (7), also known as ADAR2d, lacks
the ALU cassette insert and an alternate segment in the 3' coding
region, compared to variant 2. The resulting isoform (7) lacks an
internal segment and has a shorter and distinct C-terminus,
compared to isoform 2, and contains the short C-terminal region.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB194373.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
undergoes RNA editing :: PMID: 11717408, 12045112
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-22 BC030663.1 10-31
23-2802 AB194373.1 1-2780
2803-3083 AB194373.1 2782-3062
3084-3464 AB194373.1 3064-3444
3465-3485 BU726292.1 1-21 c
FEATURES Location/Qualifiers
source 1..3485
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="21"
/map="21q22.3"
gene 1..3485
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="adenosine deaminase, RNA-specific, B1"
/db_xref="GeneID:104"
/db_xref="HGNC:226"
/db_xref="MIM:601218"
exon 1..216
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
exon 217..388
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
misc_feature 259..261
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="upstream in-frame stop codon"
variation 284
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190895413"
exon 389..463
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
CDS 436..2460
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="isoform 7 is encoded by transcript variant 7;
adenosine deaminase, RNA-specific, B1 (RED1 homolog rat);
adenosine deaminase, RNA-specific, B1 (homolog of rat
RED1); RNA editase; double-stranded RNA-specific editase
1; RNA editing deaminase 1; RNA-editing enzyme 1;
RNA-editing deaminase 1; dsRNA adenosine deaminase DRADA2"
/codon_start=1
/product="double-stranded RNA-specific editase 1 isoform
7"
/protein_id="NP_001153702.1"
/db_xref="GI:237681091"
/db_xref="GeneID:104"
/db_xref="HGNC:226"
/db_xref="MIM:601218"
/translation="
MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKVH
"
misc_feature 670..>813
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(685..690,808..813)
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 1138..>1275
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(1138..1140,1156..1161,1270..1275)
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 1399..2451
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="tRNA-specific and double-stranded RNA adenosine
deaminase (RNA-specific editase); Region: ADEAMc;
smart00552"
/db_xref="CDD:128825"
exon 464..1398
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 493
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142180298"
variation 494
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:375341807"
variation 511
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201653105"
variation 528
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370431644"
variation 538
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141594032"
variation 563
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200269366"
variation 569
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144363543"
variation 603
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201038678"
variation 605
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:147822904"
variation 614
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141269164"
variation 629
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201786934"
variation 631
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143795052"
variation 632
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150318827"
variation 663
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2838798"
variation 670
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148374145"
variation 713..714
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="t"
/db_xref="dbSNP:36102117"
variation 741..742
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="g"
/db_xref="dbSNP:35259738"
variation 741
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150871717"
variation 744
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115658841"
variation 753
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201356458"
variation 778
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:78867942"
variation 792
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:146833412"
variation 796
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199805536"
variation 803
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143261942"
variation 849
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374872814"
variation 853
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367618294"
variation 892
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143826821"
variation 921
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148155796"
variation 968
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142958161"
variation 993
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146135960"
variation 1008
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61735850"
variation 1024..1025
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="g"
/db_xref="dbSNP:34030195"
variation 1066
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:78152471"
variation 1070
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200222908"
variation 1102
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145235270"
variation 1106
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199697177"
variation 1128
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377458378"
variation 1158
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139706517"
variation 1188
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:73384785"
variation 1194
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200567642"
variation 1212
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150844459"
variation 1224
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139263374"
variation 1243
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370937062"
variation 1265
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149552510"
variation 1266
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201273628"
variation 1278
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61735851"
variation 1294
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142476560"
