ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2024-04-27 23:11:35, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_022619 2497 bp mRNA linear ROD 22-DEC-2022
DEFINITION Rattus norvegicus solute carrier family 7 member 2 (Slc7a2),
transcript variant 1, mRNA.
ACCESSION NM_022619
VERSION NM_022619.3
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2497)
AUTHORS Hultstrom M, Helle F and Iversen BM.
TITLE AT(1) receptor activation regulates the mRNA expression of CAT1,
CAT2, arginase-1, and DDAH2 in preglomerular vessels from
angiotensin II hypertensive rats
JOURNAL Am J Physiol Renal Physiol 297 (1), F163-F168 (2009)
PUBMED 19386725
REMARK GeneRIF: CAT1, CAT2, DDAH2, and arginase-1 expression in renal
resistance vessels is regulated through the AT(1) receptor.
REFERENCE 2 (bases 1 to 2497)
AUTHORS Huang TY, Tsai PS and Huang CJ.
TITLE HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes
expression
JOURNAL J Surg Res 148 (2), 172-180 (2008)
PUBMED 18028947
REMARK GeneRIF: HO-1 overexpression significantly attenuates
endotoxin-induced increases in nitric oxide and l-arginine
transport, as well as the expression of iNOS and CAT-2 isozymes in
septic rats.
REFERENCE 3 (bases 1 to 2497)
AUTHORS Schwartz IF, Chernichovsky T, Hagin D, Ingbir M, Reshef R, Chernin
G, Levo Y and Schwartz D.
TITLE Differential regulation of L-arginine transporters (cationic amino
acid transporter-1 and -2) by peroxynitrite in rat mesangial cells
JOURNAL Nephrol Dial Transplant 21 (12), 3409-3414 (2006)
PUBMED 16998217
REFERENCE 4 (bases 1 to 2497)
AUTHORS Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer
KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N.
TITLE Cationic amino acid transporter 2 regulates inflammatory
homeostasis in the lung
JOURNAL Proc Natl Acad Sci U S A 103 (40), 14895-14900 (2006)
PUBMED 17003120
REFERENCE 5 (bases 1 to 2497)
AUTHORS Yeramian A, Martin L, Arpa L, Bertran J, Soler C, McLeod C,
Modolell M, Palacin M, Lloberas J and Celada A.
TITLE Macrophages require distinct arginine catabolism and transport
systems for proliferation and for activation
JOURNAL Eur J Immunol 36 (6), 1516-1526 (2006)
PUBMED 16703566
REFERENCE 6 (bases 1 to 2497)
AUTHORS Stevens BR, Kakuda DK, Yu K, Waters M, Vo CB and Raizada MK.
TITLE Induced nitric oxide synthesis is dependent on induced
alternatively spliced CAT-2 encoding L-arginine transport in brain
astrocytes
JOURNAL J Biol Chem 271 (39), 24017-24022 (1996)
PUBMED 8798637
REFERENCE 7 (bases 1 to 2497)
AUTHORS Gill DJ, Low BC and Grigor MR.
TITLE Interleukin-1 beta and tumor necrosis factor-alpha stimulate the
cat-2 gene of the L-arginine transporter in cultured vascular
smooth muscle cells
JOURNAL J Biol Chem 271 (19), 11280-11283 (1996)
PUBMED 8626679
REFERENCE 8 (bases 1 to 2497)
AUTHORS Kavanaugh MP, Wang H, Zhang Z, Zhang W, Wu YN, Dechant E, North RA
and Kabat D.
TITLE Control of cationic amino acid transport and retroviral receptor
functions in a membrane protein family
JOURNAL J Biol Chem 269 (22), 15445-15450 (1994)
PUBMED 8195186
REFERENCE 9 (bases 1 to 2497)
AUTHORS Kudo H, Hirayoshi K, Kitagawa Y, Imamura S and Nagata K.
TITLE Two collagen-binding proteins, osteonectin and HSP47, are
coordinately induced in transformed keratinocytes by heat and other
stresses
JOURNAL Exp Cell Res 212 (2), 219-224 (1994)
PUBMED 8187816
REFERENCE 10 (bases 1 to 2497)
AUTHORS Closs EI, Albritton LM, Kim JW and Cunningham JM.
TITLE Identification of a low affinity, high capacity transporter of
cationic amino acids in mouse liver
JOURNAL J Biol Chem 268 (10), 7538-7544 (1993)
PUBMED 8385111
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF245001.1.
On Aug 30, 2012 this sequence version replaced NM_022619.2.
