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2024-03-28 17:47:01, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_019250               3684 bp    mRNA    linear   ROD 03-FEB-2023
DEFINITION  Rattus norvegicus ral guanine nucleotide dissociation stimulator
            (Ralgds), transcript variant 1, mRNA.
ACCESSION   NM_019250 XM_001079127
VERSION     NM_019250.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ,
            Clevers H and Bos JL.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Kawai M, Kawashima S, Sakoda T, Toh R, Kikuchi A, Yamauchi-Takihara
            K, Kunisada K and Yokoyama M.
  TITLE     Ral GDP dissociation stimulator and Ral GTPase are involved in
            myocardial hypertrophy
  JOURNAL   Hypertension 41 (4), 956-962 (2003)
   PUBMED   12642511
  REMARK    GeneRIF: Ral GDP dissociation stimulator is involved in myocardial
            hypertrophy.
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Huang,L., Weng,X., Hofer,F., Martin,G.S. and Kim,S.H.
  TITLE     Three-dimensional structure of the Ras-interacting domain of RalGDS
  JOURNAL   Nat Struct Biol 4 (8), 609-615 (1997)
   PUBMED   9253406
  REMARK    Erratum:[Nat Struct Biol 1997 Oct;4(10):840]
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Hofer F, Fields S, Schneider C and Martin GS.
  TITLE     Activated Ras interacts with the Ral guanine nucleotide
            dissociation stimulator
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11089-11093 (1994)
   PUBMED   7972015
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA.
  TITLE     Characterization of a guanine nucleotide dissociation stimulator
            for a ras-related GTPase
  JOURNAL   EMBO J 12 (1), 339-347 (1993)
   PUBMED   8094051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L07925.1, JACYVU010000115.1, CB775259.1 and CO561927.1.
            
            On Oct 20, 2007 this sequence version replaced NM_019250.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               L07925.1           1-459
            460-460             JACYVU010000115.1  5324316-5324316
            461-1046            L07925.1           461-1046
            1047-1047           JACYVU010000115.1  5327572-5327572
            1048-1399           L07925.1           1048-1399
            1400-1631           CB775259.1         72-303
            1632-2148           L07925.1           1632-2148
            2149-2631           CO561927.1         231-713
            2632-2959           L07925.1           2632-2959
            2960-3684           JACYVU010000115.1  5336156-5336880
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3684
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="ral guanine nucleotide dissociation stimulator"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
     exon            1..384
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2889
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ralGEF; ral guanine nucleotide exchange factor"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation stimulator
                     isoform 1"
                     /protein_id="NP_062123.2"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
                     /translation="
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLHPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF"
     misc_feature    535..909
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(592..594,736..738,748..753,760..762,769..774,
                     883..888,895..897,916..918)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    <922..>1245
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    1102..1173
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03386.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1288..2076
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(1387..1395,1432..1437,1441..1449,1453..1458,
                     1465..1470,1477..1479,1582..1584,1591..1596,1600..1608,
                     1612..1623,1627..1632,1690..1692,1699..1701,1714..1722,
                     1729..1731,1840..1848,1855..1863,1867..1875,1879..1890,
                     1933..1935,1945..1947,2050..2052,2059..2064)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
     misc_feature    2323..2463
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03386.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2536..2793
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Ras-associating (RA) domain found in Ral guanine
                     nucleotide dissociation stimulator (RalGDS) and similar
                     proteins; Region: RA_RalGDS; cd17209"
                     /db_xref="CDD:340729"
     misc_feature    order(2536..2547,2551..2553,2572..2598,2608..2613,
                     2635..2637,2644..2649,2653..2655)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="RA-Ras interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:340729"
     misc_feature    2584..2586
