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2025-05-09 17:34:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001137667 6782 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript
variant 2, mRNA.
ACCESSION NM_001137667
VERSION NM_001137667.1 GI:212549781
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6782)
AUTHORS Yang,X.C., Sabath,I., Debski,J., Kaus-Drobek,M., Dadlez,M.,
Marzluff,W.F. and Dominski,Z.
TITLE A complex containing the CPSF73 endonuclease and other
polyadenylation factors associates with U7 snRNP and is recruited
to histone pre-mRNA for 3'-end processing
JOURNAL Mol. Cell. Biol. 33 (1), 28-37 (2013)
PUBMED 23071092
REMARK GeneRIF: FLASH/Lsm11 complex bind a unique combination of
polyadenylation factors
REFERENCE 2 (bases 1 to 6782)
AUTHORS Lee,K.D., Pai,M.Y., Hsu,C.C., Chen,C.C., Chen,Y.L., Chu,P.Y.,
Lee,C.H., Chen,L.T., Chang,J.Y., Huang,T.H., Hsiao,S.H. and
Leu,Y.W.
TITLE Targeted Casp8AP2 methylation increases drug resistance in
mesenchymal stem cells and cancer cells
JOURNAL Biochem. Biophys. Res. Commun. 422 (4), 578-585 (2012)
PUBMED 22595458
REMARK GeneRIF: These data demonstrate that methylation within the
Casp8AP2 promoter correlates with the development of drug
resistance and might serve as a biomarker and treatment target for
drug resistance in cancer cells.
REFERENCE 3 (bases 1 to 6782)
AUTHORS De Cola,A., Bongiorno-Borbone,L., Bianchi,E., Barcaroli,D.,
Carletti,E., Knight,R.A., Di Ilio,C., Melino,G., Sette,C. and De
Laurenzi,V.
TITLE FLASH is essential during early embryogenesis and cooperates with
p73 to regulate histone gene transcription
JOURNAL Oncogene 31 (5), 573-582 (2012)
PUBMED 21725362
REMARK GeneRIF: Data show that show that the transcription factor p73
binds to Flice-Associated Huge Protein (FLASH) and is part of the
complex that regulates histone gene transcription.
REFERENCE 4 (bases 1 to 6782)
AUTHORS Chen,S., Evans,H.G. and Evans,D.R.
TITLE FLASH knockdown sensitizes cells to Fas-mediated apoptosis via
down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip
short
JOURNAL PLoS ONE 7 (3), E32971 (2012)
PUBMED 22427918
REMARK GeneRIF: FLASH knockdown in HT1080 mutant cells defective in p53
did not significantly accelerate Fas mediated apoptosis indicating
that the effect was dependent on functional p53.
REFERENCE 5 (bases 1 to 6782)
AUTHORS Hummon,A.B., Pitt,J.J., Camps,J., Emons,G., Skube,S.B., Huppi,K.,
Jones,T.L., Beissbarth,T., Kramer,F., Grade,M.,
Difilippantonio,M.J., Ried,T. and Caplen,N.J.
TITLE Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional
deregulation of the replication-dependent histone genes and
extensive effects on the transcriptome of colorectal cancer cells
JOURNAL Mol. Cancer 11, 1 (2012)
PUBMED 22216762
REMARK GeneRIF: This study further defines the role CASP8AP2/FLASH plays
in the regulating expression of the replication-dependent histones
and shows that its LOF results in broad and reproducible effects on
the transcriptome of colorectal cancer cells
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6782)
AUTHORS Jun,J.I., Chung,C.W., Lee,H.J., Pyo,J.O., Lee,K.N., Kim,N.S.,
Kim,Y.S., Yoo,H.S., Lee,T.H., Kim,E. and Jung,Y.K.
TITLE Role of FLASH in caspase-8-mediated activation of NF-kappaB:
dominant-negative function of FLASH mutant in NF-kappaB signaling
pathway
JOURNAL Oncogene 24 (4), 688-696 (2005)
PUBMED 15592525
REMARK GeneRIF: endogenous caspase-8 mediates tumor necrosis
factor-alpha-induced activation of NF-kappaB via FLASH
REFERENCE 7 (bases 1 to 6782)
AUTHORS Kino,T. and Chrousos,G.P.
