2024-05-04 18:20:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_171988 5092 bp mRNA linear ROD 12-JUN-2023 DEFINITION Rattus norvegicus Bcl2-like 11 (Bcl2l11), mRNA. ACCESSION NM_171988 XM_006234986 VERSION NM_171988.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 5092) AUTHORS Zhang X, Ge J, Zhu X, Zhang H, Wang Y, Xu T, Jiang W and Zhang B. TITLE Effects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim Pathway JOURNAL Biomed Res Int 2022, 8644356 (2022) PUBMED 35036441 REMARK GeneRIF: Effects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim Pathway. Publication Status: Online-Only REFERENCE 2 (bases 1 to 5092) AUTHORS Huang J, Huang Y, Feng Z, Guo W, Wang X and Liao Z. TITLE MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2 JOURNAL J Recept Signal Transduct Res 41 (1), 6-14 (2021) PUBMED 32605511 REMARK GeneRIF: MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2. REFERENCE 3 (bases 1 to 5092) AUTHORS Qin X, Gao S, Yang Y, Wu L and Wang L. TITLE microRNA-25 promotes cardiomyocytes proliferation and migration via targeting Bim JOURNAL J Cell Physiol 234 (12), 22103-22115 (2019) PUBMED 31058341 REMARK GeneRIF: our study demonstrates that miR-25 downregulation inhibits cardiomyocytes proliferation and migration...by targeting Bim REFERENCE 4 (bases 1 to 5092) AUTHORS Kennedy D, Mnich K, Oommen D, Chakravarthy R, Almeida-Souza L, Krols M, Saveljeva S, Doyle K, Gupta S, Timmerman V, Janssens S, Gorman AM and Samali A. TITLE HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis JOURNAL Cell Death Dis 8 (8), e3026 (2017) PUBMED 29048431 REMARK GeneRIF: HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis. Publication Status: Online-Only REFERENCE 5 (bases 1 to 5092) AUTHORS Gilley J and Ham J. TITLE Evidence for increased complexity in the regulation of Bim expression in sympathetic neurons: involvement of novel transcriptional and translational mechanisms JOURNAL DNA Cell Biol 24 (9), 563-573 (2005) PUBMED 16153157 REFERENCE 6 (bases 1 to 5092) AUTHORS Gilley J, Coffer PJ and Ham J. TITLE FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons JOURNAL J Cell Biol 162 (4), 613-622 (2003) PUBMED 12913110 REFERENCE 7 (bases 1 to 5092) AUTHORS Harris CA and Johnson EM Jr. TITLE BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons JOURNAL J Biol Chem 276 (41), 37754-37760 (2001) PUBMED 11495903 REFERENCE 8 (bases 1 to 5092) AUTHORS Leo CP, Hsu SY, Chun SY, Bae HW and Hsueh AJ. TITLE Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary JOURNAL Endocrinology 140 (12), 5469-5477 (1999) PUBMED 10579309 REFERENCE 9 (bases 1 to 5092) AUTHORS Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM and Strasser A. TITLE Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity JOURNAL Science 286 (5445), 1735-1738 (1999) PUBMED 10576740 REFERENCE 10 (bases 1 to 5092) AUTHORS Hsu SY, Lin P and Hsueh AJ. TITLE BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members JOURNAL Mol Endocrinol 12 (9), 1432-1440 (1998) PUBMED 9731710 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000118.1. On Feb 10, 2021 this sequence version replaced NM_171988.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF065433.1, AF065431.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00132269, SAMD00132270 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 16153157 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-250 JACYVU010000118.1 39233848-39234097 251-645 JACYVU010000118.1 39236495-39236889 646-755 JACYVU010000118.1 39256120-39256229 756-5092 JACYVU010000118.1 39266797-39271133 FEATURES Location/Qualifiers source 1..5092 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="3" /map="3q36" gene 1..5092 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Bcl2-like 11" /db_xref="GeneID:64547" /db_xref="RGD:628774" exon 1..250 