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Previous release (v1)
2024-04-29 12:08:00, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_012731 4755 bp mRNA linear ROD 30-OCT-2023
DEFINITION Rattus norvegicus neurotrophic receptor tyrosine kinase 2 (Ntrk2),
transcript variant 1, mRNA.
ACCESSION NM_012731
VERSION NM_012731.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4755)
AUTHORS Andreska T, Luningschror P, Wolf D, McFleder RL, Ayon-Olivas M,
Rattka M, Drechsler C, Perschin V, Blum R, Aufmkolk S, Granado N,
Moratalla R, Sauer M, Monoranu C, Volkmann J, Ip CW, Stigloher C
and Sendtner M.
TITLE DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
direct pathway striatal medium spiny neurons
JOURNAL Cell Rep 42 (6), 112575 (2023)
PUBMED 37252844
REMARK GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE 2 (bases 1 to 4755)
AUTHORS Fogarty MJ, Dasgupta D, Khurram OU and Sieck GC.
TITLE Chemogenetic inhibition of TrkB signalling reduces phrenic motor
neuron survival and size
JOURNAL Mol Cell Neurosci 125, 103847 (2023)
PUBMED 36958643
REMARK GeneRIF: Chemogenetic inhibition of TrkB signalling reduces phrenic
motor neuron survival and size.
REFERENCE 3 (bases 1 to 4755)
AUTHORS Serra MP, Sanna F, Boi M, Trucas M, Fernandez-Teruel A, Corda MG,
Giorgi O and Quartu M.
TITLE Effects of Tail Pinch on BDNF and trkB Expression in the
Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats
JOURNAL Int J Mol Sci 24 (11), 9498 (2023)
PUBMED 37298449
REMARK GeneRIF: Effects of Tail Pinch on BDNF and trkB Expression in the
Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4755)
AUTHORS Ruiz-Viroga V, de Ceglia M, Morelli L, Castano EM, Calvo EB, Suarez
J, Rodriguez de Fonseca F, Galeano P and Lagos P.
TITLE Acute intrahippocampal administration of melanin-concentrating
hormone impairs memory consolidation and decreases the expression
of MCHR-1 and TrkB receptors
JOURNAL Prog Neuropsychopharmacol Biol Psychiatry 123, 110703 (2023)
PUBMED 36565982
REMARK GeneRIF: Acute intrahippocampal administration of
melanin-concentrating hormone impairs memory consolidation and
decreases the expression of MCHR-1 and TrkB receptors.
REFERENCE 5 (bases 1 to 4755)
AUTHORS Cheng S, Xu J, Wang W, Wang R, Li H, Jiang Z, Liu D and Pan F.
TITLE Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the
prefrontal cortex and hippocampus and ameliorates PTSD-like
behavior in rats
JOURNAL Psychopharmacology (Berl) 240 (4), 837-851 (2023)
PUBMED 36725696
REMARK GeneRIF: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression
in the prefrontal cortex and hippocampus and ameliorates PTSD-like
behavior in rats.
Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. PMID:
37145309]
REFERENCE 6 (bases 1 to 4755)
AUTHORS Eide FF, Vining ER, Eide BL, Zang K, Wang XY and Reichardt LF.
TITLE Naturally occurring truncated trkB receptors have dominant
inhibitory effects on brain-derived neurotrophic factor signaling
JOURNAL J Neurosci 16 (10), 3123-3129 (1996)
PUBMED 8627351
REFERENCE 7 (bases 1 to 4755)
AUTHORS Middlemas DS, Meisenhelder J and Hunter T.
TITLE Identification of TrkB autophosphorylation sites and evidence that
phospholipase C-gamma 1 is a substrate of the TrkB receptor
JOURNAL J Biol Chem 269 (7), 5458-5466 (1994)
PUBMED 8106527
REFERENCE 8 (bases 1 to 4755)
AUTHORS Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL and
Barbacid M.
TITLE Targeted disruption of the trkB neurotrophin receptor gene results
in nervous system lesions and neonatal death
JOURNAL Cell 75 (1), 113-122 (1993)
PUBMED 8402890
REFERENCE 9 (bases 1 to 4755)
AUTHORS Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J,
Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K and Parada
LF.
TITLE The neurotrophic factors brain-derived neurotrophic factor and
neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
JOURNAL Cell 65 (5), 895-903 (1991)
PUBMED 1645620
REFERENCE 10 (bases 1 to 4755)
AUTHORS Middlemas DS, Lindberg RA and Hunter T.
TITLE trkB, a neural receptor protein-tyrosine kinase: evidence for a
full-length and two truncated receptors
JOURNAL Mol Cell Biol 11 (1), 143-153 (1991)
PUBMED 1846020
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000284.1.
