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2025-05-09 17:22:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001080467 9520 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens myosin VB (MYO5B), mRNA.
ACCESSION NM_001080467 XM_371116
VERSION NM_001080467.2 GI:239915992
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9520)
AUTHORS Gidon,A., Bardin,S., Cinquin,B., Boulanger,J., Waharte,F.,
Heliot,L., de la Salle,H., Hanau,D., Kervrann,C., Goud,B. and
Salamero,J.
TITLE A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling
steps of langerin from the ERC to the plasma membrane
JOURNAL Traffic 13 (6), 815-833 (2012)
PUBMED 22420646
REMARK GeneRIF: Rab11A/myosin Vb/Rab11-FIP2 complex frames two late
recycling steps of langerin from the ERC to the plasma membrane
REFERENCE 2 (bases 1 to 9520)
AUTHORS Dong,W., Chen,X., Chen,P., Yue,D., Zhu,L. and Fan,Q.
TITLE Inactivation of MYO5B promotes invasion and motility in gastric
cancer cells
JOURNAL Dig. Dis. Sci. 57 (5), 1247-1252 (2012)
PUBMED 22134786
REMARK GeneRIF: Inactivation of MYO5B by siRNA against MYO5B can promote
cell proliferation, invasion and motility.The expression of MYO5B
was downregulated in gastric cancer and inactivation of MYO5B may
contribute to tumorigenesis.
REFERENCE 3 (bases 1 to 9520)
AUTHORS Golachowska,M.R., van Dael,C.M., Keuning,H., Karrenbeld,A.,
Hoekstra,D., Gijsbers,C.F., Benninga,M.A., Rings,E.H. and van
Ijzendoorn,S.C.
TITLE MYO5B mutations in patients with microvillus inclusion disease
presenting with transient renal Fanconi syndrome
JOURNAL J. Pediatr. Gastroenterol. Nutr. 54 (4), 491-498 (2012)
PUBMED 22441677
REMARK GeneRIF: MYO5B mutations have divergent effects on the apical
membrane system in kidney and intestinal epithelial cells.
REFERENCE 4 (bases 1 to 9520)
AUTHORS Szperl,A.M., Golachowska,M.R., Bruinenberg,M., Prekeris,R.,
Thunnissen,A.M., Karrenbeld,A., Dijkstra,G., Hoekstra,D.,
Mercer,D., Ksiazyk,J., Wijmenga,C., Wapenaar,M.C., Rings,E.H. and
van IJzendoorn,S.C.
TITLE Functional characterization of mutations in the myosin Vb gene
associated with microvillus inclusion disease
JOURNAL J. Pediatr. Gastroenterol. Nutr. 52 (3), 307-313 (2011)
PUBMED 21206382
REMARK GeneRIF: Our functional analysis indicates that MYO5B mutations can
be correlated with an aberrant subcellular distribution of the
myosin Vb protein, and apical recycling endosomes...
REFERENCE 5 (bases 1 to 9520)
AUTHORS Roland,J.T., Bryant,D.M., Datta,A., Itzen,A., Mostov,K.E. and
Goldenring,J.R.
TITLE Rab GTPase-Myo5B complexes control membrane recycling and
epithelial polarization
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (7), 2789-2794 (2011)
PUBMED 21282656
REMARK GeneRIF: In polarized epithelial cyst cultures, Myo5B was required
for apical membrane trafficking and de novo lumen formation,
dependent on association with both Rab8a and Rab11a.
REFERENCE 6 (bases 1 to 9520)
AUTHORS Lapierre,L.A., Kumar,R., Hales,C.M., Navarre,J., Bhartur,S.G.,
Burnette,J.O., Provance,D.W. Jr., Mercer,J.A., Bahler,M. and
Goldenring,J.R.
TITLE Myosin vb is associated with plasma membrane recycling systems
JOURNAL Mol. Biol. Cell 12 (6), 1843-1857 (2001)
PUBMED 11408590
REMARK GeneRIF: Dominant negative approach suggests MYO5B plays a role in
plasma membrane recycling (through early endosomes).
