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Previous release (v1)
2024-04-28 05:27:08, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_017263 4141 bp mRNA linear ROD 04-OCT-2022
DEFINITION Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 4
(Gria4), transcript variant 1, mRNA.
ACCESSION NM_017263
VERSION NM_017263.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4141)
AUTHORS Rossner B, Klingler M, Bulat T, Sase A, Zeilinger A, Spitzwieser M,
Aradska J, Cichna-Markl M and Lubec G.
TITLE Hippocampal GluA2 and GluA4 protein but not corresponding mRNA and
promoter methylation levels are modulated at retrieval in spatial
learning of the rat
JOURNAL Amino Acids 49 (1), 117-127 (2017)
PUBMED 27714514
REMARK GeneRIF: Hippocampal GluA2 and GluA4 protein but not corresponding
mRNA and promoter methylation levels are modulated at retrieval in
spatial learning of the rat.
REFERENCE 2 (bases 1 to 4141)
AUTHORS Luchkina NV, Coleman SK, Huupponen J, Cai C, Kivisto A, Taira T,
Keinanen K and Lauri SE.
TITLE Molecular mechanisms controlling synaptic recruitment of GluA4
subunit-containing AMPA-receptors critical for functional
maturation of CA1 glutamatergic synapses
JOURNAL Neuropharmacology 112 (Pt A), 46-56 (2017)
PUBMED 27157711
REMARK GeneRIF: Data show that PKA activation leads to insertion of GluA4
to synaptic sites with initially weak or silent AMPAR-mediated
transmission. This suggests that the GluA4-mediated activation of
silent synapses is a critical mechanism facilitating the functional
maturation of glutamatergic circuitry during the critical period of
experience-dependent fine-tuning.
REFERENCE 3 (bases 1 to 4141)
AUTHORS Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J,
Ho H and Greger IH.
TITLE Structure and organization of heteromeric AMPA-type glutamate
receptors
JOURNAL Science 352 (6285), aad3873 (2016)
PUBMED 26966189
REFERENCE 4 (bases 1 to 4141)
AUTHORS Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A,
Teunissen CE, de Wit H and Jimenez CR.
TITLE Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
comprehensive dataset
JOURNAL J Proteomics 106, 191-204 (2014)
PUBMED 24769233
REFERENCE 5 (bases 1 to 4141)
AUTHORS Aruscavage PJ and Bass BL.
TITLE A phylogenetic analysis reveals an unusual sequence conservation
within introns involved in RNA editing
JOURNAL RNA 6 (2), 257-269 (2000)
PUBMED 10688364
REFERENCE 6 (bases 1 to 4141)
AUTHORS Lomeli H, Mosbacher J, Melcher T, Hoger T, Geiger JR, Kuner T,
Monyer H, Higuchi M, Bach A and Seeburg PH.
TITLE Control of kinetic properties of AMPA receptor channels by nuclear
RNA editing
JOURNAL Science 266 (5191), 1709-1713 (1994)
PUBMED 7992055
REFERENCE 7 (bases 1 to 4141)
AUTHORS Gallo V, Upson LM, Hayes WP, Vyklicky L Jr, Winters CA and Buonanno
A.
TITLE Molecular cloning and development analysis of a new glutamate
receptor subunit isoform in cerebellum
JOURNAL J Neurosci 12 (3), 1010-1023 (1992)
PUBMED 1372042
REFERENCE 8 (bases 1 to 4141)
AUTHORS Wenthold RJ, Yokotani N, Doi K and Wada K.
TITLE Immunochemical characterization of the non-NMDA glutamate receptor
using subunit-specific antibodies. Evidence for a hetero-oligomeric
structure in rat brain
JOURNAL J Biol Chem 267 (1), 501-507 (1992)
PUBMED 1309749
REFERENCE 9 (bases 1 to 4141)
AUTHORS Sommer B, Keinanen K, Verdoorn TA, Wisden W, Burnashev N, Herb A,
Kohler M, Takagi T, Sakmann B and Seeburg PH.
