LOCUS       XM_008760310            7344 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus dedicator of cytokinesis 8 (Dock8),
            transcript variant X1, mRNA.
ACCESSION   XM_008760310
VERSION     XM_008760310.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_008760310.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7344
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7344
                     /gene="Dock8"
                     /note="dedicator of cytokinesis 8; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 50 ESTs, 10 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     44 samples with support for all annotated introns"
                     /db_xref="GeneID:499337"
                     /db_xref="RGD:1561588"
     CDS             173..6268
                     /gene="Dock8"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 8 isoform X1"
                     /protein_id="XP_008758532.1"
                     /db_xref="GeneID:499337"
                     /db_xref="RGD:1561588"
                     /translation="

MTHLNSLDAELAQELGDLTDDDLHVAFTPKECRTLQHSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEFCSFRKTGSRRDFHKTLQKQTFESETLECSEPATQTGPRHRFNVLCDVSGKGPITSCDFDLRSLQPDERLENLLQLSAEDFEKEKEEARKTNRTAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKVLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVDPSSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFCQRLGKYRMPFAWAPISLASFFNVSTLERESTDLEPGAGRNSVGERRSLSQSRRPSERTLSFEENGVGSNFKTTTLATNIFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGSLRLEIAPAPDVMNCCLTPEMLPVKPFPENRTRPHKEILEFPIREVYVPHTVYRNLLYVYPQRLNFANKLASARNITIKIQFMCGEDPSNAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKITENTLEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQHGRNCLLASYVHYVFRLPELHRDAPKSGGPTAVVPDPRYHTYGRTSAAAVSSKLMQARVMSSSNPDLAGTHCAADEEVKNIMSSKIADRNCSRMSYYCSGNSDVPGSTAAPRPVSKKHFHEELALQMVVSTGLVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRTRFSDRFKDDITTIVNVVTSEIAALLVKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCTQLSAKLNTLPTLISMRLEFLRILCSHEHYLNLNLLFMNPDTAPASPCPSISSQNSSSCSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLSSHDLDPRCLKPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVALAIAGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMVCFLWIMKNADQSLIRKWIADLPSMQLNRILDLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGEMMRRRIPGTDRFPGLNENLRWRKEQTQWRQANEKLDKTKAELDQEALISGNLATEANLIILDMQENIIQASSSLDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFGDLLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMALASLVGKAPDFNEEHLRKSLRTILAYSEEDTAMRATLFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKRKCFTEAAMCLVHAAALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSKFGDLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQHRRNTVLTTMHAFPYIKTRIRVSQKEEFVLTPIEVAIEDMKKKTLQLAVATHQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNRRLITAEQREYQQELKKNYNRLKDSLRPMIERKIPELYKPIFRVDSQKRDSFHRSSFRKCETQLSQGS"

     misc_feature    173..466
