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2025-05-09 17:30:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001077242 1774 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant
1, mRNA.
ACCESSION NM_001077242
VERSION NM_001077242.1 GI:116256341
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1774)
AUTHORS Gawin,B., Niederfuhr,A., Schumacher,N., Hummerich,H., Little,P.F.
and Gessler,M.
TITLE A 7.5 Mb sequence-ready PAC contig and gene expression map of human
chromosome 11p13-p14.1
JOURNAL Genome Res. 9 (11), 1074-1086 (1999)
PUBMED 10568747
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC030970.1 and AJ245600.1.
Transcript Variant: This variant (1) represents the more frequently
occurring transcript and it encodes the longer protein (isoform 1).
##Evidence-Data-START##
Transcript exon combination :: BC030970.1, BC011446.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-45 BC030970.1 1-45
46-874 AJ245600.1 1-829
875-1434 BC030970.1 875-1434
1435-1774 AJ245600.1 1390-1729
FEATURES Location/Qualifiers
source 1..1774
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p13"
gene 1..1774
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="DEP domain containing 7"
/db_xref="GeneID:91614"
/db_xref="HGNC:29899"
/db_xref="MIM:612294"
exon 1..165
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 27
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138524582"
variation 49
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375775065"
variation 57
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:144143644"
variation 82
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376201426"
variation 92
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115832789"
CDS 93..1628
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="isoform 1 is encoded by transcript variant 1; DEP
domain-containing protein 7; novel 58.3 KDA protein;
dJ85M6.4 (novel 58.3 KDA protein)"
/codon_start=1
/product="DEP domain-containing protein 7 isoform 1"
/protein_id="NP_001070710.1"
/db_xref="GI:116256342"
/db_xref="CCDS:CCDS41632.1"
/db_xref="GeneID:91614"
/db_xref="HGNC:29899"
/db_xref="MIM:612294"
/translation="
MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
"
misc_feature 207..491
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
found in DEPDC4-like proteins. DEPDC4 is a DEP domain
containing protein of unknown function; Region:
DEP_DEPDC4; cd04446"
/db_xref="CDD:80329"
misc_feature 546..548
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96QD5.1); phosphorylation site"
misc_feature 672..1373
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein
[GAP] for Rho-like small GTPases) domain of BRCC3-like
proteins. This subgroup also contains two groups of
closely related proteins, BRCC3 and DEPDC7, which both
contain a C-terminal RhoGAP-like domain...; Region:
RhoGAP_BRCC3-like; cd04405"
/db_xref="CDD:63874"
misc_feature order(855..857,1011..1013,1023..1025,1233..1235,
1242..1247,1308..1310)
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="putative GTPase interaction site [polypeptide
binding]; other site"
/db_xref="CDD:63874"
misc_feature 855..857
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/note="catalytic residue [active]"
/db_xref="CDD:63874"
exon 166..556
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 173
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375593314"
variation 198
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368794067"
variation 204
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79199473"
variation 231
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200073795"
variation 264
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374733737"
variation 270
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:369053359"
variation 274
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200057806"
variation 289
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138325318"
variation 329
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:74559182"
variation 380
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369355382"
variation 394
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372513278"
variation 463
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376814687"
variation 472
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371496330"
variation 482
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202173561"
variation 543
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374632275"
exon 557..684
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 584
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367903882"
variation 624
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200200424"
variation 638
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:17852860"
variation 643
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200498367"
variation 666
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:34161108"
exon 685..874
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 688
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144655252"
variation 703
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:375290990"
variation 721
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201784282"
variation 725
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371231815"
variation 782
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190343171"
variation 792
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374772959"
variation 804
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199885269"
variation 805
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148509454"
variation 843
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373000064"
variation 855
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201199439"