TITLE Flip and flop: a cell-specific functional switch in
glutamate-operated channels of the CNS
JOURNAL Science 249 (4976), 1580-1585 (1990)
PUBMED 1699275
REFERENCE 10 (bases 1 to 4141)
AUTHORS Keinanen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA,
Sakmann B and Seeburg PH.
TITLE A family of AMPA-selective glutamate receptors
JOURNAL Science 249 (4968), 556-560 (1990)
PUBMED 2166337
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB761818.1, BC093608.1,
M38063.1, M85037.1, BF413680.1, BF390245.1 and BF390683.1.
On Jan 2, 2008 this sequence version replaced NM_017263.1.
Summary: Glutamate receptors are the predominant excitatory
neurotransmitter receptors in the mammalian brain and are activated
in a variety of normal neurophysiologic processes. These receptors
are heteromeric protein complexes composed of multiple subunits,
arranged to form ligand-gated ion channels. The classification of
glutamate receptors is based on their activation by different
pharmacologic agonists. The subunit encoded by this gene belongs to
a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole
propionate)-sensitive glutamate receptors, and is subject to RNA
editing (AGA->GGA; R->G). Alternative splicing of this gene results
in transcript variants encoding different isoforms, which may vary
in their signal transduction properties. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (1) encodes isoform 1 (also known
as flip isoform). RNA editing (AGA->GGA) changes Arg765Gly.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMEA5760383,
SAMEA5760386 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
undergoes RNA editing :: PMID: 10688364
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-28 CB761818.1 1-28
29-1719 BC093608.1 1-1691
1720-2650 M38063.1 1270-2200
2651-3071 M85037.1 2362-2782
3072-3156 M38063.1 2622-2706
3157-3249 M85037.1 2868-2960
3250-3671 BF413680.1 11-432 c
3672-3993 BF390245.1 146-467 c
3994-4141 BF390683.1 1-148 c
FEATURES Location/Qualifiers
source 1..4141
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q11"
gene 1..4141
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="glutamate ionotropic receptor AMPA type subunit 4"
/db_xref="GeneID:29629"
/db_xref="RGD:61863"
exon 1..361
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 362..538
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
misc_feature 385..387
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="upstream in-frame stop codon"
CDS 451..3159
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="isoform 1 precursor is encoded by transcript
variant 1; glutamate receptor, ionotropic, AMPA4 (alpha
4); AMPA-selective glutamate receptor 4; glutamate
receptor, ionotrophic, AMPA 4; glutamate receptor,
ionotropic, AMPA 4"
/codon_start=1
/product="glutamate receptor 4 isoform 1 precursor"
/protein_id="NP_058959.2"
/db_xref="GeneID:29629"
/db_xref="RGD:61863"
/translation="
MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP"
sig_peptide 451..513
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 514..3156
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/product="glutamate receptor 4 isoform 1"
misc_feature 532..1650
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="N-terminal leucine-isoleucine-valine binding
protein (LIVBP)-like domain of the GluR4 subunit of the
AMPA receptor; Region: PBP1_iGluR_AMPA_GluR4; cd06388"
/db_xref="CDD:380611"
misc_feature order(673..681,688..693,700..702,775..777,784..786,
