2024-05-08 12:04:44, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_012731 4755 bp mRNA linear ROD 30-OCT-2023 DEFINITION Rattus norvegicus neurotrophic receptor tyrosine kinase 2 (Ntrk2), transcript variant 1, mRNA. ACCESSION NM_012731 VERSION NM_012731.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4755) AUTHORS Andreska T, Luningschror P, Wolf D, McFleder RL, Ayon-Olivas M, Rattka M, Drechsler C, Perschin V, Blum R, Aufmkolk S, Granado N, Moratalla R, Sauer M, Monoranu C, Volkmann J, Ip CW, Stigloher C and Sendtner M. TITLE DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons JOURNAL Cell Rep 42 (6), 112575 (2023) PUBMED 37252844 REMARK GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons. REFERENCE 2 (bases 1 to 4755) AUTHORS Fogarty MJ, Dasgupta D, Khurram OU and Sieck GC. TITLE Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size JOURNAL Mol Cell Neurosci 125, 103847 (2023) PUBMED 36958643 REMARK GeneRIF: Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size. REFERENCE 3 (bases 1 to 4755) AUTHORS Serra MP, Sanna F, Boi M, Trucas M, Fernandez-Teruel A, Corda MG, Giorgi O and Quartu M. TITLE Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats JOURNAL Int J Mol Sci 24 (11), 9498 (2023) PUBMED 37298449 REMARK GeneRIF: Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats. Publication Status: Online-Only REFERENCE 4 (bases 1 to 4755) AUTHORS Ruiz-Viroga V, de Ceglia M, Morelli L, Castano EM, Calvo EB, Suarez J, Rodriguez de Fonseca F, Galeano P and Lagos P. TITLE Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors JOURNAL Prog Neuropsychopharmacol Biol Psychiatry 123, 110703 (2023) PUBMED 36565982 REMARK GeneRIF: Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. REFERENCE 5 (bases 1 to 4755) AUTHORS Cheng S, Xu J, Wang W, Wang R, Li H, Jiang Z, Liu D and Pan F. TITLE Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats JOURNAL Psychopharmacology (Berl) 240 (4), 837-851 (2023) PUBMED 36725696 REMARK GeneRIF: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats. Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. PMID: 37145309] REFERENCE 6 (bases 1 to 4755) AUTHORS Eide FF, Vining ER, Eide BL, Zang K, Wang XY and Reichardt LF. TITLE Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling JOURNAL J Neurosci 16 (10), 3123-3129 (1996) PUBMED 8627351 REFERENCE 7 (bases 1 to 4755) AUTHORS Middlemas DS, Meisenhelder J and Hunter T. TITLE Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor JOURNAL J Biol Chem 269 (7), 5458-5466 (1994) PUBMED 8106527 REFERENCE 8 (bases 1 to 4755) AUTHORS Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL and Barbacid M. TITLE Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death JOURNAL Cell 75 (1), 113-122 (1993) PUBMED 8402890 REFERENCE 9 (bases 1 to 4755) AUTHORS Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J, Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K and Parada LF. TITLE The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor JOURNAL Cell 65 (5), 895-903 (1991) PUBMED 1645620 REFERENCE 10 (bases 1 to 4755) AUTHORS Middlemas DS, Lindberg RA and Hunter T. TITLE trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors JOURNAL Mol Cell Biol 11 (1), 143-153 (1991) PUBMED 1846020 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000284.1. On Sep 24, 2021 this sequence version replaced NM_012731.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55291.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132297, SAMD00132307 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-322 JACYVU010000284.1 5868805-5869126 c 323-878 JACYVU010000284.1 5867876-5868431 c 879-953 JACYVU010000284.1 5836449-5836523 c 954-1025 JACYVU010000284.1 5836259-5836330 c 1026-1094 JACYVU010000284.1 5831504-5831572 c 1095-1249 JACYVU010000284.1 5828052-5828206 c 1250-1386 JACYVU010000284.1 5814097-5814233 c 1387-1519 JACYVU010000284.1 5813077-5813209 c 1520-1825 JACYVU010000284.1 5811893-5812198 c 1826-1861 JACYVU010000284.1 5801928-5801963 c 1862-1959 JACYVU010000284.1 5799638-5799735 c 1960-2059 JACYVU010000284.1 5794679-5794778 c 2060-2248 JACYVU010000284.1 5693911-5694099 c 2249-2379 JACYVU010000284.1 5636824-5636954 c 2380-2552 JACYVU010000284.1 5622589-5622761 c 2553-2787 JACYVU010000284.1 5616551-5616785 c 2788-2946 JACYVU010000284.1 5562513-5562671 c 2947-4755 JACYVU010000284.1 5559043-5560851 c FEATURES Location/Qualifiers source 1..4755 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="17" /map="17p14" gene 