LOCUS       XM_006251171            4370 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus calcium/calmodulin-dependent protein
            kinase II beta (Camk2b), transcript variant X2, mRNA.
ACCESSION   XM_006251171
VERSION     XM_006251171.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051349.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_006251171.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4370
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="calcium/calmodulin-dependent protein kinase II
                     beta; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 55 ESTs, 6 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 20 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
     CDS             255..2210
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     II subunit beta isoform X2"
                     /protein_id="XP_006251233.1"
                     /db_xref="GeneID:24245"
                     /db_xref="RGD:2262"
                     /translation="

MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALESSDSTNTTIEDEDAKAPRVPDVLSLVRRGSGAPEAEGPLSCPSPVPISPLPAPSPRISDILNSVRRGCGTPEAEGPLSVGPPPCLSPGLLGPLPTPSPRISDILNSVRRGSGTPEAEGLPPVGPPPCPSPTLPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"

     misc_feature    288..1163
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calcium/calmodulin-dependent protein kinase Type II;
                     Region: STKc_CaMKII; cd14086"
                     /db_xref="CDD:270988"
     misc_feature    order(312..326,336..338,375..377,381..383,474..476,
                     522..533,543..545,549..551,657..662,666..668,672..677,
                     681..683,720..725,732..734,777..791,795..797)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="active site"
                     /db_xref="CDD:270988"
     misc_feature    order(312..323,336..338,375..377,381..383,474..476,
                     522..533,543..545,672..677,681..683,720..725)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(324..326,543..545,549..551,657..662,666..668,
                     672..674,732..734,777..791,795..797)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    order(720..752,759..791)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270988"
     misc_feature    order(1134..1136,1140..1163)
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="CaM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:270988"
     misc_feature    1809..2192
                     /gene="Camk2b"
                     /gene_synonym="Ck2b"
                     /note="Calcium/calmodulin dependent protein kinase II
                     association domain; Region: CaMKII_AD; pfam08332"
                     /db_xref="CDD:285524"
ORIGIN      

