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2025-05-09 16:45:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001081640 13416 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens protein kinase, DNA-activated, catalytic polypeptide
(PRKDC), transcript variant 2, mRNA.
ACCESSION NM_001081640
VERSION NM_001081640.1 GI:126032349
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 13416)
AUTHORS Davis,A.J., Lee,K.J. and Chen,D.J.
TITLE The N-terminal region of the DNA-dependent protein kinase catalytic
subunit is required for its DNA double-stranded break-mediated
activation
JOURNAL J. Biol. Chem. 288 (10), 7037-7046 (2013)
PUBMED 23322783
REMARK GeneRIF: Results show the N-terminal region mediates the
interaction between DNA-PKcs and the Ku70/Ku80-DNA complex and is
required for its DNA double-stranded breaks (DSBs)-induced
enzymatic activity.
REFERENCE 2 (bases 1 to 13416)
AUTHORS Munoz,D.P., Kawahara,M. and Yannone,S.M.
TITLE An autonomous chromatin/DNA-PK mechanism for localized DNA damage
signaling in mammalian cells
JOURNAL Nucleic Acids Res. 41 (5), 2894-2906 (2013)
PUBMED 23325849
REMARK GeneRIF: Allosteric regulation of DNA-PK by DNA termini protruding
from chromatin constitutes an autonomous mechanism for
break-localized protein phosphorylation that generates sub-nuclear
foci.
REFERENCE 3 (bases 1 to 13416)
AUTHORS Zhang,J., Wu,X.H. and Gan,Y.
TITLE Current evidence on the relationship between three polymorphisms in
the XRCC7 gene and cancer risk
JOURNAL Mol. Biol. Rep. 40 (1), 81-86 (2013)
PUBMED 23108991
REMARK GeneRIF: XRCC7 rs7003908 polymorphism may contribute to cancer
susceptibility for prostate cancer, which is recommended to be
included in future large-sample studies and functional assays.
REFERENCE 4 (bases 1 to 13416)
AUTHORS Pyun,B.J., Seo,H.R., Lee,H.J., Jin,Y.B., Kim,E.J., Kim,N.H.,
Kim,H.S., Nam,H.W., Yook,J.I. and Lee,Y.S.
TITLE Mutual regulation between DNA-PKcs and Snail1 leads to increased
genomic instability and aggressive tumor characteristics
JOURNAL Cell Death Dis 4, E517 (2013)
PUBMED 23449453
REMARK GeneRIF: DNA-PKcs phosphorylates snail1 at ser100 led to increased
snail 1 stability and inhibited the kinase activity of DNA-Pkcs.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 13416)
AUTHORS Rahimi,M., Fayaz,S., Fard-Esfahani,A., Modarressi,M.H., Akrami,S.M.
and Fard-Esfahani,P.
TITLE The role of Ile3434Thr XRCC7 gene polymorphism in differentiated
thyroid cancer risk in an Iranian population
JOURNAL Iran. Biomed. J. 16 (4), 218-222 (2012)
PUBMED 23183621
REMARK GeneRIF: Allele 3434Thr in XRCC7 gene might be associated with
differentiated thyroid cancer risk.
REFERENCE 6 (bases 1 to 13416)
AUTHORS Poltoratsky,V.P., Shi,X., York,J.D., Lieber,M.R. and Carter,T.H.
TITLE Human DNA-activated protein kinase (DNA-PK) is homologous to
phosphatidylinositol kinases
JOURNAL J. Immunol. 155 (10), 4529-4533 (1995)
PUBMED 7594449
REFERENCE 7 (bases 1 to 13416)
AUTHORS Sipley,J.D., Menninger,J.C., Hartley,K.O., Ward,D.C., Jackson,S.P.
and Anderson,C.W.
TITLE Gene for the catalytic subunit of the human DNA-activated protein
kinase maps to the site of the XRCC7 gene on chromosome 8
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (16), 7515-7519 (1995)
PUBMED 7638222
REFERENCE 8 (bases 1 to 13416)
AUTHORS Iijima,S., Teraoka,H., Date,T. and Tsukada,K.
TITLE DNA-activated protein kinase in Raji Burkitt's lymphoma cells.
Phosphorylation of c-Myc oncoprotein
JOURNAL Eur. J. Biochem. 206 (2), 595-603 (1992)
PUBMED 1597196
REFERENCE 9 (bases 1 to 13416)
AUTHORS Carter,T., Vancurova,I., Sun,I., Lou,W. and DeLeon,S.
