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2025-05-09 17:31:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001128177 7553 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens thyroid hormone receptor, beta (THRB), transcript
variant 3, mRNA.
ACCESSION NM_001128177
VERSION NM_001128177.1 GI:189491770
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7553)
AUTHORS Kim,W.G., Zhu,X., Kim,D.W., Zhang,L., Kebebew,E. and Cheng,S.Y.
TITLE Reactivation of the silenced thyroid hormone receptor beta gene
expression delays thyroid tumor progression
JOURNAL Endocrinology 154 (1), 25-35 (2013)
PUBMED 23183175
REMARK GeneRIF: THRB mRNA expression in DTC was 90% lower than in normal
controls, and this decrease was associated with a higher
tumor/lymph node staging.
REFERENCE 2 (bases 1 to 7553)
AUTHORS Yuan,C., Nguyen,P., Baxter,J.D. and Webb,P.
TITLE Distinct ligand-dependent and independent modes of thyroid hormone
receptor (TR)/PGC-1alpha interaction
JOURNAL J. Steroid Biochem. Mol. Biol. 133, 58-65 (2013)
PUBMED 22974658
REMARK GeneRIF: TRbeta1 binds PGC-1alpha in a second ligand and LxxLL
motif independent mode and show this interaction requires the
TRbeta1 N-terminal domain and the PGC-1alpha N-terminal activation
domain at amino acids 1-130.
REFERENCE 3 (bases 1 to 7553)
AUTHORS van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
TITLE Seventy-five genetic loci influencing the human red blood cell
JOURNAL Nature 492 (7429), 369-375 (2012)
PUBMED 23222517
REFERENCE 4 (bases 1 to 7553)
AUTHORS Liu,Y.Y., Kogai,T., Schultz,J.J., Mody,K. and Brent,G.A.
TITLE Thyroid hormone receptor isoform-specific modification by small
ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent
gene regulation
JOURNAL J. Biol. Chem. 287 (43), 36499-36508 (2012)
PUBMED 22930759
REMARK GeneRIF: conjugation of SUMO to TR has a TR-isoform preference and
is important for T3-dependent gene induction and repression.
REFERENCE 5 (bases 1 to 7553)
AUTHORS Miki,I., Nakamura,T., Kuwahara,A., Yamamori,M., Nishiguchi,K.,
Tamura,T., Okuno,T., Omatsu,H., Mizuno,S., Hirai,M., Azuma,T. and
Sakaeda,T.
TITLE THRB genetic polymorphisms can predict severe myelotoxicity after
definitive chemoradiotherapy in patients with esophageal squamous
cell carcinoma
JOURNAL Int J Med Sci 9 (9), 748-756 (2012)
PUBMED 23136537
REMARK GeneRIF: THRB intronic SNPs can provide useful information on
chemoradiotherapy-related severe myelotoxicity in patients with
esophageal squamous cell carcinoma
REFERENCE 6 (bases 1 to 7553)
AUTHORS Falcone,M., Miyamoto,T., Fierro-Renoy,F., Macchia,E. and
DeGroot,L.J.
TITLE Antipeptide polyclonal antibodies specifically recognize each human
thyroid hormone receptor isoform
JOURNAL Endocrinology 131 (5), 2419-2429 (1992)
PUBMED 1425440
REFERENCE 7 (bases 1 to 7553)
AUTHORS Behr,M. and Loos,U.
TITLE A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA
beta thyroid hormone receptor gene in a family with generalized
thyroid hormone resistance
JOURNAL Mol. Endocrinol. 6 (7), 1119-1126 (1992)
PUBMED 1324420
REFERENCE 8 (bases 1 to 7553)
AUTHORS Cugini,C.D. Jr., Leidy,J.W. Jr., Chertow,B.S., Berard,J.,
Bradley,W.E., Menke,J.B., Hao,E.H. and Usala,S.J.
TITLE An arginine to histidine mutation in codon 315 of the c-erbA beta
thyroid hormone receptor in a kindred with generalized resistance
to thyroid hormones results in a receptor with significant
3,5,3'-triiodothyronine binding activity
JOURNAL J. Clin. Endocrinol. Metab. 74 (5), 1164-1170 (1992)
PUBMED 1314846
REFERENCE 9 (bases 1 to 7553)
AUTHORS Schmidt,E.D., Schmidt,E.D., van der Gaag,R., Ganpat,R.,
Broersma,L., de Boer,P.A., Moorman,A.F., Lamers,W.H.,
Wiersinga,W.M. and Koornneef,L.
