2024-05-04 17:29:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_019250 3684 bp mRNA linear ROD 03-FEB-2023 DEFINITION Rattus norvegicus ral guanine nucleotide dissociation stimulator (Ralgds), transcript variant 1, mRNA. ACCESSION NM_019250 XM_001079127 VERSION NM_019250.2 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3684) AUTHORS Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H and Bos JL. TITLE Rap2A links intestinal cell polarity to brush border formation JOURNAL Nat Cell Biol 14 (8), 793-801 (2012) PUBMED 22797597 REFERENCE 2 (bases 1 to 3684) AUTHORS Kawai M, Kawashima S, Sakoda T, Toh R, Kikuchi A, Yamauchi-Takihara K, Kunisada K and Yokoyama M. TITLE Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy JOURNAL Hypertension 41 (4), 956-962 (2003) PUBMED 12642511 REMARK GeneRIF: Ral GDP dissociation stimulator is involved in myocardial hypertrophy. REFERENCE 3 (bases 1 to 3684) AUTHORS Huang,L., Weng,X., Hofer,F., Martin,G.S. and Kim,S.H. TITLE Three-dimensional structure of the Ras-interacting domain of RalGDS JOURNAL Nat Struct Biol 4 (8), 609-615 (1997) PUBMED 9253406 REMARK Erratum:[Nat Struct Biol 1997 Oct;4(10):840] REFERENCE 4 (bases 1 to 3684) AUTHORS Hofer F, Fields S, Schneider C and Martin GS. TITLE Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator JOURNAL Proc Natl Acad Sci U S A 91 (23), 11089-11093 (1994) PUBMED 7972015 REFERENCE 5 (bases 1 to 3684) AUTHORS Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA. TITLE Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase JOURNAL EMBO J 12 (1), 339-347 (1993) PUBMED 8094051 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L07925.1, JACYVU010000115.1, CB775259.1 and CO561927.1. On Oct 20, 2007 this sequence version replaced NM_019250.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-459 L07925.1 1-459 460-460 JACYVU010000115.1 5324316-5324316 461-1046 L07925.1 461-1046 1047-1047 JACYVU010000115.1 5327572-5327572 1048-1399 L07925.1 1048-1399 1400-1631 CB775259.1 72-303 1632-2148 L07925.1 1632-2148 2149-2631 CO561927.1 231-713 2632-2959 L07925.1 2632-2959 2960-3684 JACYVU010000115.1 5336156-5336880 FEATURES Location/Qualifiers source 1..3684 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="3" /map="3p12" gene 1..3684 /gene="Ralgds" /gene_synonym="Rgds" /note="ral guanine nucleotide dissociation stimulator" /db_xref="GeneID:29622" /db_xref="RGD:3533" exon 1..384 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" CDS 202..2889 /gene="Ralgds" /gene_synonym="Rgds" /note="isoform 1 is encoded by transcript variant 1; ralGEF; ral guanine nucleotide exchange factor" /codon_start=1 /product="ral guanine nucleotide dissociation stimulator isoform 1" /protein_id="NP_062123.2" /db_xref="GeneID:29622" /db_xref="RGD:3533" /translation="
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLHPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF"
misc_feature 535..909 /gene="Ralgds" /gene_synonym="Rgds" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; Region: RasGEFN; smart00229" /db_xref="CDD:214571" misc_feature order(592..594,736..738,748..753,760..762,769..774, 883..888,895..897,916..918) /gene="Ralgds" /gene_synonym="Rgds" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:100121" misc_feature <922..>1245 /gene="Ralgds" /gene_synonym="Rgds" /note="DNA polymerase III subunit gamma/tau; Region: PRK07003" /db_xref="CDD:235906" misc_feature 1102..1173 /gene="Ralgds" /gene_synonym="Rgds" /note="propagated from UniProtKB/Swiss-Prot (Q03386.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1288..2076 /gene="Ralgds" /gene_synonym="Rgds" /note="Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cd00155" /db_xref="CDD:238087" misc_feature order(1387..1395,1432..1437,1441..1449,1453..1458, 1465..1470,1477..1479,1582..1584,1591..1596,1600..1608, 1612..1623,1627..1632,1690..1692,1699..1701,1714..1722, 1729..1731,1840..1848,1855..1863,1867..1875,1879..1890, 1933..1935,1945..1947,2050..2052,2059..2064) /gene="Ralgds" /gene_synonym="Rgds" /note="Ras interaction site [polypeptide binding]; other site" /db_xref="CDD:238087" misc_feature 2323..2463 /gene="Ralgds" /gene_synonym="Rgds" /note="propagated from UniProtKB/Swiss-Prot (Q03386.