variation 1305
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200806468"
variation 1317
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140656510"
variation 1354
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147692665"
variation 1366
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145945840"
variation 1376
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370266307"
exon 1399..1513
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1410
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114027650"
variation 1413
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112127672"
variation 1464..1465
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="c"
/db_xref="dbSNP:35834898"
variation 1509
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147573765"
exon 1514..1682
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1521
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199843457"
variation 1563
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370335315"
variation 1627
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200625156"
exon 1683..1831
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1707
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:139637757"
variation 1719
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142574659"
variation 1740
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150188818"
variation 1792
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138735662"
exon 1832..2000
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1875
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="a"
/db_xref="dbSNP:34353015"
variation 1876
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183960739"
variation 1890
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190183213"
variation 1916
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201477864"
variation 1925
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150948356"
variation 1938
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:151225586"
variation 1944
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140716415"
variation 1971
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149878224"
exon 2001..2182
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2007
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139203173"
variation 2013
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201987444"
variation 2017
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146201109"
variation 2044
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367731799"
variation 2064
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372954828"
variation 2076
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146663117"
variation 2091
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370522638"
variation 2092
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183042891"
variation 2112
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377171441"
variation 2114
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187662077"
variation 2135
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192150622"
variation 2152
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142974408"
variation 2154
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:141463450"
exon 2183..2361
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2185
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202213478"
variation 2193
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371862858"
variation 2214
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374114165"
variation 2250
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200514838"
variation 2266
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143903410"
variation 2275
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188207954"
variation 2285
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148687014"
variation 2305
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:145150920"
variation 2306
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138974538"
variation 2307
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202057345"
variation 2328
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149395488"
exon 2362..2451
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2367
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367997843"
variation 2389
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143716305"
variation 2397
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051367"
variation 2422
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201552994"
variation 2427
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:141891675"
exon 2452..3468
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2457
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368699178"
variation 2470
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374500062"
variation 2476
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144075386"
variation 2536
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370941785"
variation 2544
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187657496"
variation 2705
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:4819035"
variation 2716
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146517855"
variation 2722
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141163172"
variation 2739
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804760"
variation 2747
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144872642"
variation 2783
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146796369"
variation 2872
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192150217"
variation 2959
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77712126"
variation 2970
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:79322398"
variation 2988
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:185670032"
variation 2995
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2838820"
variation 3003
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:116146935"
variation 3062
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111308125"
variation 3103
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370390751"
variation 3165
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375264198"