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q12967; propagated from
                     UniProtKB/Swiss-Prot (Q03386.1); phosphorylation site"
     exon            385..495
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            496..689
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            690..749
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            750..943
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1341
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1557
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1661
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1746
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1815
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1902
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1935
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2057
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2153
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2355
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2598
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2713
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..3684
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
ccaccaggcctaacaactagaggaggcttacggccctcggaaaccacgcccccatcagtcagtccccaccctcagctgacatcagcgagtccggccctgggcgcagagcgcaggcagcgcggagccgcgccggccggccctgcgcccacgccgccccgggtctcgcggcccgccggccacccgcgccaccgggagtcgtccatggtgcagcgcatgtgggccgaggcgtccgggcccatagggggcgccgagccgttgtttcccggctcccggcgcagccgcagcgtgtgggacgccgtgcgtctggaggtgggcgtccctgacagctgtccagtggtgctgcacagcttcacgcagctcgaccccgatctgccgcgcctggagagctctacgcaggagattggggaggagctgatcaacggggtcatctactccatctccctgcgcaaggttcagctacacccaggagccaccaagggccagcgctggctagggtgcgagaatgagtcagctctgaacctctacgagacttgcaaggtgcgcacggtgaaggccggtactctggagaagctggtggaacacctggtgcctgccttccagggcagtgacctttcctacgtcaccgtattcctgtgcacctacagagccttcacaaccactcagcaggtgctagacctgctgttcaaaagatatggctgcatccttccctactccagtgaggacggcggaccacaggaccaactcaaaaatgccatctcttccatcctgggcacctggctggaccaatactccgaggacttctgtcaacccccggactttccctgcctcaagcagctggtggcttatgtgcagctcaacatgcctggctcagacctggagcgccgtgctcaccttctcctggcccagctggaggacctggagcccagtgaggttgagcctgaggccctgtccccagctccagtgctgtctctgaaaccagcttcacagctagaaccagctcccgccctgcttctgacgcccagccgagctgtggcatccactccagtccgagagccagccccggtgccagtactggcatccagcccggtggtggcgccagcctctgagctagaaccagctctggagccgcccctagaccctgagccaaccctcgcacctgctccagagctggaccccactgtctcacagagcctccacctcgagcccgctcccgtgcccgctcctgcattagagccttcctggcctctgcctgaaaccacggagaacggactgtgtgcaaagcctcacctactgctgttccctccagacttggtggctgaacagtttacgctgatggacgcagagctattcaagaaagttgtgccctaccactgcctgggctccatctggtcccagcgggacaagaagggcaaggagcacctcgcgcccaccatccgtgccactgtcgcccagttcaacaacgtggccaactgtgtcatcaccacctgccttggggaccagagtatgaaagcttcggacagggcccgggtggtggaacactggatcgaggtggccagggagtgcagggtgctcaagaatttctcctccctctacgccatcctctctgccctacagagcaatgccatccaccgcctaaagaagacatgggaagaggtctccaggggcagctttcgagtgttccagaaactgtcagaaatcttctctgatgagaacaactactccttgagcagagagctgctcatcaaggaaggaacctccaagtttgccacgctggagatgaaccctaggagaacccagaggcggcagaaggagacaggtgtcatccagggcactgtcccctacctgggcacattcctcactgacctggtgatgctggacacagccatgaaggactatctatatgggagactgatcaactttgaaaagaggaggaaggagttcgaagtcatcgcccagatcaagttgctccagtcggcctgcaacaactacagcattgttcccgaggagcactttggagcctggttccgagccatgggacggctcagcgaggctgagagctacaacctgtcgtgtgagctggagcccccgtctgagtcagccagcaacaccctgaggagcaagaaaagcacagctatcgtcaagcgctggagcgaccgccaggctcccagcacggagctcagcaccagtagcagtgcacactccaagtcatgtgaccagctccggtgcagcccctacctcagcagcggggacatcacggacgcactcagtgtgcactcagctggttcatccagctctgacgtggaggagatcaacatgagctttgttccagagtctcctgatggccaggaaaagaagttctgggagtcagcctcccagtcgtccccagagacctctggcatcagctcggcctccagcagcacctcctcttcgtcagcctctaccacaccggtgtctaccacacgcacccacaagcgctctgtctcaggggtctgcagctacagctcctcactgccactctacaaccagcaggtgggcgactgctgcatcatcagggtcagcctggatgtggacaacggcaacatgtacaagagcatcctggtgaccagccaggataaggctccgactgtcatccggaaagccatggacaaacacaacctagatgaggacgagcccgaggactatgagctgctgcagatcatctcagaggaccacaagctgaaaattccagagaacgccaatgtgttctatgccatgaactctgccgccaactatgacttcatcctaaagaagcgggccttcactaagggggctaaagtcaagcatggagccagctccactctccctcgaatgaagcagaagggactcaggattgccagaggcatcttctaaggacgtctcccaggggctggctggctggctggggactaagcacttacagactagagtggcccaggccacacaggtacctctgccctcctgccagcccaggctactcccagactccactttcaccccgaacctgtcctgctgccgggattgacacctgccactgacaggctgacctggcctccggggaccgctcaccgccttaggtgccttctgctctctgcaaccagaggactagctgactttgccaaggggtgctgccagctgggcatggagcctcgcctgccctggacaatgtccaccacactttcctgtcacctccccaagtgcagatcactgccacccatgctcccagatgctccaggacacccacacacccagcggggctgccaactgcgttctctccttgtgcccataggcactggcctgggaccttcatggaggtcctagcctttcttaggctgcaccaaagattccaccttcagggcctacagagtgagggagtctcgcccaccacgagcccaagccctcccatggatcagagagagaagccctctcatggaccgcctggttggcattgaaccccataccactgaaagtgccattcaccaccgctgcgtcccgggtgtacaagactacatgcaatgggaggtttgtggggagggggaagacgactggatatttgtataaaacgtaaaaagtttactgattggggtggggcaatatttatttgttgtaaatagaaaatgctagacttgaatattatattaaaatcccgtttctactatggcctggtca
//

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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]