LOCUS       NM_030866               1445 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear factor I X (Nfix), mRNA.
ACCESSION   NM_030866 XM_001071608 XM_213849
VERSION     NM_030866.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Tian,M., Xue,J., Dai,C., Jiang,E., Zhu,B. and Pang,H.
  TITLE     CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers
            for sudden cardiac death caused by acute ischemic heart disease
  JOURNAL   Sci Rep 11 (1), 4695 (2021)
   PUBMED   33633191
  REMARK    GeneRIF: CircSLC8A1 and circNFIX can be used as auxiliary
            diagnostic markers for sudden cardiac death caused by acute
            ischemic heart disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Deak,F., Mates,L., Korpos,E., Zvara,A., Szenasi,T., Kiricsi,M.,
            Mendler,L., Keller-Pinter,A., Ozsvari,B., Juhasz,H., Sorokin,L.,
            Dux,L., Mermod,N., Puskas,L.G. and Kiss,I.
  TITLE     Extracellular deposition of matrilin-2 controls the timing of the
            myogenic program during muscle regeneration
  JOURNAL   J Cell Sci 127 (Pt 15), 3240-3256 (2014)
   PUBMED   24895400
  REMARK    GeneRIF: activates the expression of Matn2, and activate myoblast
            differentiation
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Piper,M., Harris,L., Barry,G., Heng,Y.H., Plachez,C.,
            Gronostajski,R.M. and Richards,L.J.
  TITLE     Nuclear factor one X regulates the development of multiple cellular
            populations in the postnatal cerebellum
  JOURNAL   J Comp Neurol 519 (17), 3532-3548 (2011)
   PUBMED   21800304
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Riffel,A.K., Schuenemann,E. and Vyhlidal,C.A.
  TITLE     Regulation of the CYP3A4 and CYP3A7 promoters by members of the
            nuclear factor I transcription factor family
  JOURNAL   Mol Pharmacol 76 (5), 1104-1114 (2009)
   PUBMED   19706729
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Satoh,S., Noaki,T., Ishigure,T., Osada,S., Imagawa,M., Miura,N.,
            Yamada,K. and Noguchi,T.
  TITLE     Nuclear factor 1 family members interact with hepatocyte nuclear
            factor 1alpha to synergistically activate L-type pyruvate kinase
            gene transcription
  JOURNAL   J Biol Chem 280 (48), 39827-39834 (2005)
   PUBMED   16204235
  REMARK    GeneRIF: cooperative interaction between NF1 family members and
            HNF1alpha plays an important role in hepatic L-PK transcription
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Baumeister,H., Gronostajski,R.M., Lyons,G.E. and Margolis,F.L.
  TITLE     Identification of NFI-binding sites and cloning of NFI-cDNAs
            suggest a regulatory role for NFI transcription factors in
            olfactory neuron gene expression
  JOURNAL   Brain Res Mol Brain Res 72 (1), 65-79 (1999)
   PUBMED   10521600
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Osada,S., Matsubara,T., Daimon,S., Terazu,Y., Xu,M., Nishihara,T.
            and Imagawa,M.
  TITLE     Expression, DNA-binding specificity and transcriptional regulation
            of nuclear factor 1 family proteins from rat
  JOURNAL   Biochem J 342 (Pt 1) (Pt 1), 189-198 (1999)
   PUBMED   10432316
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Chaudhry,A.Z., Vitullo,A.D. and Gronostajski,R.M.
  TITLE     Nuclear factor I (NFI) isoforms differentially activate simple
            versus complex NFI-responsive promoters
  JOURNAL   J Biol Chem 273 (29), 18538-18546 (1998)
   PUBMED   9660824
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB012235.1 and AB012234.1.
            
            On or before May 24, 2007 this sequence version replaced
            XM_213849.4, XM_001071608.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-844               AB012235.1         1-844
            845-1445            AB012234.1         16-616
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1445
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /note="nuclear factor I X"
                     /db_xref="GeneID:81524"
                     /db_xref="RGD:69080"
     exon            1..66
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1365
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /note="NF1-X1 protein; nuclear factor 1 X; nuclear factor
                     I/X (CCAAT-binding transcription factor)"
                     /codon_start=1
                     /product="nuclear factor 1 X-type"
                     /protein_id="NP_110493.1"
                     /db_xref="GeneID:81524"
                     /db_xref="RGD:69080"
                     /translation="

MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQHSQRQAPPLPTGLSASDPGTATF"

     misc_feature    64..177
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /note="Nuclear factor I protein pre-N-terminus; Region:
                     NfI_DNAbd_pre-N; pfam10524"
                     /db_xref="CDD:463134"
     misc_feature    241..549
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /note="MH1 domain; Region: MH1; pfam03165"
                     /db_xref="CDD:460833"
     misc_feature    676..>1293
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /note="CTF/NF-I family transcription modulation region;
                     Region: CTF_NFI; pfam00859"
                     /db_xref="CDD:459967"
     exon            67..598
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            599..661
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            662..736
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            737..857
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            858..994
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1117
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1293
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1385
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1438
                     /gene="Nfix"
                     /gene_synonym="Nf1x"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccgcggccggcctctgcgctcgcgcccgggcgcccagcgatgtactccccgtactgcctcacccaggatgagttccacccgttcatcgaggcgctgctgcctcacgtccgagccttctcctacacctggttcaacctgcaggcgcggaagcgcaagtacttcaagaagcacgagaagcggatgtcaaaggacgaggagcgcgcagtgaaggacgagctgctgggcgagaagcctgagatcaagcagaagtgggcatcccggctgttggccaagctgcgcaaagacatccggcccgagttccgcgaggactttgtgctaaccatcacgggcaagaagcccccctgctgcgtgctctccaaccccgaccagaagggcaagatccggcggattgactgcctgcgccaggctgacaaggtgtggcggctggacctggtcatggtgattttgtttaaagggatccctttggaaagtactgatggggagcggctctacaagtcgccccagtgctcgaaccccggcctgtgcgtccagccacatcacattggagtcacaatcaaagaactggacctttatctggcttactttgtccacactccggaatccggacaatcagatagttcaaaccagcaaggagatgcggacatcaaaccactgcccaacgggcacttaagtttccaggactgctttgtgacgtctggggtctggaacgtgacagagctggtgagagtgtcacagactcctgttgcaactgcatcagggcccaacttctcactggcagatctggagagccccagttactacaacataaatcaagtgaccctgggacgccggtccatcacctcccctccttccaccagcaccaccaagcgccccaagtccatcgacgacagtgagatggagagtccagtcgatgatgtattctatcctgggacaggccgctccccagcagctggcagcagccagtctagcggatggcccaacgacgtggatgcaggccctgcttctctaaagaagtcaggaaagctggacttctgcagcgccctctcctctcagggcagctccccacgcatggctttcacccaccacccgctgcctgtgcttgctggagtcagaccagggagcccccgggccacagcatcagcactgcacttcccttccacctccatcattcagcagtcgagcccgtacttcacacacccaaccatccgctaccaccaccaccatgggcaggactcgctgaaggagttcgtacagtttgtgtgctctgacggctcgggtcaggccaccgggcagcattcacaacgacaggcgcctcctctgccaaccggtttgtcagcatcggatcccgggacagcaactttctgaacatcccacagcagtctcagtcctggttcctctgattaagatcaacaaagaaacaacaaaattttaaaaaaaaaaaaaaa

//