STS 3206..3419
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="Cda0pa11"
/db_xref="UniSTS:74782"
variation 3254
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051385"
STS 3266..3437
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="D21S1720E"
/db_xref="UniSTS:150776"
variation 3280
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140433470"
variation 3285
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73386760"
STS 3327..3450
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="G23228"
/db_xref="UniSTS:83279"
variation 3336
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11537553"
variation 3351
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377315991"
variation 3407
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:188985880"
variation 3410
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150434591"
variation 3467
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192378418"
ORIGIN
ctgaggcgctgaggcggccgtggcggcggcggcggcggcggcggcagcggcggccaagcggccaggttggcggccggggctccgggccgcgcgaggccacggccacgccgcgccgctgcgcacaaccaacgaggcagagcgccgcccggcgcgagactgcggccgaagcgtggggcgcgcgtgcggaggaccaggcgcggcgcggctgcggctgagagtggagcctttcaggctggcatggagagcttaaggggcaactgaaggagacacactggccaagcgcggagttctgcttacttcagtcctgctgagatactctctcagtccgctcgcaccgaaggaagctgccttgggatcagagcagacataaagctagaaaaatttcaagacagaaacagtctccgccagtcaagaaaccctcaaaagtattttgccatggatatagaagatgaagaaaacatgagttccagcagcactgatgtgaaggaaaaccgcaatctggacaacgtgtcccccaaggatggcagcacacctgggcctggcgagggctctcagctctccaatgggggtggtggtggccccggcagaaagcggcccctggaggagggcagcaatggccactccaagtaccgcctgaagaaaaggaggaaaacaccagggcccgtcctccccaagaacgccctgatgcagctgaatgagatcaagcctggtttgcagtacacactcctgtcccagactgggcccgtgcacgcgcctttgtttgtcatgtctgtggaggtgaatggccaggtttttgagggctctggtcccacaaagaaaaaggcaaaactccatgctgctgagaaggccttgaggtctttcgttcagtttcctaatgcctctgaggcccacctggccatggggaggaccctgtctgtcaacacggacttcacatctgaccaggccgacttccctgacacgctcttcaatggttttgaaactcctgacaaggcggagcctcccttttacgtgggctccaatggggatgactccttcagttccagcggggacctcagcttgtctgcttccccggtgcctgccagcctagcccagcctcctctccctgtcttaccaccattcccacccccgagtgggaagaatcccgtgatgatcttgaacgaactgcgcccaggactcaagtatgacttcctctccgagagcggggagagccatgccaagagcttcgtcatgtctgtggtcgtggatggtcagttctttgaaggctcggggagaaacaagaagcttgccaaggcccgggctgcgcagtctgccctggccgccatttttaacttgcacttggatcagacgccatctcgccagcctattcccagtgagggtcttcagctgcatttaccgcaggttttagctgacgctgtctcacgcctggtcctgggtaagtttggtgacctgaccgacaacttctcctcccctcacgctcgcagaaaagtgctggctggagtcgtcatgacaacaggcacagatgttaaagatgccaaggtgataagtgtttctacaggaacaaaatgtattaatggtgaatacatgagtgatcgtggccttgcattaaatgactgccatgcagaaataatatctcggagatccttgctcagatttctttatacacaacttgagctttacttaaataacaaagatgatcaaaaaagatccatctttcagaaatcagagcgaggggggtttaggctgaaggagaatgtccagtttcatctgtacatcagcacctctccctgtggagatgccagaatcttctcaccacatgagccaatcctggaagaaccagcagatagacacccaaatcgtaaagcaagaggacagctacggaccaaaatagagtctggtgaggggacgattccagtgcgctccaatgcgagcatccaaacgtgggacggggtgctgcaaggggagcggctgctcaccatgtcctgcagtgacaagattgcacgctggaacgtggtgggcatccagggatccctgctcagcattttcgtggagcccatttacttctcgagcatcatcctgggcagcctttaccacggggaccacctttccagggccatgtaccagcggatctccaacatagaggacctgccacctctctacaccctcaacaagcctttgctcagtggcatcagcaatgcagaagcacggcagccagggaaggcccccaacttcagtgtcaactggacggtaggcgactccgctattgaggtcatcaacgccacgactgggaaggatgagctgggccgcgcgtcccgcctgtgtaagcacgcgttgtactgtcgctggatgcgtgtgcacggcaaggttccctcccacttactacgctccaagattaccaagcccaacgtgtaccatgagtccaagctggcggcaaaggagtaccaggccgccaaggtacactgaggaggggacggctccgtcttcacattgtgcacagatctgaggatgggattagcgaagctgtggagactgcacatccggacctgcccatgtctcaaaacaaacacatgtacagtggctctttttccttctcaaacactttaccccagaagcaggtggtctgccccaggcataaagaaggaaaattggccatctttcccacctctaaattctgtaaaattatagacttgctcaaaagattcctttttatcatccccacgctgtgtaagtggaaagggcattgtgttccgtgtgtgtccagtttacagcgtctctgccccctagcgtgttttgtgacaatctccctgggtgaggagtgggtgcacccagccccgaggccagtggttgctcggggccttccgtgtgagttctagtgttcacttgatgccggggaatagaattagagaaaactctgacctgccgggttccagggactggtggaggtggatggcaggtccgactcgaccatgacttagttgtaagggtgtgtcggctttttcagtctcatgtgaaaatcctcctgtctctggcagcactgtctgcactttcttgtttactgtttgaagggacgagtaccaagccacaagaacacttcttttggccacagcataagctgatggtatgtaaggaaccgatgggccattaaacatgaactgaacggttaaaagcacagtctatggaacgctaatggagtcagcccctaaagctgtttgctttttcaggctttggattacatgcttttaatttgattttagaatctggacactttctatgaatgtaattcggctgagaaacatgttgctgagatgcaatcctcagtgttctctgtatgtaaatctgtgtatacaccacacgttacaactgcatgagcttcctctcgcacaagaccagctggaactgagcatgagacgctgtcaaatacagacaaaggatttgagatgttctcaataaaaagaaaatgtttcactactcaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:104 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
GeneID:104 -> Molecular function: GO:0003725 [double-stranded RNA binding] evidence: IDA
GeneID:104 -> Molecular function: GO:0003726 [double-stranded RNA adenosine deaminase activity] evidence: IDA
GeneID:104 -> Molecular function: GO:0003729 [mRNA binding] evidence: TAS
GeneID:104 -> Molecular function: GO:0004000 [adenosine deaminase activity] evidence: IEA
GeneID:104 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:104 -> Biological process: GO:0006382 [adenosine to inosine editing] evidence: IDA
GeneID:104 -> Biological process: GO:0006382 [adenosine to inosine editing] evidence: TAS
GeneID:104 -> Biological process: GO:0006396 [RNA processing] evidence: IDA
GeneID:104 -> Biological process: GO:0006397 [mRNA processing] evidence: IEA
GeneID:104 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:104 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:104 -> Biological process: GO:0016553 [base conversion or substitution editing] evidence: IC
GeneID:104 -> Biological process: GO:0016556 [mRNA modification] evidence: TAS
GeneID:104 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IDA
GeneID:104 -> Biological process: GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation] evidence: IDA
GeneID:104 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: IMP
GeneID:104 -> Biological process: GO:0045087 [innate immune response] evidence: IEA
GeneID:104 -> Biological process: GO:0051607 [defense response to virus] evidence: IEA
GeneID:104 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IDA
GeneID:104 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:104 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:104 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
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