2024-05-06 12:19:47, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_019218 2489 bp mRNA linear ROD 14-JUL-2023 DEFINITION Rattus norvegicus neuronal differentiation 1 (Neurod1), mRNA. ACCESSION NM_019218 XM_001067404 VERSION NM_019218.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2489) AUTHORS Li R, Li X, Huang Y, Qiu H, Li L and Bi Z. TITLE LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis JOURNAL World Neurosurg 147, e293-e305 (2021) PUBMED 33340723 REMARK GeneRIF: LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis. REFERENCE 2 (bases 1 to 2489) AUTHORS Jeon SJ, Kim JW, Kim KC, Han SM, Go HS, Seo JE, Choi CS, Ryu JH, Shin CY and Song MR. TITLE Translational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells JOURNAL Cell Mol Neurobiol 34 (2), 297-305 (2014) PUBMED 24338128 REMARK GeneRIF: NeuroD1, an essential regulator of glutamatergic neuronal differentiation, as a new mRNA target interacting with FMRP in co-immunoprecipitation experiments. REFERENCE 3 (bases 1 to 2489) AUTHORS Ahmed M, Xu J and Xu PX. TITLE EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear JOURNAL Development 139 (11), 1965-1977 (2012) PUBMED 22513373 REFERENCE 4 (bases 1 to 2489) AUTHORS Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan YF and Zhou CY. TITLE The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2 JOURNAL J Mol Biol 392 (3), 566-577 (2009) PUBMED 19619559 REFERENCE 5 (bases 1 to 2489) AUTHORS Mehmood R, Yasuhara N, Oe S, Nagai M and Yoneda Y. TITLE Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization JOURNAL Exp Cell Res 315 (10), 1639-1652 (2009) PUBMED 19272376 REMARK GeneRIF: The nuclear import of NeuroD1 and E47 is energy-dependent and involves the Ran-mediated pathway. REFERENCE 6 (bases 1 to 2489) AUTHORS Miyata T, Maeda T and Lee JE. TITLE NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus JOURNAL Genes Dev 13 (13), 1647-1652 (1999) PUBMED 10398678 REFERENCE 7 (bases 1 to 2489) AUTHORS Noma T, Yoon YS and Nakazawa A. TITLE Overexpression of NeuroD in PC12 cells alters morphology and enhances expression of the adenylate kinase isozyme 1 gene JOURNAL Brain Res Mol Brain Res 67 (1), 53-63 (1999) PUBMED 10101232 REFERENCE 8 (bases 1 to 2489) AUTHORS Mutoh H, Naya FJ, Tsai MJ and Leiter AB. TITLE The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells JOURNAL Genes Dev 12 (6), 820-830 (1998) PUBMED 9512516 REFERENCE 9 (bases 1 to 2489) AUTHORS Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB and Tsai MJ. TITLE Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice JOURNAL Genes Dev 11 (18), 2323-2334 (1997) PUBMED 9308961 REFERENCE 10 (bases 1 to 2489) AUTHORS Kawakami H, Maruyama H, Yasunami M, Ohkubo H, Hara H, Saida T, Nakanishi S and Nakamura S. TITLE Cloning and expression of a rat brain basic helix-loop-helix factor JOURNAL Biochem Biophys Res Commun 221 (1), 199-204 (1996) PUBMED 8660336 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000115.1. On Mar 15, 2021 this sequence version replaced NM_019218.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092367.1, FQ099449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5760393, SAMEA5760396 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-76 JACYVU010000115.1 57820272-57820347 c 77-2489 JACYVU010000115.1 57816375-57818787 c FEATURES Location/Qualifiers source 1..2489 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="3" /map="3q24" gene 1..2489 /gene="Neurod1" /note="neuronal differentiation 1" /db_xref="GeneID:29458" /db_xref="RGD:3165" exon 1..76 /gene="Neurod1" /inference="alignment:Splign:2.1.0" exon 77..2489 /gene="Neurod1" /inference="alignment:Splign:2.1.0" CDS 88..1161 /gene="Neurod1" /note="BHF-1; basic helix-loop-helix factor 1; neurogenic differentiation 1" /codon_start=1 /product="neurogenic differentiation factor 1" /protein_id="NP_062091.1" /db_xref="GeneID:29458" /db_xref="RGD:3165" /translation="
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEEDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSTEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD"
