LOCUS       NM_171988               5092 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus Bcl2-like 11 (Bcl2l11), mRNA.
ACCESSION   NM_171988 XM_006234986
VERSION     NM_171988.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Zhang X, Ge J, Zhu X, Zhang H, Wang Y, Xu T, Jiang W and Zhang B.
  TITLE     Effects and Mechanism of Oxymatrine Combined with Compound Yinchen
            Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim
            Pathway
  JOURNAL   Biomed Res Int 2022, 8644356 (2022)
   PUBMED   35036441
  REMARK    GeneRIF: Effects and Mechanism of Oxymatrine Combined with Compound
            Yinchen Granules on the Apoptosis of Hepatocytes through the
            Akt/FoxO3a/Bim Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Huang J, Huang Y, Feng Z, Guo W, Wang X and Liao Z.
  TITLE     MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2
  JOURNAL   J Recept Signal Transduct Res 41 (1), 6-14 (2021)
   PUBMED   32605511
  REMARK    GeneRIF: MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Qin X, Gao S, Yang Y, Wu L and Wang L.
  TITLE     microRNA-25 promotes cardiomyocytes proliferation and migration via
            targeting Bim
  JOURNAL   J Cell Physiol 234 (12), 22103-22115 (2019)
   PUBMED   31058341
  REMARK    GeneRIF: our study demonstrates that miR-25 downregulation inhibits
            cardiomyocytes proliferation and migration...by targeting Bim
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Kennedy D, Mnich K, Oommen D, Chakravarthy R, Almeida-Souza L,
            Krols M, Saveljeva S, Doyle K, Gupta S, Timmerman V, Janssens S,
            Gorman AM and Samali A.
  TITLE     HSPB1 facilitates ERK-mediated phosphorylation and degradation of
            BIM to attenuate endoplasmic reticulum stress-induced apoptosis
  JOURNAL   Cell Death Dis 8 (8), e3026 (2017)
   PUBMED   29048431
  REMARK    GeneRIF: HSPB1 facilitates ERK-mediated phosphorylation and
            degradation of BIM to attenuate endoplasmic reticulum
            stress-induced apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Gilley J and Ham J.
  TITLE     Evidence for increased complexity in the regulation of Bim
            expression in sympathetic neurons: involvement of novel
            transcriptional and translational mechanisms
  JOURNAL   DNA Cell Biol 24 (9), 563-573 (2005)
   PUBMED   16153157
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Gilley J, Coffer PJ and Ham J.
  TITLE     FOXO transcription factors directly activate bim gene expression
            and promote apoptosis in sympathetic neurons
  JOURNAL   J Cell Biol 162 (4), 613-622 (2003)
   PUBMED   12913110
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Harris CA and Johnson EM Jr.
  TITLE     BH3-only Bcl-2 family members are coordinately regulated by the JNK
            pathway and require Bax to induce apoptosis in neurons
  JOURNAL   J Biol Chem 276 (41), 37754-37760 (2001)
   PUBMED   11495903
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Leo CP, Hsu SY, Chun SY, Bae HW and Hsueh AJ.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Hsu SY, Lin P and Hsueh AJ.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000118.1.
            
            On Feb 10, 2021 this sequence version replaced NM_171988.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF065433.1, AF065431.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132269, SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            regulatory uORF           :: PMID: 16153157
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JACYVU010000118.1  39233848-39234097
            251-645             JACYVU010000118.1  39236495-39236889
            646-755             JACYVU010000118.1  39256120-39256229
            756-5092            JACYVU010000118.1  39266797-39271133
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..5092
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Bcl2-like 11"
                     /db_xref="GeneID:64547"