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2536..2793 /gene="Ralgds" /gene_synonym="Rgds" /note="Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins; Region: RA_RalGDS; cd17209" /db_xref="CDD:340729" misc_feature order(2536..2547,2551..2553,2572..2598,2608..2613, 2635..2637,2644..2649,2653..2655) /gene="Ralgds" /gene_synonym="Rgds" /note="RA-Ras interaction site [polypeptide binding]; other site" /db_xref="CDD:340729" misc_feature 2584..2586 /gene="Ralgds" /gene_synonym="Rgds" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:Q12967; propagated from UniProtKB/Swiss-Prot (Q03386.1); phosphorylation site" exon 385..495 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 496..689 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 690..749 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 750..943 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 944..1341 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1342..1557 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1558..1661 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1662..1746 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1747..1815 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1816..1902 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1903..1935 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1936..2057 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2058..2153 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2154..2355 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2356..2598 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2599..2713 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2714..3684 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" ORIGIN
ccaccaggcctaacaactagaggaggcttacggccctcggaaaccacgcccccatcagtcagtccccaccctcagctgacatcagcgagtccggccctgggcgcagagcgcaggcagcgcggagccgcgccggccggccctgcgcccacgccgccccgggtctcgcggcccgccggccacccgcgccaccgggagtcgtccatggtgcagcgcatgtgggccgaggcgtccgggcccatagggggcgccgagccgttgtttcccggctcccggcgcagccgcagcgtgtgggacgccgtgcgtctggaggtgggcgtccctgacagctgtccagtggtgctgcacagcttcacgcagctcgaccccgatctgccgcgcctggagagctctacgcaggagattggggaggagctgatcaacggggtcatctactccatctccctgcgcaaggttcagctacacccaggagccaccaagggccagcgctggctagggtgcgagaatgagtcagctctgaacctctacgagacttgcaaggtgcgcacggtgaaggccggtactctggagaagctggtggaacacctggtgcctgccttccagggcagtgacctttcctacgtcaccgtattcctgtgcacctacagagccttcacaaccactcagcaggtgctagacctgctgttcaaaagatatggctgcatccttccctactccagtgaggacggcggaccacaggaccaactcaaaaatgccatctcttccatcctgggcacctggctggaccaatactccgaggacttctgtcaacccccggactttccctgcctcaagcagctggtggcttatgtgcagctcaacatgcctggctcagacctggagcgccgtgctcaccttctcctggcccagctggaggacctggagcccagtgaggttgagcctgaggccctgtccccagctccagtgctgtctctgaaaccagcttcacagctagaaccagctcccgccctgcttctgacgcccagccgagctgtggcatccactccagtccgagagccagccccggtgccagtactggcatccagcccggtggtggcgccagcctctgagctagaaccagctctggagccgcccctagaccctgagccaaccctcgcacctgctccagagctggaccccactgtctcacagagcctccacctcgagcccgctcccgtgcccgctcctgcattagagccttcctggcctctgcctgaaaccacggagaacggactgtgtgcaaagcctcacctactgctgttccctccagacttggtggctgaacagtttacgctgatggacgcagagctattcaagaaagttgtgccctaccactgcctgggctccatctggtcccagcgggacaagaagggcaaggagcacctcgcgcccaccatccgtgccactgtcgcccagttcaacaacgtggccaactgtgtcatcaccacctgccttggggaccagagtatgaaagcttcggacagggcccgggtggtggaacactggatcgaggtggccagggagtgcagggtgctcaagaatttctcctccctctacgccatcctctctgccctacagagcaatgccatccaccgcctaaagaagacatgggaagaggtctccaggggcagctttcgagtgttccagaaactgtcagaaatcttctctgatgagaacaactactccttgagcagagagctgctcatcaaggaaggaacctccaagtttgccacgctggagatgaaccctaggagaacccagaggcggcagaaggagacaggtgtcatccagggcactgtcccctacctgggcacattcctcactgacctggtgatgctggacacagccatgaaggactatctatatgggagactgatcaactttgaaaagaggaggaaggagttcgaagtcatcgcccagatcaagttgctccagtcggcctgcaacaactacagcattgttcccgaggagcactttggagcctggttccgagccatgggacggctcagcgaggctgagagctacaacctgtcgtgtgagctggagcccccgtctgagtcagccagcaacaccctgaggagcaagaaaagcacagctatcgtcaagcgctggagcgaccgccaggctcccagcacggagctcagcaccagtagcagtgcacactccaagtcatgtgaccagctccggtgcagcccctacctcagcagcggggacatcacggacgcactcagtgtgcactcagctggttcatccagctctgacgtggaggagatcaacatgagctttgttccagagtctcctgatggccaggaaaagaagttctgggagtcagcctcccagtcgtccccagagacctctggcatcagctcggcctccagcagcacctcctcttcgtcagcctctaccacaccggtgtctaccacacgcacccacaagcgctctgtctcaggggtctgcagctacagctcctcactgccactctacaaccagcaggtgggcgactgctgcatcatcagggtcagcctggatgtggacaacggcaacatgtacaagagcatcctggtgaccagccaggataaggctccgactgtcatccggaaagccatggacaaacacaacctagatgaggacgagcccgaggactatgagctgctgcagatcatctcagaggaccacaagctgaaaattccagagaacgccaatgtgttctatgccatgaactctgccgccaactatgacttcatcctaaagaagcgggccttcactaagggggctaaagtcaagcatggagccagctccactctccctcgaatgaagcagaagggactcaggattgccagaggcatcttctaaggacgtctcccaggggctggctggctggctggggactaagcacttacagactagagtggcccaggccacacaggtacctctgccctcctgccagcccaggctactcccagactccactttcaccccgaacctgtcctgctgccgggattgacacctgccactgacaggctgacctggcctccggggaccgctcaccgccttaggtgccttctgctctctgcaaccagaggactagctgactttgccaaggggtgctgccagctgggcatggagcctcgcctgccctggacaatgtccaccacactttcctgtcacctccccaagtgcagatcactgccacccatgctcccagatgctccaggacacccacacacccagcggggctgccaactgcgttctctccttgtgcccataggcactggcctgggaccttcatggaggtcctagcctttcttaggctgcaccaaagattccaccttcagggcctacagagtgagggagtctcgcccaccacgagcccaagccctcccatggatcagagagagaagccctctcatggaccgcctggttggcattgaaccccataccactgaaagtgccattcaccaccgctgcgtcccgggtgtacaagactacatgcaatgggaggtttgtggggagggggaagacgactggatatttgtataaaacgtaaaaagtttactgattggggtggggcaatatttatttgttgtaaatagaaaatgctagacttgaatattatattaaaatcccgtttctactatggcctggtca
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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