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /inference="alignment:Splign:2.1.0" regulatory 215..283 /regulatory_class="uORF" /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /experiment="DESCRIPTION:regulatory uORF[PMID:16153157]" /note="this uORF is predicted to encode a 22 aa peptide (PMID:16153157)" exon 251..645 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /inference="alignment:Splign:2.1.0" CDS 264..854 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="bcl-2-related ovarian death protein; bcl2-interacting mediator of cell death; Bcl-2 related apoptotic gene product BimL; BCL2-like 11 (apoptosis facilitator)" /codon_start=1 /product="bcl-2-like protein 11" /protein_id="NP_741985.1" /db_xref="GeneID:64547" /db_xref="RGD:628774" /translation="
MAKQPSDVNSECDREGGQLQPAERPPQLRPGAPTSLQTESQGNPDGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNETYTRRAFANDYREAEDHPQMVILQLLRFIFRLVWRRH"
misc_feature 264..467 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="propagated from UniProtKB/Swiss-Prot (O88498.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 273..380 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Bim protein N-terminus; Region: Bim_N; pfam06773" /db_xref="CDD:429111" misc_feature 456..458 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Phosphoserine, by MAPK. /evidence=ECO:0000250|UniProtKB:O43521; propagated from UniProtKB/Swiss-Prot (O88498.1); phosphorylation site" misc_feature 480..482 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88498.1); phosphorylation site" misc_feature 510..512 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88498.1); phosphorylation site" misc_feature 531..605 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="propagated from UniProtKB/Swiss-Prot (O88498.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 531..533 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:O43521; propagated from UniProtKB/Swiss-Prot (O88498.1); phosphorylation site" misc_feature 648..755 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="Bcl-x interacting, BH3 domain; Region: Bclx_interact; pfam08945" /db_xref="CDD:430337" misc_feature 699..743 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /note="propagated from UniProtKB/Swiss-Prot (O88498.1); Region: BH3" exon 646..755 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /inference="alignment:Splign:2.1.0" exon 756..5092 /gene="Bcl2l11" /gene_synonym="Bim; BimL; Bod" /inference="alignment:Splign:2.1.0" ORIGIN
agtggctggggcaggctgctttcacttcgctccccgcaggcactgggtcaacagcttgttggagctctgcggtccttgccgccgccgccgttgtcgttgcagtcaccggattcctgcagccgctccgcgagctgtgttccacttggattcacaccacctccgctgcccccgccgccaccgcctcggcgcccttcccctggccctcgtccacccaatgtctgactctgattctcggactgagaaacgcaagaaaaaaagaccaaatggccaagcaaccttctgatgtaaattctgagtgtgacagagaaggtggacaattgcagcctgctgagaggcctccccagctcaggcctggggcccctacctccctacagacagaatcgcaaggtaatcccgacggcgaaggggaccgctgcccccacggcagccctcagggcccgctggccccaccggccagccctggtccttttgctaccagatccccacttttcatctttgtgagaagatcttctctgctgtcccggtcctccagtgggtatttctcttttgacacagacaggagcccggcacccatgagttgtgacaagtcaacacaaaccccaagtcctccttgccaggccttcaaccattatctcagtgcaatggcttccataaggcagtctcaggaggaacctgaagatctgcgcccagagatacggatcgcacaggagctgcggcggatcggagacgagttcaatgagacttacacgaggagggcgtttgcaaacgattaccgagaggcggaagaccacccgcaaatggttatcttacaactgttacgattcatcttccgtctggtctggagaaggcactgacaggagcttcgtgcagccaggacaaatggcggacatcgctcttgttcagaccgggagaaccccagcacctccatctcttggcgctgcgacagtccggccggtggctctgtcccagagaggcgtgcggagcacggacagcgctcagcactgtgtcgatgtggacggaacctctgtccatcaccacatggccggattttcagtaaataattgttgtgaatgtaaacaagggagggtttttctcttttaaatgtacagatcctagggacagagaaatatgcaagagaggtgtttacatgtggtgtgttaatttttttaaacccactttctttgataactgttttttgtttttttttttttttttttggtcttgtttttgtttcagaaaggaaaacttttagacaatttatggataatttttttatactcattcttaacccattaccttctcagaggactgcgtaaccctgcagtgggaactgagccagccgatttataaggctgccttagtttatttttagatattactgtacagaattttttaaacaggaagagtatggcgttgccctctctcctctgccatgcctccgagtttccttttgaatttttactaccaaaacagttgttatgaaatggaatgggctcgagtggcagagggtctgttctggtacgccacttccgttttgtaaatatttacctccttagctcagttgctcctgtggcaaaaaagttcacacttttcatgctttccctcaactcttcggacccctcggtctgtctccacaccgatgcacaggttcagcccagggtcctttccaatgtgtttgtgtcggcaagggctaggggctgcccggattgttcccagctccatcaatcaggctgacttcatgggaagggctcctgggcacttcacttcactgcggtggcttcgtttgtctctcttatcctgagagaacgtgggcttgcacgccacttgctaaagctgttggctcttctggttgcccgctctgctgcctgccgcaggctctgctggctgtgtgtaccagatgagctggagcccacactttctccgggattggccaggtcatttcaggagcaaggagctcaggtgatccttttccgtgcttcttggtatgtagccccgctcatccctcctggcctgtggctcctggatttcgtctccattcccatgagtcaggggctggctctacttcatcagtttccatacacaggaaacctccattttaccaagtaaaacatttgtcttcacaagatgtctgcctgctttgctctctcccattttcttaacacctgaaccttcttgggcctcctgtgtctggggcgggggtggggtgctatttcttggtaccctgcctcttaggaccagcagcccatacattggtcagttatttcaagagcaggcaggactggtctagtggaagagcgcttcctaatgtgtagaggccctgtgtcctatccccggcacctcctaaaacaacagcacacctgtcagacagacagacaaacgggagattaaaaaagggggggggggcaaagaagaaagaacataggaggggtggggggcagtgacaaaccctctaacttgtgagaacgtcagacattaggcagcttgcttagagaggtgtatgcgtttccaagcaagtcagcggtgccaatgactgtgtgctttgggcctgtagacagccagtgttttttcttatgtaaaggaatccatttattcctactttcctgcgtgtgtgtgtgtgtgtgtgtctgtgtgtgtctgtgtgtgtctgtgtgtgtctgtacatttccttctagattgaaatcatccgattccaaataatgtttataaatgctttcccagcttccatagatttgtaatagactgaaagctgttttggcattcacctcctttcctaatgcattgagcctgctcatgggttcccatgaggcctatggttgtaagttggtgttaagagtgcaaccatggctctgctacacacactcacacacacacacacactcacataaacacacacacacacacacacacacacacaccccaaagacatacttggttctgggccatcccctccctaggacctccattctcatgtgccagtctccccgactggagcactttactgtctcagccccgtggctctgtggtactgcctaggcgggtgcagaaggctcccagagccaggtgccagtggcatgtgtggcccctaaaacgtgcttacctccagcctggggctggccgctgaagcagctcatagggtagtaagagagtctatgaattgtagaagtattcaagaacaggatgcggcacccagaacttaaacatgatgactggatgtccctgtactgtatctgtttcttaaaatgcaagtgtctcctgcagaaagtgtctcagcttactgtgggtagggctttgtgcttaattgttagtttatcattctctcttctgtgctagaacagaaactagatctccctcctccgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaacataatgcgggttttgtgccttgacaacctccccatgtgaggtttgtaaatagtgtcctgtgacttcacctcaagttggaataaacgtacaaaatggcgtcctgagtgattcttcaaattttctttccagaaaagagttgagttcgggggagggagggtgtctgaaaaatcagcttaaagtccctctttattaaagtctgtaatggataatgtctgcttctcctgtttcctccttccagtgttgtatatattctgactatttattagattaggaagtcatgtttcactcgtcaactgagccaaatgtctgtgtgcaattgtattctcgttacctttctttgtaaaatattgtacagcataaatgagtaaaaaaaaaatcactgttttttcaaacttctcattattaaggattgtaaataccgtaggttctccttctgtgtaatgtgccctactgttccataatgctgtaacttgtagagtcattgtatatttattttctgcttatttaatgtcttacgttcttgaaagtgttgacatccctatccctgacaccccagccatgccatgaattgcttcagctcctgataaaggggggcactgactgactggctctgttccccaacatggcttctgctttggcttctggcattcagtgcttggattctgctgcctctctgaggaaacgagtatttgctgccgatgagataccctagctacagtagcctggaagatcggactctaagaaaatacccatcaaacccatttataaagcagctggcttctgaggaaagcagatttaccaataagttggccatatctttagagaagtattagcaacagatggggaaggtttttttctttaattgagagtgtatctttgacaactcagtgttgaaagaaatcctgcctcttgaggtactgctgaatggccgccctgggtaagaaaagggcaggtggggcctgtttttagagcattcaacaaggccacttatgtcaccaggacacttgctggctaccttccccacctgctgtgtgcttctggtgttttgaggtctgtggactgaacttacctgtgccattcagctccctccccaccctgttcactgcatttggccagcttgctcctgcttcgctcaacagaggcccccactggcctgggtgtcaagatggaaaaaagctcactgaagctctagagccatgtgacttcatgtaaatggttttgtcctccctgctgatttagcctggtgcctgtgtgtgtccatccactcagtacgtctgtgtgcgggttgtgtccacacgtgtcgctacatcagcggggaatccttctcaaacagcgttgcacaaagcatcctcaagttcccagcaaagtacttgatctctttcaaatgtgttttatcgtctaggttctgtgaccactggtttctgtatccagaactgtcaggtatcctttggtaaacagcactgatctctgtattgtaccccatcactaacgtgtcagaacccagcgtatgtagcatttgtattgcagtttccctggcttcctttatgttttgcactgatgaattttgacagggtaattgccactgtacctgtgcaatactgctgtaaataactgcagatttttttaagaaactcaatcttttatgttcttaatgaattttatataaataaaacttgcgactagctctca
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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