                     /db_xref="RGD:628774"
     exon            1..250
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      215..283
                     /regulatory_class="uORF"
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16153157]"
                     /note="this uORF is predicted to encode a 22 aa peptide
                     (PMID:16153157)"
     exon            251..645
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..854
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="bcl-2-related ovarian death protein;
                     bcl2-interacting mediator of cell death; Bcl-2 related
                     apoptotic gene product BimL; BCL2-like 11 (apoptosis
                     facilitator)"
                     /codon_start=1
                     /product="bcl-2-like protein 11"
                     /protein_id="NP_741985.1"
                     /db_xref="GeneID:64547"
                     /db_xref="RGD:628774"
                     /translation="

MAKQPSDVNSECDREGGQLQPAERPPQLRPGAPTSLQTESQGNPDGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNETYTRRAFANDYREAEDHPQMVILQLLRFIFRLVWRRH"

     misc_feature    264..467
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="propagated from UniProtKB/Swiss-Prot (O88498.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    273..380
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Bim protein N-terminus; Region: Bim_N; pfam06773"
                     /db_xref="CDD:429111"
     misc_feature    456..458
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000250|UniProtKB:O43521; propagated from
                     UniProtKB/Swiss-Prot (O88498.1); phosphorylation site"
     misc_feature    480..482
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O88498.1); phosphorylation site"
     misc_feature    510..512
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O88498.1); phosphorylation site"
     misc_feature    531..605
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="propagated from UniProtKB/Swiss-Prot (O88498.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    531..533
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43521; propagated from
                     UniProtKB/Swiss-Prot (O88498.1); phosphorylation site"
     misc_feature    648..755
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Bcl-x interacting, BH3 domain; Region:
                     Bclx_interact; pfam08945"
                     /db_xref="CDD:430337"
     misc_feature    699..743
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="propagated from UniProtKB/Swiss-Prot (O88498.1);
                     Region: BH3"
     exon            646..755
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     exon            756..5092
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtggctggggcaggctgctttcacttcgctccccgcaggcactgggtcaacagcttgttggagctctgcggtccttgccgccgccgccgttgtcgttgcagtcaccggattcctgcagccgctccgcgagctgtgttccacttggattcacaccacctccgctgcccccgccgccaccgcctcggcgcccttcccctggccctcgtccacccaatgtctgactctgattctcggactgagaaacgcaagaaaaaaagaccaaatggccaagcaaccttctgatgtaaattctgagtgtgacagagaaggtggacaattgcagcctgctgagaggcctccccagctcaggcctggggcccctacctccctacagacagaatcgcaaggtaatcccgacggcgaaggggaccgctgcccccacggcagccctcagggcccgctggccccaccggccagccctggtccttttgctaccagatccccacttttcatctttgtgagaagatcttctctgctgtcccggtcctccagtgggtatttctcttttgacacagacaggagcccggcacccatgagttgtgacaagtcaacacaaaccccaagtcctccttgccaggccttcaaccattatctcagtgcaatggcttccataaggcagtctcaggaggaacctgaagatctgcgcccagagatacggatcgcacaggagctgcggcggatcggagacgagttcaatgagacttacacgaggagggcgtttgcaaacgattaccgagaggcggaagaccacccgcaaatggttatcttacaactgttacgattcatcttccgtctggtctggagaaggcactgacaggagcttcgtgcagccaggacaaatggcggacatcgctcttgttcagaccgggagaaccccagcacctccatctcttggcgctgcgacagtccggccggtggctctgtcccagagaggcgtgcggagcacggacagcgctcagcactgtgtcgatgtggacggaacctctgtccatcaccacatggccggattttcagtaaataattgttgtgaatgtaaacaagggagggtttttctcttttaaatgtacagatcctagggacagagaaatatgcaagagaggtgtttacatgtggtgtgttaatttttttaaacccactttctttgataactgttttttgtttttttttttttttttttggtcttgtttttgtttcagaaaggaaaacttttagacaatttatggataatttttttatactcattcttaacccattaccttctcagaggactgcgtaaccctgcagtgggaactgagccagccgatttataaggctgccttagtttatttttagatattactgtacagaattttttaaacaggaagagtatggcgttgccctctctcctctgccatgcctccgagtttccttttgaatttttactaccaaaacagttgttatgaaatggaatgggctcgagtggcagagggtctgttctggtacgccacttccgttttgtaaatatttacctccttagctcagttgctcctgtggcaaaaaagttcacacttttcatgctttccctcaactcttcggacccctcggtctgtctccacaccgatgcacaggttcagcccagggtcctttccaatgtgtttgtgtcggcaagggctaggggctgcccggattgttcccagctccatcaatcaggctgacttcatgggaagggctcctgggcacttcacttcactgcggtggcttcgtttgtctctcttatcctgagagaacgtgggcttgcacgccacttgctaaagctgttggctcttctggttgcccgctctgctgcctgccgcaggctctgctggctgtgtgtaccagatgagctggagcccacactttctccgggattggccaggtcatttcaggagcaaggagctcaggtgatccttttccgtgcttcttggtatgtagccccgctcatccctcctggcctgtggctcctggatttcgtctccattcccatgagtcaggggctggctctacttcatcagtttccatacacaggaaacctccattttaccaagtaaaacatttgtcttcacaagatgtctgcctgctttgctctctcccattttcttaacacctgaaccttcttgggcctcctgtgtctggggcgggggtggggtgctatttcttggtaccctgcctcttaggaccagcagcccatacattggtcagttatttcaagagcaggcaggactggtctagtggaagagcgcttcctaatgtgtagaggccctgtgtcctatccccggcacctcctaaaacaacagcacacctgtcagacagacagacaaacgggagattaaaaaagggggggggggcaaagaagaaagaacataggaggggtggggggcagtgacaaaccctctaacttgtgagaacgtcagacattaggcagcttgcttagagaggtgtatgcgtttccaagcaagtcagcggtgccaatgactgtgtgctttgggcctgtagacagccagtgttttttcttatgtaaaggaatccatttattcctactttcctgcgtgtgtgtgtgtgtgtgtgtctgtgtgtgtctgtgtgtgtctgtgtgtgtctgtacatttccttctagattgaaatcatccgattccaaataatgtttataaatgctttcccagcttccatagatttgtaatagactgaaagctgttttggcattcacctcctttcctaatgcattgagcctgctcatgggttcccatgaggcctatggttgtaagttggtgttaagagtgcaaccatggctctgctacacacactcacacacacacacacactcacataaacacacacacacacacacacacacacacaccccaaagacatacttggttctgggccatcccctccctaggacctccattctcatgtgccagtctccccgactggagcactttactgtctcagccccgtggctctgtggtactgcctaggcgggtgcagaaggctcccagagccaggtgccagtggcatgtgtggcccctaaaacgtgcttacctccagcctggggctggccgctgaagcagctcatagggtagtaagagagtctatgaattgtagaagtattcaagaacaggatgcggcacccagaacttaaacatgatgactggatgtccctgtactgtatctgtttcttaaaatgcaagtgtctcctgcagaaagtgtctcagcttactgtgggtagggctttgtgcttaattgttagtttatcattctctcttctgtgctagaacagaaactagatctccctcctccgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaacataatgcgggttttgtgccttgacaacctccccatgtgaggtttgtaaatagtgtcctgtgacttcacctcaagttggaataaacgtacaaaatggcgtcctgagtgattcttcaaattttctttccagaaaagagttgagttcgggggagggagggtgtctgaaaaatcagcttaaagtccctctttattaaagtctgtaatggataatgtctgcttctcctgtttcctccttccagtgttgtatatattctgactatttattagattaggaagtcatgtttcactcgtcaactgagccaaatgtctgtgtgcaattgtattctcgttacctttctttgtaaaatattgtacagcataaatgagtaaaaaaaaaatcactgttttttcaaacttctcattattaaggattgtaaataccgtaggttctccttctgtgtaatgtgccctactgttccataatgctgtaacttgtagagtcattgtatatttattttctgcttatttaatgtcttacgttcttgaaagtgttgacatccctatccctgacaccccagccatgccatgaattgcttcagctcctgataaaggggggcactgactgactggctctgttccccaacatggcttctgctttggcttctggcattcagtgcttggattctgctgcctctctgaggaaacgagtatttgctgccgatgagataccctagctacagtagcctggaagatcggactctaagaaaatacccatcaaacccatttataaagcagctggcttctgaggaaagcagatttaccaataagttggccatatctttagagaagtattagcaacagatggggaaggtttttttctttaattgagagtgtatctttgacaactcagtgttgaaagaaatcctgcctcttgaggtactgctgaatggccgccctgggtaagaaaagggcaggtggggcctgtttttagagcattcaacaaggccacttatgtcaccaggacacttgctggctaccttccccacctgctgtgtgcttctggtgttttgaggtctgtggactgaacttacctgtgccattcagctccctccccaccctgttcactgcatttggccagcttgctcctgcttcgctcaacagaggcccccactggcctgggtgtcaagatggaaaaaagctcactgaagctctagagccatgtgacttcatgtaaatggttttgtcctccctgctgatttagcctggtgcctgtgtgtgtccatccactcagtacgtctgtgtgcgggttgtgtccacacgtgtcgctacatcagcggggaatccttctcaaacagcgttgcacaaagcatcctcaagttcccagcaaagtacttgatctctttcaaatgtgttttatcgtctaggttctgtgaccactggtttctgtatccagaactgtcaggtatcctttggtaaacagcactgatctctgtattgtaccccatcactaacgtgtcagaacccagcgtatgtagcatttgtattgcagtttccctggcttcctttatgttttgcactgatgaattttgacagggtaattgccactgtacctgtgcaatactgctgtaaataactgcagatttttttaagaaactcaatcttttatgttcttaatgaattttatataaataaaacttgcgactagctctca

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