2024-05-03 06:13:36, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_022619 2497 bp mRNA linear ROD 22-DEC-2022 DEFINITION Rattus norvegicus solute carrier family 7 member 2 (Slc7a2), transcript variant 1, mRNA. ACCESSION NM_022619 VERSION NM_022619.3 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2497) AUTHORS Hultstrom M, Helle F and Iversen BM. TITLE AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats JOURNAL Am J Physiol Renal Physiol 297 (1), F163-F168 (2009) PUBMED 19386725 REMARK GeneRIF: CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor. REFERENCE 2 (bases 1 to 2497) AUTHORS Huang TY, Tsai PS and Huang CJ. TITLE HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes expression JOURNAL J Surg Res 148 (2), 172-180 (2008) PUBMED 18028947 REMARK GeneRIF: HO-1 overexpression significantly attenuates endotoxin-induced increases in nitric oxide and l-arginine transport, as well as the expression of iNOS and CAT-2 isozymes in septic rats. REFERENCE 3 (bases 1 to 2497) AUTHORS Schwartz IF, Chernichovsky T, Hagin D, Ingbir M, Reshef R, Chernin G, Levo Y and Schwartz D. TITLE Differential regulation of L-arginine transporters (cationic amino acid transporter-1 and -2) by peroxynitrite in rat mesangial cells JOURNAL Nephrol Dial Transplant 21 (12), 3409-3414 (2006) PUBMED 16998217 REFERENCE 4 (bases 1 to 2497) AUTHORS Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N. TITLE Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung JOURNAL Proc Natl Acad Sci U S A 103 (40), 14895-14900 (2006) PUBMED 17003120 REFERENCE 5 (bases 1 to 2497) AUTHORS Yeramian A, Martin L, Arpa L, Bertran J, Soler C, McLeod C, Modolell M, Palacin M, Lloberas J and Celada A. TITLE Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation JOURNAL Eur J Immunol 36 (6), 1516-1526 (2006) PUBMED 16703566 REFERENCE 6 (bases 1 to 2497) AUTHORS Stevens BR, Kakuda DK, Yu K, Waters M, Vo CB and Raizada MK. TITLE Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes JOURNAL J Biol Chem 271 (39), 24017-24022 (1996) PUBMED 8798637 REFERENCE 7 (bases 1 to 2497) AUTHORS Gill DJ, Low BC and Grigor MR. TITLE Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells JOURNAL J Biol Chem 271 (19), 11280-11283 (1996) PUBMED 8626679 REFERENCE 8 (bases 1 to 2497) AUTHORS Kavanaugh MP, Wang H, Zhang Z, Zhang W, Wu YN, Dechant E, North RA and Kabat D. TITLE Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family JOURNAL J Biol Chem 269 (22), 15445-15450 (1994) PUBMED 8195186 REFERENCE 9 (bases 1 to 2497) AUTHORS Kudo H, Hirayoshi K, Kitagawa Y, Imamura S and Nagata K. TITLE Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses JOURNAL Exp Cell Res 212 (2), 219-224 (1994) PUBMED 8187816 REFERENCE 10 (bases 1 to 2497) AUTHORS Closs EI, Albritton LM, Kim JW and Cunningham JM. TITLE Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver JOURNAL J Biol Chem 268 (10), 7538-7544 (1993) PUBMED 8385111 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF245001.1. On Aug 30, 2012 this sequence version replaced NM_022619.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF245001.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760400, SAMEA5760476 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2497 AF245001.1 2-2498 FEATURES Location/Qualifiers source 1..2497 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="W" /db_xref="taxon:10116" /chromosome="16" /map="16q12.1" gene 1..2497 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="solute carrier family 7 member 2" /db_xref="GeneID:64554" /db_xref="RGD:68387" exon 1..164 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 165..555 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" CDS 180..2153 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="isoform a is encoded by transcript variant 1; low affinity cationic amino acid transporter 2; CAT-2; cationic amino acid transporter-2A; solute carrier family 7 (cationic amino acid transporter, y+ system), member 2" /codon_start=1 /product="cationic amino acid transporter 2 isoform a" /protein_id="NP_072141.2" /db_xref="GeneID:64554" /db_xref="RGD:68387" /translation="
MIPCRAVLTFTRCLIRRKIVTLDSLEDSKLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYTPEKDILESCTNATSKSESQVTMLQGQGFSLRTLFNPSALPTRQSASLVSFLVGFLAFLIAGLSILTTYGVQAIARLEAWSLALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMVLGFLIYFAYGIRHSLEGNPRDEEEDEDVCPDNVNAAAEEKSAMQANDHHQRNLSLPFILHEKTSEC"