REFERENCE 7 (bases 1 to 9520)
AUTHORS Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
Jenkins,N.A.
TITLE Mapping of unconventional myosins in mouse and human
JOURNAL Genomics 36 (3), 431-439 (1996)
PUBMED 8884266
REFERENCE 8 (bases 1 to 9520)
AUTHORS Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
TITLE [IMAGE: molecular integration of the analysis of the human genome
and its expression]
JOURNAL C. R. Acad. Sci. III, Sci. Vie 318 (2), 263-272 (1995)
PUBMED 7757816
REFERENCE 9 (bases 1 to 9520)
AUTHORS Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
TITLE Identification and overlapping expression of multiple
unconventional myosin genes in vertebrate cell types
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (14), 6549-6553 (1994)
PUBMED 8022818
REMARK Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. PMID:
7972138]
REFERENCE 10 (bases 1 to 9520)
AUTHORS Huang,W.M., Reed-Fourquet,L., Wu,E. and Wu,J.Y.
TITLE Molecular cloning and amino acid sequence of brain L-glutamate
decarboxylase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (21), 8491-8495 (1990)
PUBMED 2236059
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC032511.2, AY274809.1,
AB290160.1, AK025336.1, BX641287.1, DA350416.1 and Z38208.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 13, 2009 this sequence version replaced gi:122937344.
Summary: The protein encoded by this gene, together with other
proteins, may be involved in plasma membrane recycling. Mutations
in this gene are associated with microvillous inclusion disease.
[provided by RefSeq, Sep 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB290160.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-663 BC032511.2 1-663
664-2193 AY274809.1 724-2253
2194-3453 AB290160.1 2011-3270
3454-4232 AK025336.1 597-1375
4233-6799 AB290160.1 4053-6619
6800-6879 BX641287.1 17-96
6880-7755 AB290160.1 6700-7575
7756-8106 DA350416.1 223-573
8107-9490 AB290160.1 7927-9310
9491-9520 Z38208.1 1-30 c
FEATURES Location/Qualifiers
source 1..9520
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21"
gene 1..9520
/gene="MYO5B"
/note="myosin VB"
/db_xref="GeneID:4645"
/db_xref="HGNC:7603"
/db_xref="MIM:606540"
exon 1..315
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
misc_feature 235..237
/gene="MYO5B"
/note="upstream in-frame stop codon"
CDS 289..5835
/gene="MYO5B"
/note="myosin-Vb; MYO5B variant protein"
/codon_start=1
/product="unconventional myosin-Vb"
/protein_id="NP_001073936.1"
/db_xref="GI:122937345"
/db_xref="CCDS:CCDS42436.1"
/db_xref="GeneID:4645"
/db_xref="HGNC:7603"
/db_xref="MIM:606540"
/translation="
MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV
"
misc_feature 478..2568
/gene="MYO5B"
/note="Myosin. Large ATPases; Region: MYSc; smart00242"
/db_xref="CDD:197599"
misc_feature 496..2568
/gene="MYO5B"
/note="Myosin motor domain, type V myosins. Myosins V
transport a variety of intracellular cargo processively
along actin filaments, such as membraneous organelles and
mRNA. This catalytic (head) domain has ATPase activity and
belongs to the larger group of...; Region: MYSc_type_V;
cd01380"
/db_xref="CDD:30102"
misc_feature order(619..630,634..639,781..804)
/gene="MYO5B"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:30102"
misc_feature 937..951
/gene="MYO5B"
/note="switch I region; other site"
/db_xref="CDD:30102"
misc_feature 1603..1626
/gene="MYO5B"
/note="switch II region; other site"
/db_xref="CDD:30102"
