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Previous release (v1)
2024-04-25 18:00:08, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_019362 3551 bp mRNA linear ROD 15-SEP-2023
DEFINITION Rattus norvegicus serine threonine kinase 39 (Stk39), mRNA.
ACCESSION NM_019362 XM_001057901
VERSION NM_019362.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3551)
AUTHORS Liu J, Shelton EL, Crescenzi R, Colvin DC, Kirabo A, Zhong J,
Delpire EJ, Yang HC and Kon V.
TITLE Kidney Injury Causes Accumulation of Renal Sodium That Modulates
Renal Lymphatic Dynamics
JOURNAL Int J Mol Sci 23 (3), 1428 (2022)
PUBMED 35163352
REMARK GeneRIF: Kidney Injury Causes Accumulation of Renal Sodium That
Modulates Renal Lymphatic Dynamics.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3551)
AUTHORS Gong Y, Wu M, Gao F, Shi M, Gu H, Gao R, Dang BQ and Chen G.
TITLE Inhibition of the p-SPAK/p-NKCC1 signaling pathway protects the
blood-brain barrier and reduces neuronal apoptosis in a rat model
of surgical brain injury
JOURNAL Mol Med Rep 24 (4) (2021)
PUBMED 34396440
REMARK GeneRIF: Inhibition of the pSPAK/pNKCC1 signaling pathway protects
the bloodbrain barrier and reduces neuronal apoptosis in a rat
model of surgical brain injury.
REFERENCE 3 (bases 1 to 3551)
AUTHORS Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner
GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang
J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR and Kahle KT.
TITLE Functional kinomics establishes a critical node of volume-sensitive
cation-Cl- cotransporter regulation in the mammalian brain
JOURNAL Sci Rep 6, 35986 (2016)
PUBMED 27782176
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3551)
AUTHORS Kochl R, Thelen F, Vanes L, Brazao TF, Fountain K, Xie J, Huang CL,
Lyck R, Stein JV and Tybulewicz VL.
TITLE WNK1 kinase balances T cell adhesion versus migration in vivo
JOURNAL Nat Immunol 17 (9), 1075-1083 (2016)
PUBMED 27400149
REMARK Erratum:[Nat Immunol. 2017 Jan 19;18(2):246. PMID: 28102214]
REFERENCE 5 (bases 1 to 3551)
AUTHORS Fezai M, Elvira B, Borras J, Ben-Attia M, Hoseinzadeh Z and Lang F.
TITLE Negative regulation of the creatine transporter SLC6A8 by SPAK and
OSR1
JOURNAL Kidney Blood Press Res 39 (6), 546-554 (2014)
PUBMED 25531585
REFERENCE 6 (bases 1 to 3551)
AUTHORS Dowd BF and Forbush B.
TITLE PASK (proline-alanine-rich STE20-related kinase), a regulatory
kinase of the Na-K-Cl cotransporter (NKCC1)
JOURNAL J Biol Chem 278 (30), 27347-27353 (2003)
PUBMED 12740379
REMARK GeneRIF: roles in phosphorylation and activation of the Na-K-Cl
cotransporter (NKCC1)
REFERENCE 7 (bases 1 to 3551)
AUTHORS Piechotta K, Lu J and Delpire E.
TITLE Cation chloride cotransporters interact with the stress-related
kinases Ste20-related proline-alanine-rich kinase (SPAK) and
oxidative stress response 1 (OSR1)
JOURNAL J Biol Chem 277 (52), 50812-50819 (2002)
PUBMED 12386165
REFERENCE 8 (bases 1 to 3551)
AUTHORS Miao N, Fung B, Sanchez R, Lydon J, Barker D and Pang K.
TITLE Isolation and expression of PASK, a serine/threonine kinase, during
rat embryonic development, with special emphasis on the pancreas
JOURNAL J Histochem Cytochem 48 (10), 1391-1400 (2000)
PUBMED 10990492
REFERENCE 9 (bases 1 to 3551)
AUTHORS Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC and
DeAizpurua HJ.