ggcgggcgcggcggcgacagcggcgcccgcgcctctgcgcgcgtaggtgtgcggcgcgctcctggcggggacagagcgagcagatctcgcgtgcgctcgccgcccggcgcagcccagcccggcccccgcccggcgccgcgagccgaggtgtctcccgcgcccgcgcccgtgtcgccgccgtgcccgcgagcgggagccggagtcgccgccgcccgagcgcagccgagcgcacgccgagcccaatcgccaccgccatggccaccacggtgacctgcacccgtttcacggacgagtaccagctatacgaggatattggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtatgcagctaagatcattaacaccaagaagctgtcagctagagatcaccagaagctggagagggaggctcggatctgccgcctgctgaagcattccaacattgtacgcctccatgacagcatctctgaagagggcttccactacctggtcttcgacctggtcactggtggggagctctttgaagacattgtggcgagagagtactacagtgaggctgacgccagtcactgtatccagcagatcctggaggctgttctccattgtcaccaaatgggggtcgtccacagagacctcaagcctgaaaacctgctcctggccagcaaatgcaaaggggccgcagtgaaactggcagacttcggcctggccatcgaggttcagggagaccagcaggcatggtttggatttgcgggaacaccaggctacctgtctcccgaagttcttcggaaggaggcctatggcaaaccagtggatatctgggcatgtggggtgatcctgtatatcctgctggtgggatacccacctttctgggatgaggaccagcacaagctgtaccagcagatcaaggctggggcctatgacttcccatcccccgagtgggacaccgttacccctgaagccaaaaacctcatcaaccagatgttgaccatcaaccccgccaagcgcatcacggcccacgaggccctgaagcacccatgggtctgccaacgatccacggtggcctccatgatgcacagacaggagactgtggaatgtctgaagaagttcaatgcaaggaggaagctcaagggagccatcctcaccactatgctggccacacggaatttctcagtgggcagacagaccaccgctccggccacaatgtccaccgcggcctccggcaccaccatggggctggtggaacaagccaagagtttactcaacaagaaagcagacggagtcaagccccagacaaacagcaccaaaaacagctcggccatcaccagccccaaaggatccctccctcctgccgccctggaatcttccgacagcaccaacacaaccatagaggacgaagatgccaaagcccccagggtccctgatgtcctgagcttggtgaggaggggctcaggagccccagaagccgagggccccctgtcctgtccatctccagttcccattagtccccttccagccccgtcccccaggatctctgacatcctgaactcagtgagaaggggctgtggaaccccagaagccgagggacccctatcagtggggcccccgccctgcttgtctccgggtctcctaggccccctgcccaccccgtcccccaggatctctgacatcctcaactcagtgaggcggggctcagggaccccagaagctgagggcctcccaccagtgggccccccaccctgcccatctccgactctccctggccccttgcccaccccatcccggaagcaggaaatcatcaagaccacagagcagctcatcgaggccgtcaacaacggcgactttgaggcctatgcgaaaatctgtgacccaggcctgacctcatttgagcctgaagctctgggcaacctggtcgaagggatggatttccacagattctactttgagaacctgctggccaagaacagcaagccgatccacaccactatcctgaacccgcacgtgcacgtcatcggcgaggatgcagcctgcatcgcttacatccgcctcacacagtacatcgacggccagggcagaccccgcaccagccagtccgaagagacccgtgtgtggcaccgccgcgacggcaagtggcagaatgtccatttccactgctcgggcgctccagtggccccactgcagtgagagctgcgcctggtttcaccggacagagttggtgtttggagcccagccgccctcgggcgcacggcctgcctgtcgcatgtttgtgtctgcctcgtcccctcccctggtgcctgtgtctgcagaaaaacaagaccagatgtgatttgtttttttaaaaaaaaaaaaaaagtaagatgatgacaacgacaaccacatgcaaacaaacaaacaaaaaatattggcatcggatgaaatggaaaacaaacaaacaaacctaaagaaaggaaaaagctgtaaaaatctggcatttgtggggccgcccccccacccaagctccacatgtgtctgttgcgctcctggctttggggaccctcagggcgtgaatgtgcccatgccgactgtgttagtctgtaggtaccgcactcaccccacaccttgggcgtctgcatcctcctcccatgcatgggccccacgtgctaacctggctgttgtggcgtcaggtgtcttgggaagggctgggggctgcctcctttcctgctagttgtgcctgaaagctgctgctgttcctgcttcccctacccgtccctcatcccgagaaggactgggagggtgctcctctagccaaggacctacctttgccccatggagtgtgtaggagaagctcgtcctcaagatcatcagaaagtaacctggttctttggggagtgaggtatggaggtatgtatctcgcctccaagcctctcgcctggcagggattggttaggaaggcaggctggctgcagcacccacccatctagctacgaagagaggactgggcagggatggactccttcctgtttggggttcttgtcccttccctgccaccagcagctgagcgagagtggcccacccctggcccgggcagttcctctctgaagttggcaacagaccctcacgaagacggagttgccgagatactggacagagctgggagcagacgctggctgcatctagggggtttgtccactgagcttgaagtctgggtgctcgagacttggttaaatgttgcagaatgtgataaagaggggccagaagtcgggttttagactgctgggcaatgcaggtccatgtgagggtttgatggtaggagtgctttcctaacctgagcctagagaagaaataagccagaggatgtgcctcctcagaggcacatggaaggccaaaattggttaggtagggctgtattgtgtgaggcctttccaggtaggccagagatacgtagtagagagaaggcaggctgggggcagagatatatgggtgtggggcctggataccagtgggtggagggagggtccattaggacagtgtgccacccccagggcccagtggtgctcctaggtgccggctgcctggactcgtgggtggcccttggtgacagagggaatcatcaaggctggacatgttacaaagtcaggctagggagataggtataaagccgggttgggtgggggtggtcaggggctttgatcgcagaggtccgtgggcctccaccccaatgctgcccactttaaattcacgtcattttcaaccaggattttctttatcttttactacaaatcaagccaagggaggggcacgaagtggggaacgggacacaggatcctaaactccaaggggactgtccacctacagacactcagtggataccacctttgatccacactgtgcccaggacagctgccccctacccatggacacagggtaaacatctgccaggctccatgagtggcccaaggccatggaatagaggcagggcttgtcacagacagcgtgaggccctgtggcctgccaccctgacatcctggggtctcctttcctctcccacccaccttgttatctccacaaagctgcctgtctgggataatttggggattttttttctgggggacaattcttttgcatgaccctctaaagagcaggacacgtctgctctactggctaggtgttcgcaggtggtggcgtcgactgtggccagtgctggagcgtgtcactgcctgcagtactggtgaccctcctctcttctctttttgctgagttccattgtcttttctttccgagccttgtaggtgtacaaaacttattcttattttgttctgtctcgggaaactgcaaataaaaaaaaaaaaaaaaaaaaagaacgaa

//