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2025-05-09 17:20:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001130527 8243 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens sperm associated antigen 9 (SPAG9), transcript variant
2, mRNA.
ACCESSION NM_001130527
VERSION NM_001130527.2 GI:354682001
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8243)
AUTHORS Yu,P., Yan,L., Zhang,H., Lin,X. and Zhao,X.
TITLE Expression and clinical significance of sperm-associated antigen 9
in patients with endometrial carcinoma
JOURNAL Int. J. Gynecol. Cancer 22 (1), 87-93 (2012)
PUBMED 22146769
REMARK GeneRIF: SPAG9 is positively expressed in endometrial cancer, and
with a high humoral immune response in patients. It may serve as a
new type of endometrial cancer markers for early detection,
diagnosis and treatment.
REFERENCE 2 (bases 1 to 8243)
AUTHORS Ando,K., Uemura,K., Kuzuya,A., Maesako,M., Asada-Utsugi,M.,
Kubota,M., Aoyagi,N., Yoshioka,K., Okawa,K., Inoue,H., Kawamata,J.,
Shimohama,S., Arai,T., Takahashi,R. and Kinoshita,A.
TITLE N-cadherin regulates p38 MAPK signaling via association with
JNK-associated leucine zipper protein: implications for
neurodegeneration in Alzheimer disease
JOURNAL J. Biol. Chem. 286 (9), 7619-7628 (2011)
PUBMED 21177868
REMARK GeneRIF: N-cadherin expression had an inhibitory effect on
JLP-mediated p38 MAPK signal activation by decreasing the
interaction between JLP and p38 MAPK
REFERENCE 3 (bases 1 to 8243)
AUTHORS Kanojia,D., Garg,M., Gupta,S., Gupta,A. and Suri,A.
TITLE Sperm-associated antigen 9 is a novel biomarker for colorectal
cancer and is involved in tumor growth and tumorigenicity
JOURNAL Am. J. Pathol. 178 (3), 1009-1020 (2011)
PUBMED 21356354
REMARK GeneRIF: These findings collectively suggest that SPAG9 may have a
role in tumor development and early spread.
REFERENCE 4 (bases 1 to 8243)
AUTHORS Kanojia,D., Garg,M., Saini,S., Agarwal,S., Kumar,R. and Suri,A.
TITLE Sperm associated antigen 9 expression and humoral response in
chronic myeloid leukemia
JOURNAL Leuk. Res. 34 (7), 858-863 (2010)
PUBMED 20138665
REMARK GeneRIF: SPAG9 mRNA& protein are expressed in CML patients (88%)
and in K562 & KCL-22 cells. 90% CML chronic-phase patients showed
humoral response against SPAG9.
REFERENCE 5 (bases 1 to 8243)
AUTHORS Garg,M., Kanojia,D., Suri,S., Gupta,S., Gupta,A. and Suri,A.
TITLE Sperm-associated antigen 9: a novel diagnostic marker for thyroid
cancer
JOURNAL J. Clin. Endocrinol. Metab. 94 (11), 4613-4618 (2009)
PUBMED 19820019
REMARK GeneRIF: Findings support a potential role for SPAG9 as diagnostic
biomarker as well as a possible therapeutic target in thyroid
cancer treatment.
REFERENCE 6 (bases 1 to 8243)
AUTHORS Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
Superti-Furga,G.
TITLE A physical and functional map of the human TNF-alpha/NF-kappa B
signal transduction pathway
JOURNAL Nat. Cell Biol. 6 (2), 97-105 (2004)
PUBMED 14743216
REMARK Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE 7 (bases 1 to 8243)
AUTHORS Yasuoka,H., Ihn,H., Medsger,T.A. Jr., Hirakata,M., Kawakami,Y.,
Ikeda,Y. and Kuwana,M.
TITLE A novel protein highly expressed in testis is overexpressed in
systemic sclerosis fibroblasts and targeted by autoantibodies
JOURNAL J. Immunol. 171 (12), 6883-6890 (2003)
PUBMED 14662895
REMARK GeneRIF: Testicular antigen PHET is an auutoantigen recognized by
sera from systemic sclerosis (SSc) patients with extensive fibrotic
changes; the autoantibody response to PHET is induced by ectopic
overexpression of PHET in dermal fibroblasts of SSc patients.