misc_feature 192..2000 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="cationic amino acid transport permease; Region: 2A0303; TIGR00906" /db_xref="CDD:273330" misc_feature 249..251 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P52569; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site" misc_feature 294..356 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 378..440 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 492..554 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 648..650 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site" misc_feature 669..731 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 756..818 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 858..860 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site" misc_feature 894..896 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); glycosylation site" misc_feature 924..986 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1047..1109 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1197..1259 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1335..1397 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1407..1469 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1566..1568 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P52569; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site" misc_feature 1647..1709 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1749..1811 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1842..1904 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 1923..1985 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="propagated from UniProtKB/Swiss-Prot (B5D5N9.1); transmembrane region" misc_feature 2112..2114 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (B5D5N9.1); phosphorylation site" exon 556..711 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 712..877 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 878..1011 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1012..1234 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1235..1371 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1372..1474 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1475..1680 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1681..1847 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1848..1956 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" exon 1957..2497 /gene="Slc7a2" /gene_synonym="Cat2; Cat2a; Cat2b" /inference="alignment:Splign:2.1.0" ORIGIN
gtgcccagcccgccttctgcagctcggcggcgggagcttctgtctgcgcggacctggaagacggcggcagctcgtctagccttcgagagcttgggaaccgcagagcgctgcagccggtcgtccgctggtgcccgtctccgtcgcgcagccagggcactgccccagttgctcccttcaccatgattccctgcagagcagtgctgactttcacacgatgtctgatccggagaaaaattgtcacactggacagtctggaagattccaaactctgccgctgcttaaccaccatggacctcatcgccctgggagttggaagcactctcggcgctggggtttacgtcctggctggagaagtcgccaaagctgactccggccctagtattgtggtgtctttcctcatcgctgccctggcttcggtgatggccggcctttgctacgctgaatttggggcccgagtaccaaagactggatctgcgtatctatacacatacgtcacggttggagagctgtgggccttcatcactggttggaatctcattctgtcatatgtcataggtacgtccagtgtcgcaagagcttggagtggcaccttcgatgagcttcttaacaaacagattggccagtttttcaagacctacttcaaaatgaattacaccggtctggcggagtatccggacttctttgccgtgtgccttgtattacttctggcaggtcttttatcttttggagtaaaggagtctgcttgggtgaataaattttttacagctattaatatcctggtccttctctttgtcatggtggctgggtttgtgaaaggaaatgtggctaactggaagatcagtgaagaatttctcaagaatatatcagcaagtgccagagaaccaccttctgaaaatggaacaagcatctacggggctggcggcttcatgccttatggctttacagggacgctggctggtgctgcaacgtgcttttatgcctttgtgggctttgactgcattgcaacaaccggcgaagaggtccggaatccccaaaaggctattcccattggaatagtaacttccttacttgtttgctttatggcctattttggggtttctgcagctttaacacttatgatgccttactacctcctggatgagaaaagcccactccctgttgcatttgaatatgtcggatggggtcctgctaaatacgttgtcgccgcaggctccctctgcgccttatcaacaagtcttctgggttctatgttccccttaccccgcattctgtttgccatggcccgggatggcttactgtttagatttcttgcaagagtgagtaagaggcagtcacccgttgctgccacgatgactgcaggggtcatttctgctgtgatggcctttctttttgacctgaaggctctcgtggacatgatgtctattggcaccctcatggcctactctctggtcgcagcctgtgtgctcattctcaggtaccaacctggcttgtgttatgagcagcccaaatacacccctgagaaagacattctggagtcatgtaccaatgcgacctcgaagagcgagtcccaggtcaccatgctgcaaggacagggtttcagcctacgaaccctcttcaacccctctgctctgcccacacgacagtcagcctccctcgtgagcttcctggtgggattcctggctttcctcatcgccggcttgagtattctgaccacgtacggagtccaggccatcgccagactggaagcctggagcctggctcttctcgccctgttccttgtcctctgcgctgccgtcatcctgaccatttggaggcagccacagaatcagcaaaaagtagccttcatggtcccgttcttaccgtttctgccggccttcagcatcctggtcaacatttacttgatggtccagttaagcgcggacacttgggtcagattcagcatctggatggtgcttggctttctgatttacttcgcctatggcattagacacagcttggagggtaaccccagggatgaagaagaagatgaagatgtctgtccagacaacgtcaatgcagcagcagaagaaaagtctgccatgcaggcaaatgaccatcaccaaagaaacctcagcttgcctttcatacttcatgaaaagacaagtgaatgttgatgccggtccgcagccctaccacacatgccttaacaatgagtactttacggcaggaagccaccatcgtgctgggttgtcatgggtttgctgcagccacggtttgcctaacttatacttcctcctccggacagcttcttttcaaatggtggattatgtgtttggggagactgcctgagagcactcctcagtgatacgtatccccaaaacagtatgtctgtgtgggtacatgtgtgcttgggaatgtgagtgttcaatgttgttggttcttactctgtgacatgattccagtgcagtaactggtggcatgtactgcacatgctagtaaacagtatattgctgaatag
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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