variation 870
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:369472957"
exon 875..1086
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 941
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:202124209"
STS 952..1079
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/standard_name="AB070065"
/db_xref="UniSTS:480067"
variation 956
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:36077875"
variation 973
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370729400"
variation 987
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75979055"
variation 1025..1026
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace=""
/replace="g"
/db_xref="dbSNP:35988670"
variation 1032
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377186754"
variation 1035
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370596448"
variation 1058
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:966191"
exon 1087..1229
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1098
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:371828635"
variation 1100
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:183771544"
variation 1166
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375119204"
variation 1188
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:369520659"
exon 1230..1355
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1276
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374663038"
exon 1356..1434
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
variation 1396
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:373073447"
variation 1402
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376408973"
variation 1409
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370490867"
variation 1424
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:185768707"
exon 1435..1755
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/inference="alignment:Splign:1.39.8"
STS 1446..1631
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/standard_name="RH99094"
/db_xref="UniSTS:83970"
variation 1449
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148565354"
variation 1453
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:374445520"
variation 1464
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202020074"
variation 1477
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368852267"
variation 1483
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:17852859"
variation 1504
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374403792"
variation 1571
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="g"
/replace="t"
/db_xref="dbSNP:367948856"
variation 1580
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199502210"
variation 1585
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142956576"
variation 1595
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:377079128"
variation 1624
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201413831"
variation 1643
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202246545"
variation 1652
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:151112215"
variation 1667
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200612237"
variation 1705
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1059432"
variation 1712
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374578661"
polyA_signal 1735..1740
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
polyA_site 1755
/gene="DEPDC7"
/gene_synonym="dJ85M6.4; TR2"
ORIGIN
gagccacgccccgcacagttaacagacgggcgctcagggagctagggagctgtgaagctgctggaggagttggcgtccggggagcaagggccatggccaccgtgcaggagaaggctgctgcgctgaacctctcggctctccacagccccgcgcacaggcctccgggtttcagtgtagctcagaagccatttggagccacgtatgtatggagcagcatcataaacactcttcaaacacaagtggaagtgaaaaaacgaaggcaccgtttaaaacgacataatgactgctttgttggttcagaagctgtggatgtcattttttctcacctaattcagaataagtattttggtgatgtagatattcctcgagccaaagtggtgagagtgtgtcaagcgcttatggactacaaagtatttgaagcagttccaaccaaagtctttggaaaagacaaaaaacctacatttgaagatagtagttgcagcctttatagattcaccacaatacctaaccaagacagtcagttaggcaaagagaacaaactatattcacctgccaggtatgcagatgcattatttaagtcatccgatatcagatcagccagtttagaggacctgtgggaaaatctgagtttaaagcctgccaactcccctcatgtaaatatctctgcaaccttgtctccacaagttattaatgaagtgtggcaagaagaaacaattgggcgtctactacaacttgtagaccttccacttcttgactccttactgaaacagcaagaggctgtacctaaaattcctcaacctaagaggcagtccaccatggtcaacagcagtaactatctggatcgagggattctcaaggcttatagtgactctcaggaagatgagtggctctcggcagcaattgactgtttagaataccttccagaccaaatggtggtggaaataagcagaagctttcctgagcaaccagaccgaacagacttagtgaaagaacttctgtttgatgccattggcagatattacagtagtagggaacctctgttaaatcacttatctgacgttcataatggaattgcagaactcttagtgaatgggaagacggaaatagctttagaagctacccagctccttctaaagcttttagatttccaaaatagagaagaatttagaagactactgtatttcatggctgttgcagcaaatccttctgagtttaaattacagaaagaaagtgacaaccgaatggttgtgaaaaggatattctcaaaagctattgttgacaataaaaatttatccaaaggcaaaacagatcttctggtactctttttaatggatcatcagaaagatgtttttaagattcctggaactctacataaaattgtaagtgttaagcttatggccatacagaacggaagagatccaaatagagatgcaggatatatttattgccagagaattgatcaacgtgactattccaacaatacagagaagacaaccaaagatgagctgttgaatttactaaaaactcttgatgaggattcaaaactttctgccaaagagaagaaaaaattgctaggtcaattctataagtgtcacccagacatctttattgagcattttggagactgagtttttaatatctgtatataagttgtgtattttaagaataaattatgtatcctaaatatccaatcacatttgtaagcgtggaagctctaaatttgaaactgtacttaataaaaatttttttgtataaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:91614 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:91614 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:91614 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:91614 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: TAS
GeneID:91614 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:91614 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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