REFERENCE 8 (bases 1 to 8243)
AUTHORS Lee,C.M., Onesime,D., Reddy,C.D., Dhanasekaran,N. and Reddy,E.P.
TITLE JLP: A scaffolding protein that tethers JNK/p38MAPK signaling
modules and transcription factors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14189-14194 (2002)
PUBMED 12391307
REFERENCE 9 (bases 1 to 8243)
AUTHORS Ichijo,H.
TITLE From receptors to stress-activated MAP kinases
JOURNAL Oncogene 18 (45), 6087-6093 (1999)
PUBMED 10557099
REMARK Review article
REFERENCE 10 (bases 1 to 8243)
AUTHORS Shankar,S., Mohapatra,B. and Suri,A.
TITLE Cloning of a novel human testis mRNA specifically expressed in
testicular haploid germ cells, having unique palindromic sequences
and encoding a leucine zipper dimerization motif
JOURNAL Biochem. Biophys. Res. Commun. 243 (2), 561-565 (1998)
PUBMED 9480848
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA631864.1, AF327452.1,
AY236487.1 and AC005920.1.
On Oct 28, 2011 this sequence version replaced gi:194578920.
Summary: This gene encodes a member of the cancer testis antigen
gene family. The encoded protein functions as a scaffold protein
that structurally organizes mitogen-activated protein kinases and
mediates c-Jun-terminal kinase signaling. This protein also binds
to kinesin-1 and may be involved in microtubule-based membrane
transport. This protein may play a role in tumor growth and
development. Alternate splicing results in multiple transcript
variants. [provided by RefSeq, Oct 2011].
Transcript Variant: This variant (2) has multiple differences in
the coding region but maintains the reading frame, compared to
variant 1. This variant encodes isoform 2, which is shorter than
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF327452.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-131 DA631864.1 1-131
132-4429 AF327452.1 1-4298
4430-4754 AY236487.1 2587-2911
4755-8243 AC005920.1 62450-65938 c
FEATURES Location/Qualifiers
source 1..8243
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.33"
gene 1..8243
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/note="sperm associated antigen 9"
/db_xref="GeneID:9043"
/db_xref="HGNC:14524"
/db_xref="MIM:605430"
exon 1..512
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
misc_feature 24..26
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/note="upstream in-frame stop codon"
CDS 210..4145
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/note="isoform 2 is encoded by transcript variant 2; sperm
surface protein; cancer/testis antigen 89;
JNK/SAPK-associated protein; JNK interacting protein;
c-Jun NH2-terminal kinase-associated leucine zipper
protein; Max-binding protein; C-Jun-amino-terminal
kinase-interacting protein 4; proliferation-inducing gene
6; lung cancer oncogene 4; sunday driver 1; protein highly
expressed in testis; human lung cancer oncogene 6 protein;
mitogen-activated protein kinase 8-interacting protein 4"
/codon_start=1
/product="C-Jun-amino-terminal kinase-interacting protein
4 isoform 2"
/protein_id="NP_001123999.1"
/db_xref="GI:194578921"
/db_xref="CCDS:CCDS58578.1"
/db_xref="GeneID:9043"
/db_xref="HGNC:14524"
/db_xref="MIM:605430"
/translation="
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE
"
misc_feature 279..752
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/note="JNK_SAPK-associated protein-1; Region:
Jnk-SapK_ap_N; pfam09744"
/db_xref="CDD:150420"
misc_feature <294..611
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/note="The Bin/Amphiphysin/Rvs (BAR) domain, a
dimerization module that binds membranes and detects
membrane curvature; Region: BAR; cl12013"
/db_xref="CDD:209413"
misc_feature 534..536
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 756..758
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 762..764
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 789..791
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 816..818
