LOCUS       XM_006251174            4304 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus calcium/calmodulin-dependent protein
            kinase II beta (Camk2b), transcript variant X6, mRNA.
ACCESSION   XM_006251174
VERSION     XM_006251174.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051349.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_006251174.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4304
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="calcium/calmodulin-dependent protein kinase II
                     beta; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 mRNAs, 57 ESTs, 12 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 20 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
     CDS             261..2144
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit beta isoform X6"
                     /protein_id="XP_006251236.1"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
                     /translation="

MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALESSDSTNTTIEDEDAKAPRVPDVLSLVRRGSGAPEAEGPLSCPSPVPISPLPAPSPRISDILNSVRRGCGTPEAEGPLSVGPPPCLSPGLLGPLPTPSPRISDILNSVRRGSGTPEAEGLPPVGPPPCPSPTLPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"

     misc_feature    294..1169
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(318..332,342..344,381..383,387..389,480..482,
                     528..539,549..551,555..557,663..668,672..674,678..683,
                     687..689,726..731,738..740,783..797,801..803)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(318..329,342..344,381..383,387..389,480..482,
                     528..539,549..551,678..683,687..689,726..731)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(330..332,549..551,555..557,663..668,672..674,
                     678..680,738..740,783..797,801..803)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(726..758,765..797)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1140..1142,1146..1169)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1743..2126
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
ORIGIN      

