LOCUS       XM_039095371            4188 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus neurotrophic receptor tyrosine kinase
            2 (Ntrk2), transcript variant X5, mRNA.
ACCESSION   XM_039095371
VERSION     XM_039095371.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051352.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4188
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="neurotrophic receptor tyrosine kinase 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 13 ESTs, 15 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     40 samples with support for all annotated introns"
                     /db_xref="GeneID:25054"
                     /db_xref="RGD:3213"
     CDS             1..2514
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /codon_start=1
                     /product="BDNF/NT-3 growth factors receptor isoform X1"
                     /protein_id="XP_038951299.1"
                     /db_xref="GeneID:25054"
                     /db_xref="RGD:3213"
                     /translation="

MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKDVSWFGIGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG"

     misc_feature    274..450
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Leucine rich repeat; Region: LRR_8; pfam13855"
                     /db_xref="CDD:404697"
     misc_feature    451..585
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Tyrosine-protein kinase receptor C2 Ig-like domain;
                     Region: TPKR_C2; pfam16920"
                     /db_xref="CDD:435654"
     misc_feature    613..849
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:448366"
     misc_feature    640..654
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    679..690
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    733..756
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    784..804
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    826..837
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    856..1137
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptor
                     TrkB; member of the I-set of Ig superfamily (IgSF)
                     domains; Region: IgI_TrkB_d5; cd05855"
                     /db_xref="CDD:409441"
     misc_feature    856..882
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409441"
     misc_feature    883..894
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409441"
     misc_feature    901..927
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409441"
     misc_feature    928..930
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="interdomain interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409441"
     misc_feature    934..957
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409441"
     misc_feature    964..975
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409441"
     misc_feature    988..1005
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409441"
     misc_feature    order(1003..1005,1045..1050,1057..1059)
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="receptor binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409441"
     misc_feature    1021..1047
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409441"
     misc_feature    1069..1095
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409441"
     misc_feature    1102..1128
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409441"
     misc_feature    1639..2502
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase B; Region: PTKc_TrkB; cd05093"
                     /db_xref="CDD:270675"
     misc_feature    order(1675..1689,1699..1701,1753..1755,1759..1761,
                     1894..1905,1912..1917,2071..2073,2083..2088,2092..2094,
                     2125..2127,2179..2193,2218..2220,2320..2322)
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="active site"
                     /db_xref="CDD:270675"
     misc_feature    order(1675..1680,1684..1689,1699..1701,1753..1755,
                     1759..1761,1894..1905,1912..1917,2083..2088,2092..2094,
                     2125..2127)
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270675"
     misc_feature    order(2071..2073,2083..2085,2179..2193,2218..2220,
                     2320..2322)
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270675"
     misc_feature    2122..2199
                     /gene="Ntrk2"
                     /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270675"
ORIGIN      