misc_feature 88..369 /gene="Neurod1" /note="propagated from UniProtKB/Swiss-Prot (Q64289.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 310..567 /gene="Neurod1" /note="basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; Region: bHLH_TS_NeuroD1; cd19719" /db_xref="CDD:381562" misc_feature 346..366 /gene="Neurod1" /note="propagated from UniProtKB/Swiss-Prot (Q64289.1); Region: Nuclear localization signal. /evidence=ECO:0000255" misc_feature order(406..408,415..420,424..426,430..432,439..441, 499..504) /gene="Neurod1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381562" misc_feature order(436..438,445..450,454..459,466..471,502..507, 514..516,526..528,532..537,544..549,553..558) /gene="Neurod1" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:381562" misc_feature 565..939 /gene="Neurod1" /note="Neuronal helix-loop-helix transcription factor; Region: Neuro_bHLH; pfam12533" /db_xref="CDD:432616" misc_feature 571..573 /gene="Neurod1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q60867; propagated from UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site" misc_feature 862..864 /gene="Neurod1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q60867; propagated from UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site" misc_feature 883..885 /gene="Neurod1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q60867; propagated from UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site" misc_feature 907..909 /gene="Neurod1" /note="Phosphoserine. /evidence=ECO:0000305|PubMed:12297313; propagated from UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site" misc_feature 1093..1095 /gene="Neurod1" /note="Phosphoserine, by CaMK2. /evidence=ECO:0000269|PubMed:14741104; propagated from UniProtKB/Swiss-Prot (Q64289.1); phosphorylation site" ORIGIN
cgcccacgcagaaggcaaggtgtcccgaggctccagggttatgagatcgtcactattcagaaccttttaacaacaggaagtggaaacatgaccaaatcatacagcgagagcgggctgatgggcgagcctcagccccaaggtcccccaagctggacagacgagtgcctcagttctcaggacgaggaacacgaggcagacaagaaggaggatgagcttgaagccatgaatgcagaggaggactctctgagaaatgggggagaggaggaggatgaagatgaggatctggaagaggaggaagaggaggaggaagaggaggatgatcaaaagcccaagagacggggccccaaaaagaaaaagatgaccaaggcgcgcctagagcgttttaaattaagacgcatgaaggccaatgcccgcgagcggaaccgcatgcacgggctgaatgcggcgctggacaacctgagaaaggtggtaccctgctactctaagacacagaagctgtctaagatagagacactgcgcttggccaagaactatatctgggctctgtcagagatcctgcgctcaggcaaaagcccagacctcgtctcctttgtacagacactctgcaaaggtttgtcccagcccactaccaatttggtggctggctgcttgcagctcaacccccggactttcttgcctgagcagaatccggacatgcccccacacctgccaaccgccagcgcttccttcccggtgcatccctactcctaccagtcccctggactgcccagcccgccctacggcaccatggacagctcccatgtcttccacgtcaagccgccgccacacgcctacagcgcagccctggagcccttctttgaaagccccctaactgattgcaccagcccttcctttgacggacccctcagcccgccgctcagcatcaatggcaacttctctttcaaacacgaaccatccaccgagtttgaaaaaaattatgcctttaccatgcactaccctgcagcgaccctggcagggccccaaagccacggatcaatcttctcctcgggtgccgctgctcctcgctgtgagatccccatagacaatattatgtctttcgatagccattcgcatcatgagcgagtcatgagtgcccagcttaatgccatctttcacgattagaggcacgtcagtttcaccattcccgggaaacgaatccactgtgcttacagtgactgtcctgtttacagaaggcagcccttttgataacattgctgcaaagtgcaaatactcgaagcttcaagggatatatgtatttattgtcgttactgcctttggaagaaacaggggatcaaagttcctgttcaccttatctattgttttctatagctcttctattttaaaaaataatagtacagtaaagtaaaaaaggaaaatgtgtaccacgaatttcgtgtagctgtattcagatcgtattaattatctgatcgggataaaaaaatcaagcaataattaggatctatgcaatttttaaactagtaatgggccaattaaagtatatataaatatatatttttcaaccagcattttactacttgttacctttcccatgccgaattattttgttgtgattttgtacagaatttttaatgactttttataacgtggatttcctattttaaaaccatgcagcttcatcaatttttatacatatcagaaaagtagaattatatctaatttatacaaaaataatttaactaatttaaaccagcagaaaagtgcttagaaagttattgcgttgccttagcacttctttcttctctaattgtaaaaaaaaaaaaatagaaaagaaaagagaaaaacaacaaattgcacaatttgagcaattcatctcactttaaagtctttccctctccctaaagtagaaaccagacccataacactcaagaggaaaaaaagaaatgcattccttatcaaaacatatcgattcattccttgcacacgcttgtaaatacataatataaataaatgccaacacacactcctttaaatcaaaagctgctcgactatcacccacaatttgcactctttctttttagtctttcacttctttgaagtcaatgatttttatggagtgtctgacgttattgatgtttcgagaaaatataaatgcatgattttatacatagtcaaacaaatggtggcttgtcatctattcatgtaataaatctgagcctaaatttattcaggttgttgatgttggggtttatacctgtgtagtcaattagtacagtagtttaaataaaattcaaaccatctgatccataattagaacaatagctattgcatgtaaaatgcagtccagaataagtgctgtttgcgatgtgatgctggtactactggaatggacatgtactgtaatcttgttcgtaatcctgtgtattatggtgtaatgcacaatttagaaaactctcatgcagttgcaataaaaatagtattgaaaatcaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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