gggcggggcgggcgcggcggcgacagcggcgcccgcgcctctgcgcgcgtaggtgtgcggcgcgctcctggcggggacagagcgagcagatctcgcgtgcgctcgccgcccggcgcagcccagcccggcccccgcccggcgccgcgagccgaggtgtctcccgcgcccgcgcccgtgtcgccgccgtgcccgcgagcgggagccggagtcgccgccgcccgagcgcagccgagcgcacgccgagcccaatcgccaccgccatggccaccacggtgacctgcacccgtttcacggacgagtaccagctatacgaggatattggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtatgcagctaagatcattaacaccaagaagctgtcagctagagatcaccagaagctggagagggaggctcggatctgccgcctgctgaagcattccaacattgtacgcctccatgacagcatctctgaagagggcttccactacctggtcttcgacctggtcactggtggggagctctttgaagacattgtggcgagagagtactacagtgaggctgacgccagtcactgtatccagcagatcctggaggctgttctccattgtcaccaaatgggggtcgtccacagagacctcaagcctgaaaacctgctcctggccagcaaatgcaaaggggccgcagtgaaactggcagacttcggcctggccatcgaggttcagggagaccagcaggcatggtttggatttgcgggaacaccaggctacctgtctcccgaagttcttcggaaggaggcctatggcaaaccagtggatatctgggcatgtggggtgatcctgtatatcctgctggtgggatacccacctttctgggatgaggaccagcacaagctgtaccagcagatcaaggctggggcctatgacttcccatcccccgagtgggacaccgttacccctgaagccaaaaacctcatcaaccagatgttgaccatcaaccccgccaagcgcatcacggcccacgaggccctgaagcacccatgggtctgccaacgatccacggtggcctccatgatgcacagacaggagactgtggaatgtctgaagaagttcaatgcaaggaggaagctcaagggagccatcctcaccactatgctggccacacggaatttctcagcagccaagagtttactcaacaagaaagcagacggagtcaagccccagacaaacagcaccaaaaacagctcggccatcaccagccccaaaggatccctccctcctgccgccctggaatcttccgacagcaccaacacaaccatagaggacgaagatgccaaagcccccagggtccctgatgtcctgagcttggtgaggaggggctcaggagccccagaagccgagggccccctgtcctgtccatctccagttcccattagtccccttccagccccgtcccccaggatctctgacatcctgaactcagtgagaaggggctgtggaaccccagaagccgagggacccctatcagtggggcccccgccctgcttgtctccgggtctcctaggccccctgcccaccccgtcccccaggatctctgacatcctcaactcagtgaggcggggctcagggaccccagaagctgagggcctcccaccagtgggccccccaccctgcccatctccgactctccctggccccttgcccaccccatcccggaagcaggaaatcatcaagaccacagagcagctcatcgaggccgtcaacaacggcgactttgaggcctatgcgaaaatctgtgacccaggcctgacctcatttgagcctgaagctctgggcaacctggtcgaagggatggatttccacagattctactttgagaacctgctggccaagaacagcaagccgatccacaccactatcctgaacccgcacgtgcacgtcatcggcgaggatgcagcctgcatcgcttacatccgcctcacacagtacatcgacggccagggcagaccccgcaccagccagtccgaagagacccgtgtgtggcaccgccgcgacggcaagtggcagaatgtccatttccactgctcgggcgctccagtggccccactgcagtgagagctgcgcctggtttcaccggacagagttggtgtttggagcccagccgccctcgggcgcacggcctgcctgtcgcatgtttgtgtctgcctcgtcccctcccctggtgcctgtgtctgcagaaaaacaagaccagatgtgatttgtttttttaaaaaaaaaaaaaaagtaagatgatgacaacgacaaccacatgcaaacaaacaaacaaaaaatattggcatcggatgaaatggaaaacaaacaaacaaacctaaagaaaggaaaaagctgtaaaaatctggcatttgtggggccgcccccccacccaagctccacatgtgtctgttgcgctcctggctttggggaccctcagggcgtgaatgtgcccatgccgactgtgttagtctgtaggtaccgcactcaccccacaccttgggcgtctgcatcctcctcccatgcatgggccccacgtgctaacctggctgttgtggcgtcaggtgtcttgggaagggctgggggctgcctcctttcctgctagttgtgcctgaaagctgctgctgttcctgcttcccctacccgtccctcatcccgagaaggactgggagggtgctcctctagccaaggacctacctttgccccatggagtgtgtaggagaagctcgtcctcaagatcatcagaaagtaacctggttctttggggagtgaggtatggaggtatgtatctcgcctccaagcctctcgcctggcagggattggttaggaaggcaggctggctgcagcacccacccatctagctacgaagagaggactgggcagggatggactccttcctgtttggggttcttgtcccttccctgccaccagcagctgagcgagagtggcccacccctggcccgggcagttcctctctgaagttggcaacagaccctcacgaagacggagttgccgagatactggacagagctgggagcagacgctggctgcatctagggggtttgtccactgagcttgaagtctgggtgctcgagacttggttaaatgttgcagaatgtgataaagaggggccagaagtcgggttttagactgctgggcaatgcaggtccatgtgagggtttgatggtaggagtgctttcctaacctgagcctagagaagaaataagccagaggatgtgcctcctcagaggcacatggaaggccaaaattggttaggtagggctgtattgtgtgaggcctttccaggtaggccagagatacgtagtagagagaaggcaggctgggggcagagatatatgggtgtggggcctggataccagtgggtggagggagggtccattaggacagtgtgccacccccagggcccagtggtgctcctaggtgccggctgcctggactcgtgggtggcccttggtgacagagggaatcatcaaggctggacatgttacaaagtcaggctagggagataggtataaagccgggttgggtgggggtggtcaggggctttgatcgcagaggtccgtgggcctccaccccaatgctgcccactttaaattcacgtcattttcaaccaggattttctttatcttttactacaaatcaagccaagggaggggcacgaagtggggaacgggacacaggatcctaaactccaaggggactgtccacctacagacactcagtggataccacctttgatccacactgtgcccaggacagctgccccctacccatggacacagggtaaacatctgccaggctccatgagtggcccaaggccatggaatagaggcagggcttgtcacagacagcgtgaggccctgtggcctgccaccctgacatcctggggtctcctttcctctcccacccaccttgttatctccacaaagctgcctgtctgggataatttggggattttttttctgggggacaattcttttgcatgaccctctaaagagcaggacacgtctgctctactggctaggtgttcgcaggtggtggcgtcgactgtggccagtgctggagcgtgtcactgcctgcagtactggtgaccctcctctcttctctttttgctgagttccattgtcttttctttccgagccttgtaggtgtacaaaacttattcttattttgttctgtctcgggaaactgcaaataaaaaaaaaaaaaaaaaaaaagaacgaa

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