Transcript Variant: This variant (1) represents the shorter
transcript and encodes the shorter protein (isoform a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF245001.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760400, SAMEA5760476
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2497 AF245001.1 2-2498
FEATURES Location/Qualifiers
source 1..2497
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="W"
/db_xref="taxon:10116"
/chromosome="16"
/map="16q12.1"
gene 1..2497
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="solute carrier family 7 member 2"
/db_xref="GeneID:64554"
/db_xref="RGD:68387"
exon 1..164
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 165..555
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
CDS 180..2153
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="isoform a is encoded by transcript variant 1; low
affinity cationic amino acid transporter 2; CAT-2;
cationic amino acid transporter-2A; solute carrier family
7 (cationic amino acid transporter, y+ system), member 2"
/codon_start=1
/product="cationic amino acid transporter 2 isoform a"
/protein_id="NP_072141.2"
/db_xref="GeneID:64554"
/db_xref="RGD:68387"
/translation="
MIPCRAVLTFTRCLIRRKIVTLDSLEDSKLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYTPEKDILESCTNATSKSESQVTMLQGQGFSLRTLFNPSALPTRQSASLVSFLVGFLAFLIAGLSILTTYGVQAIARLEAWSLALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMVLGFLIYFAYGIRHSLEGNPRDEEEDEDVCPDNVNAAAEEKSAMQANDHHQRNLSLPFILHEKTSEC"
misc_feature 192..2000
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="cationic amino acid transport permease; Region:
2A0303; TIGR00906"
/db_xref="CDD:273330"
misc_feature 249..251
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P52569; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site"
misc_feature 294..356
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 378..440
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 492..554
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 648..650
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site"
misc_feature 669..731
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 756..818
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 858..860
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site"
misc_feature 894..896
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site"
misc_feature 924..986
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1047..1109
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1197..1259
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1335..1397
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1407..1469
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1566..1568
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P52569; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site"
misc_feature 1647..1709
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1749..1811
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1842..1904
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 1923..1985
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1);
transmembrane region"
misc_feature 2112..2114
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site"
exon 556..711
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 712..877
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 878..1011
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1012..1234
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1235..1371
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1372..1474
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1475..1680
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1681..1847
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1848..1956
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
exon 1957..2497
/gene="Slc7a2"
/gene_synonym="Cat2; Cat2a; Cat2b"
/inference="alignment:Splign:2.1.0"
ORIGIN
gtgcccagcccgccttctgcagctcggcggcgggagcttctgtctgcgcggacctggaagacggcggcagctcgtctagccttcgagagcttgggaaccgcagagcgctgcagccggtcgtccgctggtgcccgtctccgtcgcgcagccagggcactgccccagttgctcccttcaccatgattccctgcagagcagtgctgactttcacacgatgtctgatccggagaaaaattgtcacactggacagtctggaagattccaaactctgccgctgcttaaccaccatggacctcatcgccctgggagttggaagcactctcggcgctggggtttacgtcctggctggagaagtcgccaaagctgactccggccctagtattgtggtgtctttcctcatcgctgccctggcttcggtgatggccggcctttgctacgctgaatttggggcccgagtaccaaagactggatctgcgtatctatacacatacgtcacggttggagagctgtgggccttcatcactggttggaatctcattctgtcatatgtcataggtacgtccagtgtcgcaagagcttggagtggcaccttcgatgagcttcttaacaaacagattggccagtttttcaagacctacttcaaaatgaattacaccggtctggcggagtatccggacttctttgccgtgtgccttgtattacttctggcaggtcttttatcttttggagtaaaggagtctgcttgggtgaataaattttttacagctattaatatcctggtccttctctttgtcatggtggctgggtttgtgaaaggaaatgtggctaactggaagatcagtgaagaatttctcaagaatatatcagcaagtgccagagaaccaccttctgaaaatggaacaagcatctacggggctggcggcttcatgccttatggctttacagggacgctggctggtgctgcaacgtgcttttatgcctttgtgggctttgactgcattgcaacaaccggcgaagaggtccggaatccccaaaaggctattcccattggaatagtaacttccttacttgtttgctttatggcctattttggggtttctgcagctttaacacttatgatgccttactacctcctggatgagaaaagcccactccctgttgcatttgaatatgtcggatggggtcctgctaaatacgttgtcgccgcaggctccctctgcgccttatcaacaagtcttctgggttctatgttccccttaccccgcattctgtttgccatggcccgggatggcttactgtttagatttcttgcaagagtgagtaagaggcagtcacccgttgctgccacgatgactgcaggggtcatttctgctgtgatggcctttctttttgacctgaaggctctcgtggacatgatgtctattggcaccctcatggcctactctctggtcgcagcctgtgtgctcattctcaggtaccaacctggcttgtgttatgagcagcccaaatacacccctgagaaagacattctggagtcatgtaccaatgcgacctcgaagagcgagtcccaggtcaccatgctgcaaggacagggtttcagcctacgaaccctcttcaacccctctgctctgcccacacgacagtcagcctccctcgtgagcttcctggtgggattcctggctttcctcatcgccggcttgagtattctgaccacgtacggagtccaggccatcgccagactggaagcctggagcctggctcttctcgccctgttccttgtcctctgcgctgccgtcatcctgaccatttggaggcagccacagaatcagcaaaaagtagccttcatggtcccgttcttaccgtttctgccggccttcagcatcctggtcaacatttacttgatggtccagttaagcgcggacacttgggtcagattcagcatctggatggtgcttggctttctgatttacttcgcctatggcattagacacagcttggagggtaaccccagggatgaagaagaagatgaagatgtctgtccagacaacgtcaatgcagcagcagaagaaaagtctgccatgcaggcaaatgaccatcaccaaagaaacctcagcttgcctttcatacttcatgaaaagacaagtgaatgttgatgccggtccgcagccctaccacacatgccttaacaatgagtactttacggcaggaagccaccatcgtgctgggttgtcatgggtttgctgcagccacggtttgcctaacttatacttcctcctccggacagcttcttttcaaatggtggattatgtgtttggggagactgcctgagagcactcctcagtgatacgtatccccaaaacagtatgtctgtgtgggtacatgtgtgcttgggaatgtgagtgttcaatgttgttggttcttactctgtgacatgattccagtgcagtaactggtggcatgtactgcacatgctagtaaacagtatattgctgaatag
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]