On Sep 24, 2021 this sequence version replaced NM_012731.2.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M55291.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMD00132297, SAMD00132307
[ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-322 JACYVU010000284.1 5868805-5869126 c
323-878 JACYVU010000284.1 5867876-5868431 c
879-953 JACYVU010000284.1 5836449-5836523 c
954-1025 JACYVU010000284.1 5836259-5836330 c
1026-1094 JACYVU010000284.1 5831504-5831572 c
1095-1249 JACYVU010000284.1 5828052-5828206 c
1250-1386 JACYVU010000284.1 5814097-5814233 c
1387-1519 JACYVU010000284.1 5813077-5813209 c
1520-1825 JACYVU010000284.1 5811893-5812198 c
1826-1861 JACYVU010000284.1 5801928-5801963 c
1862-1959 JACYVU010000284.1 5799638-5799735 c
1960-2059 JACYVU010000284.1 5794679-5794778 c
2060-2248 JACYVU010000284.1 5693911-5694099 c
2249-2379 JACYVU010000284.1 5636824-5636954 c
2380-2552 JACYVU010000284.1 5622589-5622761 c
2553-2787 JACYVU010000284.1 5616551-5616785 c
2788-2946 JACYVU010000284.1 5562513-5562671 c
2947-4755 JACYVU010000284.1 5559043-5560851 c
FEATURES Location/Qualifiers
source 1..4755
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="17"
/map="17p14"
gene 1..4755
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="neurotrophic receptor tyrosine kinase 2"
/db_xref="GeneID:25054"
/db_xref="RGD:3213"
exon 1..322
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 323..878
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
misc_feature 475..477
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="upstream in-frame stop codon"
CDS 667..3132
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/EC_number="2.7.10.1"
/note="isoform 1 precursor is encoded by transcript
variant 1; BDNF/NT-3 growth factors receptor;
GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; neural
receptor protein-tyrosine kinase (trkB); neurotrophic
tyrosine receptor kinase type 2; neurotrophic tyrosine
kinase, receptor, type 2"
/codon_start=1
/product="BDNF/NT-3 growth factors receptor isoform 1
precursor"
/protein_id="NP_036863.1"
/db_xref="GeneID:25054"
/db_xref="RGD:3213"
/translation="
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG"
sig_peptide 667..759
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 760..3129
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/product="BDNF/NT-3 growth factors receptor.
/id=PRO_0000016729"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1)"
misc_feature 865..867
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 940..1116
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Leucine rich repeat; Region: LRR_8; pfam13855"
/db_xref="CDD:404697"
misc_feature 940..1005
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1);
Region: LRR 1"
misc_feature 949..951
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1012..1077
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1);
Region: LRR 2"
misc_feature 1027..1029
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1117..1251
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Tyrosine-protein kinase receptor C2 Ig-like domain;
Region: TPKR_C2; pfam16920"
/db_xref="CDD:435654"
misc_feature 1198..1200
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1279..1515
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:448366"
misc_feature 1279..1281
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1306..1320
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409353"
misc_feature 1345..1356
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409353"
misc_feature 1387..1389
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1399..1422
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409353"
misc_feature 1426..1428
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1450..1470
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409353"
misc_feature 1492..1503
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand G [structural motif]; Region: Ig strand
G"
/db_xref="CDD:409353"
misc_feature 1504..1506
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1522..1803
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Fifth domain (immunoglobulin-like) of Trk receptor
TrkB; member of the I-set of Ig superfamily (IgSF)
domains; Region: IgI_TrkB_d5; cd05855"
/db_xref="CDD:409441"
misc_feature 1522..1548
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand A [structural motif]; Region: Ig strand
A"
/db_xref="CDD:409441"
misc_feature 1549..1560
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand A' [structural motif]; Region: Ig strand
A'"
/db_xref="CDD:409441"
misc_feature 1567..1593
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409441"
misc_feature 1594..1596
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="interdomain interface [polypeptide binding]; other
site"
/db_xref="CDD:409441"
misc_feature 1600..1623
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409441"
misc_feature 1630..1641
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand C' [structural motif]; Region: Ig strand
C'"
/db_xref="CDD:409441"
misc_feature 1639..1641
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1654..1671
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand D [structural motif]; Region: Ig strand
D"
/db_xref="CDD:409441"
misc_feature order(1669..1671,1711..1716,1723..1725)
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="receptor binding site [polypeptide binding]; other
site"
/db_xref="CDD:409441"
misc_feature 1678..1680
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1687..1713
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409441"
misc_feature 1714..1716
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1735..1761
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409441"
misc_feature 1768..1794
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Ig strand G [structural motif]; Region: Ig strand
G"
/db_xref="CDD:409441"
misc_feature 1897..1899
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63604.1); glycosylation site"
misc_feature 1954..2025
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1);
transmembrane region"
misc_feature 2026..2061
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1);
Region: Interaction with MAPK8IP3/JIP3.