TITLE A DNA-activated protein kinase from HeLa cell nuclei
JOURNAL Mol. Cell. Biol. 10 (12), 6460-6471 (1990)
PUBMED 2247066
REFERENCE 10 (bases 1 to 13416)
AUTHORS Lees-Miller,S.P. and Anderson,C.W.
TITLE The human double-stranded DNA-activated protein kinase
phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two
NH2-terminal threonine residues
JOURNAL J. Biol. Chem. 264 (29), 17275-17280 (1989)
PUBMED 2507541
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U47077.5 and U34994.3.
Summary: This gene encodes the catalytic subunit of the
DNA-dependent protein kinase (DNA-PK). It functions with the
Ku70/Ku80 heterodimer protein in DNA double strand break repair and
recombination. The protein encoded is a member of the
PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
Transcript Variant: This variant (2) lacks an exon in the coding
region, compared to variant 1. The encoded isoform (2) is shorter
than isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U34994.3 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-11453 U47077.5 1-11453
11454-12409 U34994.3 11449-12404
12410-13416 U47077.5 12503-13509
FEATURES Location/Qualifiers
source 1..13416
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q11"
gene 1..13416
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="protein kinase, DNA-activated, catalytic
polypeptide"
/db_xref="GeneID:5591"
/db_xref="HGNC:9413"
/db_xref="MIM:600899"
exon 1..211
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
CDS 58..12351
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 2;
DNA-dependent protein kinase catalytic subunit;
hyper-radiosensitivity of murine scid mutation,
complementing 1; p460; DNA-PK catalytic subunit"
/codon_start=1
/product="DNA-dependent protein kinase catalytic subunit
isoform 2"
/protein_id="NP_001075109.1"
/db_xref="GI:126032350"
/db_xref="GeneID:5591"
/db_xref="HGNC:9413"
/db_xref="MIM:600899"
/translation="
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
"
misc_feature 406..408
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 919..1026
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: HEAT 1"
misc_feature 2539..2541
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 2734..2736
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78527.3); phosphorylation site"
misc_feature 3067..3177
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: HEAT 2"
misc_feature 3682..3684
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 4564..4671
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: Interaction with C1D"
misc_feature 4564..4671
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: Leucine-zipper"
misc_feature 5224..5325
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: TPR 1"
misc_feature 5500..6687
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="NUC194 domain; Region: NUC194; pfam08163"
/db_xref="CDD:203865"
misc_feature 5965..5967
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 6115..6120
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage, by caspase-3 (Probable); propagated from
UniProtKB/Swiss-Prot (P78527.3); cleavage site"
misc_feature 6832..6834
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 7363..9693
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78527.3);
Region: KIP-binding"
misc_feature 7882..7884
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
misc_feature 7891..7893
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
misc_feature 7891..7893
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 7969..7971
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
misc_feature 7969..7971
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 7996..7998
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
misc_feature 7996..7998
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8080..8082
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8086..8088
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 8284..8286
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 9124..10467
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="FAT domain; Region: FAT; pfam02259"
/db_xref="CDD:202179"
misc_feature 9670..9672
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78527.3); phosphorylation site"
misc_feature 9670..9672
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 9778..9780
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 9835..9837
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 10918..10920
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 10969..10971
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 10981..10983
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P78527.3); acetylation site"
misc_feature 11212..12009
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="DNA-dependent protein kinase (DNA-PK), catalytic
