LOCUS       NM_080887               1301 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus thioredoxin-like 1 (Txnl1), mRNA.
ACCESSION   NM_080887 XM_001059942
VERSION     NM_080887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Felberbaum-Corti M, Morel E, Cavalli V, Vilbois F and Gruenberg J.
  TITLE     The redox sensor TXNL1 plays a regulatory role in fluid phase
            endocytosis
  JOURNAL   PLoS One 2 (11), e1144 (2007)
   PUBMED   17987124
  REMARK    GeneRIF: TXNL1 acts as an effector of oxidants or a redox sensor by
            converting redox changes into changes of GDI capacity to capture
            Rab5, which in turn modulates fluid phase endocytosis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K
            and Yonehara S.
  TITLE     Purification, molecular cloning, and characterization of TRP32, a
            novel thioredoxin-related mammalian protein of 32 kDa
  JOURNAL   J Biol Chem 273 (30), 19160-19166 (1998)
   PUBMED   9668102
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098908.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001059942.1, NM_080887.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098908.1, AF140358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1301
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="thioredoxin-like 1"
                     /db_xref="GeneID:140922"
                     /db_xref="RGD:621717"
     exon            1..305
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    163..165
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="upstream in-frame stop codon"
     CDS             208..1077
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="thioredoxin-related protein; thioredoxin-like
                     (32kD)"
                     /codon_start=1
                     /product="thioredoxin-like protein 1"
                     /protein_id="NP_543163.1"
                     /db_xref="GeneID:140922"
                     /db_xref="RGD:621717"
                     /translation="

MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDLSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH"

     misc_feature    241..519
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="TRX family; composed of two groups: Group I, which
                     includes proteins that exclusively encode a TRX domain;
                     and Group II, which are composed of fusion proteins of TRX
                     and additional domains. Group I TRX is a small ancient
                     protein that alter the redox...; Region: TRX_family;
                     cd02947"
                     /db_xref="CDD:239245"
     misc_feature    order(307..309,316..318)
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239245"
     misc_feature    544..546
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q920J4.3); phosphorylation site"
     misc_feature    583..1011
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /note="PITH domain; Region: PITH; pfam06201"
                     /db_xref="CDD:428821"
     exon            306..402
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            403..576
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            577..699
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            700..769
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            770..942
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1047
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1280
                     /gene="Txnl1"
                     /gene_synonym="Txnl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gctcccctcccagcccgcgtctcctccccctccgctcgcctgctccctggcgtgactcggcactcgcagcaccgggaggacacgtcgtggtcgccgttcccgcccaggccccggcctcctgcagcctctctccggcctctctcgggctttcgtcttaagttttgaggccggaggcgtcgtggccgtcctgccgggctctctgtaaggatggtgggagtgaagccggtcgggagcgatccagatttccagccggagctgagtggggcgggctccagacttgctgtggtcaagttcaccatgagagggtgtggaccatgtttgaggatcgccccggcattcagttctatgagtaataagtacccacaggcagtcttcttggaagtagatgtgcatcagtgccagggaacagctgccaccaacaatatatcagcaacacctacatttttgttttttcgaaacaaagtgagaattgatcagtatcaaggagcagatgctgtgggactggaagaaaaaatcaagcagcatttagaaaatgaccctggaagcaatgaggacacagacattcccaagggctatatggatttaatgccttttattaacaaagctggctgcgaatgtctcaatgaaagtgatgagcacggctttgacaactgcttacgaaaagacctgtccttcttggagtctgactgcgacgagcagctgcttattactgtggcattcaatcaaccagttaaactttattccatgaagtttcaaggaccagataatggtcagggtcctaaatatgtaaaaatttttatcaacctaccccgatctatggactttgaggaggcagaaaggagtgagccaacccaagctctggaactgacagaagatgacattaaagaagatggcattgttcctcttcgttatgttaaatttcagaatgtgaacagtgtaactttgtttgttcagtctaatcaaggagaagaagaaacaacaagaatttcctattttactttcattggtactcccgtccaggcaacaaatatgaatgacttcaaacgagtagttggcaaaaagggggaaagccattagggtacaaaagacactggaagactactgcagtcagatttgcagctcctggataattgcttgattctcttcggaaactgttaatcttttatttgttgccagtaccaataaatcattgcttttgttcagatggtaatactagtgtttctattgtaatcttgatacatgcagttgtaaataaaagtcattactttgccaagcttaaaaaaaaaaaaaaaaaaaaaaaa

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