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2025-05-09 17:05:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001009 755 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ribosomal protein S5 (RPS5), mRNA.
ACCESSION NM_001009
VERSION NM_001009.3 GI:71164878
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 755)
AUTHORS Ian'shina,D.D., Malygin,A.A. and Karpova,G.G.
TITLE [Mutual effect of human ribosomal proteins S5 and S16 on their
binding with 18S rRNA fragment 1203-1236/1521-1698]
JOURNAL Mol. Biol. (Mosk.) 43 (4), 700-708 (2009)
PUBMED 19807034
REMARK GeneRIF: Mutual effect of human ribosomal proteins S5 and S16 on
their binding with 18S rRNA fragment 1203-1236/1521-1698
REFERENCE 2 (bases 1 to 755)
AUTHORS Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
TITLE Nucleophosmin serves as a rate-limiting nuclear export chaperone
for the Mammalian ribosome
JOURNAL Mol. Cell. Biol. 28 (23), 7050-7065 (2008)
PUBMED 18809582
REFERENCE 3 (bases 1 to 755)
AUTHORS Pisarev,A.V., Kolupaeva,V.G., Yusupov,M.M., Hellen,C.U. and
Pestova,T.V.
TITLE Ribosomal position and contacts of mRNA in eukaryotic translation
initiation complexes
JOURNAL EMBO J. 27 (11), 1609-1621 (2008)
PUBMED 18464793
REFERENCE 4 (bases 1 to 755)
AUTHORS Galkin,O., Bentley,A.A., Gupta,S., Compton,B.A., Mazumder,B.,
Kinzy,T.G., Merrick,W.C., Hatzoglou,M., Pestova,T.V., Hellen,C.U.
and Komar,A.A.
TITLE Roles of the negatively charged N-terminal extension of
Saccharomyces cerevisiae ribosomal protein S5 revealed by
characterization of a yeast strain containing human ribosomal
protein S5
JOURNAL RNA 13 (12), 2116-2128 (2007)
PUBMED 17901157
REMARK GeneRIF: Transfected into yeast cells, plays an important role in
maintaining the accuracy of translation.
REFERENCE 5 (bases 1 to 755)
AUTHORS Yu,Y., Ji,H., Doudna,J.A. and Leary,J.A.
TITLE Mass spectrometric analysis of the human 40S ribosomal subunit:
native and HCV IRES-bound complexes
JOURNAL Protein Sci. 14 (6), 1438-1446 (2005)
PUBMED 15883184
REFERENCE 6 (bases 1 to 755)
AUTHORS Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
TITLE Characterization of the human small-ribosomal-subunit proteins by
N-terminal and internal sequencing, and mass spectrometry
JOURNAL Eur. J. Biochem. 239 (1), 144-149 (1996)
PUBMED 8706699
REFERENCE 7 (bases 1 to 755)
AUTHORS Wool,I.G., Chan,Y.L. and Gluck,A.
TITLE Structure and evolution of mammalian ribosomal proteins
JOURNAL Biochem. Cell Biol. 73 (11-12), 933-947 (1995)
PUBMED 8722009
REMARK Review article
REFERENCE 8 (bases 1 to 755)
AUTHORS Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
TITLE Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
S9, S10 and S29 human ribosomal protein mRNAs
JOURNAL Biochim. Biophys. Acta 1262 (1), 64-68 (1995)
PUBMED 7772601
REFERENCE 9 (bases 1 to 755)
AUTHORS Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
Yokoyama-Kobayashi,M. and Aoki,T.
TITLE Construction of a human full-length cDNA bank
JOURNAL Gene 150 (2), 243-250 (1994)
PUBMED 7821789
REFERENCE 10 (bases 1 to 755)
AUTHORS Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
and Karpova,G.G.
TITLE Structural arrangement of the codon-anticodon interaction area in
human placenta ribosomes. Affinity labelling of the 40S subunits by
derivatives of oligoribonucleotides containing the AUG codon
JOURNAL Biochim. Biophys. Acta 1173 (3), 273-282 (1993)
PUBMED 8318536
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Francesco Amaldi. The reference sequence was
derived from BG687415.1 and BC015405.1.
On Jul 26, 2005 this sequence version replaced gi:13904869.