TITLE Distribution of the nuclear thyroid-hormone receptor in extraocular
and skeletal muscles
JOURNAL J. Endocrinol. 133 (1), 67-74 (1992)
PUBMED 1517709
REFERENCE 10 (bases 1 to 7553)
AUTHORS Adams,M., Nagaya,T., Tone,Y., Jameson,J.L. and Chatterjee,V.K.
TITLE Functional properties of a novel mutant thyroid hormone receptor in
a family with generalized thyroid hormone resistance syndrome
JOURNAL Clin. Endocrinol. (Oxf) 36 (3), 281-289 (1992)
PUBMED 1563081
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M26747.1, AC012087.10,
AK096628.1, AC098971.2, AK095776.1, BC028910.1 and AW449568.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The protein encoded by this gene is a nuclear hormone
receptor for triiodothyronine. It is one of the several receptors
for thyroid hormone, and has been shown to mediate the biological
activities of thyroid hormone. Knockout studies in mice suggest
that the different receptors, while having certain extent of
redundancy, may mediate different functions of thyroid hormone.
Mutations in this gene are known to be a cause of generalized
thyroid hormone resistance (GTHR), a syndrome characterized by
goiter and high levels of circulating thyroid hormone (T3-T4), with
normal or slightly elevated thyroid stimulating hormone (TSH).
Several alternatively spliced transcript variants encoding the same
protein have been observed for this gene. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (3) differs in the 5' UTR compared
to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AK096628.1, BC106929.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 M26747.1 1-10
11-12 AC012087.10 124182-124183
13-380 AK096628.1 2-369
381-1914 AK096628.1 468-2001
1915-3162 AC098971.2 146200-147447 c
3163-4468 AK095776.1 455-1760
4469-5705 BC028910.1 622-1858
5706-7303 AC098971.2 142059-143656 c
7304-7553 AW449568.1 1-250 c
FEATURES Location/Qualifiers
source 1..7553
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p24.2"
gene 1..7553
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="thyroid hormone receptor, beta"
/db_xref="GeneID:7068"
/db_xref="HGNC:11799"
/db_xref="MIM:190160"
exon 1..171
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 172..243
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 244..380
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 381..444
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
misc_feature 417..419
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="upstream in-frame stop codon"
CDS 423..1808
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="oncogene ERBA2; thyroid hormone nuclear receptor
beta variant 1; nuclear receptor subfamily 1 group A
member 2; thyroid hormone receptor, beta (erythroblastic
leukemia viral (v-erb-a) oncogene homolog 2, avian)"
/codon_start=1
/product="thyroid hormone receptor beta"
/protein_id="NP_001121649.1"
/db_xref="GI:189491771"
/db_xref="CCDS:CCDS2641.1"
/db_xref="GeneID:7068"
/db_xref="HGNC:11799"
/db_xref="MIM:190160"
/translation="
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
"
misc_feature 423..740
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P10828.2);
Region: Modulating"
misc_feature 738..983
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="DNA-binding domain of thyroid hormone receptors
(TRs) is composed of two C4-type zinc fingers; Region:
NR_DBD_TR; cd06961"
/db_xref="CDD:143519"
misc_feature order(741..743,750..752,792..794,801..803,855..857,
873..875,903..905,912..914)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:143519"
misc_feature order(771..779,795..800,804..806,810..812,816..821,
828..830,894..899,906..908,915..917,954..962,975..977)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143519"
misc_feature order(771..773,780..782,945..947,951..956)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:143519"
misc_feature 1068..1796
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="The ligand binding domain of thyroid hormone
