2024-04-20 23:29:24, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_021739 3864 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus calcium/calmodulin-dependent protein kinase II beta (Camk2b), transcript variant 2, mRNA. ACCESSION NM_021739 VERSION NM_021739.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3864) AUTHORS Yang C, Zhang M, Li S, Yi F, Huang H, Xie H, Liu H, Huang R and Zhou J. TITLE Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons JOURNAL Neuroscience 503, 58-68 (2022) PUBMED 36041587 REMARK GeneRIF: Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons. REFERENCE 2 (bases 1 to 3864) AUTHORS Liu W, Li L, Kuang H, Xia Y, Wang Z, Liu S and Yin D. TITLE Proteomic Profile of Carbonylated Proteins Screen Regulation of Apoptosis via CaMK Signaling in Response to Regular Aerobic Exercise JOURNAL Biomed Res Int 2018, 2828143 (2018) PUBMED 30662904 REMARK GeneRIF: Significantly upregulated the expression levels of CaMKIIbeta. Publication Status: Online-Only REFERENCE 3 (bases 1 to 3864) AUTHORS Yamazaki H, Sasagawa Y, Yamamoto H, Bito H and Shirao T. TITLE CaMKIIbeta is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools JOURNAL J Neurochem 146 (2), 145-159 (2018) PUBMED 29675826 REMARK GeneRIF: This study provides the first evidence to show that CaMKIIbeta interacts with drebrin in dendritic spines. REFERENCE 4 (bases 1 to 3864) AUTHORS Kury S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denomme-Pichon AS, Lesca G, Sellars EA, Berg J, Carre W, Busk OL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla OL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogne B, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bezieau S, Odent S, Elgersma Y and Mercier S. CONSRTM Undiagnosed Diseases Network; GEM HUGO; Deciphering Developmental Disorders Study TITLE De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability JOURNAL Am J Hum Genet 101 (5), 768-788 (2017) PUBMED 29100089 REFERENCE 5 (bases 1 to 3864) AUTHORS Yan X, Liu J, Ye Z, Huang J, He F, Xiao W, Hu X and Luo Z. TITLE CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation JOURNAL PLoS One 11 (9), e0162784 (2016) PUBMED 27611779 REMARK GeneRIF: these data establish a potential signaling pathway of Ca2+-CaMKII-CREB in neuronal activation. Publication Status: Online-Only REFERENCE 6 (bases 1 to 3864) AUTHORS Bayer KU, Harbers K and Schulman H. TITLE alphaKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle JOURNAL EMBO J 17 (19), 5598-5605 (1998) PUBMED 9755160 REFERENCE 7 (bases 1 to 3864) AUTHORS Urquidi V and Ashcroft SJ. TITLE A novel pancreatic beta-cell isoform of calcium/calmodulin-dependent protein kinase II (beta 3 isoform) contains a proline-rich tandem repeat in the association domain JOURNAL FEBS Lett 358 (1), 23-26 (1995) PUBMED 7821422 REFERENCE 8 (bases 1 to 3864) AUTHORS Ochiishi T, Terashima T and Yamauchi T. TITLE Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain JOURNAL Brain Res 659 (1-2), 179-193 (1994) PUBMED 7820660 REFERENCE 9 (bases 1 to 3864) AUTHORS Malinow R, Schulman H and Tsien RW. TITLE Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP JOURNAL Science 245 (4920), 862-866 (1989) PUBMED 2549638 REFERENCE 10 (bases 1 to 3864) AUTHORS Bennett,M.K. and Kennedy,M.B. TITLE Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning JOURNAL Proc Natl Acad Sci U S A 84 (7), 1794-1798 (1987) PUBMED 3470758 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB616255.1, M16112.1, CO395982.1 and JACYVU010000254.1. On Jun 12, 2006 this sequence version replaced NM_021739.1. Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M16112.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760396 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-20 CB616255.1 1-20 21-1646 M16112.1 1-1626 1647-2289 CO395982.1 20-662 2290-3864 JACYVU010000254.1 34546551-34548125 c FEATURES Location/Qualifiers source 1..3864 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="14" /map="14q21" gene 1..3864 /gene="Camk2b" /gene_synonym="Ck2b" /note="calcium/calmodulin-dependent protein kinase II beta" /db_xref="GeneID:24245" /db_xref="RGD:2262" exon 1..147 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" CDS 83..1711 /gene="Camk2b" /gene_synonym="Ck2b" /EC_number="2.7.11.17" /note="isoform 2 is encoded by transcript variant 2; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II subunit beta; caMK-II subunit beta; caM-kinase II beta chain; caM kinase II subunit beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; Ca++/calmodulin-dependent protein kinase II beta subunit" /codon_start=1 /product="calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2" /protein_id="NP_068507.2" /db_xref="GeneID:24245" /db_xref="RGD:2262" /translation="