1..4755 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="neurotrophic receptor tyrosine kinase 2" /db_xref="GeneID:25054" /db_xref="RGD:3213" exon 1..322 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 323..878 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" misc_feature 475..477 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="upstream in-frame stop codon" CDS 667..3132 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /EC_number="2.7.10.1" /note="isoform 1 precursor is encoded by transcript variant 1; BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine receptor kinase type 2; neurotrophic tyrosine kinase, receptor, type 2" /codon_start=1 /product="BDNF/NT-3 growth factors receptor isoform 1 precursor" /protein_id="NP_036863.1" /db_xref="GeneID:25054" /db_xref="RGD:3213" /translation="
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG"
sig_peptide 667..759 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 760..3129 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /product="BDNF/NT-3 growth factors receptor. /id=PRO_0000016729" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1)" misc_feature 865..867 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 940..1116 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Leucine rich repeat; Region: LRR_8; pfam13855" /db_xref="CDD:404697" misc_feature 940..1005 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1); Region: LRR 1" misc_feature 949..951 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0007744|PubMed:24090084; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1012..1077 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1); Region: LRR 2" misc_feature 1027..1029 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1117..1251 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Tyrosine-protein kinase receptor C2 Ig-like domain; Region: TPKR_C2; pfam16920" /db_xref="CDD:435654" misc_feature 1198..1200 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1279..1515 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:448366" misc_feature 1279..1281 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1306..1320 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 1345..1356 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 1387..1389 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0007744|PubMed:24090084; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1399..1422 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 1426..1428 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1450..1470 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 1492..1503 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 1504..1506 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1522..1803 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains; Region: IgI_TrkB_d5; cd05855" /db_xref="CDD:409441" misc_feature 1522..1548 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand A [structural motif]; Region: Ig strand A" /db_xref="CDD:409441" misc_feature 1549..1560 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand A' [structural motif]; Region: Ig strand A'" /db_xref="CDD:409441" misc_feature 1567..1593 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409441" misc_feature 1594..1596 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="interdomain interface [polypeptide binding]; other site" /db_xref="CDD:409441" misc_feature 1600..1623 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409441" misc_feature 1630..1641 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand C' [structural motif]; Region: Ig strand C'" /db_xref="CDD:409441" misc_feature 1639..1641 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1654..1671 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand D [structural motif]; Region: Ig strand D" /db_xref="CDD:409441" misc_feature order(1669..1671,1711..1716,1723..1725) /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="receptor binding site [polypeptide binding]; other site" /db_xref="CDD:409441" misc_feature 1678..1680 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1687..1713 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409441" misc_feature 1714..1716 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1735..1761 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409441" misc_feature 1768..1794 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409441" misc_feature 1897..1899 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (Q63604.1); glycosylation site" misc_feature 1954..2025 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1); transmembrane region" misc_feature 2026..2061 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1); Region: Interaction with MAPK8IP3/JIP3. /evidence=ECO:0000269|PubMed:21775604" misc_feature 2086..2157 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="propagated from UniProtKB/Swiss-Prot (Q63604.