TITLE Tumor necrosis factor alpha receptor- and Fas-associated FLASH
inhibit transcriptional activity of the glucocorticoid receptor by
binding to and interfering with its interaction with p160 type
nuclear receptor coactivators
JOURNAL J. Biol. Chem. 278 (5), 3023-3029 (2003)
PUBMED 12477726
REFERENCE 8 (bases 1 to 6782)
AUTHORS Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
TITLE FLASH coordinates NF-kappa B activity via TRAF2
JOURNAL J. Biol. Chem. 276 (27), 25073-25077 (2001)
PUBMED 11340079
REFERENCE 9 (bases 1 to 6782)
AUTHORS Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
TITLE Apoptosis. Searching for FLASH domains
JOURNAL Nature 401 (6754), 662 (1999)
PUBMED 10537104
REFERENCE 10 (bases 1 to 6782)
AUTHORS Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
Yonehara,S.
TITLE The CED-4-homologous protein FLASH is involved in Fas-mediated
activation of caspase-8 during apoptosis
JOURNAL Nature 398 (6730), 777-785 (1999)
PUBMED 10235259
REMARK Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP363682.1, BC132828.1 and
AF154415.1.
Summary: This protein is highly similar to FLASH, a mouse apoptotic
protein identified by its interaction with the death-effector
domain (DED) of caspase 8. Studies of FLASH protein suggested that
this protein may be a component of the death-inducing signaling
complex that includes Fas receptor, Fas-binding adapter FADD, and
caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
Alternative splicing results in multiple transcript variants
encoding the same protein.[provided by RefSeq, Nov 2008].
Transcript Variant: This variant (2) differs in the 5' UTR,
compared to variant 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC132828.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-153 BP363682.1 1-153
154-6672 BC132828.1 1-6519
6673-6782 AF154415.1 6673-6782
FEATURES Location/Qualifiers
source 1..6782
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q15"
gene 1..6782
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="caspase 8 associated protein 2"
/db_xref="GeneID:9994"
/db_xref="HGNC:1510"
/db_xref="MIM:606880"
variation 4
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375731771"
variation 10
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:368340936"
variation 24
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:183190155"
variation 46
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:150333903"
variation 65
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:73752810"
variation 70
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:137975335"
variation 92
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:143660157"
variation 105
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:367700022"
misc_feature 173..175
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="upstream in-frame stop codon"
variation 188
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371341158"
CDS 197..6145
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="FLICE associated huge; CASP8 associated protein 2;
FLICE-associated huge protein; human FLASH; FLASH homolog
RIP25"
/codon_start=1
/product="CASP8-associated protein 2"
/protein_id="NP_001131139.1"
/db_xref="GI:212549782"
/db_xref="GeneID:9994"
/db_xref="HGNC:1510"
/db_xref="MIM:606880"
/translation="
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR
"
misc_feature 200..202
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q9UKL3.1); acetylation site"
misc_feature 254..256
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKL3.1); phosphorylation site"
misc_feature 5243..5257
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 1 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5321..6142
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: NCOA2-binding"
misc_feature 5405..5419
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 2 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5576..5590
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
Region: SUMO interaction motif 3 (SIM), mediates the
binding to polysumoylated substrates (By similarity)"
misc_feature 5942..6136
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/note="Caspase 8-associated protein 2 myb-like domain;
Region: CASP8AP2; cd12202"
/db_xref="CDD:213401"
variation 205
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371635635"
variation 244
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:35891026"
variation 247
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376288172"
variation 272
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377117590"
variation 341
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:138471825"
variation 358
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374871939"
variation 370
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369309364"
variation 475
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369328"
variation 544
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375845338"
variation 547
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370454326"
variation 691
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:191794738"
variation 707
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:375746744"
variation 713
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371046529"
variation 788
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:79485882"
variation 828
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199979891"
variation 849
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:115337779"
variation 851
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374867724"
variation 859
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:182729426"
variation 868
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372111972"
variation 882
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:377049861"
variation 905
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:368353175"
variation 906
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:202238236"