misc_feature order(1687..1722,1729..1758)
/gene="MYO5B"
/note="relay loop; other site"
/db_xref="CDD:30102"
misc_feature 2206..2274
/gene="MYO5B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9ULV0.3);
Region: Actin-binding (Potential)"
misc_feature 2326..2370
/gene="MYO5B"
/note="SH1 helix; other site"
/db_xref="CDD:30102"
misc_feature order(2365..2370,2377..2379,2395..2397,2404..2409,
2416..2418,2503..2505,2512..2514,2518..2523,2527..2535,
2545..2547,2554..2562)
/gene="MYO5B"
/note="converter subdomain; other site"
/db_xref="CDD:30102"
misc_feature 2866..2931
/gene="MYO5B"
/note="Calmodulin-binding motif; Region: IQ; smart00015"
/db_xref="CDD:197470"
misc_feature 2983..3393
/gene="MYO5B"
/note="TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2;
pfam07926"
/db_xref="CDD:149160"
misc_feature 4624..4626
/gene="MYO5B"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9ULV0.3); phosphorylation site"
misc_feature 5326..5643
/gene="MYO5B"
/note="DIL domain; Region: DIL; pfam01843"
/db_xref="CDD:202006"
exon 316..426
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 427..598
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 599..743
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 664
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1815930"
exon 744..900
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 901..1044
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1045..1126
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1127..1234
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1235..1344
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1345..1610
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1611..1692
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1693..1833
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1834..1956
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 1957..2040
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 2041..2193
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 2081
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:75107667"
exon 2194..2291
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 2256
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:1627232"
exon 2292..2378
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 2331
/gene="MYO5B"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2969930"
variation 2343
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:2721078"
exon 2379..2490
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 2491..2702
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 2703..2859
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 2860..3099
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 3100..3333
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 3113
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:2277716"
exon 3334..3418
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 3419..3564
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 3518
/gene="MYO5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:596220"
exon 3565..3684
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 3685..3825
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 3826..3891
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 3879
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:3826579"
exon 3892..4131
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4132..4232
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4233..4310