TITLE SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
JOURNAL Oncogene 19 (37), 4290-4297 (2000)
PUBMED 10980603
REFERENCE 10 (bases 1 to 3551)
AUTHORS Ushiro H, Tsutsumi T, Suzuki K, Kayahara T and Nakano K.
TITLE Molecular cloning and characterization of a novel Ste20-related
protein kinase enriched in neurons and transporting epithelia
JOURNAL Arch Biochem Biophys 355 (2), 233-240 (1998)
PUBMED 9675032
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from D88190.1.
On Jun 25, 2006 this sequence version replaced XM_001057901.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D88190.1, AF099990.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMD00132261, SAMD00132262
[ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..3551
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="3"
/map="3q21"
gene 1..3551
/gene="Stk39"
/gene_synonym="Spak"
/note="serine threonine kinase 39"
/db_xref="GeneID:54348"
/db_xref="RGD:621643"
exon 1..651
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
misc_feature 60..62
/gene="Stk39"
/gene_synonym="Spak"
/note="upstream in-frame stop codon"
CDS 417..2078
/gene="Stk39"
/gene_synonym="Spak"
/EC_number="2.7.11.1"
/function="Ste20-related protein kinase"
/note="PS/TK; PSTK1; ste-20-related kinase;
serine/threonine-protein kinase 39; pancreatic
serine/threonine-protein kinase; Ste-20 related kinase"
/codon_start=1
/product="STE20/SPS1-related proline-alanine-rich protein
kinase"
/protein_id="NP_062235.1"
/db_xref="GeneID:54348"
/db_xref="RGD:621643"
/translation="
MAEPSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS"
misc_feature 417..581
/gene="Stk39"
/gene_synonym="Spak"
/note="propagated from UniProtKB/Swiss-Prot (O88506.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 624..1454
/gene="Stk39"
/gene_synonym="Spak"
/note="Catalytic domain of the Serine/Threonine Kinases,
Oxidative stress response kinase and Ste20-related proline
alanine-rich kinase; Region: STKc_OSR1_SPAK; cd06610"
/db_xref="CDD:270787"
misc_feature order(648..662,672..674,711..713,717..719,807..809,
855..866,873..878,885..887,1017..1019,1023..1034,
1038..1040,1068..1073,1080..1082,1137..1148,1152..1154,
1236..1238,1263..1265)
/gene="Stk39"
/gene_synonym="Spak"
/note="active site"
/db_xref="CDD:270787"
misc_feature order(648..662,672..674,711..713,717..719,807..809,
855..866,873..878,885..887,1023..1025,1029..1034,
1038..1040,1071..1073)
/gene="Stk39"
/gene_synonym="Spak"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:270787"
misc_feature order(657..662,1017..1019,1023..1031,1080..1082,
1137..1148,1152..1154,1236..1238,1263..1265)
/gene="Stk39"
/gene_synonym="Spak"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:270787"
misc_feature order(1020..1025,1095..1103,1140..1181,1185..1193,
1203..1205,1212..1217,1224..1229,1236..1238,1254..1256,
1275..1277,1284..1292,1296..1301,1401..1403,1407..1412,
1416..1418)
/gene="Stk39"
/gene_synonym="Spak"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:270787"
misc_feature order(1068..1109,1128..1154)
/gene="Stk39"
/gene_synonym="Spak"
/note="activation loop (A-loop); other site"
/db_xref="CDD:270787"
misc_feature 1134..1136
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphothreonine, by WNK1.
/evidence=ECO:0000269|PubMed:16083423; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1146..1148
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q9Z1W9; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1368..1370
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphoserine, by PKC/PRKCQ.
/evidence=ECO:0000250|UniProtKB:Q9UEW8; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1371..2048
/gene="Stk39"
/gene_synonym="Spak"
/note="propagated from UniProtKB/Swiss-Prot (O88506.2);
Region: Interaction with RELT.
