LOCUS       XM_008761922            3270 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus serine threonine kinase 39 (Stk39),
            transcript variant X1, mRNA.
ACCESSION   XM_008761922
VERSION     XM_008761922.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051338.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_008761922.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3270
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="serine threonine kinase 39; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 49
                     ESTs, 1 long SRA read, 3 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 25 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:54348"
                     /db_xref="RGD:621643"
     CDS             278..1795
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /codon_start=1
                     /product="STE20/SPS1-related proline-alanine-rich protein
                     kinase isoform X1"
                     /protein_id="XP_008760144.1"
                     /db_xref="GeneID:54348"
                     /db_xref="RGD:621643"
                     /translation="

MVFPLGVPLWRGRPPGLLSSTCSYSTVSWKGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS"

     misc_feature    368..1171
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Oxidative stress response kinase and Ste20-related proline
                     alanine-rich kinase; Region: STKc_OSR1_SPAK; cd06610"
                     /db_xref="CDD:270787"
     misc_feature    order(368..379,389..391,428..430,434..436,524..526,
                     572..583,590..595,602..604,734..736,740..751,755..757,
                     785..790,797..799,854..865,869..871,953..955,980..982)
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="active site"
                     /db_xref="CDD:270787"
     misc_feature    order(368..379,389..391,428..430,434..436,524..526,
                     572..583,590..595,602..604,740..742,746..751,755..757,
                     788..790)
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(374..379,734..736,740..748,797..799,854..865,
                     869..871,953..955,980..982)
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(737..742,812..820,857..898,902..910,920..922,
                     929..934,941..946,953..955,971..973,992..994,1001..1009,
                     1013..1018,1118..1120,1124..1129,1133..1135)
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(785..826,845..871)
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270787"
     misc_feature    1511..1684
                     /gene="Stk39"
                     /gene_synonym="Spak"
                     /note="Oxidative-stress-responsive kinase 1 C-terminal
                     domain; Region: OSR1_C; pfam12202"
                     /db_xref="CDD:432397"
ORIGIN      

gtctgcagtgtccaggagagagtgtcacgtaccctagagctagaggctgttgtgagctctctgatacgggggctacttttctttgtggtgctaggccaggagccgtggccctgtgcggaggctgagattgacagctacagtggagaccagtgctgtcttttcctggttttatttttacatttctcagagtaagccacttcccctcctatgactcgtgactgattttaattcctccactggtctcttcctccagcctttcacctcgaccagcacagcaatggtgttccctctgggggtccctctgtggcggggaagaccccctggtctgctgtcttccacctgcagttattctacagtgtcctggaagggcagtggagcgaccgccgtggttcaggcagccctgtgcaaacccaggcaagaacgcgtagccataaagcggatcaacttggaaaagtgccagacgagtatggatgaactcttaaaagaaattcaagccatgagccagtgcagccatcccaacgtagtgacttattatacttcctttgtggtcaaagatgaactttggctggtcatgaaattactaagtggaggttccatgttggatatcatcaaatacatcgtcaatcggggagagcataagaatggtgtcctggaagaggcaataatcgcaacaatccttaaggaggttttggaaggattagactatctgcatagaaatggtcagatccatagggatttgaaagctggcaatattcttctgggtgaggatggatcagtacagatagcagattttggagtaagtgcattcttagcaacagggggtgatgtcacaaggaataaagtcagaaaaacatttgttggtaccccatgttggatggcccctgaggtcatggaacaggtgagaggctatgacttcaaggctgacatgtggagttttggaataacagccattgaattagcaacgggagcagcgccttaccacaaataccctccaatgaaagtgctaatgttgactttgcaaaatgacccgcccactttagaaaccggcgtagaggataaagaaatgatgaaaaaatacggcaagtccttcagaaagttactttcactgtgtctccagaaagatccttccaaaaggcccacagcagcagaacttttaaaatgcaaattcttccagaaagccaagaacagagagtacctgatcgagaagttgctgacacgaacaccagacatagcccaaagagccaagaaggtcaggcgagttcctgggtcaagcggtcaccttcacaagactgaagatggcgactgggagtggagtgatgatgagatggatgagaagagtgaggaggggaaagcggctgcctctcaagagaagtcacgaagagtaaaagaagagaacccagagatctcggtgaacgctggtggcatccccgagcaaatacagtccctctccgtgcacgactctcagggccaaccaaatgctaatgaagactacagagaaggtccttgtgcggtcaaccttgttttaagattaagaaactccagaaaggaacttaatgacatacgatttgagtttactccaggaagagatacagcagatggtgtgtctcaggagctcttctctgctggcttggttgacggtcatgatgtagttatagtggctgctaatttacagaagattgtagatgaccccaaagctttaaaaacgttgacatttaagttggcttctggctgtgatggggcggagattcctgacgaagtgaagctgatcgggttcgcccagttgagtgtgagctgatgtatgtcccttgctgtcaccctcatctgtcgtgccctcccccccttccagccccctctttgcctccttcctctcaccccctcactcccaaatcccagcaaataagaagattgtgaagaggctggcttcgatgaagtgggataaaaaaaataataattttaaaaaaaaactccgagcactctgagttctgctttattctccagcaatccacagtgtgagcacaggcaagtgctgcaatagtgcattgctgatttctttccagagagctatttactattcttagcagtcaatttggatagcccttaagtgaggagtctgaaacacactcaggtggtcctatctcttggcaacaaaaggaatcttctaccagaagccttttctcctcttactgttgtatttctgtttaataattaataataattaattgtacatctgacaatactgcctcttttatgttgtcttagaaattaatatacttataaaattaagatttattagccagacttgaattctagttttaaaactgactgtgaattttatttttcatatatttatgctttacacaccttagctatgagggaaaaagttttgattataatgctttccgcggttgatctcttgttatttaaacaaatggtttcaggtcaatctttggagtatttgtagcttctaatttttgaaatgactgaattgaaaatttgaatgctttctcttttggttggtttgcctaaaatccagtccacaatccagtcgtctcttgggagagggaggtgccttgtaaactttcatacttcgaatgtgcctgagactgcttaaccctggactagtctcagatctcaaacccgcactacacatggaggcatacgtttgcttcatctggacatttagaatactgtacctgtgctgccgttctgttagatcgctgactacatccccgtgtctgattcggctctccttaggtgataggattcattgtttgtaaggcgataaacttgaccacaccagaatctgagttttacttgaaactctgcagaatacacagggggtatgaaaaacaaaacaaaacaaaacagaaagatttttttgtgcaatggcaaaaggtaaaaatgctgtaaacgttcgagaataaatatttccaacccaagaacctcctgcttgactatgtattatgaacctaacaaaccttaggattttcaaatttggagtcaaaaccctcaagaaggtggctccggggatggcaccattgctccttacaagctaaccctagatgcggcagctctttaacgtactttaaaaagcaaatatatattactaaggaaagaagttatttataattgccttgtcataatcgttaaggtgttctagaaccatttgcatacaatttaatgtaattccattccattctattgtttacacaattactcaaagatggctgcaaaggtaaaaggaaaaataaaagcgtcttgcacagtgca

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