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2209..2211 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Interaction with SHC1; propagated from UniProtKB/Swiss-Prot (Q63604.1); other site" misc_feature 2209..2211 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Phosphotyrosine, by autocatalysis. /evidence=ECO:0000250|UniProtKB:P15209; propagated from UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site" misc_feature 2257..3120 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; Region: PTKc_TrkB; cd05093" /db_xref="CDD:270675" misc_feature order(2293..2307,2317..2319,2371..2373,2377..2379, 2512..2523,2530..2535,2689..2691,2701..2706,2710..2712, 2743..2745,2797..2811,2836..2838,2938..2940) /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="active site" /db_xref="CDD:270675" misc_feature order(2293..2298,2302..2307,2317..2319,2371..2373, 2377..2379,2512..2523,2530..2535,2701..2706,2710..2712, 2743..2745) /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270675" misc_feature order(2689..2691,2701..2703,2797..2811,2836..2838, 2938..2940) /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270675" misc_feature 2740..2817 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="activation loop (A-loop); other site" /db_xref="CDD:270675" misc_feature 2767..2769 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Phosphotyrosine, by autocatalysis. /evidence=ECO:0000269|PubMed:8106527; propagated from UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site" misc_feature 2779..2781 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Interaction with SH2D1A; propagated from UniProtKB/Swiss-Prot (Q63604.1); other site" misc_feature 2779..2781 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Phosphotyrosine, by autocatalysis. /evidence=ECO:0000269|PubMed:8106527; propagated from UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site" misc_feature 2782..2784 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Phosphotyrosine, by autocatalysis. /evidence=ECO:0000269|PubMed:8106527; propagated from UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site" misc_feature 3112..3114 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Interaction with PLCG1. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (Q63604.1); other site" misc_feature 3112..3114 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /note="Phosphotyrosine, by autocatalysis. /evidence=ECO:0000269|PubMed:8106527; propagated from UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site" exon 879..953 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 954..1025 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1026..1094 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1095..1249 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1250..1386 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1387..1519 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1520..1825 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1826..1861 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1862..1959 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 1960..2059 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2060..2248 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2249..2379 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2380..2552 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2553..2787 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2788..2946 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" exon 2947..4755 /gene="Ntrk2" /gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1" /inference="alignment:Splign:2.1.0" ORIGIN
gtgcgtgtgcgtgcgtgcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgagcgtgtgtgtttttggatttcatactaattttctggagtttctgcccctgctctgcgtcagccctcacgtcacttcgccagcagtagcagaggcggcggcggccgccggttagagcccagtcgctgcttcagctgctgttgctgcttctgcggcgctctgctccctgcgctggctacgggaggccgggggagccgcgccgacagtcctctgtggccagggccggcactgtcctgctaccgcagttgctccccagccctgaggtgcgcaccgatatcgatatccgtgccggtttagcggttctgcgacccaaagagtccagggagagccaccgagtggcgcctggcgtataggaccatgcagccgccttgtggcttggagcagcggcccgtgatgttccagccactgtgaaccatttggtcagcgccaacctgctcagccccagcaccgacaggctcagcctctggtacgctcctctcggcgggaggccatcagcaccaagcagcaagagggctcagggaaggcctcccccctccggcgggggacgcctggctcagcgtagggacacgcactctgactgactggcactggcagctcgggatgtcgccctggccgaggtggcatggacccgccatggcgcggctctggggcttatgcttgctggtcttgggcttctggagggcttctcttgcctgccccatgtcctgcaaatgcagcaccactaggatttggtgtaccgagccttctcctggcatcgtggcatttccgaggttggaacctaacagcattgacccagagaacatcaccgaaattctcattgcaaaccagaaaaggttagaaatcatcaatgaagatgatgtcgaagcttacgtggggctgaaaaaccttacaattgtggattccggcttaaagtttgtggcttacaaggcgtttctgaagaacggcaacctgcggcacatcaatttcactcgaaacaagctgacgagtttgtccaggagacatttccgccaccttgacttgtctgacctgatcctgacgggtaatccgttcacgtgttcctgtgacatcatgtggctcaagactctccaggagacgaaatccagccccgacactcaggatttgtattgcctcaatgagagcagcaagaatacccctctggcgaacctgcagattcccaattgtggtctgccgtctgcacgtctggccgctcctaacctcacggtggaggaagggaagtctgtgaccatttcctgcagcgtcgggggtgacccgctccccaccttgtactgggacgttgggaatttggtttccaaacacatgaatgaaacaagccacacacagggctccttaaggataacaaacatttcatcggatgacagtgggaaacaaatctcttgtgtggcagaaaacctcgttggagaagatcaagactctgtgaacctcactgtgcattttgcaccaaccatcacatttctcgaatctccaacctcagaccaccactggtgcatcccattcactgtgagaggcaaccccaagccagcacttcagtggttctacaacggagccatactgaatgaatccaagtacatctgtaccaaaatacacgtcaccaatcacacggagtaccacggctgcctccagctggataaccccactcatatgaataatggagactacaccctaatggccaagaatgaatatgggaaggacgagagacagatttctgctcacttcatgggccggcctggagttgactatgagacaaacccaaattaccctgaagtcctctatgaagactggaccacgccaactgacatcggggatactacaaacaaaagtaatgagatcccctccacggatgttgctgaccaaaccaatcgggagcatctctcggtctatgccgtggtggtgattgcctctgtggtaggattctgcctgctggtgatgctgcttctgctcaagttggcgagacattccaagtttggcatgaaaggcccagcttccgtcatcagcaacgacgatgactctgccagccctctccaccacatctccaacgggagcaacactccgtcttcttcggagggcgggcccgatgctgtcatcattgggatgaccaagatccctgtcattgaaaacccccagtacttcggtatcaccaacagccagctcaagccggacacatttgttcagcacatcaagagacacaacatcgttctgaagagggagcttggagaaggagcctttgggaaagttttcctagcggagtgctataacctctgccccgagcaggataagatcctggtggccgtgaagacgctgaaggacgccagcgacaatgctcgcaaggactttcatcgcgaagccgagctgctgaccaacctccagcacgagcacattgtcaagttctacggtgtctgtgtggagggcgacccactcatcatggtctttgagtacatgaagcacggggacctcaacaagttccttagggcacacgggccagatgcagtgctgatggcagagggtaacccgcccaccgagctgacgcagtcgcagatgctgcacatcgctcagcaaatcgcagcaggcatggtctacctggcatcccaacacttcgtgcaccgagacctggccacccggaactgcttggtaggagagaacctgctggtgaaaattggggacttcgggatgtcccgggatgtatacagcaccgactactaccgggttggtggccacacaatgttgcccatccgatggatgcctccagagagcatcatgtacaggaaattcaccaccgagagtgacgtctggagcctgggagttgtgttgtgggagatcttcacctacggcaagcagccctggtatcagctatcaaacaacgaggtgatagaatgcatcacccagggcagagtccttcagcggcctcgcacgtgtccccaggaggtgtacgagctgatgctgggatgctggcagcgggaaccacacacaaggaagaacatcaagaacatccacacactccttcagaacttggcgaaggcgtcgcccgtctacctggacatcctaggctagactccctcttctcccagacggcccttcccaaggcacccctcagacctcttaactgccgctgatgtcaccaccttgctgtccttcgctctgacagtgttaacaagacaaggagcggctctccggggtgaggcagtgcgcacttccccatccacagacagtatcgactcgcttctggctttgtcgctttctctccctttggtttgtttctttcttttgcccattctccatttatttatttatttatttatttatttatttatttatttatctatctatctatctatctatctatctatttatttatttattggtcttcactgcttcatggtcctcggcctctctccttgaccgatctggcttctgtactcctattcactgtacatagacaaaggccttaacaaacctgatttgttatatcagcagacactccagtttgcccaccacaactaacaatgccttgttgtattcctgcctttgatgtggatgaaaaaaagggaaaaaaaaataatcaaacatctgacttaaaccgtcacttccgatgtacagacacggggcgtttctatggattcacttctatctatctatttatttatttatctatttatttatttctcttctttgttgttttccggtggttttagcctgtgtatgagaagggaaagtcatgtacagtctgggaaaactttatctgtgggaaatggaaaccagaaagggaaagaagctttaccataaagcacagcaggagtgagacacagaaaagccattggatcagccagagtccgtcctgcataggaaaacccagcagccatcaggctggaggatcatgttcggcactgacccccgaggacctttctgaggaggacacagaatgttaaactctgcatcatggacacagtttccgatcacagatactggccttcaatggaaaaaaaaaaaaacccagatagttcttgtgagacctggacagcacgtccaacatccagacattgtggtcgggcacagtgacagagttgatgcatttctcacgggttattctacagagcttttgtcaagtccaatggaaggaggtagattcttgttcagatatgatttcgggaaaaaccgagtccttgacaaagacaggagacaccctcagttgggaggcaagtttctcttaccttggactttctcacacagcaattctcacccccaccccctccactctcacctgtcttgtaactgtgcaaacaaaagtgtgcatggtctttgtcagttgatacctttgtgcacctctgtgcagaaactgctgtctgtcccggctgtggtacccgatcagtggggtagatccacgaaaggtctcattttaggccgctttgggaaggtaaccagatcggtagctggaagcactctccagtaggtggcgaagggtgagtgggtctgctgaagcctgcatatcttcacccacctcaaacccaccgggctgcacaggggacaggcacaggccacccctgagggacagggaagctctcttgggataccacctgagtttacattcagtgtgctcaggtcaagtctctcgctcggggctctgtttcggggagaatggtttcattccaacgcactcattatcaggattctgttttc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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