LOCUS       NM_019218               2489 bp    mRNA    linear   ROD 14-JUL-2023
DEFINITION  Rattus norvegicus neuronal differentiation 1 (Neurod1), mRNA.
ACCESSION   NM_019218 XM_001067404
VERSION     NM_019218.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Li R, Li X, Huang Y, Qiu H, Li L and Bi Z.
  TITLE     LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced
            Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis
  JOURNAL   World Neurosurg 147, e293-e305 (2021)
   PUBMED   33340723
  REMARK    GeneRIF: LncRNA SOX2OT Knockdown Alleviates
            Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating
            miR-331-3p/Neurod1 Axis.
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Jeon SJ, Kim JW, Kim KC, Han SM, Go HS, Seo JE, Choi CS, Ryu JH,
            Shin CY and Song MR.
  TITLE     Translational regulation of NeuroD1 expression by FMRP: involvement
            in glutamatergic neuronal differentiation of cultured rat primary
            neural progenitor cells
  JOURNAL   Cell Mol Neurobiol 34 (2), 297-305 (2014)
   PUBMED   24338128
  REMARK    GeneRIF: NeuroD1, an essential regulator of glutamatergic neuronal
            differentiation, as a new mRNA target interacting with FMRP in
            co-immunoprecipitation experiments.
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Ahmed M, Xu J and Xu PX.
  TITLE     EYA1 and SIX1 drive the neuronal developmental program in
            cooperation with the SWI/SNF chromatin-remodeling complex and SOX2
            in the mammalian inner ear
  JOURNAL   Development 139 (11), 1965-1977 (2012)
   PUBMED   22513373
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan YF and Zhou
            CY.
  TITLE     The LIM-homeodomain protein ISL1 activates insulin gene promoter
            directly through synergy with BETA2
  JOURNAL   J Mol Biol 392 (3), 566-577 (2009)
   PUBMED   19619559
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Mehmood R, Yasuhara N, Oe S, Nagai M and Yoneda Y.
  TITLE     Synergistic nuclear import of NeuroD1 and its partner transcription
            factor, E47, via heterodimerization
  JOURNAL   Exp Cell Res 315 (10), 1639-1652 (2009)
   PUBMED   19272376
  REMARK    GeneRIF: The nuclear import of NeuroD1 and E47 is energy-dependent
            and involves the Ran-mediated pathway.
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Miyata T, Maeda T and Lee JE.
  TITLE     NeuroD is required for differentiation of the granule cells in the
            cerebellum and hippocampus
  JOURNAL   Genes Dev 13 (13), 1647-1652 (1999)
   PUBMED   10398678
REFERENCE   7  (bases 1 to 2489)
  AUTHORS   Noma T, Yoon YS and Nakazawa A.
  TITLE     Overexpression of NeuroD in PC12 cells alters morphology and
            enhances expression of the adenylate kinase isozyme 1 gene
  JOURNAL   Brain Res Mol Brain Res 67 (1), 53-63 (1999)
   PUBMED   10101232
REFERENCE   8  (bases 1 to 2489)
  AUTHORS   Mutoh H, Naya FJ, Tsai MJ and Leiter AB.
  TITLE     The basic helix-loop-helix protein BETA2 interacts with p300 to
            coordinate differentiation of secretin-expressing enteroendocrine
            cells
  JOURNAL   Genes Dev 12 (6), 820-830 (1998)
   PUBMED   9512516
REFERENCE   9  (bases 1 to 2489)
  AUTHORS   Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB and Tsai
            MJ.
  TITLE     Diabetes, defective pancreatic morphogenesis, and abnormal
            enteroendocrine differentiation in BETA2/neuroD-deficient mice
  JOURNAL   Genes Dev 11 (18), 2323-2334 (1997)
   PUBMED   9308961
REFERENCE   10 (bases 1 to 2489)
  AUTHORS   Kawakami H, Maruyama H, Yasunami M, Ohkubo H, Hara H, Saida T,
            Nakanishi S and Nakamura S.
  TITLE     Cloning and expression of a rat brain basic helix-loop-helix factor
  JOURNAL   Biochem Biophys Res Commun 221 (1), 199-204 (1996)
   PUBMED   8660336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000115.1.
            
            On Mar 15, 2021 this sequence version replaced NM_019218.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092367.1, FQ099449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JACYVU010000115.1  57820272-57820347   c
            77-2489             JACYVU010000115.1  57816375-57818787   c
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2489
                     /gene="Neurod1"
                     /note="neuronal differentiation 1"
                     /db_xref="GeneID:29458"
                     /db_xref="RGD:3165"
     exon            1..76
                     /gene="Neurod1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..2489
                     /gene="Neurod1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1161
                     /gene="Neurod1"
                     /note="BHF-1; basic helix-loop-helix factor 1; neurogenic
                     differentiation 1"
                     /codon_start=1
                     /product="neurogenic differentiation factor 1"
                     /protein_id="NP_062091.1"
                     /db_xref="GeneID:29458"
                     /db_xref="RGD:3165"
                     /translation="

MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEEDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSTEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD"

     misc_feature    88..369
                     /gene="Neurod1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64289.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    310..567
                     /gene="Neurod1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     neurogenic differentiation factor 1 (NeuroD1) and similar
                     proteins; Region: bHLH_TS_NeuroD1; cd19719"
                     /db_xref="CDD:381562"
     misc_feature    346..366
                     /gene="Neurod1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64289.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    order(406..408,415..420,424..426,430..432,439..441,
                     499..504)
                     /gene="Neurod1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381562"
     misc_feature    order(436..438,445..450,454..459,466..471,502..507,
                     514..516,526..528,532..537,544..549,553..558)
                     /gene="Neurod1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:381562"
     misc_feature    565..939
                     /gene="Neurod1"
                     /note="Neuronal helix-loop-helix transcription factor;
                     Region: Neuro_bHLH; pfam12533"
                     /db_xref="CDD:432616"
     misc_feature    571..573
                     /gene="Neurod1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q60867; propagated from
                     UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site"
     misc_feature    862..864
                     /gene="Neurod1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q60867; propagated from
                     UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site"
     misc_feature    883..885
                     /gene="Neurod1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q60867; propagated from
                     UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site"
     misc_feature    907..909
                     /gene="Neurod1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000305|PubMed:12297313; propagated from
                     UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site"
     misc_feature    1093..1095
                     /gene="Neurod1"
                     /note="Phosphoserine, by CaMK2.
                     /evidence=ECO:0000269|PubMed:14741104; propagated from
                     UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site"
ORIGIN      

cgcccacgcagaaggcaaggtgtcccgaggctccagggttatgagatcgtcactattcagaaccttttaacaacaggaagtggaaacatgaccaaatcatacagcgagagcgggctgatgggcgagcctcagccccaaggtcccccaagctggacagacgagtgcctcagttctcaggacgaggaacacgaggcagacaagaaggaggatgagcttgaagccatgaatgcagaggaggactctctgagaaatgggggagaggaggaggatgaagatgaggatctggaagaggaggaagaggaggaggaagaggaggatgatcaaaagcccaagagacggggccccaaaaagaaaaagatgaccaaggcgcgcctagagcgttttaaattaagacgcatgaaggccaatgcccgcgagcggaaccgcatgcacgggctgaatgcggcgctggacaacctgagaaaggtggtaccctgctactctaagacacagaagctgtctaagatagagacactgcgcttggccaagaactatatctgggctctgtcagagatcctgcgctcaggcaaaagcccagacctcgtctcctttgtacagacactctgcaaaggtttgtcccagcccactaccaatttggtggctggctgcttgcagctcaacccccggactttcttgcctgagcagaatccggacatgcccccacacctgccaaccgccagcgcttccttcccggtgcatccctactcctaccagtcccctggactgcccagcccgccctacggcaccatggacagctcccatgtcttccacgtcaagccgccgccacacgcctacagcgcagccctggagcccttctttgaaagccccctaactgattgcaccagcccttcctttgacggacccctcagcccgccgctcagcatcaatggcaacttctctttcaaacacgaaccatccaccgagtttgaaaaaaattatgcctttaccatgcactaccctgcagcgaccctggcagggccccaaagccacggatcaatcttctcctcgggtgccgctgctcctcgctgtgagatccccatagacaatattatgtctttcgatagccattcgcatcatgagcgagtcatgagtgcccagcttaatgccatctttcacgattagaggcacgtcagtttcaccattcccgggaaacgaatccactgtgcttacagtgactgtcctgtttacagaaggcagcccttttgataacattgctgcaaagtgcaaatactcgaagcttcaagggatatatgtatttattgtcgttactgcctttggaagaaacaggggatcaaagttcctgttcaccttatctattgttttctatagctcttctattttaaaaaataatagtacagtaaagtaaaaaaggaaaatgtgtaccacgaatttcgtgtagctgtattcagatcgtattaattatctgatcgggataaaaaaatcaagcaataattaggatctatgcaatttttaaactagtaatgggccaattaaagtatatataaatatatatttttcaaccagcattttactacttgttacctttcccatgccgaattattttgttgtgattttgtacagaatttttaatgactttttataacgtggatttcctattttaaaaccatgcagcttcatcaatttttatacatatcagaaaagtagaattatatctaatttatacaaaaataatttaactaatttaaaccagcagaaaagtgcttagaaagttattgcgttgccttagcacttctttcttctctaattgtaaaaaaaaaaaaatagaaaagaaaagagaaaaacaacaaattgcacaatttgagcaattcatctcactttaaagtctttccctctccctaaagtagaaaccagacccataacactcaagaggaaaaaaagaaatgcattccttatcaaaacatatcgattcattccttgcacacgcttgtaaatacataatataaataaatgccaacacacactcctttaaatcaaaagctgctcgactatcacccacaatttgcactctttctttttagtctttcacttctttgaagtcaatgatttttatggagtgtctgacgttattgatgtttcgagaaaatataaatgcatgattttatacatagtcaaacaaatggtggcttgtcatctattcatgtaataaatctgagcctaaatttattcaggttgttgatgttggggtttatacctgtgtagtcaattagtacagtagtttaaataaaattcaaaccatctgatccataattagaacaatagctattgcatgtaaaatgcagtccagaataagtgctgtttgcgatgtgatgctggtactactggaatggacatgtactgtaatcttgttcgtaatcctgtgtattatggtgtaatgcacaatttagaaaactctcatgcagttgcaataaaaatagtattgaaaatcaaaa

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