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 858..860
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O60271.4); phosphorylation site"
misc_feature 960..962
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 969..971
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 981..983
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 1098..1100
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 1152..1154
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 1161..1163
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 1206..1208
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 1209..1211
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O60271.4); phosphorylation site"
misc_feature 1419..1421
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O60271.4); phosphorylation site"
misc_feature 1935..1937
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O60271.4); phosphorylation site"
misc_feature 2367..2369
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
misc_feature 2376..2378
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O60271.4); phosphorylation site"
exon 513..633
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 634..704
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 705..799
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
variation 790
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="g"
/db_xref="dbSNP:35028363"
exon 800..950
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
variation 936
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="c"
/replace="g"
/db_xref="dbSNP:34733235"
exon 951..1158
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1159..1258
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1259..1380
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1381..1438
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1439..1591
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1592..1643
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1644..1774
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1775..1831
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1832..1843
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 1844..2017
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2018..2147
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2148..2237
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2238..2405
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2406..2577
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2578..2796
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2797..2992
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 2993..3118
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3119..3199
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3200..3267
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3268..3416
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3417..3588
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3589..3702
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3703..3879
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 3880..4029
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
exon 4030..8243
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/inference="alignment:Splign:1.39.8"
variation 4430
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="g"
/db_xref="dbSNP:8125"
STS 4514..4740
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="D17S2022"
/db_xref="UniSTS:17055"
STS 4547..4732
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="RH91778"
/db_xref="UniSTS:87223"
STS 4610..4733
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="D17S1393E"
/db_xref="UniSTS:150444"
polyA_signal 4741..4746
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
polyA_signal 4769..4774
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
polyA_site 4770
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
variation 4771