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALEPQTTVIHNPVDGIKESSDSTNTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ"
misc_feature 116..991 /gene="Camk2b" /gene_synonym="Ck2b" /note="Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; Region: STKc_CaMKII; cd14086" /db_xref="CDD:270988" misc_feature 131..133 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:P28652; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature order(140..154,164..166,203..205,209..211,302..304, 350..361,371..373,377..379,485..490,494..496,500..505, 509..511,548..553,560..562,605..619,623..625) /gene="Camk2b" /gene_synonym="Ck2b" /note="active site" /db_xref="CDD:270988" misc_feature order(140..151,164..166,203..205,209..211,302..304, 350..361,371..373,500..505,509..511,548..553) /gene="Camk2b" /gene_synonym="Ck2b" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270988" misc_feature order(152..154,371..373,377..379,485..490,494..496, 500..502,560..562,605..619,623..625) /gene="Camk2b" /gene_synonym="Ck2b" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270988" misc_feature order(548..580,587..619) /gene="Camk2b" /gene_synonym="Ck2b" /note="activation loop (A-loop); other site" /db_xref="CDD:270988" misc_feature 929..958 /gene="Camk2b" /gene_synonym="Ck2b" /note="propagated from UniProtKB/Swiss-Prot (P08413.1); Region: Autoinhibitory domain. /evidence=ECO:0000250" misc_feature 941..943 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphothreonine, by autocatalysis. /evidence=ECO:0000269|PubMed:17272343; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 953..985 /gene="Camk2b" /gene_synonym="Ck2b" /note="propagated from UniProtKB/Swiss-Prot (P08413.1); Region: Calmodulin-binding" misc_feature order(962..964,968..991) /gene="Camk2b" /gene_synonym="Ck2b" /note="CaM binding site [polypeptide binding]; other site" /db_xref="CDD:270988" misc_feature 998..1000 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphothreonine, by autocatalysis. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1001..1003 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphothreonine, by autocatalysis. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1127..1210 /gene="Camk2b" /gene_synonym="Ck2b" /note="propagated from UniProtKB/Swiss-Prot (P08413.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1181..1183 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1193..1195 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P28652; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1262..1264 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1271..1273 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1280..1282 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:P28652; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1283..1285 /gene="Camk2b" /gene_synonym="Ck2b" /note="Phosphothreonine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P08413.1); phosphorylation site" misc_feature 1310..1693 /gene="Camk2b" /gene_synonym="Ck2b" /note="Calcium/calmodulin dependent protein kinase II association domain; Region: CaMKII_AD; pfam08332" /db_xref="CDD:285524" exon 148..242 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 243..302 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 303..357 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 358..423 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 424..496 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 497..599 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 600..683 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 684..778 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 779..901 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 902..985 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 986..1028 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1029..1103 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1104..1141 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1142..1213 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1214..1258 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1259..1307 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1308..1383 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1384..1478 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1479..1712 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" exon 1713..3864 /gene="Camk2b" /gene_synonym="Ck2b" /inference="alignment:Splign:2.1.0" ORIGIN