domain; The DNA-PK catalytic domain subfamily is part of a
larger superfamily that includes the catalytic domains of
other kinases such as the typical
serine/threonine/tyrosine protein kinases (PKs); Region:
PIKKc_DNA-PK; cd05172"
/db_xref="CDD:119432"
misc_feature order(11242..11244,11248..11256,11260..11262,11308..11310,
11314..11316,11323..11325,11428..11430,11539..11550,
11563..11565,11743..11745,11749..11751,11782..11787)
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:119432"
misc_feature 11305..12015
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="Phosphoinositide 3-kinase, catalytic domain;
Region: PI3Kc; smart00146"
/db_xref="CDD:197542"
misc_feature 11719..11745
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="catalytic loop [active]"
/db_xref="CDD:119432"
misc_feature order(11785..11817,11821..11856)
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="activation loop (A-loop); other site"
/db_xref="CDD:119432"
misc_feature 12040..12042
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78527.3); phosphorylation site"
misc_feature 12253..12348
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/note="FATC domain; Region: FATC; pfam02260"
/db_xref="CDD:202180"
variation 73
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="g"
/replace="t"
/db_xref="dbSNP:8177999"
exon 212..288
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 289..381
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 382..456
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 457..565
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 566..678
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 679..778
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 779..834
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 835..865
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 866..1023
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 1024..1170
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 1056
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178017"
exon 1171..1335
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 1336..1504
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 1505..1554
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 1555..1680
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
STS 1566..1645
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/standard_name="PMC84245P1"
/db_xref="UniSTS:273442"
exon 1681..1833
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 1834..1949
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 1848
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178032"
variation 1871
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="g"
/db_xref="dbSNP:8178033"
exon 1950..2109
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 1968
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:45438803"
variation 2097
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178040"
exon 2110..2196
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 2140
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178046"
exon 2197..2316
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2317..2476
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2477..2583
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2584..2674
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2675..2838
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2839..2991
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 2992..3099
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 3100..3326
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 3269
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178070"
exon 3327..3421
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 3422..3521
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 3522..3655
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 3656..3904
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 3816
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178087"
variation 3891
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178088"
exon 3905..4128
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 3998
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="g"
/replace="t"
/db_xref="dbSNP:8178090"
exon 4129..4337
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 4338..4470
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 4471..4629
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 4630..4833
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 4820
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="t"
/db_xref="dbSNP:8178104"
exon 4834..5019
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 4866
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="g"