variation 924
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376835324"
variation 941
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369918159"
variation 966
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371653827"
variation 967
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:116832209"
variation 984
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200917530"
variation 1006
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:201596073"
variation 1008
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369118984"
variation 1066
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3734656"
variation 1067
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:376169756"
variation 1068
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369927994"
variation 1090
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:373400557"
variation 1105
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377422956"
variation 1175
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:200248550"
variation 1197
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374722055"
variation 1225
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:9444715"
variation 1243
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370574439"
variation 1253
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375447849"
variation 1301
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:368346657"
variation 1312
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372317117"
variation 1360
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374277382"
variation 1456
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:75673851"
variation 1500
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:74395498"
variation 1533
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:187658864"
variation 1538
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372268202"
variation 1539
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374708182"
variation 1548
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:202104748"
variation 1552
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:34701151"
variation 1568
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201785439"
variation 1627
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:192787612"
variation 1720
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369303003"
variation 1746
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200323558"
variation 1802
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376777596"
variation 1808
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370049023"
variation 1814
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374581994"
variation 1864
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:377395999"
variation 1874
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370348129"
variation 1912
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370445193"
variation 1914
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200220681"
variation 1936
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:377095494"
variation 1986
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370562618"
variation 2064
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:375044202"
variation 2066
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368459977"
variation 2112
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372157483"
variation 2134
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374796247"
variation 2135
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139622677"
variation 2159
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:367672377"
variation 2161
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371194420"
variation 2176
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375013992"
variation 2182
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368221756"
variation 2198
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201489639"
variation 2218
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376398807"
variation 2251
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369747236"
variation 2266
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374435750"
variation 2308
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:373095386"
variation 2332
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:185478571"
variation 2346
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369938492"
variation 2399
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199531988"
variation 2443
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:376213760"
variation 2463
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370683344"
variation 2493
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:189475790"
variation 2568
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:118038939"
variation 2580
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:377330360"
variation 2587
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:3799895"
variation 2593
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370853193"
variation 2603
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:374310883"
variation 2628
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:373335807"
variation 2719
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:191911199"
variation 2728
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201271265"
variation 2734
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368553205"
variation 2760
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371069501"
variation 2799
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:184335133"
variation 2819
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:201494268"
variation 2873
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:202224866"
variation 2913
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:137945652"
variation 2946
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199818755"
variation 3050