receptor, a members of a superfamily of nuclear receptors;
Region: NR_LBD_TR; cd06935"
/db_xref="CDD:132733"
misc_feature 1152..1805
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P10828.2);
Region: Interaction with NR2F6"
misc_feature 1152..1805
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P10828.2);
Region: Ligand-binding"
misc_feature order(1227..1229,1236..1241,1245..1250,1257..1259,
1266..1268,1350..1352,1359..1361,1371..1373,1407..1415,
1443..1445,1452..1454,1458..1460,1479..1481,1725..1727,
1746..1748,1785..1787)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:132733"
misc_feature order(1263..1265,1272..1274,1284..1286,1314..1316,
1326..1328,1335..1337,1779..1784,1791..1793)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="coactivator recognition site [polypeptide binding];
other site"
/db_xref="CDD:132733"
misc_feature order(1464..1466,1599..1601,1689..1691,1698..1703,
1710..1712,1719..1724,1728..1733)
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:132733"
exon 445..705
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 706..806
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 807..954
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 955..1160
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
variation 1157
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3752874"
exon 1161..1307
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
exon 1308..1566
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
variation 1412
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:267607113"
variation 1432
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1054624"
exon 1567..7539
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/inference="alignment:Splign:1.39.8"
STS 1646..1808
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/standard_name="SHGC-76783"
/db_xref="UniSTS:76713"
variation 3162
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="a"
/replace="g"
/db_xref="dbSNP:844107"
variation 4469
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201503958"
variation 6796
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1349265"
variation 7175
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2167116"
polyA_signal 7519..7524
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
polyA_site 7539
/gene="THRB"
/gene_synonym="C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2;
PRTH; THR1; THRB1; THRB2"
ORIGIN
cggcggggattaactttgcatgaataatgtgagtgcgcttggaaaagagacctcctgctccgcgggctcggggcaagagcccgcaggctaccttccccgggcaggggcgctcaacccaaccggctccagggcactggtaatttggctagaggaccgcgcggaggcagcgggatctgcgatttccttctggttggctgtcctgcgtgggtgccaagttccacacatgatttaatgaataagaagggggcttggaggctcatagcaaaggtccttgaagagagcaagaaaaagtcttcccaggaaaagtggacacctgagtgagtgttacaacgagaaggggggcatcccaggcaaggcagctaccaagcacaggtgtgaaggagatgtcagtgaaaaaagggatccagaatgattactaacctatgactcccaacagtatgacagaaaatggccttacagcctgggacaaaccgaagcactgtccagaccgagaacacgactggaagctagtaggaatgtctgaagcctgcctacataggaagagccattcagagaggcgcagcacgttgaaaaatgaacagtcgtcgccacatctcatccagaccacttggactagctcaatattccatctggaccatgatgatgtgaacgaccagagtgtctcaagtgcccagaccttccaaacggaggagaagaaatgtaaagggtacatccccagttacttagacaaggacgagctctgtgtagtgtgtggtgacaaagccaccgggtatcactaccgctgtatcacgtgtgaaggctgcaagggtttctttagaagaaccattcagaaaaatctccatccatcctattcctgtaaatatgaaggaaaatgtgtcatagacaaagtcacgcgaaatcagtgccaggaatgtcgctttaagaaatgcatctatgttggcatggcaacagatttggtgctggatgacagcaagaggctggccaagaggaagctgatagaggagaaccgggagaaaagacggcgggaagagctgcagaagtccatcgggcacaagccagagcccacagacgaggaatgggagctcatcaaaactgtcaccgaagcccatgtggcgaccaacgcccaaggcagccactggaagcaaaaacggaaattcctgccagaagacattggacaagcaccaatagtcaatgccccagaaggtggaaaggttgacttggaagccttcagccattttacaaaaatcatcacaccagcaattaccagagtggtggattttgccaaaaagttgcctatgttttgtgagctgccatgtgaagaccagatcatcctcctcaaaggctgctgcatggagatcatgtcccttcgcgctgctgtgcgctatgacccagaaagtgagactttaaccttgaatggggaaatggcagtgacacggggccagctgaaaaatgggggtcttggggtggtgtcagacgccatctttgacctgggcatgtctctgtcttctttcaacctggatgacactgaagtagccctccttcaggccgtcctgctgatgtcttcagatcgcccggggcttgcctgtgttgagagaatagaaaagtaccaagatagtttcctgctggcctttgaacactatatcaattaccgaaaacaccacgtgacacacttttggccaaaactcctgatgaaggtgacagatctgcggatgataggagcctgccatgccagccgcttcctgcacatgaaggtggaatgccccacagaactcttcccccctttgttcttggaagtgttcgaggattagactgactggattcattctcataattcctacagcactactgggtgtcatttcattccattgcctagctcttttttgtttgtttctttgtgttgggagggattatttgggagggaaaagggaagtagtccttggcatagacatggatgaaattgccccttgaatgcgggtacttgaaactattgcatttcgttctccggtcctgtgatgtgaatgctctgaaggttttatggttgtggaggtggggtgggggacaatcattaactcaccagcaccaagcatcaccagctcccacccgtccctggtccaagacttgagtcagcaaaatggcgccacaggacactaaagaagccttaaaaccaagataatacgaccacctccacccaatcctgatgttcgcagggctgaagttaacagagcacagaccacctttagttagatgtggctttcagccttttagggaaagactcgaacaaattttcatctattcaagagcatgctgtttgcagcactctttatggtctcctaggagcataacttggaatgtacaggaatatttgtgtcctaaaaaaatcagctgcccttccaatatcatttttataacgttatggtttaattcaagttatacaaaggtgtgactcaaggatgtgcaggtattgactgatggaggccaacaaggaaaatattttttttcagtgagcccagagaaattagaaatcttcaccaatgtcagtgactgcatggtttccaaaaattcacatagtattacctcacagtaggaaggcttctttcccatttaggctcagagaacacttttacagaaatcaaacctatttacagggtggcaccccttttctgtggcatctgatctgtcatctcccaagctcctgaagttctttatccaggttgtatctttgctgagctgacaacagatttctctatggatcaaatattctaatcaaggaaagatacggtgaaacttcagtcttcttctggagaaatgctgaggcgagattagtgcagctacattctgagttgaaggaaatgcagtgttctgagggcccctttgtgtcctgatggctggaggacgcttcctcctggttagatcctcaagctccttgcctcattgacaaatgtctcctagtcccctttttccctctgactctgaggaactaaatagcttgactatctctaaacagagactggccctgccactgaccctcctgtccctctcatagcataccctgacagatactcaatagaaaacacctgcagaccatgtgcacacttaactttcctgcccaacctgcctccccaacggcccatgctagaatagcttgtgcccagaaaacaaacagtgacacttcatctcttcagcgtcagaaaatgggcatagaatgtacccatgcaattgaatgtatctcattctccactggcatagtagatataaactattcctttgcctaccttttactgccttatcctggaaatattggggaaaataagccatatcagtgagatttacctaaaaacaaaggaaggaaagtcactatggaaaccaagtagatgctttttgtaagtttggtggagcataactggcccagaagtctgggtgcctgagttctagttcgtgctctgtcaactggtagatttgtaattctaggtcttggttttcttacctggtgaataagtcatgatctctaaaacccttcctgcccttaatattgtctgaatttcaaggggaaaaaaaaaatctggttcctttaattatttttttttaacacttaaattcctaactttattagacaagaagtatggcccacttaacagttaaggaacgtaaatttgttattggctcgaaataataatttgacacaatactagtcaaccatttagaggccttggaaaaagaagaggaacagcactgaaaattccaagtatgattggaaattatctgggagcggggaattaaatattcaatgcatgaaagcaattgtactggcttctgggaaaaaggaaacaagaacattgctatggaacttgttacccagagaaaggaagtgaaaagatttacaattataagcacgaaattcattggcagattacctgctttatctacagacagattgttttggggtttggttttgtctaggcagcctctggccaggctccttaattgcttgctctgctaatatttcagcttcctctcttgactccttgaggaaccaaccgctctttggaagacaaacacttagccacctctgtgctccagggtaaccctgagaagctctgctgtctggggcaagctttctttccaaagggaatgagaggaaggcaagcaggcagggtcctgcagcgtcaggccttctggggaaagtttcctcattttgtttgacagggtcctcagtacatcagacacccagatttgaatataagttcagagcctgatctcaagctaaatcagaatgctttggggactaaccatgatcgagaattggccaaatagtatggcatataaacagccatccagccagccgcaagtaaaggaacgtttgatccttggcaccttaaatgattgattgccttcaataggcaaactgctggtctggaaatctcgttgaaggctgaatacttcatgcggagtaggacaagccttagcccaccttcaggttgaaaggaaaggccataggactcaaaagataatgactctgaaactaaactccttccttctgaagctgacagaggtacttagtgcatctcaagactccatctcataaaactcatttgtgagggatttgctctagatttttctaaacattttttcatctattgtccagacttgcaaatccagtgtggacctgatggagatacccttcacacctgcgctcccaccccctcggcagggagacgtctcagtagaggagaacacacccattatgctgggatttgtatttataaatcacttcccttttagggatgagcggtgtggggcgtgtgtgcgtgtgagtgtatgcgcgtgcgtgtgtgaccctcaagtgtactttgctcaatttagacgtgcagtatttccagaaacaatgaaaaaagtaagatgttttcttctttatgattctgctcaaaacaccacgtgccgcctcagagctttttctagagcctcggtcctcaatgacgcgcttgacctgttgatgcctcagcccagcgaagcccctcacctgtgccccgggcgacagctcttcagtgtgcagtgcaggcctggggtggactgccaggccttcgctctgtgccagcaacgccgttcttgttgctcctccatgaacaggggtacaagccctggcccctcctcgacactaagccccccacagactcagcctccaaggaaccgctgagcacccttgaagcatgtcattgtcagtgatacctttttattctatggaactctaacctattcgtgtcatattgaccttttgctgcatgagtcataaattatgaaatcagtcttacagtttttgaaatgtagccagcatttgtaaggctaaacctttttcatgaactgaatttaagtgaataaccaagccacagttcctcctcaaatggagagtgatgatcgacatttgaatctctttgccctttccaacggctatggcatcaggttctaaaataagctcgtaatttttcctgttattttaataatatggaaatattagcatagtgtttcttttgatagtgatagactataatccatatttaaattttatagagaagaaattttattgtactgtgatgtagatatttattatccaggtaaggatttgcccggtgtgtattttttacaattgagacattttactttaatctttaaaaaaaatgcattaaaaacacactcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaccagactgggggaaaaaaggtttggccttatcacagaatttttactgtgctgtataaatgtttgcaaatgcgaaaagtgtgcatttatagtgtgtttccacattaattaatgccgccttcaagagcaatattgtgcaggtaaaacgctgtttgtggctttctgttgcacagttaaagctgacccaccctatgcacaagacaatcaaatataaatctgtcctcctcaggatgcagataatactcatgtaaattatggagcacaatgtaagacaaaaggagacactttacatatgtattgttgatacagaaattatcagggcatgaatgagctgatgtgacattatgccacttctttcttttggttctcccttattaacttggcatttttaatttgaccatagagccaaattagttctccatgctttcttcgtagaaaatccttttttttcccataatgttttcatgccctgagaatcagaaaaatactacagaatagaaaaagatttacagtcattggaagatttgtgttttgcaaacagtgttaagtgatattgctagatggtgatatttttttcagcctaaaactctgttgaaatctgtgatcaaaatgttttaaactatccaaaaaaaatttgtatatttgggaaaaatggatttttacatagcttttgtatgcagatataaaactgtaattatgaatatagtgggcgtagataaactcataagcttaaattctaaaaaagaaaaagcttataacagatatattttcctgtctctttctttaaatattattattttctacataggcaaagagttgcctgctcttctcacttcagctgctgccaaaagacggaaccacggatgtaaggacatttatttcataaataaacatctactagaataagcaaatttacttgagaagaaactatggagggagagaagaaactaagtaaaatgctgatggggggttacctctttggaaggggccacaaagatgaagggaggagagaggtgaagttttgcagctcaaggacaacattcatcttctcatctcaaattattcaggaatattactaatggaattatgttaacatcagctgccaacatatatctcaatctctgttgccctgaacacatgttaattgagattctttctatgacaagtaacaaaaagctaactcaaactggcttaagcagaaagctaattattgactttaatatctgggatctagggtattgcataccaaagcttcaggcatggctggatctgggtgcacttactcagtattctcaggaagctcctttttttgtcattcatgtagacttaacattcacatggcctttcaccttacggtggcctccaatagctccaggatgagctttacagctccaaatatagtgaaaggagaatttcttttctccaacaattctaatgaaaattctggcctaattctcactggcccaagttcagtcatgtgcccattcctgagccaatcactgtggtgaggaaaacagatgcataaccaaccttatcctcaggaatcctggaactgggtgaggggaaagagggacagtcagcttcatctaaactatggactgagagttgaggcaagatgattcctgaaagaaaattctaagtcttgctgctataagtggaagagaatggtgggcaagcaaaagcaaccagtgcccacaccaaaggtaaatctaaaacaacatcccatttcagtacagcaagcggttctccttcacacagaggaagctcatctccaagtttttatttggccaggacatgaaccaaataaacaccttccaaagaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7068 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:7068 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
GeneID:7068 -> Molecular function: GO:0003707 [steroid hormone receptor activity] evidence: IEA
GeneID:7068 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
GeneID:7068 -> Molecular function: GO:0004887 [thyroid hormone receptor activity] evidence: IDA
GeneID:7068 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7068 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7068 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:7068 -> Molecular function: GO:0031490 [chromatin DNA binding] evidence: IEA
GeneID:7068 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:7068 -> Molecular function: GO:0070324 [thyroid hormone binding] evidence: IDA
GeneID:7068 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:7068 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: TAS
GeneID:7068 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:7068 -> Biological process: GO:0007605 [sensory perception of sound] evidence: IEA
GeneID:7068 -> Biological process: GO:0007621 [negative regulation of female receptivity] evidence: IEA
GeneID:7068 -> Biological process: GO:0008016 [regulation of heart contraction] evidence: IEA
GeneID:7068 -> Biological process: GO:0008050 [female courtship behavior] evidence: IEA
GeneID:7068 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
GeneID:7068 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:7068 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:7068 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:7068 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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