2024-05-04 18:01:19, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_080887 1301 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus thioredoxin-like 1 (Txnl1), mRNA. ACCESSION NM_080887 XM_001059942 VERSION NM_080887.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1301) AUTHORS Felberbaum-Corti M, Morel E, Cavalli V, Vilbois F and Gruenberg J. TITLE The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis JOURNAL PLoS One 2 (11), e1144 (2007) PUBMED 17987124 REMARK GeneRIF: TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis Publication Status: Online-Only REFERENCE 2 (bases 1 to 1301) AUTHORS Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K and Yonehara S. TITLE Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa JOURNAL J Biol Chem 273 (30), 19160-19166 (1998) PUBMED 9668102 REMARK Erratum:[J Biol Chem 1998 Oct 16;273(42):27755] COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098908.1. On or before Jun 25, 2006 this sequence version replaced XM_001059942.1, NM_080887.1. ##Evidence-Data-START## Transcript exon combination :: BC098908.1, AF140358.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06621351, SAMN12840110 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1301 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="18" /map="18q12.1" gene 1..1301 /gene="Txnl1" /gene_synonym="Txnl" /note="thioredoxin-like 1" /db_xref="GeneID:140922" /db_xref="RGD:621717" exon 1..305 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" misc_feature 163..165 /gene="Txnl1" /gene_synonym="Txnl" /note="upstream in-frame stop codon" CDS 208..1077 /gene="Txnl1" /gene_synonym="Txnl" /note="thioredoxin-related protein; thioredoxin-like (32kD)" /codon_start=1 /product="thioredoxin-like protein 1" /protein_id="NP_543163.1" /db_xref="GeneID:140922" /db_xref="RGD:621717" /translation="
MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDLSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH"
misc_feature 241..519 /gene="Txnl1" /gene_synonym="Txnl" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947" /db_xref="CDD:239245" misc_feature order(307..309,316..318) /gene="Txnl1" /gene_synonym="Txnl" /note="catalytic residues [active]" /db_xref="CDD:239245" misc_feature 544..546 /gene="Txnl1" /gene_synonym="Txnl" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q920J4.3); phosphorylation site" misc_feature 583..1011 /gene="Txnl1" /gene_synonym="Txnl" /note="PITH domain; Region: PITH; pfam06201" /db_xref="CDD:428821" exon 306..402 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 403..576 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 577..699 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 700..769 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 770..942 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 943..1047 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" exon 1048..1280 /gene="Txnl1" /gene_synonym="Txnl" /inference="alignment:Splign:2.1.0" ORIGIN
gctcccctcccagcccgcgtctcctccccctccgctcgcctgctccctggcgtgactcggcactcgcagcaccgggaggacacgtcgtggtcgccgttcccgcccaggccccggcctcctgcagcctctctccggcctctctcgggctttcgtcttaagttttgaggccggaggcgtcgtggccgtcctgccgggctctctgtaaggatggtgggagtgaagccggtcgggagcgatccagatttccagccggagctgagtggggcgggctccagacttgctgtggtcaagttcaccatgagagggtgtggaccatgtttgaggatcgccccggcattcagttctatgagtaataagtacccacaggcagtcttcttggaagtagatgtgcatcagtgccagggaacagctgccaccaacaatatatcagcaacacctacatttttgttttttcgaaacaaagtgagaattgatcagtatcaaggagcagatgctgtgggactggaagaaaaaatcaagcagcatttagaaaatgaccctggaagcaatgaggacacagacattcccaagggctatatggatttaatgccttttattaacaaagctggctgcgaatgtctcaatgaaagtgatgagcacggctttgacaactgcttacgaaaagacctgtccttcttggagtctgactgcgacgagcagctgcttattactgtggcattcaatcaaccagttaaactttattccatgaagtttcaaggaccagataatggtcagggtcctaaatatgtaaaaatttttatcaacctaccccgatctatggactttgaggaggcagaaaggagtgagccaacccaagctctggaactgacagaagatgacattaaagaagatggcattgttcctcttcgttatgttaaatttcagaatgtgaacagtgtaactttgtttgttcagtctaatcaaggagaagaagaaacaacaagaatttcctattttactttcattggtactcccgtccaggcaacaaatatgaatgacttcaaacgagtagttggcaaaaagggggaaagccattagggtacaaaagacactggaagactactgcagtcagatttgcagctcctggataattgcttgattctcttcggaaactgttaatcttttatttgttgccagtaccaataaatcattgcttttgttcagatggtaatactagtgtttctattgtaatcttgatacatgcagttgtaaataaaagtcattactttgccaagcttaaaaaaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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