LOCUS       XM_008771376            6031 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor
            7 (Arhgef7), transcript variant X5, mRNA.
ACCESSION   XM_008771376
VERSION     XM_008771376.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_008771376.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6031
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Rho guanine nucleotide exchange factor 7; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 59 ESTs, 1 long SRA read, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 11 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:114559"
                     /db_xref="RGD:620624"
     CDS             1571..3979
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X5"
                     /protein_id="XP_008769598.2"
                     /db_xref="GeneID:114559"
                     /db_xref="RGD:620624"
                     /translation="

MTGSSHVSHPVVLGFATCCLAIMKTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVTKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSLWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL"

     misc_feature    <1622..1735
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="calponin homology (CH) domain superfamily; Region:
                     CH_SF; cl00030"
                     /db_xref="CDD:444660"
     misc_feature    1739..1879
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Unstructured region one on RhoGEF 6 and 7; Region:
                     RhoGEF67_u1; pfam16615"
                     /db_xref="CDD:435465"
     misc_feature    1889..2050
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; Region: SH3_betaPIX; cd12061"
                     /db_xref="CDD:212994"
     misc_feature    order(1904..1906,1910..1912,1919..1921,1928..1933,
                     1976..1978,1982..1990,2021..2023,2027..2029,2033..2038)
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212994"
     misc_feature    2141..2674
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
                     /db_xref="CDD:238091"
     misc_feature    order(2159..2161,2171..2173,2453..2455,2525..2530,
                     2537..2542,2546..2551,2558..2563,2570..2575,2582..2584,
                     2660..2662,2672..2674)
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238091"
     misc_feature    2765..3061
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; Region:
                     PH_Cool_Pix; cd01225"
                     /db_xref="CDD:269932"
     misc_feature    3236..3511
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="Unstructured region two on RhoGEF 6 and 7; Region:
                     RhoGEF67_u2; pfam16614"
                     /db_xref="CDD:435464"
     misc_feature    3719..3973
                     /gene="Arhgef7"
                     /gene_synonym="P85spr; Pak3bp"
                     /note="betaPIX coiled coil; Region: betaPIX_CC; pfam16523"
                     /db_xref="CDD:435396"
ORIGIN      