                     /gene="Dock8"
                     /note="Domain of unknown function (DUF3398); Region:
                     DUF3398; pfam11878"
                     /db_xref="CDD:432155"
     misc_feature    1643..2185
                     /gene="Dock8"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; Region: C2_Dock-C; cd08696"
                     /db_xref="CDD:176078"
     misc_feature    4874..6139
                     /gene="Dock8"
                     /note="Dock Homology Region 2, a GEF domain, of Class C
                     Dedicator of Cytokinesis 8; Region: DHR2_DOCK8; cd11701"
                     /db_xref="CDD:212574"
     misc_feature    order(5225..5227,5255..5257,5261..5266,5270..5275,
                     5282..5287,5291..5296,5303..5308)
                     /gene="Dock8"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:212574"
     misc_feature    order(5345..5347,5351..5353,5420..5422,5429..5440,
                     5444..5449,5504..5512,5561..5569,5651..5662,5690..5695,
                     5702..5704,5708..5710,5819..5824,5831..5833,5879..5884,
                     5888..5893,5900..5908,5915..5923,5930..5935,5942..5944,
                     6026..6028,6092..6094,6101..6103)
                     /gene="Dock8"
                     /note="Rac/Cdc42 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:212574"
     misc_feature    5915..5932
                     /gene="Dock8"
                     /note="nucleotide sensor; other site"
                     /db_xref="CDD:212574"
ORIGIN      

ctcccgcccaacctcggacagtaccatcggcacagcctcagtacctctggtttcccttctcttcagctaccgccattttgtcgcctgtgacagtttacccaccgcgttaactgtgtatcctcagcctcagctgtatgagcccgttgagcctgtggactttgaaggacttgtgatgacgcacttaaacagcttggatgcagagctggcccaggagctgggggacctcaccgatgacgacctgcatgtggccttcacacccaaggagtgtaggactttgcagcactctctgccagaggaaggagttgaactggatcctcacgtcagggactgtgttcagacctatattcgagagtggctgattgtgaaccggaaaaaccaaggaagtccagagttttgcagcttcagaaagactggatctcgcagagattttcacaagacgcttcagaaacagacgtttgagtcagaaaccttggagtgcagtgaaccggccactcagacgggaccccgccatcgcttcaacgtgctgtgtgatgtgtctgggaagggccccatcacttcttgtgacttcgacctccgcagcctgcagcctgacgagcggctggaaaacctgcttcagctgagtgctgaggactttgagaaggagaaagaggaggcccgaaagaccaatcggacggctgagctcttcgccctctatccatccgtagatgaggaggatgctgtggaaatccgtccagtaccagaatgtcctaaggaacatctgggcaacagaatattggtgaaggtgctgaccctgaagtttgagattgaaattgaacctctgtttgccagtattgccctctatgatgttaaagaaaggaaaaagatctcagaaaacttccactgtgacctgaactccgaccagttcaaagggtttctgcgagctcacacaccctcggttgacccgtcgagtcaggcaaggtctgcagtgttctcggtcacctacccatcttcagacatctacctggttgtcaagattgaaaaggtccttcagcaaggagagatcgcagactgtgcagaaccctacatgatcatcaaagaaagcgatggtggaaagagtaaagaaaaggttgaaaaactaaaactccaagctgaatccttctgccaacgtttggggaaataccggatgcccttcgcctgggcccccatcagcttagcaagcttcttcaacgtctccacccttgaaagggagagcacagacttggagcctggggctgggagaaactctgtgggggagaggaggagtttgtcccagtccaggaggccttctgagagaaccctctcctttgaggaaaatggagttggatccaacttcaaaaccaccaccttggccactaacatcttcttcaagcaggagggagatcgccttagtgatgaagacttgttcaagtttttagctgactacaagagatcttcgtccctacagcgaagagtgaaatccatcccaggctcacttaggctggagatagccccagctcctgacgtgatgaactgctgcctgacacccgagatgctgccggtcaaacccttccctgaaaatcggacgcgtccccacaaggagattttggaatttccaatccgggaagtgtatgttccccacaccgtgtacagaaaccttctgtacgtatacccacagagactgaactttgctaacaagctagcatccgcccggaacattacaataaagattcagtttatgtgtggagaagaccccagcaatgctatgcctgtcatctttgggaagtccagtgggcctgaatttctgcaggaagtgtacacagctattacataccataataagtctcccgacttttatgaagaagtaaagattaagcttccggccaagctcacagtgaatcaccacctcctcttcaccttctaccacatcagctgtcagcagaagcaaggcgcctctggagaaagccttctgggatactcgtggctgccgattctcctgaacgaacgtcttcaaaccggatcctactgtctaccagttgccttggaaaaactaccacctaactactccatacattctgctgagaaagtccctttacagaatcctcccattaagtgggccgagggccataagggggtatttaatattgaagtgcaagctgtttcctccgttcacacccaggataaccacctggagaagttcttcaccctttgccactccctggagagccaggtgaccttccctatccgcgtgctggaccagaagatcacggagaacacgctggagcatgagcttaagctcagcatcatctgcctcaactcctcccgcctggagcccctcgtgctcttcctccacctggtgctggataagctcttccagctctctgtgcagcccatggtcatcgctggccaaacagcaaacttctcccagtttgccttcgaatctgtggtggccattgccaatagccttcacaacagcaaggacctgaggaaggaccagcacgggaggaactgcctgctggcctcctatgtgcactacgtgttccggctgcccgagctgcacagggatgcacccaagtcaggtggccccaccgccgtagtccctgacccccgataccacacatatggacgcacgtctgccgctgcagtgagttcaaagctgatgcaggcccgtgtgatgagcagcagtaacccagacctggctgggacacactgtgcagcagatgaggaggttaagaacatcatgtcttccaagattgctgatcgcaactgcagccggatgtcttactattgctctggcaacagtgacgttccaggttcaactgcagccccaaggccagtcagcaaaaagcatttccatgaggagcttgccctgcagatggtggtcagcactggactagtgagagaaaccgtcttcaagtacgcctggttcttctttgagcttctggtgaaaagcatggcacagtacgtccataacctggataaacgggacagttttcggaggactcgtttttccgaccgcttcaaggatgacataactaccattgttaatgtggtcacctcggagatagcagcccttctagtgaaacctcagaaggaaagtgagcaggccgagaagatcaacatcagcctggccttcttcctgtatgacctcctctcaatcatggacagaggcttcgtgttcaacctcatcaagcattactgcactcagctatcagccaagcttaacacccttccaaccctcatttccatgcggctggagttcctgagaatcctctgcagccacgagcactacctcaacttgaacctgctcttcatgaatcctgacaccgcaccagcctctccctgtccctccatatcctcccagaactcaagctcctgctccagtttccaggaccaaaagattgccagcatgttcgatctgaccccagagtaccgccagcagcacttcctcacagggctcctcttcacagaactggccgttgccctggatgctgaaggggacggaattagcagagtacagagaaaagccgtgagtgccatccacagccttctgagttctcacgacctggatccacggtgtctcaaaccagaagtgaaagtcaaaatcgctgccctttacctgccgttggtcggcatcattctggatgcgctgccacagctctatgactttacagatgctcgcagtggaaggagccgtgccagtggctcatatgaagaacaagatgtggccaatggaatcaaccagaatgtggccctggccatagcagggaatcattttaatttgaagaccagcggagcaatgctgtcttccttgccctataagcagtacaacatgctgaacgcggacactacccgccacctcatggtctgctttctgtggatcatgaaaaacgcggatcagagcctcatcaggaagtggatcgccgacctgccttccatgcagctcaacaggattctagacctgctgttcatctgtgtctcctgctttgaatacaagggaaagcagagttctgacaaagtcagtaaccaggtcctgcagaagtcaagagatgtcaaggccaagttggaagaagccctgctccgtggggaaggagcccggggggagatgatgcgacgtcggattccaggcactgaccggtttccaggcctaaatgagaatctgaggtggaggaaggagcagacacagtggcggcaagctaacgagaagctggacaaaacaaaggcagagttagatcaagaagccttgatcagtggcaacctggctacagaggctaatttgatcatactggacatgcaggaaaacatcatccaggcaagctcctccctggactgtaaagacagcctgctgggaggtgtcctccgggtcctggtgaattctctgagctgtgatcagagcaccacctacctgactcactgttttgcaactctccgagccctcatcgccaagtttggagacctgctgttcgaggaggaaatggagcagtgtgctgacctgtgtcagcgggtgctccatcactgcagcagtagcatggatgtcacccggagccaagcctgcgccaccctctatctactcatgcggttcagcttcggagccaccagtaactttgcaagagtaaagatgcaggtaaccatggcactggcatccttggtaggcaaagcaccagacttcaatgaggagcacctgagaaagtccttaaggaccattctggcctattcagaagaggacacggccatgcgggcaactctttttcccacgcaggtggaggagcttctctgcaatctcaacagcattttatacgacacagtgaagatgagggaattccaggaggaccctgagatgctcatggacctcatgtacagaattgccaagagctaccaggcatcccctgacctgcggctgacctggctccagaacatggcagagaaacacactaagaggaagtgcttcacagaggccgccatgtgcctggtgcatgcagcagccttggtggcagagtacctgagcatgctggaggaccacagttacctgcctgtgggcagcgtcagctttcagaatatttcttccaatgtgcttgaggaatctgcagtctccgatgacaccttgtcacctgatgaggacggtgtatgctctggtcgctacttcactgagagtggcctggtgggcctcctggagcaggctgcagagctcttcagcacgggaggcttgtacgagacagttaatgaggtctacaagctggtcattcccatcctggaagcacatagagatttccggaagctgacctctactcacgacaagctgcagaaggcctttgacaacatcatcaacaaggaccataagaggatgtttggaacttacttccgagttggtttctacggatccaaatttggggatttggatgagcaggaatttgtgtacaaggaacctgcaattacaaagctccccgagatctcacatagactagagggattttatggccagtgttttggtgccgagtttgtggaagtgataaaggactctactcccgtggataaaaccaagttggatcctaacaaggcctacatacagatcacttttgtggagccttactttgatgagtatgagatgaaagacagggtgacctacttcgagaagaatttcaaccttcggaggttcatgtacaccacccccttcaccctggaggggaggccccggggagagctgcacgagcagcatcgcaggaacacggtgctcaccaccatgcatgccttcccctacatcaagaccaggatccgagtcagccagaaagaggagttcgtcttgactccgattgaagttgccattgaagacatgaagaagaagaccttgcagttagcggtggccactcaccaggagccccctgacgcgaagatgctccagatggtactgcaaggctctgtgggagccaccgtgaatcagggcccactggaggtggcccaagtgttcttggctgaaattccggctgacccaaaactctaccggcatcacaacaagctgaggttatgcttcaaggagttcataatgcgatgcggtgaggccgtagagaagaacaggagactcattaccgcagagcagcgggagtaccagcaggaactcaagaagaactacaacaggctgaaggacagcctcaggcccatgattgagcggaaaatcccagagctctacaagcccatattcagggttgacagtcaaaagagggactctttccacagatctagtttcaggaaatgtgaaacccagttgtcacagggcagctgaaaaaagccacctttgcctgtagtgactggggccccactacctggaaggactcactggtacgtccccagcagccacccaagactgactgtccagccagtgctctggaaacttgtatttattaaaatatttttcatactgctgtacaaacaaggcctaagctgtttctgccgagtggccggtcatggtcctcccatgaagtgatgtcttctgacctatatctgaattcctaaaataaactcaaaccgtggacggaagagtggaccactgtcctgcagcctactccaagtgagcttcactcatcccttcagtgagaagaaaagataaactccagagaagtgaaacgttttccaaatcatctgtgagaggaagtcctacaggaagcctggtctcatgctggctgggaatctgggaatagatggatcgatcactctacaagctgctttttgcccctcctgcattgctggactgagtgccatctagttatctctgcgttgttgcttctgttaagctgagtgagcccacctttatccaggggacagttgtacaggacagtacagatcacccggccacacggcgctgacagcgcattccccagagcggaagcagttctcccagaacgttttgctggtttcctatacgcttgctctcactgtctcctttctcttctctgggataaggtgatttatttttttttatttttttttataggtgatttttatacaagggtaatactctgccttcgctccagaacattcgtcctctgtgtgctacaaaatatatgcttttgattctttttacagtgtattttaggaaaaagaaaaacaaagctatggtttgagaattaaattatatattttttcatacaactcacgaccttaacgaatactaaagatggaatacagacggcaagcaagtgggaagctggcacccacctttagtcctagctctcggaggccagcctggtcgacagagcgagctccaggacagccagatggacacagtgagaccaagtctcataaataaataaataaataaataaataaataaataaataaatcaatcaatcaatcaatcaa

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