cgccgccgtgcccgcgagcgggagccggagtcgccgccgcccgagcgcagccgagcgcacgccgagcccaatcgccaccgccatggccaccacggtgacctgcacccgtttcacggacgagtaccagctatacgaggatattggcaagggggctttctctgtggtccgacgctgtgtcaagctctgcaccggccatgagtatgcagctaagatcattaacaccaagaagctgtcagctagagatcaccagaagctggagagggaggctcggatctgccgcctgctgaagcattccaacattgtacgcctccatgacagcatctctgaagagggcttccactacctggtcttcgacctggtcactggtggggagctctttgaagacattgtggcgagagagtactacagtgaggctgacgccagtcactgtatccagcagatcctggaggctgttctccattgtcaccaaatgggggtcgtccacagagacctcaagcctgaaaacctgctcctggccagcaaatgcaaaggggccgcagtgaaactggcagacttcggcctggccatcgaggttcagggagaccagcaggcatggtttggatttgcgggaacaccaggctacctgtctcccgaagttcttcggaaggaggcctatggcaaaccagtggatatctgggcatgtggggtgatcctgtatatcctgctggtgggatacccacctttctgggatgaggaccagcacaagctgtaccagcagatcaaggctggggcctatgacttcccatcccccgagtgggacaccgttacccctgaagccaaaaacctcatcaaccagatgttgaccatcaaccccgccaagcgcatcacggcccacgaggccctgaagcacccatgggtctgccaacgatccacggtggcctccatgatgcacagacaggagactgtggaatgtctgaagaagttcaatgcaaggaggaagctcaagggagccatcctcaccactatgctggccacacggaatttctcagtgggcagacagaccaccgctccggccacaatgtccaccgcggcctccggcaccaccatggggctggtggaacaagccaagagtttactcaacaagaaagcagacggagtcaagccccagacaaacagcaccaaaaacagctcggccatcaccagccccaaaggatccctccctcctgccgccctggagcctcaaaccaccgttatccataacccagtggacggcattaaggaatcttccgacagcaccaacacaaccatagaggacgaagatgccaaagcccggaagcaggaaatcatcaagaccacagagcagctcatcgaggccgtcaacaacggcgactttgaggcctatgcgaaaatctgtgacccaggcctgacctcatttgagcctgaagctctgggcaacctggtcgaagggatggatttccacagattctactttgagaacctgctggccaagaacagcaagccgatccacaccactatcctgaacccgcacgtgcacgtcatcggcgaggatgcagcctgcatcgcttacatccgcctcacacagtacatcgacggccagggcagaccccgcaccagccagtccgaagagacccgtgtgtggcaccgccgcgacggcaagtggcagaatgtccatttccactgctcgggcgctccagtggccccactgcagtgagagctgcgcctggtttcaccggacagagttggtgtttggagcccagccgccctcgggcgcacggcctgcctgtcgcatgtttgtgtctgcctcgtcccctcccctggtgcctgtgtctgcagaaaaacaagaccagatgtgatttgtttttttaaaaaaaaaaaaaaagtaagatgatgacaacgacaaccacatgcaaacaaacaaacaaaaaatattggcatcggatgaaatggaaaacaaacaaacaaacctaaagaaaggaaaaagctgtaaaaatctggcatttgtggggccgcccccccacccaagctccacatgtgtctgttgcgctcctggctttggggaccctcagggcgtgaatgtgcccatgccgactgtgttagtctgtaggtaccgcactcaccccacaccttgggcgtctgcatcctcctcccatgcatgggccccacgtgctaacctggctgttgtggcgtcaggtgtcttgggaagggctgggggctgcctcctttcctgctagttgtgcctgaaagctgctgctgttcctgcttcccctacccgtccctcatcccgagaaggactgggagggtgctcctctagccaaggacctacctttgccccatggagtgtgtaggagaagctcgtcctcaagatcatcagaaagtaacctggttctttggggagtgaggtatggaggtatgtatctcgcctccaagcctctcgcctggcagggattggttaggaaggcaggctggctgcagcacccacccatctagctacgaagagaggactgggcagggatggactccttcctgtttggggttcttgtcccttccctgccaccagcagctgagcgagagtggcccacccctggcccgggcagttcctctctgaagttggcaacagaccctcacgaagacggagttgccgagatactggacagagctgggagcagacgctggctgcatctagggggtttgtccactgagcttgaagtctgggtgctcgagacttggttaaatgttgcagaatgtgataaagaggggccagaagtcgggttttagactgctgggcaatgcaggtccatgtgagggtttgatggtaggagtgctttcctaacctgagcctagagaagaaataagccagaggatgtgcctcctcagaggcacatggaaggccaaaattggttaggtagggctgtattgtgtgaggcctttccaggtaggccagagatacgtagtagagagaaggcaggctgggggcagagatatatgggtgtggggcctggataccagtgggtggagggagggtccattaggacagtgtgccacccccagggcccagtggtgctcctaggtgccggctgcctggactcgtgggtggcccttggtgacagagggaatcatcaaggctggacatgttacaaagtcaggctagggagataggtataaagccgggttgggtgggggtggtcaggggctttgatcgcagaggtccgtgggcctccaccccaatgctgcccactttaaattcacgtcattttcaaccaggattttctttatcttttactacaaatcaagccaagggaggggcacgaagtggggaacgggacacaggatcctaaactccaaggggactgtccacctacagacactcagtggataccacctttgatccacactgtgcccaggacagctgccccctacccatggacacagggtaaacatctgccaggctccatgagtggcccaaggccatggaatagaggcagggcttgtcacagacagcgtgaggccctgtggcctgccaccctgacatcctggggtctcctttcctctcccacccaccttgttatctccacaaagctgcctgtctgggataatttggggattttttttctgggggacaattcttttgcatgaccctctaaagagcaggacacgtctgctctactggctaggtgttcgcaggtggtggcgtcgactgtggccagtgctggagcgtgtcactgcctgcagtactggtgaccctcctctcttctctttttgctgagttccattgtcttttctttccgagccttgtaggtgtacaaaacttattcttattttgttctgtctcgggaaactgcaaataaaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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