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 4250
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1942418"
exon 4311..4509
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 4374
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:2969924"
exon 4510..4603
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4604..4747
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4748..4899
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4900..4989
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 4990..5140
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 5141..5426
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 5427..5601
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 5556
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:1058514"
exon 5602..5682
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
exon 5683..9520
/gene="MYO5B"
/inference="alignment:Splign:1.39.8"
variation 5736
/gene="MYO5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:1058527"
variation 5761
/gene="MYO5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:1058532"
variation 5784
/gene="MYO5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:1058536"
variation 5802
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058541"
variation 5817
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058543"
variation 5839
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:1058544"
STS 5840..5979
/gene="MYO5B"
/standard_name="RH17962"
/db_xref="UniSTS:56574"
variation 5859
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:1058548"
variation 5875
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058550"
variation 5879
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058551"
variation 5891
/gene="MYO5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1058553"
variation 5999
/gene="MYO5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:3208550"
variation 6001
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:1058554"
variation 6015
/gene="MYO5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:1058556"
polyA_signal 6026..6031
/gene="MYO5B"
polyA_site 6049
/gene="MYO5B"
variation 6143
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:555879"
variation 7020
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199681294"
variation 7421
/gene="MYO5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1787518"
variation 8299
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:371402939"
variation 8330
/gene="MYO5B"
/replace="c"
/replace="g"
/db_xref="dbSNP:377526532"
variation 8501
/gene="MYO5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:373899751"
variation 8635
/gene="MYO5B"
/replace="g"
/replace="t"
/db_xref="dbSNP:1046477"
variation 9135
/gene="MYO5B"
/replace="a"
/replace="g"
/db_xref="dbSNP:367570644"
variation 9167
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199830730"
variation 9186
/gene="MYO5B"
/replace="a"
/replace="c"
/db_xref="dbSNP:369420591"
STS 9266..9518
/gene="MYO5B"
/standard_name="D18S1018"
/db_xref="UniSTS:21508"
STS 9301..9399
/gene="MYO5B"
/standard_name="D18S1061"
/db_xref="UniSTS:154108"
variation 9341
/gene="MYO5B"
/replace="c"
/replace="t"
/db_xref="dbSNP:199813194"
polyA_signal 9474..9479
/gene="MYO5B"
polyA_site 9493
/gene="MYO5B"
ORIGIN