atgtcgccctggccgaggtggcatggacccgccatggcgcggctctggggcttatgcttgctggtcttgggcttctggagggcttctcttgcctgccccatgtcctgcaaatgcagcaccactaggatttggtgtaccgagccttctcctggcatcgtggcatttccgaggttggaacctaacagcattgacccagagaacatcaccgaaattctcattgcaaaccagaaaaggttagaaatcatcaatgaagatgatgtcgaagcttacgtggggctgaaaaaccttacaattgtggattccggcttaaagtttgtggcttacaaggcgtttctgaagaacggcaacctgcggcacatcaatttcactcgaaacaagctgacgagtttgtccaggagacatttccgccaccttgacttgtctgacctgatcctgacgggtaatccgttcacgtgttcctgtgacatcatgtggctcaagactctccaggagacgaaatccagccccgacactcaggatttgtattgcctcaatgagagcagcaagaatacccctctggcgaacctgcagattcccaattgtggtctgccgtctgcacgtctggccgctcctaacctcacggtggaggaagggaagtctgtgaccatttcctgcagcgtcgggggtgacccgctccccaccttgtactgggacgttgggaatttggtttccaaacacatgaatgaaacaagccacacacagggctccttaaggataacaaacatttcatcggatgacagtgggaaacaaatctcttgtgtggcagaaaacctcgttggagaagatcaagactctgtgaacctcactgtgcattttgcaccaaccatcacatttctcgaatctccaacctcagaccaccactggtgcatcccattcactgtgagaggcaaccccaagccagcacttcagtggttctacaacggagccatactgaatgaatccaagtacatctgtaccaaaatacacgtcaccaatcacacggagtaccacggctgcctccagctggataaccccactcatatgaataatggagactacaccctaatggccaagaatgaatatgggaaggacgagagacagatttctgctcacttcatgggccggcctggagttgactatgagacaaacccaaattaccctgaagtcctctatgaagactggaccacgccaactgacatcggggatactacaaacaaaagtaatgagatcccctccacggatgttgctgaccaaaccaatcgggagcatctctcggtctatgccgtggtggtgattgcctctgtggtaggattctgcctgctggtgatgctgcttctgctcaagttggcgagacattccaagtttggcatgaaagatgtctcatggtttggaattgggaaagtaaagtcaagacaaggtgtgggcccagcttccgtcatcagcaacgacgatgactctgccagccctctccaccacatctccaacgggagcaacactccgtcttcttcggagggcgggcccgatgctgtcatcattgggatgaccaagatccctgtcattgaaaacccccagtacttcggtatcaccaacagccagctcaagccggacacatttgttcagcacatcaagagacacaacatcgttctgaagagggagcttggagaaggagcctttgggaaagttttcctagcggagtgctataacctctgccccgagcaggataagatcctggtggccgtgaagacgctgaaggacgccagcgacaatgctcgcaaggactttcatcgcgaagccgagctgctgaccaacctccagcacgagcacattgtcaagttctacggtgtctgtgtggagggcgacccactcatcatggtctttgagtacatgaagcacggggacctcaacaagttccttagggcacacgggccagatgcagtgctgatggcagagggtaacccgcccaccgagctgacgcagtcgcagatgctgcacatcgctcagcaaatcgcagcaggcatggtctacctggcatcccaacacttcgtgcaccgagacctggccacccggaactgcttggtaggagagaacctgctggtgaaaattggggacttcgggatgtcccgggatgtatacagcaccgactactaccgggttggtggccacacaatgttgcccatccgatggatgcctccagagagcatcatgtacaggaaattcaccaccgagagtgacgtctggagcctgggagttgtgttgtgggagatcttcacctacggcaagcagccctggtatcagctatcaaacaacgaggtgatagaatgcatcacccagggcagagtccttcagcggcctcgcacgtgtccccaggaggtgtacgagctgatgctgggatgctggcagcgggaaccacacacaaggaagaacatcaagaacatccacacactccttcagaacttggcgaaggcgtcgcccgtctacctggacatcctaggctagactccctcttctcccagacggcccttcccaaggcacccctcagacctcttaactgccgctgatgtcaccaccttgctgtccttcgctctgacagtgttaacaagacaaggagcggctctccggggtgaggcagtgcgcacttccccatccacagacagtatcgactcgcttctggctttgtcgctttctctccctttggtttgtttctttcttttgcccattctccatttatttatttatttatttatttatttatttatttatttatctatctatctatctatctatctatctatttatttatttattggtcttcactgcttcatggtcctcggcctctctccttgaccgatctggcttctgtactcctattcactgtacatagacaaaggccttaacaaacctgatttgttatatcagcagacactccagtttgcccaccacaactaacaatgccttgttgtattcctgcctttgatgtggatgaaaaaaagggaaaaaaaaataatcaaacatctgacttaaaccgtcacttccgatgtacagacacggggcgtttctatggattcacttctatctatctatttatttatttatctatttatttatttctcttctttgttgttttccggtggttttagcctgtgtatgagaagggaaagtcatgtacagtctgggaaaactttatctgtgggaaatggaaaccagaaagggaaagaagctttaccataaagcacagcaggagtgagacacagaaaagccattggatcagccagagtccgtcctgcataggaaaacccagcagccatcaggctggaggatcatgttcggcactgacccccgaggacctttctgaggaggacacagaatgttaaactctgcatcatggacacagtttccgatcacagatactggccttcaatggaaaaaaaaaaaaacccagatagttcttgtgagacctggacagcacgtccaacatccagacattgtggtcgggcacagtgacagagttgatgcatttctcacgggttattctacagagcttttgtcaagtccaatggaaggaggtagattcttgttcagatatgatttcgggaaaaaccgagtccttgacaaagacaggagacaccctcagttgggaggcaagtttctcttaccttggactttctcacacagcaattctcacccccaccccctccactctcacctgtcttgtaactgtgcaaacaaaagtgtgcatggtctttgtcagttgatacctttgtgcacctctgtgcagaaactgctgtctgtcccggctgtggtacccgatcagtggggtagatccacgaaaggtctcattttaggccgctttgggaaggtaaccagatcggtagctggaagcactctccagtaggtggcgaagggtgagtgggtctgctgaagcctgcatatcttcacccacctcaaacccaccgggctgcacaggggacaggcacaggccacccctgagggacagggaagctctcttgggataccacctgagtttacattcagtgtgctcaggtcaagtctctcgctcggggctctgtttcggggagaatggtttcattccaacgcactcattatcaggattctgttttcttaactatactccattaaaaaggttttttttacaaaaaagaaaaaaaaaaa

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