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:201306147"
variation 3065
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:368026528"
variation 3085..3086
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="c"
/db_xref="dbSNP:34572105"
variation 3111
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:117850701"
variation 3135
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:149473817"
variation 3152
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201974982"
variation 3156
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376299045"
variation 3175
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:369795421"
variation 3192
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:114897724"
variation 3258
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:375785540"
variation 3324
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369132664"
variation 3355
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370730058"
STS 3584..3740
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="STS-H50583"
/db_xref="UniSTS:2284"
variation 3599
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:373329038"
variation 3636
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064002"
variation 3664
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:143076875"
variation 3701
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:182864217"
variation 3828
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:41273333"
variation 3854
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:116614248"
variation 3908
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201597048"
variation 3910
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199918891"
variation 3912
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:73752819"
variation 3915
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:201506096"
variation 3943
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376295745"
variation 3950
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:200866261"
variation 3951
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374748337"
variation 3967
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369576046"
variation 3997
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:367664392"
variation 4010
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370073401"
variation 4012
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374343288"
variation 4040
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:186180164"
variation 4047
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:148256815"
variation 4056
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375610839"
variation 4063
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:141249173"
variation 4089
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372787304"
variation 4090
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375991831"
variation 4133
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370120781"
variation 4153
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:371257885"
variation 4159
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374774067"
variation 4212
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:369180336"
variation 4218
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:78396072"
variation 4249
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:147437828"
variation 4256
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376211225"
variation 4333
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:369714914"
variation 4366
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:373655186"
variation 4501
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:376852526"
variation 4583
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139736386"
variation 4584
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:143016644"
variation 4588
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371559146"
variation 4622
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:190118214"
variation 4734
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:75601500"
variation 4789
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:60966143"
variation 4837
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:200433993"
variation 4894..4911
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="gacatctttgcccagaca"
/db_xref="dbSNP:202116886"
variation 4899
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:202101805"
variation 4901
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:200213073"
variation 4907
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201189413"
variation 4910
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:202111256"
variation 4912
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199694900"
variation 4913
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200862023"
variation 4914
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201534830"
variation 4915
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:199515704"
variation 5034
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:139983441"
variation 5063
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:150022229"
variation 5087
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:369757511"
variation 5113
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368260598"
variation 5131
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371881005"
variation 5144
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:111766212"
variation 5163
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:375182927"
variation 5171
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:3799896"
variation 5174
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:372893351"
variation 5231..5232
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="t"
/db_xref="dbSNP:34373654"
variation 5238
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374695928"
variation 5246
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200556402"
variation 5318