ggtgttcccttgtgacccacattcatgcagcaagctgcttctggaagctgacagatgtgacactgtggggctctgctcttcatgccctgagtgtagagagtggctgtgggcacgtgtgcttcctcagctgcccagggctgacaccgtggagaggctcagtataggccagggtagaagagtccacctgggttgtttgtcctcttctgcctcacaatctgtcacctactgaaggacacagtggggtcctctgggtaggaatgctcctcacagcagattagtatcctctgaatgtctgtgaagccttagctgccaacactatataagtactgtgttttagatttgcggtggaaggggacccttgtttgacaagcacttactcaaaatcacctttattttgagtcacagcgtcttgagagtaggagacactatgttaaagttcttttgatctaggtggtctgatgtttctgaaagttttttttgtgtttggagttggaaggtctcaccttgctgactgacactgcttgtgtacaccccctcccccacccccgtctttaagcagaggcttctctgaccacttctggctgtagtagttgtcctgataggaaagttctgggtaagattggtttttagcaactatgctaggtaggcttttgtttgtccttctgttcttttgattgagacaatgttacagtttgttcagaactgtaacattgtatccggggccacaggtgaccaggtaccttcgtgcccgctcacaggatcaccttgatggtgacaatttgttaggcagacactgggcagttgataccaaatttttcctgtttcatgtatttgtaaaagagctaagcctgacactgcatttgcataccattaacaaccataaaataaggagtatgcccaggcagagtactttagagatatagaagaaggtgtggcaggaagtggcattgtagagtcttcggtggcttgaggagccatggtcccaggcttctgctactcctggatagaaggaccgtcatggtaggagatgggcaggcagaccttcctgaagcagatgtacctctggtctgcatggcaacagtggcctactccttccgagtactgtaaaagccaacctccccgccagcctggggggttggcttcttggtgaagcccagagtgtgtctaaggtgtgcattctgtcctagacacctcatggctctgggcgcagtttccacgtgtcactgactggcttgtgagaggtgtttcagggaagctccagggcctctctcctagttcctttggcacgaacactctttgcattaaaggacttttgctttttgttgtctagattgctgtttgggaaagtaatctgttctgctccctggaaaagcagtcctgtctgaacgctctcaggcttagagtgtgccttctggtttgtctcatctcattgttgggtttcctgagcaggaaggtagtgagcggtgggcccactgagttctgacatcatgccgaagcccattcattggcagcagatgcagtcagtcaggtgctctgtggcatccgggtaggagagctatatagtccgggaatgacaggaagctcccatgtttcacatcctgttgttctggggtttgcgacttgctgtcttgccataatgaagacttttgatgcaaatgatttgtatcaggggcagaactttaacaaggtcctcagctccttggtgacactaaataaagtgacagcagacattggactaggaagtgattctgtgtgtgcccggccctcgtcacataggataaagtcttttgattccctgggatcccagtcttcacacagtaggacttcaaaattgctgcagagccagtaccgaagcttggacatgactgataacgccaacagccaactggtagtacgagccaagtttaacttccagcagaccaatgaagatgagctctccttctcgaagggtgacgtcatccatgtcactcgagtggaggaaggaggctggtgggaaggcacacacaatggcaggaccggctggttccccagcaactacgtacgagagatcaagccaagtgagaagcctgtgtcacccaaatcagggaccttgaagagccctcccaaagggttcgatacgactgccatcaacaagagctattacaatgtggtgctacagaacatcctggaaacagagcatgagtattccaaggagctgcagtctgtgctgtcaacctacctgtggccgctgcagaccagcgagaagttgagttcagcaaacacttcatatttaatgggaaatctagaggaaatatcttccttccagcaagtgcttgtacagtccctagaagaatgcacaaagtctcctgaagcccagcagagagtcggtggctgcttcctgagcctgatgccgcagatgaggaccctgtaccttgcctactgtgccaaccacccatctgctgtgagcgtcctcacagagcacagtgaggacctgggagagttcatggagacaaaaggtgccagcagccctgggatcctggtgctgactaccggcctgagcaagcccttcatgcgcctggacaagtaccccacactgctgaaggagctggagagacacatggaggattatcatcctgatagacaagatattcagaaatctatgactgccttcaaaaacctttcagcccagtgtcaagaagtacgaaaaaggaaagagctggagctgcagatcctgacagagcccatcaggagctgggagggggatgacataaagacgttgggcagtgttacatacatgtcccaagtcacaattcagtgtgcaggaagcgaggagaagaatgagaggtacctcctgctcttcccaaaccttctgctcatgttgtctgccagtcccaggatgagcggtttcatctatcagggaaagctgccaacaacaggaatgacaatcacaaaactcgaggacagtgagaaccataggaatgcatttgagatatcagggagcatgatcgagcgcatcctggtgtcctgcaacaaccaacaggacttgcacgaatgggtggagcatctgcagaggcagacgaaggtcacgtctgtgagcaaccccaccatcaagccccactcggtgccatcgcacacacttccttcccatcctctcactccatccagcaaacacgcggacagcaagcctgtggcactgacgcctgcgtaccacacactcccccacccctctcaccatggcaccccacataccaccatcagctggggacccctggagcctccgaagacccccaagccttggagcctgagttgcctgcggcctgcccctcccctccggccctcagctgctctctgctacaaggaggatctcagcaggagtcccaagaccatgaaaaagctgctgccaaaacgcaagcccgagcgcaagccttcagacgaggagttcgctgtgaccaagagcacagccgctctggaggaagacgctcagatcctgaaggttattgaagcttactgcacaagtgcaaagacgaggcagaccctgaactcaacatggcaaggcactgacctgatgcataatcacgtcttggctgatgacgaccaatcaagtctagactccttgggtcgtcgcagtagcctttctcgtttggagccctcagacctctcggaagactctgagtatgacagtctatggacagcccatagttacagaatgggttctgcatcccgttcacgcaaagagtctgctccacaagtgttgcttccagaagaagagaaaattatagtcgaagaaaccaaaagcaacgggcagacagtgatagaggaaaagagcctcgtggataccgtgtacgcactaaaggatgaagtccaagagttacgacaggataacaagaagatgaagaaatccttagaggaggaacagagggcccgcaaggacctagagaagctggtgaggaaggttctaaagaacatgaacgaccctgcttgggatgagaccaatctataggctgacttcattctcataggctgaagaccagcagctcctggacaaggctggggcccttggtccccagcacagtgacattcaggactaaggaggtggtcttcaaaaggcaagcagcagtgatgagctgttgctgaagtagctacatgtgagttctagacaccgaggcctgggctgagtgagcacctcgctgtacacctctccctgcagtgactgaccagagtcctcggctttgggacttgagttgaatctataaatagcttacctgtgtactccttgtaaatactgagatctgaatgaacatgtacctgagaggtgactaggctaaccctcttgctaggatttccttctcagcctttctggccacagggatctgaagttgtgttcctaaagtgttggaagcagagaggtgaagggatgcccgggcagcatctgactcgtgtgcagtgtaggctccttggtgccatcaggagcaggcactcaggcacagtggatttgtgtgtctcttttaactgcagtattccagtcccgagctacggcagtacccagggcaccatgggttctaggagggtgagactggtgcccgcctctgctgcgctgtcctgcctgggccctgggtcacagtgtggagtagtgggctagcctggtgtatcttggccctgtacatagttgtgttatttattccatattctttagccggtgctgccgggcagggtttggctgcaggccgttttcatccacaacctctgctctgcctttggctgcagccagcgttgtccaggccactgagagccctcttaaccctgagcaagactaaagcaatacacaccgcactggagcagcgcggagagcctcagtgctgtgcccccgccctcccttgctgcctccccaggcccagatgggccctggaaggctggtggcttccaagaggccctgcttctgttgggccaggcttgcccttgatttggcaacagtgacagtgacctcaggagcttagctgtccccttcctttctccaaagaggttgttttgaagtcagagatacttccccatagaaaggtgtttgtctttaaacactgaggagcagtgtggctggggcctcagcatagcctaggttgtgacccagctcctggccgctcgtcctccgtgcaggtttctgagtgggtgtgtggaggccctttgtgctctccttcctccacactctggctgggtgcagcgtctgtcaggatccaccagagcctcccgctcctgttagcattttaccagcccagtctgtgccgggtgagaaaagctgaggtgttctttctctttggtaagccctgcttcccaagcactctccgacccaaaagacactacagcagaggacagtgtgttcgctgtcacagtggacctcacctcaggaacaacgctccttgcaactccactgctggcgactggtgcctggggttgctggacagctcctccgccaagagcaagcgaagaccatctctgacgcggtcctcaccccgccgaggtggctgtgcaggccccaaggacagtttttacagacctgccttaatgattcgcttggagacttccatgagtatccctaccctggacagggtggtagcgttgtgtcagcacgccaccctgtccttctgagatccagtgtcttccaggctctcagggagcgagaatctgcacccggagcagtcctttttaaagctggcacacaccccgttctcctcctgcatctctgcggtggagctctgacacccacagcacagggtgcctctcaccaactccaactcctccgcgctctgtgagggatgagggggattaagccatttcctgtcctctagtgaagcactttccgttctgaaccatgctgctgcgtgcagcctctgaagctccactcttccctcccagttgttgcccacgctccctgtgcacctcatgccaacccctccttccctgcgacactgcaggagccggtgctggcagaccgcaccggtgtgactgctgcagtgtgtgtgctgccccctccaattattaaactccttattttcctatctca

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