gcctcctccccacacctgggaggggagtggtgcggcgcggcctcctcccccggcgctcgcaactcctgtccggccgtagctgcgccgccgcggcgggagtaaaggtcgcgccgccgggagcgagccggccgcggcgcctgcgggaagccggcggggcaggtcggagaagagcgagaagatcgagaaactccaggccagcccgggaacatggcgccaggcgggccagccgcggactgagagccgcggggcagccaggagccggggcccgagccccgcccggcccgggccatgtcggtgggcgagctctacagccagtgcacaagggtctggatccctgaccctgatgaggtatggcgctcagctgagttaaccaaggactacaaagaaggagacaagagcctacagctcagactggaggatgaaacgattctggaatacccaattgatgtacaacgcaaccagctgcccttcttacggaatccagatatcttggtgggagaaaatgacctgactgcccttagctatcttcatgagcctgcagttttgcataatttgaaggtccgtttcctggagtccaaccatatctacacttactgtggtatcgtacttgttgccattaatccttatgaacagttgccaatctatggacaagatgtcatctatacctacagtggccaaaacatgggagacatggacccccacatctttgctgtggcagaagaagcctacaagcagatggccagagatgagaagaatcagtccatcatagtcagtggggagtctggagccgggaagacggtatcagccaagtatgccatgcgctatttcgccaccgttggtggctcggccagtgaaaccaacatcgaagagaaggtgctggcatccagtcccatcatggaggccattggaaatgccaagaccacccgcaatgacaacagcagccgttttggcaagtacatccagattggctttgacaaaaggtaccacatcatcggggccaacatgaggacttacctcttggagaagtccagagtggtcttccaggcagatgatgagaggaattaccacatcttttaccagctctgtgctgctgccggtcttccagaatttaaagagcttgcactaacaagtgcagaggactttttctatacatcacagggaggagacacttccatcgagggtgtggacgatgctgaggactttgagaagactcgacaagccttcacactcctcggagtgaaagagtcccatcagatgagcatttttaagataattgcttctatcttgcaccttggaagtgtggcgattcaggctgagcgtgatggtgattcctgtagtatatcaccccaggatgtatacctaagcaacttctgccgactgctaggggtggagcacagtcagatggagcactggctgtgtcatcgcaagctggtcaccacctcggagacctacgtcaagaccatgtccctgcagcaggtgatcaatgcgcgcaacgccctggcgaagcacatctatgcccagttgttcggctggattgtggagcacatcaacaaggccctgcacacctccctcaagcagcactccttcatcggggtcctggacatctatgggtttgagacatttgaggtaaacagctttgagcagttctgtatcaactatgcaaatgaaaagctccagcagcagttcaactcgcatgttttcaaactggagcaagaagaatacatgaaggaacagatcccttggaccctgattgatttttatgataaccaaccttgtatcgacctcattgaagccaagctgggtatcttggacctgttggatgaagaatgtaaggtccccaaaggaactgaccagaactgggctcagaagctctatgaccggcactccagcagccagcacttccagaagccccgcatgtccaacacggccttcatcatcgtccactttgcagacaaggtggagtacctctctgatggttttctggagaaaaacagagacacggtgtatgaagagcagatcaatatcctgaaggccagcaagttcccactagtggctgacttgtttcatgatgacaaggaccctgttcctgccaccacccctgggaaggggtcatcttcgaagatcagcgtccgttctgccagaccccccatgaaagtctccaacaaggagcacaagaaaaccgttggccaccagttccgtacctccctgcatctgctcatggagaccctgaatgccacgacacctcactatgtccgctgcatcaagcccaacgatgagaagctcccctttcactttgacccaaagagagcagtgcagcaactcagagcctgcggggtgttggagacgattcgaatcagtgcagctggctacccatccaggtgggcctaccatgactttttcaaccggtatcgggtgctggtcaagaagagagagctcgccaacacagacaaaaaggccatctgcaggtctgtcctggagaacctcatcaaggaccccgacaagttccagtttggccgcaccaagatcttctttcgagcaggccaggtggcctacctggagaagctgcgggctgacaagttccggacagccaccatcatgatccagaaaactgtccggggatggctgcagaaggtgaaatatcacaggctgaagggggctaccttaaccctgcagaggtactgccggggacacctggcccgcaggctggctgagcacctgcggaggatcagagcggctgtggtgctccagaaacattaccgcatgcagagggcccgccaggcctaccagagggtccgcagagctgccgttgttatccaggccttcacccgggccatgtttgtgcggagaacctaccgccaggtcctcatggagcacaaggccaccaccatccagaagcacgtgcggggctggatggcacgcaggcacttccagcggctgcgggatgcagccattgtcatccagtgtgccttccggatgctcaaggccaggcgggagctgaaggccctcaggattgaggcccgctcagcagagcatctgaaacgtctcaacgtgggcatggagaacaaggtggtccagctgcagcggaagatcgatgagcagaacaaagagttcaagacactttcagagcagttgtccgtgaccacctcaacatacaccatggaggtagagcggctgaagaaggagctggtgcactaccagcagagcccaggtgaggacaccagcctcaggctgcaggaggaggtggagagcctgcgcacagagctgcagagggcccactcggagcgcaagatcttggaggacgcccacagcagggagaaagatgagctgaggaagcgagttgcagacctggagcaagaaaatgctctcttgaaagatgagaaagaacagctcaacaaccaaatcctgtgccagtctaaagatgaatttgcccagaactctgtgaaggaaaatctcatgaagaaagaactggaggaggagcgatcccggtaccagaaccttgtgaaggaatattcacagttggagcagagatacgacaaccttcgggatgaaatgaccatcataaagcaaactccaggtcataggcggaacccatcaaaccaaagtagcttagaatctgactccaattacccctccatctccacatctgagatcggagacactgaggatgccctccagcaggtggaggaaattggcctggagaaggcagccatggacatgacggtcttcctgaagctgcagaagagagtacgggagctggagcaggagaggaaaaagctgcaagtgcagctggagaagagagaacagcaggacagcaagaaagtccaggcggaaccaccacagactgacatagatttggacccgaatgcagatctggcctacaatagtctgaagaggcaagagctggagtcagagaacaaaaagctgaagaatgacctgaatgagctgaggaaagccgtggccgaccaagccacgcagaataactccagccacggctccccagatagctacagcctcctgctgaaccagctcaagctggcccacgaggagctcgaggtgcgcaaggaggaggtgctcatcctcaggacccagatcgtgagcgccgaccagcggcgactcgccggcaggaacgcggagccgaacattaatgccagatcaagttggcctaacagtgaaaagcatgttgaccaggaggatgccattgaggcctatcacggggtctgccagacaaacagcaagactgaggattggggatatttaaatgaagatggagaactcggcttggcctaccaaggcctaaagcaagttgccaggctgctggaggctcagctgcaggcccagagcctggagcatgaggaggaggtggagcatctcaaggctcagctcgaggccctgaaggaggagatggacaaacagcagcagaccttctgccagacgctactgctctccccagaggcccaggtggaattcggcgttcagcaggaaatatcccggctgaccaacgagaatctggaccttaaagaactggtagaaaagctggaaaagaatgagaggaagctcaaaaagcaactgaagatttacatgaagaaagcccaggacctagaagctgcccaggcattggcccagagtgagaggaagcgccatgagctcaacaggcaggtcacggtccagcggaaagagaaggatttccagggcatgctggagtaccacaaagaggacgaggccctcctcatccggaacctggtgacagacttgaagccccagatgctgtcgggcacagtgccctgtctccccgcctacatcctctacatgtgcatccggcacgcggactacaccaacgacgatctcaaggtgcactccctgctgacctccaccatcaacggcattaagaaagtcctgaaaaagcacaatgatgactttgagatgacgtcattctggttatccaacacctgccgccttcttcactgtctgaagcagtacagcggggatgagggcttcatgactcagaacactgcaaagcagaatgaacactgtcttaagaattttgacctcaccgaataccgtcaggtgctgagtgacctttccattcagatctaccagcagctcattaaaattgccgagggcgtgttacagccgatgatagtttctgccatgttggaaaatgagagcattcagggtctatctggtgtgaagcccaccggctaccggaagcgctcctccagcatggcagatggggataactcatactgcctggaagctatcatccgccagatgaatgcctttcatacagtcatgtgtgaccagggcttggaccctgagatcatcctgcaggtattcaaacagctcttctacatgatcaacgcagtgactcttaacaacctgctcttgcggaaggacgtctgctcttggagcacaggcatgcaactcaggtacaatataagtcagcttgaggagtggcttcggggaagaaaccttcaccagagtggagcagttcagaccatggaacctctgatccaagcagcccagctcctgcaattaaagaagaaaacccaggaggacgcagaggctatctgctccctgtgtacctccctcagcacccagcagattgtcaaaattttaaacctttatactcccctgaatgaatttgaagaacgggtaacagtggcctttatacgaacaatccaggcacaactacaagagcggaatgaccctcagcaactgctattagatgccaagcacatgtttcctgttttgtttccatttaatccatcttctctaaccatggactcaatccacatcccagcgtgtctcaatctggaattcctcaatgaagtctgaagatgcatgtttccagcattagtttgattcccaatgtgagcaagaaggaagtatatacagtaaagtaaattcaaggatctgttaaatctggtaaaagtagatcaaatcagagattgacagcctgtggagggtgctgaactatacagaattagacacaactatgtcattattttttgtacctactgctcagaataaaaacacttgaaatatggaagattttaagtttgatttcagtccaacacatatacataatttatagacaccaagcagtccccatagacatataaaaggtgtcaattctataaaacgaagctgcctagttttgatctttgcatagaactagagaatgtccaaattaaaataccaaatatatataagtcacataaattgccttcaaagggctttaacaaataatggtactaataaccatgataatggcatatactgacatttcccaaagtttgcaaaccataggtgtggttgagtttgtggtgagatgttttaagaacaaaaatatggggatgagacttctgagaaatattcccaaaatattttttaatggctgattatacacagacagtggtgtaactgacctccagaccagacattttgagtactggtttctgaagcaaaattagaagtgccagtcctcagtgtgctcaaacgcttttgtgttatcttgatttaatggaagagattattaaaatgctgctatcccaaactccaagtgagaaagatggaaaaatattttgtttctgatgctagtccatacactttccaagtcccacaaaactttcacaaaaatgtatataagctaaatattagaaacggataacaaacttgttttatttatagatgtaaaaaccaaacaagtcaatatgaaagcttttaatctcttaataccattaagcttccagtaagagcatcacataatgctctactgttccagaaaccaaatagtaaaacaaactaaagttcgcacatcagatcatctgaaaaaccttcaaaaataatcagttcagggatattatacaaaagtttgggttttttttttttaagagaataaaatggcttaggtcaactttcccttttcaggttattttcaacgtttttcaaatttagcacacaaaaaattgtaaatatctctcccacaaaataaggattttaaaaaagtaattcagtaatataacaggcttagatgtttgctgctcttagaattttttttaacttgtttttggtttcttcaaaagcaagcattcaattggaaacccatattctttccacacttttttttactgtcttttctgtatttcttgatagcagtatgctgttcccataagaaaaaaatggtatttgcaaatcatggaagaacagcctctgtattacattgagaaaataagatttatccatgaattggaagtagaacagcctgccttcaccctcttttactcaaccacccaacttaaaaggctcttggaaacacagcacactccacgctaccttctgcactgtgcccttagagcacagcttcctcagttgttctctgcatctcctggggcttaggccagtcttagcctgggttaaggctgctgacattgtgttccaatcagttgtcatgggcattatcccctctacatccacattaaacatgccggcttctcttgggcatcggcagagctgtgcctttttctttcagttacagttacataatcactgacgtccatgacacttacccatggatccatgtgctgacttcatttagaaggccaatctaaaacaactgggtttgtggctacctctttaaagttgtttgtgaaggataatttgttttttaatgcactttagtttgaaagtgagtctcttatgtaaggaccatccttaaaagaccaaaaatgccttgttagagtgttaaggagttttgacatgcagtggttccacaaacacagtggcttactatccttatacactgtcttataccatcattctctccatctctcttggtcactactctctgctgtcactggttaatcactaggtgccaagagcttactgaataaaagcttggcaattagaataaatggggagggaaggaccttatgaatagtccatttagcctaagaaatggcagatttagttcttctcttccaaaagataaaggtatatcctggaattgtacttaaaacttacagatgactaacaaatatatactttatatgtagttaatatttagatctgtcttatttaatacttggaggctagaagaagcatctttaggggaactatataatcttttgttagcattttctctgcattttaaaaaatcatttcaattcaaacatttatcagtgtcatgaaatcagtaatgactctttaacaattcaggtttgaactctgcattagatgtctctttaattttttaatatttaaaatttagttgacatttttttcaccaggtgcctttagcggttactaagataactgacatcagttgtttctctgaaataagtgttgctgtgggaataattttaatgttcaaggtgatatcatgggggagttttgtcttttaaaacattagaagcattttaaatattaagaatcaaatatttatagatcaaaacttgtgttttaagtattatacgggacctgtttacttatagtaaatgtgaatgtacacatgagttgttgctgaagctgacaagcatattacatacatgcattttccctgtgccctcatagttgcagttagagttccagtacctgtaggctcacctgggaggcagattagacccaaaggtagatgtttttcccctttccatgaagcatgtcagtgggagttgcttcctttgatttccctagtactaaattttaaggcttttgtaaaaacaaaacaaaactaggagcttggaacagttaaaaatcaacactgctaccatcaattcatcaaatatttacttagagctttcatacattaagattccagtaaccaataaattagaattcatttcttctgcataaagtaaattttcatacacttgacctactaagacagcaagggtgtcctaaattgaggcatttgtataatgcctgcataactaaatggtcactaaaatgggacagcatggggcaagaccttgtagttcttcacagaatatttgtggtcagtttctccaattaatttgctgcatgagccaaataaccataattcactttttatacccactggtgccataattagagaattagagggtgtagacagaggttaatgccaatgagaaacacaggacagggttttttttattataaaggtcattagatacaaaagattgtttttcaaaaaatttctaattctaacaaaggggatcaatcagaaatgaaactaagctactttctaaagtgacactgtatcagaataatccagatttgaatataacattttgccaccaactgacatttagatgaaggactgcctctctgaaagagttcagatcatattcaggggtgaatccaacaccatggaagaaagactactgatgaaaatattttcccactttgcacaaatctgtaaactacacctttgtttatagaaaaatgcttgtaatagtcactgtaatatttagctgtggataaaaatttgtggaaataaatacttttgaataaagaggtgtgccaaatctaaatgaaattt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4645 -> Molecular function: GO:0000146 [microfilament motor activity] evidence: TAS
GeneID:4645 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:4645 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4645 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
GeneID:4645 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4645 -> Molecular function: GO:0017137 [Rab GTPase binding] evidence: IPI
GeneID:4645 -> Biological process: GO:0006833 [water transport] evidence: TAS
GeneID:4645 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:4645 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IMP
GeneID:4645 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
GeneID:4645 -> Cellular component: GO:0016459 [myosin complex] evidence: IEA
GeneID:4645 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: TAS
GeneID:4645 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
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