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369072391"
variation 5319
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:371594163"
variation 5334
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199714955"
variation 5338
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369451328"
variation 5356
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:200853389"
variation 5379
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:377357235"
variation 5400
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369858460"
variation 5402
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:117650507"
variation 5422
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377396142"
variation 5433
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370442854"
variation 5494
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:374893112"
variation 5500
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377482246"
variation 5505
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:73752820"
variation 5515
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374232968"
variation 5522
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368605777"
variation 5532
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371085535"
variation 5563
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374618973"
variation 5596
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:368658707"
STS 5598..5835
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="SHGC-52865"
/db_xref="UniSTS:38874"
variation 5617
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:371166110"
variation 5621
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200564116"
variation 5711
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:201549866"
variation 5714
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:200157861"
variation 5802
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062121"
variation 5847
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:199771380"
variation 5873
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:182937785"
variation 5894
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:367942163"
variation 5928
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372229978"
variation 6011
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:369939894"
variation 6027
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200753477"
variation 6061
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="c"
/db_xref="dbSNP:374433157"
variation 6146
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370975833"
variation 6171
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376095529"
variation 6181
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:367794675"
variation 6218
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="t"
/db_xref="dbSNP:11752373"
variation 6285
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368628751"
variation 6293
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:112756481"
variation 6331
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="c"
/replace="g"
/db_xref="dbSNP:371344448"
variation 6490
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:372563597"
variation 6510
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="g"
/replace="t"
/db_xref="dbSNP:370145460"
STS 6539..6680
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/standard_name="RH47433"
/db_xref="UniSTS:49695"
variation 6620
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace="a"
/replace="g"
/db_xref="dbSNP:142161883"
variation 6687..6688
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
/replace=""
/replace="tt"
/db_xref="dbSNP:71864478"
polyA_signal 6746..6751
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
polyA_site 6772
/gene="CASP8AP2"
/gene_synonym="CED-4; FLASH; RIP25"
ORIGIN
aaaggaaccgggttgtcttgggccgggcagggcgggtaagttgtcgtaggggcccggtccgtgagggactgctaaggaagaggctgcatggcgcggtagtcccccgagtggaggtcggctgcccctgggaaaccagagagtcggagggagtccatctggagcggccaagtggtgactctcaaaaggaaataggatcatggcagcagatgatgacaatggtgatggaacaagtttatttgatgtcttttctgcttctcctcttaagaacaatgatgaaggctcactggacatatacgctgggttggacagtgctgtttctgacagcgcttccaaatcctgtgtaccatcaagaaattgtttggacttatatgaagagatcctgactgaagaaggaactgcaaaggaggcaacatataatgatttgcaagtagaatatggaaaatgtcaactacaaatgaaagagctgatgaaaaaatttaaagaaatacagacacagaatttcagcttaataaacgaaaaccagtctcttaagaagaatatttcagcacttatcaaaactgccagagtggaaataaaccgcaaggatgaagaaataagtaatcttcaccaaagattgtctgagtttccacattttcgaaataatcataaaactgcaaggacatttgatacagttaaaacaaaagatcttaaatctagatctccacatttggatgattgttcaaagactgatcacagagctaaaagtgatgtttctaaagatgtacatcatagcacttcactgccaaatctggaaaaggaaggaaaaccacattctgataaaaggagtacttcacatttacctacatctgttgagaaacactgcactaatggtgtttggtcacgttctcattatcaggttggcgagggtagctcaaatgaggatagtagaagaggaagaaaagatattagacatagccagtttaacagaggaactgaaagagtacgaaaagacttaagtactggctgtggtgatggtgaaccaaggatattggaggctagtcaaaggctacaaggacatcctgagaaatatggtaaaggtgaaccaaagactgaaagcaaaagttcgaagtttaaaagtaactcagattctgactataaaggtgaacgcattaactcttcttgggagaaagagacccctggagaaaggtcacacagtcgagtagactctcaaagtgacaaaaaactagaaagacaaagtgaaagatcacaaaatataaataggaaagaagttaaatcacaagacaaagaagaaagaaaagttgatcaaaaacctaaatcagtagtaaaggaccaagatcactggagaagatctgaacgagcatcacttcctcattccaagaatgaaataacattttctcataattcaagtaaataccatctagaagagagaagaggatgggaagattgtaaaagagacaagagtgtaaacagtcatagttttcaagatggaagatgtccatcttctctttcaaacagtagaactcacaaaaacattgactctaaggaagttgatgccatgcatcagtgggaaaatacacctttaaaagcagaaagacatagaactgaagataagaggaaaagagaacaagaaagcaaagaagaaaataggcatattagaaatgaaaaaagagtacctacagaacatttgcagaagactaataaggaaactaagaaaaccactactgatttaaagaaacagaatgaaccaaagactgataagggagaagtccttgataatggtgtttctgaaggagcagataataaagagcttgcaatgaaagctgagagtggtccaaatgaaacaaaaaacaaggacctaaaattgagttttatgaaaaaattgaacttaactctttctcctgctaaaaagcaacctgtttcccaggataatcagcataaaataactgatattcccaagtccagtggtgtatgtgattcagagtcttcaatgcaagttaaaacagtggcatatgttccctccataagtgaacatatcttgggggaagcagctgtcagtgaacataccatgggggaaaccaagtcaacgttattggaaccaaaggttgctcttctagcagtgactgaacccaggatcggtatctcagaaaccaacaaggaagacgaaaatagtttgttagttaggtctgttgacaatactatgcattgtgaagagcccatttgtggtacagagacttccttcccatctcctatggaaatacaacagacagaatccttgtttccatcaacaggaatgaaacaaaccattaataatggaagggcagcagctcctgtggtaatggatgtattacaaacagatgtgtctcaaaactttggcttggaattggataccaaaagaaatgataattcagattattgtggtatttctgaaggtatggagatgaaggtggcactttcaacaacagtgagtgaaaccactgaaagcattttgcagccttcaattgaggaagctgatattttgccaataatgctttcagaagataataacccaaaatttgagccttctgttatagttacaccactggttgagagtaagtcgtgtcatctggagccttgcttacctaaagagactctagattcttcacttcagcagactgagttaatggaccacagaatggcaactggtgaaacaaactcagtatatcatgatgatgataactcggttttgagcattgaccttaatcacctgagacctattccagaagccatcagtcctctgaatagtccagtgagacctgtagcaaaagttcttagaaatgaaagcccacctcaagttccagtgtataataacagtcataaagatgtgtttttaccaaattcagctcattctacctctaagagtcagtctgatctcaataaggaaaatcaaaagccaatttacaaatctgacaaatgtacagaagcagacacatgtaagaattcaccattagatgaattagaagaaggagaaattagaagtgatagtgaaacatctaaaccacaagaaagttttgaaaaaaattccaaacgtagagtgtcagctgatgtgcggaagtcaaagactatcccacgacgtgggaaaagtactgtgtgtttagataaagacagtaggaaaacacatgtaagaatccatcagaccaataacaaatggaataaaagacctgataaatctagcagatcttcaaaaacagagaagaaagataaagtgatgagcacttccagcttggaaaaaatagttccaattattgctgtaccctcttctgaacaagagatcatgcacatgttacgaatgataagaaaacatgtaagaaaaaattatatgaaattcaaggcaaaattttcattaatacaatttcacagaattattgagtcagcaattttgagttttacatctttaattaaacatctcaacttacacaaaatctctaagtcagtgactaccttacagaagaatctctgtgatattatagagtctaaacttaagcaagttaaaaagaatggcatagttgatcgtttatttgaacagcaactaccagatatgaaaaaaaaattgtggaagtttgtagatgaccaacttgattatttgtttgcaaagcttaagaaaatcttagtatgtgattccaaaagctttggaagagatagtgatgaaggcaaacttgaaaaaacaagtaaacagaatgcacagtattcaaatagtcagaaaaggagtgtggacaactccaacagagaattgctgaaagaaaaattatcaaaatcagaagaccctgttcattataagtctttagtgggatgtaaaaaatctgaggaaaattatcaagaccaaaataactccagtattaacactgtaaagcatgacattaaaaaaaattttaacatctgctttgataatataaagaactctcaatccgaagagcgctccttggaagtacactgtccaagcaccccaaagtcagaaaaaaacgaaggaagcagcatagaggatgcacagacatcccagcatgcaactttgaagccagaacgaagtttcgagattcttaccgaacagcaagcatcgagccttacttttaatttagtgagtgatgcacaaatgggtgaaatatttaaaagtttgttgcaaggttctgatcttttagacagcagtgttaactgtactgaaaaaagtgagtgggagttaaagactccagagaagcagctgctagagactcttaagtgcgagtctataccagcttgtacaacagaagagctagtttcaggggtggcttctccatgtcctaaaatgattagtgatgataattggtcattattatcatctgaaaaaggtccatctctgtcttcagggctttcattgccggttcatcctgatgtgttggatgaaagttgtatgtttgaagtgtctactaacctacctttaagtaaagataatgtgtgtagtgtagaaaagagcaagccctgcgtttcttccatacttcttgaagatctagcagtctctttaacagtaccatcgcctctgaagtcagatggtcatctcagttttttaaagcctgatatgtcgtccagttcaactcctgaagaagtcattagtgctcattttagtgaagatgccttacttgaggaagaggatgcatctgagcaagatattcatttagctctggagtctgataattcaagcagtaaatcaagttgttcttcttcctggacaagccgatctgttgctccaggctttcagtaccaccctaatctacctatgcatgccgtcataatggaaaagtccaatgatcatttcattgtgaaaatacgacgtgcaacaccatctacctcttctggccttaaacagagtatgatgcctgatgaattattgacatctttgcccagacatggaaaggaagctgatgaaggaccagagaaagaatatatttcatgtcagaacacagtttttaaatctgtggaggaattggaaaactccaacaaaaatgttgatggcagcaagtcaactcatgaagaacagagctctatgatacaaacacaggttcctgatatatatgaatttcttaaagatgcttcagataagatgggtcatagtgatgaagtggctgatgaatgtttcaaattgcatcaagtatgggaaacaaaagtgcctgaaagcattgaagaattgccttcaatggaagaaatctcacactctgttggggaacatcttccaaacacatacgtagatctaacgaaagatccagtcactgaaaccaaaaacttgggggaattcatagaagtaacagttttacatattgatcagttgggatgttctggaggcaatttaaatcagagtgctcaaatattagacaattctttgcaggctgatactgtaggtgcttttattgatttgacacaagatgcttcaagtgaggctaaaagtgaaggtaatcatcctgcattagctgtggaagacttgggatgtggggtgatacaggtagatgaagataattgtaaggaagaaaaggcacaagtggcaaacaggcctttaaaatgcattgttgaggaaacctatatcgacttgaccacagaatctcccagttcatgtgaagtaaaaaaagatgagttaaaatcagagccaggatcaaattgtgataactcggagttgcctgggactttgcataattctcacaaaaagagaagaaacatttctgatctaaatcatcctcataaaaaacaaagaaaggaaacagacttaactaataaggaaaagaccaagaaacctacccaagattcttgtgagaatactgaagctcaccaaaagaaagccagtaagaagaaggcccctcctgtgactaaagatccctcatcattaaaggcaaccccagggattaaggattcatcagcagcacttgccacttctacaagtctttctgcaaaaaatgttattaaaaagaagggagaaattatcattttatggacaagaaatgatgaccgggaaattttattggagtgtcagaaaagagggccatcatttaaaacatttgcatatttagccgccaagttggataaaaatccaaatcaggtctcagaaagattccagcagctaatgaagctctttgaaaagtcaaaatgcagataagttgctgaattcctgggactcttaactgatattgcatactacacagaagcttcaaattcctcatgttttaaatgagcactagagggaggtttatcacctttttggttaccagatgataatctatatttgttattactcagtgactctctaatttcacatcagcatgttcagcttgtgctagtcatcattctgatttgcttatctgtttttggtcaaaatatttatttttaaacatgttagaacttaccaaaatgaaagcaacagtgatgtattgaaatcttagttttgatattttaaagaaatgactttctagattaaaaaaatagttttgtagcattttaaacttagtgactatttagttcaattgttcatccattttttatttgcttttataattgcctccttgttttggtatattgtaaaataatttaaataatgtatttataaatatgtataattatgatgtaaaataccgtgtgtatatgtatgtatgtgtgtttctgtatatgcacacacataaacggctttgcctagccaaggattttttttatctgtataaaactttttgtataaagtttgctttcaataacagtaatgtataataaaaccatgtaaagttttgttgtaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9994 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:9994 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
GeneID:9994 -> Molecular function: GO:0005123 [death receptor binding] evidence: TAS
GeneID:9994 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9994 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Molecular function: GO:0016505 [peptidase activator activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Molecular function: GO:0032184 [SUMO polymer binding] evidence: IDA
GeneID:9994 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:9994 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IMP
GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS
GeneID:9994 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:9994 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: ISS
GeneID:9994 -> Biological process: GO:0036337 [Fas signaling pathway] evidence: IMP
GeneID:9994 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:9994 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:9994 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9994 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9994 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:9994 -> Cellular component: GO:0016605 [PML body] evidence: IDA
by
@meso_cacase at
DBCLS
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