922..924,952..954,961..966,973..978,997..999,1003..1005,
1048..1050,1438..1446,1450..1452,1456..1458)
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="putative tetramer interface [polypeptide binding];
other site"
/db_xref="CDD:380611"
misc_feature order(676..681,700..702,775..777,787..789,922..924,
940..942,952..954,961..966,970..978,991..996,1000..1002,
1060..1062,1441..1455)
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:380611"
misc_feature 1690..2835
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="The ligand-binding domain of the AMPA
(alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic
acid) subtype GluR4 of ionotropic glutamate receptors, a
member of the type 2 periplasmic binding fold protein
superfamily; Region: PBP2_iGluR_AMPA_GluR4; cd13727"
/db_xref="CDD:270445"
misc_feature order(1864..1866,1948..1956,1969..1971,2464..2466,
2473..2481,2626..2631,2638..2640,2710..2712)
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="peptide binding site [polypeptide binding]; other
site"
/db_xref="CDD:270445"
misc_feature order(1957..1965,1972..1974,1987..1998,2701..2703,
2743..2745,2755..2760,2767..2769,2776..2781)
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:270445"
misc_feature order(1993..2007,2767..2769,2776..2778,2791..2796,
2803..2805)
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="putative ligand binding site [chemical binding];
other site"
/db_xref="CDD:270445"
exon 539..697
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 698..937
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 938..1122
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1123..1176
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1177..1335
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1336..1503
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1504..1608
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1609..1719
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1720..1926
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 1927..2297
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 2298..2496
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 2497..2744
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
misc_feature 2744
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/note="RNA editing at nt 2744 (AGA->GGA) changes
Arg765Gly; Region: RNA editing site"
exon 2745..2859
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 2860..2994
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
exon 2995..4125
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
/inference="alignment:Splign:2.1.0"
regulatory 4095..4100
/regulatory_class="polyA_signal_sequence"
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
polyA_site 4125
/gene="Gria4"
/gene_synonym="GluA4; GluR-D; GluR4"
ORIGIN
gctgagtggaaagagctaggagccgggaggcagcctgtcctccctcaagcctgcaaggatgcggcaggggactgagaccatggggaggtgctaacttcctcttcaaccccccagcccgggatccgggctggcatacccggccccccgggctagtttcctgccaagcgcaaccaagaagccaaaggcgatttggagggcataaaaagaaaaagagtggttctggagaggggtgcccacctccagagccggtccctctgcaaacaggcaaagataggagaaaggggatcagatactggagtgtacgcaaaatcctctgtctgtggactcgcaccagagcctcccagaaaacctgggcgatctgcgccatcgtcttcaatgcctctctgaaaagcctttagcaagactgagagaaagagaaaagagagcgcgccagagagaggagcaaagaagatgaggattatttgcaggcagattgtcttgttgttttctggattttggggactcgccatgggagcctttccaagcagcgttcaaataggtggtctcttcatccgaaacacagaccaggaatacactgcttttagactggcaatctttcttcataacaccagccccaatgcatcggaagctcctttcaatttggtacctcatgtggacaacattgagactgccaacagttttgctgtgacaaacgccttctgttcccagtattctagaggggtgtttgccatttttggactctatgacaagagatccgtgcataccttgacctcgttctgcagtgctctgcacatctctctcatcacaccaagctttcccactgaaggggagagccagtttgtgctgcagctaagaccttcactgagaggtgcactcctgagcctcctggatcactatgagtggaactgtttcgtcttcctgtatgatacagacagggggtattcaatacttcaagctataatggaaaaagcaggacaaaatggatggcatgtcagtgcaatatgtgtggaaaattttaatgatgtcagctacaggcaactgctagaagagcttgacagaagacaagagaagaaatttgtgatagattgtgagatagagaggcttcaaaacattttagaacaaattgtgagtgttgggaagcatgtcaaaggctaccattatatcatcgcaaatttgggtttcaaggatatttctcttgagagatttatacatggaggagcaaatgtaacaggattccagttggtagattttaatacacccatggtaaccaaactaatggatcggtggaagaaactagatcagagagaatatccaggttctgaaacacctccaaagtacacctctgctctcacttatgatggagtcctggtgatggctgaaactttccgaagtctcagaagacagaaaattgatatttcaaggagaggaaatgctggggactgtctggcaaaccctgctgctccctggggccagggaattgacatggagaggacactgaagcaggttcgaattcaagggctgactgggaatgttcaatttgaccattatggacgtagagttaattacacaatggatgtgtttgaactgaaaagcacaggacctcgaaaggttggctactggaatgatatggataaattagtcttgattcaagatatgcctactcttggcaatgacacagcagctattgagaacagaacagtggttgtaaccacaattatggaatctccctatgttatgtacaagaaaaatcatgaaatgtttgaaggaaatgacaagtacgaaggctactgtgtagatctggcatcggaaattgcaaaacatattggtatcaaatataaaattgccattgttcctgatggaaaatatggagcaagggacgcagacactaagatctggaatgggatggtaggagagcttgtgtatgggaaagcagagattgctattgcccctctgacaatcacattggttcgagaggaagtcatcgatttttctaagccttttatgagtttaggcatctctatcatgatcaaaaaacctcagaaatctaaaccaggagtcttttccttcttggaccctctggcctatgagatctggatgtgcatagtgtttgcatacattggtgtcagtgtggtcttgttcctagtcagtaggtttagcccatatgagtggcacacagaagaacctgaggatgggaaggaaggacccagtgaccagcctcccaatgaatttggcatctttaacagcctttggttttccctgggtgcctttatgcaacaaggatgtgacatttcacccagatccctgtcaggtcggattgttggaggcgtgtggtggttcttcacactcatcattatatcgtcctacactgctaatctggctgcattccttactgtggagagaatggtctcccccatagaaagtgcagaagacctggccaaacaaacagaaattgcctatggaacacttgattctgggtcaacaaaagaattcttcagaagatcaaaaatagcagtgtatgaaaagatgtggacctacatgcgatcggcagagccgtctgtgttcactagaactacagctgagggcgtggctcgtgtccgcaagtccaagggcaaatttgcctttctcctggagtccacgatgaatgaatacattgagcagcgaaagccctgtgacacgatgaaagtgggaggaaacctggattccaaaggctatggtgtagcaacgcccaagggttcctcattaagaactcctgtaaaccttgccgttttgaaactcagtgaggcaggcgtcttagacaagctgaaaaacaaatggtggtacgataaaggtgaatgtggacccaaggactcgggaagcaaggacaagacgagtgccttgagcctgagcaacgtagcaggcgtcttctacattctggttggcggcctgggcttggcaatgctggtggctttgatagagttctgttacaagtccagggcagaggcgaagagaatgaagctgactttttccgaagccataagaaacaaagccaggttatccatcactgggagtgtgggagaaaacggccgtgtgctgacccctgactgccccaaggccgtacacacaggaactgcaattagacaaagttcgggattggctgtcattgcatcggacctaccataaaaaccaaaaaaataattgagtgccttaatcaaactgtgttggtgactgactgaaacgcagccctgagggaaaggccaagagtgggtcttggctaaatccatcctttggcttgagagcaggaagagcatactgagtgccggacagaaccagtgcatgatttcagcacggaaatgcagactcggatttttttttatcaggaaaactcacaatttagtttttttggggatagagggtgggggatagctgggataggtgtattaacagcaacaaatttcacatgagcgcacttaaaactaatcagactggtcagttagtgcattaaactgtgaagttctttctcagaaaggtcttagtcactacagcaacagattcaacagttactagaggtcaaggaaccttctacctgtgtctccagaacacccatttagtcgatggcataatctgcagctgaaacaagcagtcactaagatgtgataagaaaataataaatatgtaaatcctgtgaaaaaaaacaacaaaatttaaagaaagtatttacagttactttggaaataaaacaatactgaaacatgcttgctttttaactgaagtaaatccagtagaggacaacacaattgttttttctaaccatcttagggaacaatacattgcaataattgataataatgccatcactgtaataaactttagagacttttttttaatgtaaaagttgtttgtcaccttgtttcctgtaaccttcactctgtcacacaagttggctcataggttgtgtttgtctatcagaaacaacaacaaaaaaaatgaagaaaatgttggcatgaagtcatccatctgcaacgtagaatttaaaagactacgggtcattcatgttatcaatataatttataatcctgttctgtgtacaaaattgtggttttgtacccacccaaaagaataaaacaacagtttttcttacagtacctaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]