Summary: Ribosomes, the organelles that catalyze protein synthesis,
consist of a small 40S subunit and a large 60S subunit. Together
these subunits are composed of 4 RNA species and approximately 80
structurally distinct proteins. This gene encodes a ribosomal
protein that is a component of the 40S subunit. The protein belongs
to the S7P family of ribosomal proteins. It is located in the
cytoplasm. Variable expression of this gene in colorectal cancers
compared to adjacent normal tissues has been observed, although no
correlation between the level of expression and the severity of the
disease has been found. As is typical for genes encoding ribosomal
proteins, there are multiple processed pseudogenes of this gene
dispersed through the genome. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CD175688.1, CD176164.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-39 BG687415.1 1-39
40-755 BC015405.1 28-743
FEATURES Location/Qualifiers
source 1..755
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.4"
gene 1..755
/gene="RPS5"
/gene_synonym="S5"
/note="ribosomal protein S5"
/db_xref="GeneID:6193"
/db_xref="HGNC:10426"
/db_xref="HPRD:04695"
/db_xref="MIM:603630"
exon 1..71
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
misc_feature 1
/gene="RPS5"
/gene_synonym="S5"
/note="predominant transcription initiation site"
variation 3
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371476239"
variation 7
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="g"
/db_xref="dbSNP:112583937"
variation 9
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="g"
/db_xref="dbSNP:111847582"
variation 15
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:114515295"
variation 39
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:111590146"
misc_feature 43..45
/gene="RPS5"
/gene_synonym="S5"
/note="upstream in-frame stop codon"
exon 72..180
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
CDS 73..687
/gene="RPS5"
/gene_synonym="S5"
/codon_start=1
/product="40S ribosomal protein S5"
/protein_id="NP_001000.2"
/db_xref="GI:13904870"
/db_xref="CCDS:CCDS12978.1"
/db_xref="GeneID:6193"
/db_xref="HGNC:10426"
/db_xref="HPRD:04695"
/db_xref="MIM:603630"
/translation="
MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
"
misc_feature 73..75
/gene="RPS5"
/gene_synonym="S5"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine, in 40S ribosomal protein S5,
alternate; propagated from UniProtKB/Swiss-Prot
(P46782.4); acetylation site"
misc_feature 76..78
/gene="RPS5"
/gene_synonym="S5"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylthreonine, in 40S ribosomal protein S5,
N-terminally processed; propagated from
UniProtKB/Swiss-Prot (P46782.4); acetylation site"
misc_feature 112..684
/gene="RPS5"
/gene_synonym="S5"
/note="40S ribosomal protein S5; Provisional; Region:
PTZ00091"
/db_xref="CDD:185439"
misc_feature 211..213
/gene="RPS5"
/gene_synonym="S5"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P46782.4); acetylation site"
variation 77
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143571102"
variation 78
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:148033938"
variation 85
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11545064"
variation 102
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:142305058"
variation 119
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:373895128"
variation 124
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200088071"
variation 153
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199912104"
variation 159
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146125110"
exon 181..390
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
variation 231
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:113669389"
variation 234
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:10853905"
variation 255
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:11545062"
variation 276
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:367711986"
variation 288
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201177783"
variation 311
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370061857"
variation 315
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200602413"
variation 321
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:374641510"
variation 339
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368930275"
variation 348
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:61731810"
variation 349
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:112637700"
variation 369
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149481790"
exon 391..519
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
variation 446
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:1802696"
variation 475
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:11545063"
exon 520..618
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
variation 523
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368894713"
variation 543
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144800741"
variation 549
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="t"
/db_xref="dbSNP:142861639"
STS 561..660
/gene="RPS5"
/gene_synonym="S5"
/standard_name="A009W25"
/db_xref="UniSTS:26278"
variation 578
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376539628"
variation 603
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:11545070"
exon 619..741
/gene="RPS5"
/gene_synonym="S5"
/inference="alignment:Splign:1.39.8"
variation 630
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369384066"
variation 645
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:3193532"
variation 654
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144955468"
variation 693
/gene="RPS5"
/gene_synonym="S5"
/replace="c"
/replace="g"
/db_xref="dbSNP:202151690"
polyA_signal 706..711
/gene="RPS5"
/gene_synonym="S5"
variation 707
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="g"
/db_xref="dbSNP:182905998"
variation 712
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:115824630"
variation 733
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2241787"
variation 739
/gene="RPS5"
/gene_synonym="S5"
/replace="a"
/replace="c"
/db_xref="dbSNP:3178234"
polyA_site 741
/gene="RPS5"
/gene_synonym="S5"
ORIGIN
ctcttcctgtctgtaccagggcggcgcgtggtctacgccgagtgacagagacgctcaggctgtgttctcaggatgaccgagtgggagacagcagcaccagcggtggcagagaccccagacatcaagctctttgggaagtggagcaccgatgatgtgcagatcaatgacatttccctgcaggattacattgcagtgaaggagaagtatgccaagtacctgcctcacagtgcagggcggtatgccgccaaacgcttccgcaaagctcagtgtcccattgtggagcgcctcactaactccatgatgatgcacggccgcaacaacggcaagaagctcatgactgtgcgcatcgtcaagcatgccttcgagatcatacacctgctcacaggcgagaaccctctgcaggtcctggtgaacgccatcatcaacagtggtccccgggaggactccacacgcattgggcgcgccgggactgtgagacgacaggctgtggatgtgtcccccctgcgccgtgtgaaccaggccatctggctgctgtgcacaggcgctcgtgaggctgccttccggaacattaagaccattgctgagtgcctggcagatgagctcatcaatgctgccaagggctcctcgaactcctatgccattaagaagaaggacgagctggagcgtgtggccaagtccaaccgctgattttcccagctgctgcccaataaacctgtctgccctttggggcagtcccagccaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6193 -> Molecular function: GO:0003723 [RNA binding] evidence: NAS
GeneID:6193 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
GeneID:6193 -> Molecular function: GO:0003735 [structural constituent of ribosome] evidence: IDA
GeneID:6193 -> Biological process: GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] evidence: TAS
GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: IC
GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: IGI
GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: NAS
GeneID:6193 -> Biological process: GO:0006412 [translation] evidence: TAS
GeneID:6193 -> Biological process: GO:0006413 [translational initiation] evidence: IC
GeneID:6193 -> Biological process: GO:0006413 [translational initiation] evidence: TAS
GeneID:6193 -> Biological process: GO:0006414 [translational elongation] evidence: TAS
GeneID:6193 -> Biological process: GO:0006415 [translational termination] evidence: TAS
GeneID:6193 -> Biological process: GO:0006450 [regulation of translational fidelity] evidence: IGI
GeneID:6193 -> Biological process: GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] evidence: TAS
GeneID:6193 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6193 -> Biological process: GO:0016032 [viral process] evidence: TAS
GeneID:6193 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:6193 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:6193 -> Biological process: GO:0019058 [viral infectious cycle] evidence: TAS
GeneID:6193 -> Biological process: GO:0019083 [viral transcription] evidence: TAS
GeneID:6193 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:6193 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6193 -> Cellular component: GO:0022627 [cytosolic small ribosomal subunit] evidence: IDA
GeneID:6193 -> Cellular component: GO:0030529 [ribonucleoprotein complex] evidence: IDA
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