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="t"
/db_xref="dbSNP:1055303"
polyA_site 4794
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
STS 5088..5242
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="RH78073"
/db_xref="UniSTS:39895"
STS 5203..5331
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="SHGC-30378"
/db_xref="UniSTS:69757"
variation 5390
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="g"
/db_xref="dbSNP:1133791"
STS 5422..5559
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="D15S1390"
/db_xref="UniSTS:474340"
variation 5459
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="c"
/replace="t"
/db_xref="dbSNP:1133792"
STS 5874..5958
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="D13S1553"
/db_xref="UniSTS:473482"
STS 5915..6003
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 6046
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="g"
/db_xref="dbSNP:1133793"
variation 6086
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="g"
/db_xref="dbSNP:1055361"
STS 7009..7127
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="RH44968"
/db_xref="UniSTS:77832"
STS 7473..7648
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="RH12095"
/db_xref="UniSTS:26178"
polyA_signal 7661..7666
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
polyA_site 7683
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
STS 7995..8200
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="RH76125"
/db_xref="UniSTS:90431"
STS 7996..8201
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="WI-20746"
/db_xref="UniSTS:76680"
STS 8111..8200
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/standard_name="STS-Z41139"
/db_xref="UniSTS:61465"
variation 8242
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
/replace="a"
/replace="t"
/db_xref="dbSNP:3180903"
polyA_site 8243
/gene="SPAG9"
/gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
PHET; PIG6"
ORIGIN
agttggtgcagcggcggttggggtgagagcgcctacgccacccctcccctcctccggccccggcccccaccccgccgggcccagccccagccccggcccgggctccagccctagtacccgtcccagcccgagtcgggtccgtcccgtgcgggcaggtgccgcccctctgccggcgacgccccgggccgcccgcccgtccgcttgccaccatggagctggaggacggtgtggtgtatcaggaggagcccggcggctccggggccgtgatgtcggagcgggtgtccggcctggccggctccatctaccgcgagttcgagcggcttatcgggcgctatgacgaggaggtggtcaaagagctgatgccgctggtggtggctgtgctggagaacctggactcggtgttcgcgcaggaccaggagcaccaggtggagctggagctgctgcgggacgacaacgagcagctcatcacccagtacgagcgggagaaggcgctgcgcaagcacgctgaggagaaattcattgaatttgaagactctcaagaacaggaaaaaaaggacttacagacccgagtggaatctttagaatctcaaacaagacaacttgagctgaaagcgaaaaactatgctgaccagattagcagacttgaagaaagagaagcagaactgaagaaggaatataatgcattacatcaaagacacactgagatgatccataattatatggaacatttagaaagaacaaaacttcatcagctctcagggagtgatcaactagaatccacagctcatagtagaattagaaaagaacgccctatatcattaggaattttcccattacctgctggagatggattgcttacacctgatgctcagaaaggaggagagacccctggatctgagcaatggaaatttcaggaattaagtcaaccacgttctcataccagcctgaaggatgagctttctgatgttagccaaggcggatctaaagctaccactccagcatcaacagctaattcagatgtggcaacaattcctactgatactcccttaaaggaagaaaacgaaggatttgtgaaggttacagatgcgccaaataaatcagagataagcaaacacattgaagtacaggtagcccaggaaactagaaatgtatctactggctctgctgaaaatgaagaaaagtcagaagttcaagcaatcatcgaatctactcctgagctggatatggacaaagatctcagtggatataaaggttcaagcactcccaccaaaggcatagagaacaaagcttttgatcgcaatacagaatctctctttgaagaactgtcttcagctggctcaggcctaataggagatgtggatgaaggagcagatttactaggaatgggtcgggaagttgagaatcttatattagaaaatacacaactgttggaaaccaaaaatgctttgaacatagtgaagaatgatttgatagcaaaagtggatgaactgacctgtgagaaagatgtgctgcaaggggaattggaggctgtgaagcaagccaaactgaaactagaggaaaagaacagagaattggaggaagagcttaggaaagctcgggcagaagctgaagatgcaaggcaaaaagcaaaagatgacgatgatagtgatattcccacagcccagaggaaacggtttactagagtagaaatggcccgtgttctcatggagcgaaaccagtataaagagagattgatggagcttcaggaagctgttcgatggacagagatgattcgggcatcacgagaaaatccagccatgcaggaaaaaaaaaggtcaagcatttggcagtttgtgccaactcgtttcagccgacttttcagctcctcaagtaacacgactaagaagcctgaaccacctgttaatctgaagtacaatgcacccacgtctcatgttactccgtccgtcaagaaaagaagcagcaccttatctcagctccctggggataagtccaaagcctttgatttccttagtgaagaaactgaagctagtttagcctcacgcagagaacaaaagagagagcagtatcgtcaggtaaaagcacatgttcagaaggaagacggtagagtgcaggcttttggctggagtctgcctcagaagtacaaacaggtaaccaatggtcaaggtgaaaataagatgaaaaatttacctgtgcctgtctatctcagacctctggatgaaaaagatacatcaatgaagctgtggtgtgctgttggagtcaatttatctggtgggaagaccagagatggtggttctgttgttggagcaagtgtattttacaaggatgttgctggtttggatacagaaggcagtaaacagcgaagtgcctctcagagtagtttagataagttagatcaggaacttaaggaacagcagaaggagttaaaaaatcaagaagaattatccagtctagtttggatctgtaccagcactcattcggctacaaaagttcttattattgatgctgttcaacctggcaacatcctagacagtttcactgtttgcaactctcatgttctgtgcattgcaagtgtgccaggtgcacgagaaacagactaccctgcaggagaagatctttcagaatctggtcaggtagacaaagcatctttatgtggaagtatgacaagcaacagctcagcagagacagacagcctgttaggaggcatcacagtggttggttgttctgcagaaggtgtgacgggagctgccacttcccctagtacaaatggtgcttctccagtgatggataaaccaccagaaatggaagcagaaaatagtgaggttgatgaaaatgttccaacagcagaagaagcaactgaagctacagaagggaatgcggggtcagctgaagacacagtggacatctcccaaactggcgtctacacagagcatgtctttacagatcctttgggagttcagatcccagaagacctctccccagtgtatcagtcgagcaatgactcagatgcatataaagatcaaatatcagtactgccaaatgaacaagacttggtgagagaagaagcccagaaaatgagtagtcttttaccaactatgtggcttggagctcaaaatggctgtttgtatgtccattcatctgtagcccagtggaggaaatgtctccattccattaaacttaaagattcgattctcagtattgtacacgtgaagggaatcgtgttagtagccctggctgacggcacccttgcaatctttcacagaggagtggatgggcagtgggatttgtcaaactatcacctcttagaccttggacggcctcatcattccatccgttgcatgactgtggtacatgacaaagtctggtgtggctataggaacaaaatctatgtggtgcagccaaaggccatgaaaatagagaaatcttttgatgcacatcccaggaaggagagccaagtgcgacagcttgcgtgggtgggggatggcgtgtgggtctccattcgcttggattctacgctccgtctctatcatgcacacacttatcaacatctacaggatgtggacattgagccttatgtaagcaaaatgttaggtactggaaaactgggcttctcttttgtgagaattacagctcttatggtgtcttgtaatcgtttgtgggtggggacaggaaatggtgtcattatctccatcccattgacagaaacaaataaaacctcaggtgtaccaggaaatcgtcctggaagtgtaatccgtgtatatggtgatgaaaacagtgataaagtgactccagggacatttataccctattgttcaatggcacatgcacagctttgcttccatgggcaccgggatgctgtgaaattctttgtggcagtcccaggtcaagtcatcagcccacaaagtagcagtagtggcacggatctgacgggtgacaaagcagggccatctgcacaggagcctggtagtcagacgcccttgaagtctatgcttgtcatcagtggaggagagggctacatcgacttccgaatgggtgatgaaggtggagaatcagaacttcttggagaggatcttccacttgaaccttctgtcaccaaagcagaaaggagtcacttgatagtgtggcaagtgatgtatggcaatgagtgagcccatgggaaacaggtggagatggggaagccgtctcttctgcatggtttattttccctctatccttttatttaatgctcttttgtgagataagtttcaccacataatgtgtgagcattttttcctgttaactttatattacaaaatccgttctaccataacaatacagaggaactagctgtgttactgcaccagtgttataggtaacttcagtatattatgaacaaatcaaagaatgtttacttcctgcaaactggtgaattatagaaagcaatccagatgtggtttactctgccacagtctaatgtcattcacttcatttgatggggtcacttgttagctgtcactaataatggaattaatgggaaacacttgataaatgaaactgtaccgttaaatacaatagctgagttttccccagtgtattgtaaaattgacacacactaatacaagatggattatcaggatgtatctaaatgtcccgagagggttaaaagctaactgtaaattactttaactttcactttcaaatctgacaaatcttgtttatatggtatataaaactttgttttcatcagatttgggggggttttatattaaagaaattaagactacactatttaaataaacgtttcctgtttctgacttattagagctctaaagtttatgaggcctacttctctgaatattctgatgggttttttttgagaccagtctcattttcatactgacatgtctgaaagatttattatttataaagcttaggacatactctgggaagcttagaagatacttcagcactgggaggattttttaaaggaaatgtgttttgtatttcttgtaccagagaatggtgatgttgattgagttttttccatgtaaaaaatgtacttgtttgccaaatgttcctagattgctcttaacctgttaatacaagtaaaactgtagtggggatggagtctggcctaagtacagaatgagggatttaattagaaaagttattttcttttgttctgtatcaaactgcagaacagctatatacttggtattttgtacgtgaataacgttttagcttttgtgcccttttgagcttgaagggttatcctcaaaggggaaaactatgaaggggaagaagacaaacctaagataccataaagtaaaggttgacattacatattttcattcacaatgcccattaaaaaaaaaaaataggttgggcatggtggctcacgcctgtaatcccaacactttaggaggctgaggcagatggattgcttgagcccaggagttcaagaccagcctgggcaacatggcgaaaccctgtctctaccaaaaaaaaaaaacaaaataaattaaccgggtgtggtggcacatgcctgtagtcccagctacttgggaggctgaggtgggaggatgacctgggcccaggaggtggaggttgcagtgagccttgatagcaccactgcactccagcctgggtgacggagcaagaccctgtctcaaaacagacaaacaagcaaaaaatagattaaagtctggatttcactgattttcttgcttaataagttttttaaaaccacgatgctgcaattttttccctctcaagcttcttgaaaatgtgtgatttacccttttttatctattactctaggcaaagctaaatatgatttttttttttttttttgagacggagtctggctctgttgcccaggctggaatgcagtggtgcgatctcagctcactgcaacctccacctctcaggttcaagtagttctcctgcctcagcctcccaagtagctgggattacaggtgtgtgccaccctgcccagctaatttttgtatttttagtagagacagggtttcaccacattggccaggctggtctcaaactcctgacctcagatgatctacccgccttggcctcccgaagtgcttgaattacaggcgtgagcccccgcgccggtccgaagcaaagctaaatgtaattttatgtactgttttaacagtataaacctatgggataaaggcccccaatcatcagaaggactactgaaaagaaaagaaagcaaacgtagatgtcaaattgtctaaacattcttaagtaccactgattttttttttctggactattatacaaagatgtctgtaaaaagtataccagtggcttttatgcatatacacgattaggctagattgtgaagtacatgggatttcatgagccagaggaggcatttggatccattgggccacatgtgactataagcacattgtgtacacaataaaattgtagccactcatgtattaaaactgttttggtaaaagctgtattaaaagaataattttttgcttgagctacttagtcacttttttgcagggcaccaaaatgtaggctacttttccatagcttgtttgctatgtttttatttcatcttaaatctgagccatttttggcaatatcttttaaaaaatcattattaaacatttattggaaatgttgtatagattcacaagaaagagacaccaaagtgtttgggaattttaatcccaagaagtaaacatcccagagtcagatcccatttgctgttgttcagccatgtttgtatgactgaatgtaatttaggaaatcaggagttagagatgaaaaatacaaacatgtcaaatggttgtaattgctttttttgaacttactggctttaacttaagtaatataggtgtgtagttgttttatctaaagatgtcagattatctgtggccctgttaattaactgcagggaccagagagaggacaaaaatgcctgtataatttgctttaaaggcttgtccttatgtttgtaatttcagttaaatattttctacagattgcttcacttcccctttcccccaataacaagttcatattcttgtaatgtttactttggtcaacgtggtaatttttggaagaaaatgccaaaatgtaagcttctcacaagcagcaaaggaatgtaactgcctgtagctaccacatcaagggagagaagaggcttgcgtactttgggttgatctcactgtacaaaaaaagtgtacccctattggaagaaataaggaatacttgaaggtttctcctttttttacacttgagtcatgtgcaaggttgaaccatatgaaattgccagtgttcaaccattgctgatctgcaaaagcgacaatatcatatgcctcaacctaacacttactcttaaatgcaggttaaaatctctgtgaggcaaagggataatattctctaggaactcacttttgagagtatttttctctaacccatgtggatctaaattttaaaaataggaatgaatctcttaattgcagcttgtggagagtataaaacattttgagcacaatatgcagcacataacttttcagattgtgtttgcatagaaaaggttaaaatcaattctttcagttactgtattgttcatttcttgtaaaggtcttcctacatttgagacgagaccctttaacataggctgccttagtaacaaaataaaacagatgtgtcataatattaactgtcctaaagaacatgtgtcttgcaaatgccatggaactgaatatttatttccttgtgagtattatgaccgttaccaaaggactcaaccagatttagggctcttcttaattgatcatgttcagaaagggactcatttggtcccactttgtaacatgggaagagtagaagagaaaattaaatgtggaaatcataaatgcttttctaacagggttatgctattctgtaacactaaatgtctgtcttttctcttaaaagattaagttttattaattttgtcatacatttctctatttgaatatatcttaaccattttatgttccaaattcgttttttgtccaagacattctatcagaattttacttgcctctataatctgaaaaatgggttctagaatgtcccacttgctgtctcttagaggctgagcttcatttctatgagcaaagagctcatttagcaatgtagttatttcagtatttatttctattatggaatccctggggttcagaatgtaactttgtacatgagatatatataaatatgtatatgaacatgta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9043 -> Molecular function: GO:0008432 [JUN kinase binding] evidence: IEA
GeneID:9043 -> Molecular function: GO:0019894 [kinesin binding] evidence: IEA
GeneID:9043 -> Molecular function: GO:0048273 [mitogen-activated protein kinase p38 binding] evidence: IEA
GeneID:9043 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: IEA
GeneID:9043 -> Biological process: GO:0007283 [spermatogenesis] evidence: TAS
GeneID:9043 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IMP
GeneID:9043 -> Biological process: GO:0042147 [retrograde transport, endosome to Golgi] evidence: IDA
GeneID:9043 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
GeneID:9043 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: IEA
GeneID:9043 -> Biological process: GO:0051146 [striated muscle cell differentiation] evidence: IEA
GeneID:9043 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
GeneID:9043 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
GeneID:9043 -> Biological process: GO:0090074 [negative regulation of protein homodimerization activity] evidence: IEA
GeneID:9043 -> Cellular component: GO:0001669 [acrosomal vesicle] evidence: IEA
GeneID:9043 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9043 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:9043 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
GeneID:9043 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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