/evidence=ECO:0000250|UniProtKB:Q9Z1W9"
misc_feature 1488..1490
/gene="Stk39"
/gene_synonym="Spak"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q9UEW8; propagated from
UniProtKB/Swiss-Prot (O88506.2); acetylation site"
misc_feature 1503..1505
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1521..1541
/gene="Stk39"
/gene_synonym="Spak"
/note="propagated from UniProtKB/Swiss-Prot (O88506.2);
Region: Nuclear localization signal.
/evidence=ECO:0000255"
misc_feature 1524..1709
/gene="Stk39"
/gene_synonym="Spak"
/note="propagated from UniProtKB/Swiss-Prot (O88506.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1551..1553
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9UEW8; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1554..1556
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphoserine, by WNK1.
/evidence=ECO:0000269|PubMed:16083423,
ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:22544747;
propagated from UniProtKB/Swiss-Prot (O88506.2);
phosphorylation site"
misc_feature 1596..1598
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1602..1616
/gene="Stk39"
/gene_synonym="Spak"
/note="propagated from UniProtKB/Swiss-Prot (O88506.2);
Region: Caspase cleavage related site"
misc_feature 1620..1622
/gene="Stk39"
/gene_synonym="Spak"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z1W9; propagated from
UniProtKB/Swiss-Prot (O88506.2); phosphorylation site"
misc_feature 1794..1967
/gene="Stk39"
/gene_synonym="Spak"
/note="Oxidative-stress-responsive kinase 1 C-terminal
domain; Region: OSR1_C; pfam12202"
/db_xref="CDD:432397"
exon 652..764
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 765..873
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 874..1015
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1016..1071
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1072..1181
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1182..1283
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1284..1417
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1418..1466
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1467..1532
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1533..1655
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1656..1685
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1686..1748
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1749..1816
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1817..1869
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1870..1938
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 1939..2003
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
exon 2004..3551
/gene="Stk39"
/gene_synonym="Spak"
/inference="alignment:Splign:2.1.0"
polyA_site 3551
/gene="Stk39"
/gene_synonym="Spak"
/note="9 a nucleotides"
ORIGIN
gtctagggcggaggcgcggctgggtaggaagggagcctggcgatccccgaaagcacccctgaagccgccaggctccgagcgcgtggaaacttccctggcggcaagcagggcgggagggggcggcggttccccccagcgctgagagcaccgcgcgcgcgaggatcggggcgcgcggcgggcgcggcggccgccgcctcctcccgtccccgcctccgcggcgcagcctcctccctccgcccggctcggcctcgggctccctcccctcgtggcaggctccggcggcggcggcggcggcggctgcggcggacggggagggcgtgcgccggtcgagaggtgtgggcgacgaggctagggaagtttcaagtggaaggtcgtccgccggccggcgcgtcccctcactctcctcccgcagcatcatggcggagccgagcggctcgcccgtgcacgtccagcttccccagcaggcggccccggtgacagccgcggcggcggctccggcggccgcgacatcagcaccggccccggccccggccccggcggcgcccgcagccccggccccggctccagctgcggctccagccccggccccggcagctcaggcggtcggctggcccatctgcagggacgcgtacgagctccaggaggttatcggcagtggagcgaccgccgtggttcaggcagccctgtgcaaacccaggcaagaacgcgtagccataaagcggatcaacttggaaaagtgccagacgagtatggatgaactcttaaaagaaattcaagccatgagccagtgcagccatcccaacgtagtgacttattatacttcctttgtggtcaaagatgaactttggctggtcatgaaattactaagtggaggttccatgttggatatcatcaaatacatcgtcaatcggggagagcataagaatggtgtcctggaagaggcaataatcgcaacaatccttaaggaggttttggaaggattagactatctgcatagaaatggtcagatccatagggatttgaaagctggcaatattcttctgggtgaggatggatcagtacagatagcagattttggagtaagtgcattcttagcaacagggggtgatgtcacaaggaataaagtcagaaaaacatttgttggtaccccatgttggatggcccctgaggtcatggaacaggtgagaggctatgacttcaaggctgacatgtggagttttggaataacagccattgaattagcaacgggagcagcgccttaccacaaataccctccaatgaaagtgctaatgttgactttgcaaaatgacccgcccactttagaaaccggcgtagaggataaagaaatgatgaaaaaatacggcaagtccttcagaaagttactttcactgtgtctccagaaagatccttccaaaaggcccacagcagcagaacttttaaaatgcaaattcttccagaaagccaagaacagagagtacctgatcgagaagttgctgacacgaacaccagacatagcccaaagagccaagaaggtcaggcgagttcctgggtcaagcggtcaccttcacaagactgaagatggcgactgggagtggagtgatgatgagatggatgagaagagtgaggaggggaaagcggctgcctctcaagagaagtcacgaagagtaaaagaagagaacccagagatctcggtgaacgctggtggcatccccgagcaaatacagtccctctccgtgcacgactctcagggccaaccaaatgctaatgaagactacagagaaggtccttgtgcggtcaaccttgttttaagattaagaaactccagaaaggaacttaatgacatacgatttgagtttactccaggaagagatacagcagatggtgtgtctcaggagctcttctctgctggcttggttgacggtcatgatgtagttatagtggctgctaatttacagaagattgtagatgaccccaaagctttaaaaacgttgacatttaagttggcttctggctgtgatggggcggagattcctgacgaagtgaagctgatcgggttcgcccagttgagtgtgagctgatgtatgtcccttgctgtcaccctcatctgtcgtgccctcccccccttccagccccctctttgcctccttcctctcaccccctcactcccaaatcccagcaaataagaagattgtgaagaggctggcttcgatgaagtgggataaaaaaaataataattttaaaaaaaaactccgagcactctgagttctgctttattctccagcaatccacagtgtgagcacaggcaagtgctgcaatagtgcattgctgatttctttccagagagctatttactattcttagcagtcaatttggatagcccttaagtgaggagtctgaaacacactcaggtggtcctatctcttggcaacaaaaggaatcttctaccagaagccttttctcctcttactgttgtatttctgtttaataattaataataattaattgtacatctgacaatactgcctcttttatgttgtcttagaaattaatatacttataaaattaagatttattagccagacttgaattctagttttaaaactgactgtgaattttatttttcatatatttatgctttacacaccttagctatgagggaaaaagttttgattataatgctttccgcggttgatctcttgttatttaaacaaatggtttcaggtcaatctttggagtatttgtagcttctaatttttgaaatgactgaattgaaaatttgaatgctttctcttttggttggtttgcctaaaatccagtccacaatccagtcgtctcttgggagagggaggtgccttgtaaactttcatacttcgaatgtgcctgagactgcttaaccctggactagtctcagatctcaaacccgcactacacatggaggcatacgtttgcttcatctggacatttagaatactgtacctgtgctgccgttctgttagatcgctgactacatccccgtgtctgattcggctctccttaggtgataggattcattgtttgtaaggcgataaacttgaccacaccagaatctgagttttacttgaaactctgcagaatacacagggggtatgaaaaacaaaacaaaacaaaacagaaagatttttttgtgcaatggcaaaaggtaaaaatgctgtaaacgttcgagaataaatatttccaacccaagaacctcctgcttgactatgtattatgaacctaacaaaccttaggattttcaaatttggagtcaaaaccctcaagaaggtggctccggggatggcaccattgctccttacaagctaaccctagatgcggcagctctttaacgtactttaaaaagcaaatatatattactaaggaaagaagttatttataattgccttgtcataatcgttaaggtgttctagaaccatttgcatacaatttaatgtaattccattccattctattgtttacacaattactcaaagatggctgcaaaggtaaaaggaaaaataaaagcgtcttgcacagtg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]