/replace="t"
/db_xref="dbSNP:8178106"
exon 5020..5124
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 5125..5292
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 5293..5420
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 5310
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178120"
exon 5421..5628
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 5622
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178122"
exon 5629..5807
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 5808..5976
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 5977..6042
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6043..6115
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6116..6264
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 6198
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178141"
exon 6265..6402
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 6341
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178147"
exon 6403..6522
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6523..6666
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6667..6818
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6819..6950
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 6951..7062
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 7063..7187
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 7188..7337
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 7338..7511
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 7512..7610
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 7611..7818
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 7704
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:4425755"
exon 7819..8008
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 8009..8209
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 8161
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178178"
exon 8210..8322
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 8323..8454
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 8455..8634
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 8635..8840
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 8752
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:4278157"
exon 8841..8979
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 8980..9168
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 9102
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:201065627"
variation 9103
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="c"
/db_xref="dbSNP:202148492"
exon 9169..9393
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 9394..9502
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 9503..9614
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 9503
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178208"
exon 9615..9804
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 9658
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178216"
exon 9805..9979
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 9980..10173
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 10174..10354
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 10179
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178224"
variation 10268
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178225"
exon 10355..10515
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 10433
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178228"
exon 10516..10727
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 10683
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178231"
exon 10728..10815
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 10741
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="t"
/db_xref="dbSNP:8178232"
exon 10816..10959
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 10960..11164
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 11133
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178235"
variation 11163
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178236"
exon 11165..11232
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 11233..11453
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 11454..11543
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 11471
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178245"
exon 11544..11615
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 11616..11817
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 11730
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178247"
variation 11758
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178248"
variation 11769
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178249"
exon 11818..12006
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 12007..12146
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
