LOCUS       NM_012933               2628 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus dihydropyrimidinase-like 4 (Dpysl4), mRNA.
ACCESSION   NM_012933 XM_001057768 XM_341953
VERSION     NM_012933.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Nakamura F, Kumeta K, Hida T, Isono T, Nakayama Y,
            Kuramata-Matsuoka E, Yamashita N, Uchida Y, Ogura K, Gengyo-Ando K,
            Mitani S, Ogino T and Goshima Y.
  TITLE     Amino- and carboxyl-terminal domains of Filamin-A interact with
            CRMP1 to mediate Sema3A signalling
  JOURNAL   Nat Commun 5, 5325 (2014)
   PUBMED   25358863
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Liu W, Zhou XW, Liu S, Hu K, Wang C, He Q and Li M.
  TITLE     Calpain-truncated CRMP-3 and -4 contribute to potassium
            deprivation-induced apoptosis of cerebellar granule neurons
  JOURNAL   Proteomics 9 (14), 3712-3728 (2009)
   PUBMED   19639589
  REMARK    GeneRIF: The findings demonstrated that calpain-truncated CRMP-3
            and -4 act as pro-apoptotic players when CGNs undergo apoptosis.
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Fukada M, Watakabe I, Yuasa-Kawada J, Kawachi H, Kuroiwa A, Matsuda
            Y and Noda M.
  TITLE     Molecular characterization of CRMP5, a novel member of the
            collapsin response mediator protein family
  JOURNAL   J Biol Chem 275 (48), 37957-37965 (2000)
   PUBMED   10956643
REFERENCE   4  (bases 1 to 2628)
  AUTHORS   Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S,
            Yamamura H and Yanagi S.
  TITLE     Identification of CRAM, a novel unc-33 gene family protein that
            associates with CRMP3 and protein-tyrosine kinase(s) in the
            developing rat brain
  JOURNAL   J Biol Chem 275 (35), 27291-27302 (2000)
   PUBMED   10851247
REFERENCE   5  (bases 1 to 2628)
  AUTHORS   Wang LH and Strittmatter SM.
  TITLE     Brain CRMP forms heterotetramers similar to liver
            dihydropyrimidinase
  JOURNAL   J Neurochem 69 (6), 2261-2269 (1997)
   PUBMED   9375656
REFERENCE   6  (bases 1 to 2628)
  AUTHORS   Wang LH and Strittmatter SM.
  TITLE     A family of rat CRMP genes is differentially expressed in the
            nervous system
  JOURNAL   J Neurosci 16 (19), 6197-6207 (1996)
   PUBMED   8815901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000044.1.
            
            On Jun 3, 2021 this sequence version replaced NM_012933.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JACYVU010000044.1  20812363-20812515
            154-242             JACYVU010000044.1  20815852-20815940
            243-427             JACYVU010000044.1  20816502-20816686
            428-592             JACYVU010000044.1  20818195-20818359
            593-654             JACYVU010000044.1  20819936-20819997
            655-735             JACYVU010000044.1  20820082-20820162
            736-804             JACYVU010000044.1  20820679-20820747
            805-925             JACYVU010000044.1  20821135-20821255
            926-1082            JACYVU010000044.1  20822459-20822615
            1083-1224           JACYVU010000044.1  20822962-20823103
            1225-1395           JACYVU010000044.1  20824274-20824444
            1396-1575           JACYVU010000044.1  20824947-20825126
            1576-1741           JACYVU010000044.1  20826150-20826315
            1742-2628           JACYVU010000044.1  20827287-20828173
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2628
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="dihydropyrimidinase-like 4"
                     /db_xref="GeneID:25417"
                     /db_xref="RGD:2409"
     exon            1..153
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    34..36
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="upstream in-frame stop codon"
     CDS             115..1833
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="DRP-4; CRMP-3; ULIP4 protein; UNC33-like
                     phosphoprotein 4; ULIP-4; Collapsin response mediator
                     protein 3"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 4"
                     /protein_id="NP_037065.1"
                     /db_xref="GeneID:25417"
                     /db_xref="RGD:2409"
                     /translation="

MSFQGKKSIPRITSDRLLIKGGKIVNDDQSFHADLYVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDAGVSLLAAYEQWRERADSAACCDYSLHVDIPRWHESTKEELEALVRDKGVNSFLVFMAYKDRCQCTDGQIYEIFSLIRDLGAVAQVHAENGDIVEEEQKRLLEQGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYITKVMSKGAADMVAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPINPDPTTADHLTSLLSSGDLQVTGSAHCTFTTAQKAVGKDNFTLIPEGINGIEERMSVVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPRATKVISAKSHNLNVEYNIFEGVECRGMPTVVISQGRVVLEDGNLLVTPGAGRFIPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMLPAKPGSGTQARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS"

     misc_feature    163..1512
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="D-hydantoinases (D-HYD) also called
                     dihydropyrimidases (DHPase) and related proteins; DHPases
                     are a family of enzymes that catalyze the reversible
                     hydrolytic ring opening of the amide bond in five- or
                     six-membered cyclic diamides, like dihydropyrimidine...;
                     Region: D-HYD; cd01314"
                     /db_xref="CDD:238639"
     misc_feature    order(196..201,205..207,244..249,652..654,715..717,
                     724..726,733..735,802..804,814..816,826..828,835..837,
                     916..921,925..930,1282..1284,1297..1299,1312..1314)
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238639"
     misc_feature    order(331..333,337..339,607..609,706..708,874..876,
                     1108..1110)
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /note="active site"
                     /db_xref="CDD:238639"
     exon            154..242
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            243..427
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            428..592
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..654
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            655..735
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..804
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..925
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1082
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1224
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1395
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1575
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1741
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2628
                     /gene="Dpysl4"
                     /gene_synonym="Crmp3; Dpys4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cccagcgctgggctagctcacactcggacttcctaagctccgcgcgtgtccccgccggcacgtccacgcccgcgcagcccctaccgaggacacccagcccgcccgtggatcaggatgtccttccaaggcaagaagagcattccccggataacgagtgaccgccttctcatcaaaggtgggaagattgtgaatgatgaccagtcctttcatgcggatctctacgtggaggacggtctgattaaacaaattggagaaaatcttatcgtccctgggggaatcaaaaccatcgatgctcatggtctgatggtactgcctgggggagttgacgtccacacccggctgcagatgcctgtgctgggcatgaccccagccgatgatttctgtcagggcaccaaggctgccctagcaggcgggaccacgatgatattggaccatgtgtttcctgatgctggcgtgagcctgctggcggcctatgagcagtggcgggagcgagcagacagtgcagcctgctgtgactactccttacacgtggacattccccgctggcatgagagcaccaaagaggagctggaggccctagtcagggacaaaggtgtgaactccttcctggtcttcatggcttacaaggacaggtgccagtgtactgatggccagatatatgaaatcttcagcctcatccgggacctgggagctgtggcccaggtgcatgcagaaaacggggacatcgtggaggaggaacagaagcgcctgctggagcagggcatcactggtcctgagggccatgtgctcagccacccagaagaggtagaggccgaagctgtgtacagagctgtgaccattgccaagcaggccaactgcccactgtatatcaccaaggtgatgagcaagggtgcggctgatatggttgcccaagccaagcgcaggggggtggtcgtctttggggaacctatcactgccagcctgggcactgatggctcacactactggagcaagaactgggccaaggctgcagccttcgtcacatcaccccctatcaacccggaccctactactgcagaccacctcacctctctgctgtccagtggggacctccaggtgacaggcagtgcacactgcaccttcactactgcccagaaggctgttggcaaagataacttcacgctgatccccgagggcatcaacggtatagaagaacgcatgtctgtggtctgggagaaatgtgtggcttcagggaaaatggacgagaatgagttcgttgccgtgaccagcacaaatgctgccaaaatcttcaatttctaccccaggaaggggcgtgtggctgtgggctctgatgctgacctggtcatctggaaccccagggccacaaaagtcatctctgccaagagccataacctgaatgtagagtacaacatcttcgaaggagtggagtgcagaggcatgcccacggtggtcataagtcagggcagagtggtgctggaggacggaaacctgcttgtcactccaggggctggccgcttcattccccggaagacattcccagactttgtctataagaggataaaggctcgtaacaggctagcagagatccacggtgtgccccgaggcctgtatgatgggcctgtccacgaagtgatgttacctgccaagccagggagcggcacacaagcccgtgcatcctgtccaggcaagatctcagtgccacccgtgcgcaacctgcaccagtcagggttcagcctatctggctctcaggctgacgatcacattgccagacgcacagctcagaagatcatggcaccccccggaggacgctccaacatcacttcactttcttagacttggggtctggcaatgcaggtgctgtccccactggcagggtgtggggactactctcttcagttagctccttcctttgtagatcattattgtgaaaggtgctcagccttgccctccccctccccataaactctcttttggaagttcccagcccccagtctgaggcaccccctccagagggctgaatccagggagggttcactgccagagtgagaggattaggcagggcagtgagctggtgcctcttgccccacccctgaccttaccatgaaggccgtccacgagagctctcagcctccagcctgtgaactttccagggcctggtggtaggcagggtgggtgtttgctgctgccaccccctcagaaatcactgccctgtggaagcccccaagcttccaccagttccatgttgctaaaggtgcagcgaccccttgggggcctgtcccctctggctgccctggtgtagggaggagagcaggtgagcggagcctccgcttggcagagctgctgtgacttcagggatccaccagttactcagtgcagggtcgctccctcccacatagtcccttgcaaggaccaaacctgagctcctatagcagccgccctctagggagtttgatgatcccttagctaagacactttccttttcctacaaagtgtgttttcataggtttattagagtagctgttttggactgtgaggaaaccatagccagggatctgcatgctgctgtaccagacaccggccaccggccaagctgatttgagtcaggtcaataaaaagtctgggttcgaa

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