exon 12147..13416
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/inference="alignment:Splign:1.39.8"
variation 12188
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:2515637"
STS 12408..12614
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/standard_name="G29848"
/db_xref="UniSTS:40531"
variation 12542
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178268"
variation 12644
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="g"
/db_xref="dbSNP:1804610"
variation 12693
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178269"
variation 12882
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="a"
/replace="g"
/db_xref="dbSNP:8178270"
variation 12986
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/replace="c"
/replace="t"
/db_xref="dbSNP:8178271"
STS 13272..13371
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/standard_name="D8S1353E"
/db_xref="UniSTS:151168"
STS 13273..13377
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
/standard_name="EST197660"
/db_xref="UniSTS:10824"
polyA_signal 13394..13399
/gene="PRKDC"
/gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
XRCC7"
ORIGIN
ggggcatttccgggtccgggccgagcgggcgcacgcgcgggagcgggactcggcggcatggcgggctccggagccggtgtgcgttgctccctgctgcggctgcaggagaccttgtccgctgcggaccgctgcggtgctgccctggccggtcatcaactgatccgcggcctggggcaggaatgcgtcctgagcagcagccccgcggtgctggcattacagacatctttagttttttccagagatttcggtttgcttgtatttgtccggaagtcactcaacagtattgaatttcgtgaatgtagagaagaaatcctaaagtttttatgtattttcttagaaaaaatgggccagaagatcgcaccttactctgttgaaattaagaacacttgtaccagtgtttatacaaaagatagagctgctaaatgtaaaattccagccctggaccttcttattaagttacttcagacttttagaagttctagactcatggatgaatttaaaattggagaattatttagtaaattctatggagaacttgcattgaaaaaaaaaataccagatacagttttagaaaaagtatatgagctcctaggattattgggtgaagttcatcctagtgagatgataaataatgcagaaaacctgttccgcgcttttctgggtgaacttaagacccagatgacatcagcagtaagagagcccaaactacctgttctggcaggatgtctgaaggggttgtcctcacttctgtgcaacttcactaagtccatggaagaagatccccagacttcaagggagatttttaattttgtactaaaggcaattcgtcctcagattgatctgaagagatatgctgtgccctcagctggcttgcgcctatttgccctgcatgcatctcagtttagcacctgccttctggacaactacgtgtctctatttgaagtcttgttaaagtggtgtgcccacacaaatgtagaattgaaaaaagctgcactttcagccctggaatcctttctgaaacaggtttctaatatggtggcgaaaaatgcagaaatgcataaaaataaactgcagtactttatggagcagttttatggaatcatcagaaatgtggattcgaacaacaaggagttatctattgctatccgtggatatggactttttgcaggaccgtgcaaggttataaacgcaaaagatgttgacttcatgtacgttgagctcattcagcgctgcaagcagatgttcctcacccagacagacactggtgacgaccgtgtttatcagatgccaagcttcctccagtctgttgcaagcgtcttgctgtaccttgacacagttcctgaggtgtatactccagttctggagcacctcgtggtgatgcagatagacagtttcccacagtacagtccaaaaatgcagctggtgtgttgcagagccatagtgaaggtgttcctagctttggcagcaaaagggccagttctcaggaattgcattagtactgtggtgcatcagggtttaatcagaatatgttctaaaccagtggtccttccaaagggccctgagtctgaatctgaagaccaccgtgcttcaggggaagtcagaactggcaaatggaaggtgcccacatacaaagactacgtggatctcttcagacatctcctgagctctgaccagatgatggattctattttagcagatgaagcatttttctctgtgaattcctccagtgaaagtctgaatcatttactttatgatgaatttgtaaaatccgttttgaagattgttgagaaattggatcttacacttgaaatacagactgttggggaacaagagaatggagatgaggcgcctggtgtttggatgatcccaacttcagatccagcggctaacttgcatccagctaaacctaaagatttttcggctttcattaacctggtggaattttgcagagagattctccctgagaaacaagcagaattttttgaaccatgggtgtactcattttcatatgaattaattttgcaatctacaaggttgcccctcatcagtggtttctacaaattgctttctattacagtaagaaatgccaagaaaataaaatatttcgagggagttagtccaaagagtctgaaacactctcctgaagacccagaaaagtattcttgctttgctttatttgtgaaatttggcaaagaggtggcagttaaaatgaagcagtacaaagatgaacttttggcctcttgtttgacctttcttctgtccttgccacacaacatcattgaactcgatgttagagcctacgttcctgcactgcagatggctttcaaactgggcctgagctatacccccttggcagaagtaggcctgaatgctctagaagaatggtcaatttatattgacagacatgtaatgcagccttattacaaagacattctcccctgcctggatggatacctgaagacttcagccttgtcagatgagaccaagaataactgggaagtgtcagctctttctcgggctgcccagaaaggatttaataaagtggtgttaaagcatctgaagaagacaaagaacctttcatcaaacgaagcaatatccttagaagaaataagaattagagtagtacaaatgcttggatctctaggaggacaaataaacaaaaatcttctgacagtcacgtcctcagatgagatgatgaagagctatgtggcctgggacagagagaagcggctgagctttgcagtgccctttagagagatgaaacctgtcattttcctggatgtgttcctgcctcgagtcacagaattagcgctcacagccagtgacagacaaactaaagttgcagcctgtgaacttttacatagcatggttatgtttatgttgggcaaagccacgcagatgccagaagggggacagggagccccacccatgtaccagctctataagcggacgtttcctgtgctgcttcgacttgcgtgtgatgttgatcaggtgacaaggcaactgtatgagccactagttatgcagctgattcactggttcactaacaacaagaaatttgaaagtcaggatactgttgccttactagaagctatattggatggaattgtggaccctgttgacagtactttaagagatttttgtggtcggtgtattcgagaattccttaaatggtccattaagcaaataacaccacagcagcaggagaagagtccagtaaacaccaaatcgcttttcaagcgactttatagccttgcgcttcaccccaatgctttcaagaggctgggagcatcacttgcctttaataatatctacagggaattcagggaagaagagtctctggtggaacagtttgtgtttgaagccttggtgatatacatggagagtctggccttagcacatgcagatgagaagtccttaggtacaattcaacagtgttgtgatgccattgatcacctatgccgcatcattgaaaagaagcatgtttctttaaataaagcaaagaaacgacgtttgccgcgaggatttccaccttccgcatcattgtgtttattggatctggtcaagtggcttttagctcattgtgggaggccccagacagaatgtcgacacaaatccattgaactcttttataaattcgttcctttattgccaggcaacagatcccctaatttgtggctgaaagatgttctcaaggaagaaggtgtctcttttctcatcaacacctttgaggggggtggctgtggccagccctcgggcatcctggcccagcccaccctcttgtaccttcgggggccattcagcctgcaggccacgctatgctggctggacctgctcctggccgcgttggagtgctacaacacgttcattggcgagagaactgtaggagcgctccaggtcctaggtactgaagcccagtcttcacttttgaaagcagtggctttcttcttagaaagcattgccatgcatgacattatagcagcagaaaagtgctttggcactggggcagcaggtaacagaacaagcccacaagagggagaaaggtacaactacagcaaatgcaccgttgtggtccggattatggagtttaccacgactctgctaaacacctccccggaaggatggaagctcctgaagaaggacttgtgtaatacacacctgatgagagtcctggtgcagacgctgtgtgagcccgcaagcataggtttcaacatcggagacgtccaggttatggctcatcttcctgatgtttgtgtgaatctgatgaaagctctaaagatgtccccatacaaagatatcctagagacccatctgagagagaaaataacagcacagagcattgaggagctttgtgccgtcaacttgtatggccctgacgcgcaagtggacaggagcaggctggctgctgttgtgtctgcctgtaaacagcttcacagagctgggcttctgcataatatattaccgtctcagtccacagatttgcatcattctgttggcacagaacttctttccctggtttataaaggcattgcccctggagatgagagacagtgtctgccttctctagacctcagttgtaagcagctggccagcggacttctggagttagcctttgcttttggaggactgtgtgagcgccttgtgagtcttctcctgaacccagcggtgctgtccacggcgtccttgggcagctcacagggcagcgtcatccacttctcccatggggagtatttctatagcttgttctcagaaacgatcaacacggaattattgaaaaatctggatcttgctgtattggagctcatgcagtcttcagtggataataccaaaatggtgagtgccgttttgaacggcatgttagaccagagcttcagggagcgagcaaaccagaaacaccaaggactgaaacttgcgactacaattctgcaacactggaagaagtgtgattcatggtgggccaaagattcccctctcgaaactaaaatggcagtgctggccttactggcaaaaattttacagattgattcatctgtatcttttaatacaagtcatggttcattccctgaagtctttacaacatatattagtctacttgctgacacaaagctggatctacatttaaagggccaagctgtcactcttcttccattcttcaccagcctcactggaggcagtctggaggaacttagacgtgttctggagcagctcatcgttgctcacttccccatgcagtccagggaatttcctccaggaactccgcggttcaataattatgtggactgcatgaaaaagtttctagatgcattggaattatctcaaagccctatgttgttggaattgatgacagaagttctttgtcgggaacagcagcatgtcatggaagaattatttcaatccagtttcaggaggattgccagaaggggttcatgtgtcacacaagtaggccttctggaaagcgtgtatgaaatgttcaggaaggatgacccccgcctaagtttcacacgccagtcctttgtggaccgctccctcctcactctgctgtggcactgtagcctggatgctttgagagaattcttcagcacaattgtggtggatgccattgatgtgttgaagtccaggtttacaaagctaaatgaatctacctttgatactcaaatcaccaagaagatgggctactataagattctagacgtgatgtattctcgccttcccaaagatgatgttcatgctaaggaatcaaaaattaatcaagttttccatggctcgtgtattacagaaggaaatgaacttacaaagacattgattaaattgtgctacgatgcatttacagagaacatggcaggagagaatcagctgctggagaggagaagactttaccattgtgcagcatacaactgcgccatatctgtcatctgctgtgtcttcaatgagttaaaattttaccaaggttttctgtttagtgaaaaaccagaaaagaacttgcttatttttgaaaatctgatcgacctgaagcgccgctataattttcctgtagaagttgaggttcctatggaaagaaagaaaaagtacattgaaattaggaaagaagccagagaagcagcaaatggggattcagatggtccttcctatatgtcttccctgtcatatttggcagacagtaccctgagtgaggaaatgagtcaatttgatttctcaaccggagttcagagctattcatacagctcccaagaccctagacctgccactggtcgttttcggagacgggagcagcgggaccccacggtgcatgatgatgtgctggagctggagatggacgagctcaatcggcatgagtgcatggcgcccctgacggccctggtcaagcacatgcacagaagcctgggcccgcctcaaggagaagaggattcagtgccaagagatcttccttcttggatgaaattcctccatggcaaactgggaaatccaatagtaccattaaatatccgtctcttcttagccaagcttgttattaatacagaagaggtctttcgcccttacgcgaagcactggcttagccccttgctgcagctggctgcttctgaaaacaatggaggagaaggaattcactacatggtggttgagatagtggccactattctttcatggacaggcttggccactccaacaggggtccctaaagatgaagtgttagcaaatcgattgcttaatttcctaatgaaacatgtctttcatccaaaaagagctgtgtttagacacaaccttgaaattataaagacccttgtcgagtgctggaaggattgtttatccatcccttataggttaatatttgaaaagttttccggtaaagatcctaattctaaagacaactcagtagggattcaattgctaggcatcgtgatggccaatgacctgcctccctatgacccacagtgtggcatccagagtagcgaatacttccaggctttggtgaataatatgtcctttgtaagatataaagaagtgtatgccgctgcagcagaagttctaggacttatacttcgatatgttatggagagaaaaaacatactggaggagtctctgtgtgaactggttgcgaaacaattgaagcaacatcagaatactatggaggacaagtttattgtgtgcttgaacaaagtgaccaagagcttccctcctcttgcagacaggttcatgaatgctgtgttctttctgctgccaaaatttcatggagtgttgaaaacactctgtctggaggtggtactttgtcgtgtggagggaatgacagagctgtacttccagttaaagagcaaggacttcgttcaagtcatgagacatagagatgatgaaagacaaaaagtatgtttggacataatttataagatgatgccaaagttaaaaccagtagaactccgagaacttctgaaccccgttgtggaattcgtttcccatccttctacaacatgtagggaacaaatgtataatattctcatgtggattcatgataattacagagatccagaaagtgagacagataatgactcccaggaaatatttaagttggcaaaagatgtgctgattcaaggattgatcgatgagaaccctggacttcaattaattattcgaaatttctggagccatgaaactaggttaccttcaaataccttggaccggttgctggcactaaattccttatattctcctaagatagaagtgcactttttaagtttagcaacaaattttctgctcgaaatgaccagcatgagcccagattatccaaaccccatgttcgagcatcctctgtcagaatgcgaatttcaggaatataccattgattctgattggcgtttccgaagtactgttctcactccgatgtttgtggagacccaggcctcccagggcactctccagacccgtacccaggaagggtccctctcagctcgctggccagtggcagggcagataagggccacccagcagcagcatgacttcacactgacacagactgcagatggaagaagctcatttgattggctgaccgggagcagcactgacccgctggtcgaccacaccagtccctcatctgactccttgctgtttgcccacaagaggagtgaaaggttacagagagcacccttgaagtcagtggggcctgattttgggaaaaaaaggctgggccttccaggggacgaggtggataacaaagtgaaaggtgcggccggccggacggacctactacgactgcgcagacggtttatgagggaccaggagaagctcagtttgatgtatgccagaaaaggcgttgctgagcaaaaacgagagaaggaaatcaagagtgagttaaaaatgaagcaggatgcccaggtcgttctgtacagaagctaccggcacggagaccttcctgacattcagatcaagcacagcagcctcatcaccccgttacaggccgtggcccagagggacccaataattgcaaaacagctctttagcagcttgttttctggaattttgaaagagatggataaatttaagacactgtctgaaaaaaacaacatcactcaaaagttgcttcaagacttcaatcgttttcttaataccaccttctctttctttccaccctttgtctcttgtattcaggacattagctgtcagcacgcagccctgctgagcctcgacccagcggctgttagcgctggttgcctggccagcctacagcagcccgtgggcatccgcctgctagaggaggctctgctccgcctgctgcctgctgagctgcctgccaagcgagtccgtgggaaggcccgcctccctcctgatgtcctcagatgggtggagcttgctaagctgtatagatcaattggagaatacgacgtcctccgtgggatttttaccagtgagataggaacaaagcaaatcactcagagtgcattattagcagaagccagaagtgattattctgaagctgctaagcagtatgatgaggctctcaataaacaagactgggtagatggtgagcccacagaagccgagaaggatttttgggaacttgcatcccttgactgttacaaccaccttgctgagtggaaatcacttgaatactgttctacagccagtatagacagtgagaaccccccagacctaaataaaatctggagtgaaccattttatcaggaaacatatctaccttacatgatccgcagcaagctgaagctgctgctccagggagaggctgaccagtccctgctgacatttattgacaaagctatgcacggggagctccagaaggcgattctagagcttcattacagtcaagagctgagtctgctttacctcctgcaagatgatgttgacagagccaaatattacattcaaaatggcattcagagttttatgcagaattattctagtattgatgtcctcttacaccaaagtagactcaccaaattgcagtctgtacaggctttaacagaaattcaggagttcatcagctttataagcaaacaaggcaatttatcatctcaagttccccttaagagacttctgaacacctggacaaacagatatccagatgctaaaatggacccaatgaacatctgggatgacatcatcacaaatcgatgtttctttctcagcaaaatagaggagaagcttacccctcttccagaagataatagtatgaatgtggatcaagatggagaccccagtgacaggatggaagtgcaagagcaggaagaagatatcagctccctgatcaggagttgcaagttttccatgaaaatgaagatgatagacagtgcccggaagcagaacaatttctcacttgctatgaaactactgaaggagctgcataaagagtcaaaaaccagagacgattggctggtgagctgggtgcagagctactgccgcctgagccactgccggagccggtcccagggctgctctgagcaggtgctcactgtgctgaaaacagtctctttgttggatgagaacaacgtgtcaagct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//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5591 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:5591 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:5591 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:5591 -> Molecular function: GO:0004677 [DNA-dependent protein kinase activity] evidence: IDA
GeneID:5591 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5591 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:5591 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:5591 -> Molecular function: GO:0019899 [enzyme binding] evidence: IEA
GeneID:5591 -> Biological process: GO:0000723 [telomere maintenance] evidence: IEA
GeneID:5591 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA
GeneID:5591 -> Biological process: GO:0002326 [B cell lineage commitment] evidence: IEA
GeneID:5591 -> Biological process: GO:0002328 [pro-B cell differentiation] evidence: IEA
GeneID:5591 -> Biological process: GO:0002360 [T cell lineage commitment] evidence: IEA
GeneID:5591 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
GeneID:5591 -> Biological process: GO:0006302 [double-strand break repair] evidence: TAS
GeneID:5591 -> Biological process: GO:0006303 [double-strand break repair via nonhomologous end joining] evidence: TAS
GeneID:5591 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS
GeneID:5591 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:5591 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:5591 -> Biological process: GO:0007507 [heart development] evidence: IEA
GeneID:5591 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IEA
GeneID:5591 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:5591 -> Biological process: GO:0031648 [protein destabilization] evidence: IEA
GeneID:5591 -> Biological process: GO:0032481 [positive regulation of type I interferon production] evidence: TAS
GeneID:5591 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
GeneID:5591 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: IEA
GeneID:5591 -> Biological process: GO:0033152 [immunoglobulin V(D)J recombination] evidence: IEA
GeneID:5591 -> Biological process: GO:0033153 [T cell receptor V(D)J recombination] evidence: IEA
GeneID:5591 -> Biological process: GO:0035234 [germ cell programmed cell death] evidence: IEA
GeneID:5591 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:5591 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5591 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:5591 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:5591 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
GeneID:5591 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:5591 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:5591 -> Cellular component: GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex] evidence: IDA
GeneID:5591 -> Cellular component: GO:0070419 [nonhomologous end joining complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001075109 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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