/evidence=ECO:0000269|PubMed:21775604"
misc_feature 2086..2157
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="propagated from UniProtKB/Swiss-Prot (Q63604.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2209..2211
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Interaction with SHC1; propagated from
UniProtKB/Swiss-Prot (Q63604.1); other site"
misc_feature 2209..2211
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:P15209; propagated from
UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site"
misc_feature 2257..3120
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Tropomyosin Related Kinase B; Region: PTKc_TrkB; cd05093"
/db_xref="CDD:270675"
misc_feature order(2293..2307,2317..2319,2371..2373,2377..2379,
2512..2523,2530..2535,2689..2691,2701..2706,2710..2712,
2743..2745,2797..2811,2836..2838,2938..2940)
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="active site"
/db_xref="CDD:270675"
misc_feature order(2293..2298,2302..2307,2317..2319,2371..2373,
2377..2379,2512..2523,2530..2535,2701..2706,2710..2712,
2743..2745)
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:270675"
misc_feature order(2689..2691,2701..2703,2797..2811,2836..2838,
2938..2940)
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:270675"
misc_feature 2740..2817
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:270675"
misc_feature 2767..2769
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000269|PubMed:8106527; propagated from
UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site"
misc_feature 2779..2781
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Interaction with SH2D1A; propagated from
UniProtKB/Swiss-Prot (Q63604.1); other site"
misc_feature 2779..2781
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000269|PubMed:8106527; propagated from
UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site"
misc_feature 2782..2784
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000269|PubMed:8106527; propagated from
UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site"
misc_feature 3112..3114
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Interaction with PLCG1. /evidence=ECO:0000250;
propagated from UniProtKB/Swiss-Prot (Q63604.1); other
site"
misc_feature 3112..3114
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000269|PubMed:8106527; propagated from
UniProtKB/Swiss-Prot (Q63604.1); phosphorylation site"
exon 879..953
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 954..1025
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1026..1094
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1095..1249
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1250..1386
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1387..1519
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1520..1825
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1826..1861
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1862..1959
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 1960..2059
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2060..2248
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2249..2379
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2380..2552
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2553..2787
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2788..2946
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
exon 2947..4755
/gene="Ntrk2"
/gene_synonym="RATTRKB1; Tkrb; trk-B; trkB; TRKB1"
/inference="alignment:Splign:2.1.0"
ORIGIN
gtgcgtgtgcgtgcgtgcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgagcgtgtgtgtttttggatttcatactaattttctggagtttctgcccctgctctgcgtcagccctcacgtcacttcgccagcagtagcagaggcggcggcggccgccggttagagcccagtcgctgcttcagctgctgttgctgcttctgcggcgctctgctccctgcgctggctacgggaggccgggggagccgcgccgacagtcctctgtggccagggccggcactgtcctgctaccgcagttgctccccagccctgaggtgcgcaccgatatcgatatccgtgccggtttagcggttctgcgacccaaagagtccagggagagccaccgagtggcgcctggcgtataggaccatgcagccgccttgtggcttggagcagcggcccgtgatgttccagccactgtgaaccatttggtcagcgccaacctgctcagccccagcaccgacaggctcagcctctggtacgctcctctcggcgggaggccatcagcaccaagcagcaagagggctcagggaaggcctcccccctccggcgggggacgcctggctcagcgtagggacacgcactctgactgactggcactggcagctcgggatgtcgccctggccgaggtggcatggacccgccatggcgcggctctggggcttatgcttgctggtcttgggcttctggagggcttctcttgcctgccccatgtcctgcaaatgcagcaccactaggatttggtgtaccgagccttctcctggcatcgtggcatttccgaggttggaacctaacagcattgacccagagaacatcaccgaaattctcattgcaaaccagaaaaggttagaaatcatcaatgaagatgatgtcgaagcttacgtggggctgaaaaaccttacaattgtggattccggcttaaagtttgtggcttacaaggcgtttctgaagaacggcaacctgcggcacatcaatttcactcgaaacaagctgacgagtttgtccaggagacatttccgccaccttgacttgtctgacctgatcctgacgggtaatccgttcacgtgttcctgtgacatcatgtggctcaagactctccaggagacgaaatccagccccgacactcaggatttgtattgcctcaatgagagcagcaagaatacccctctggcgaacctgcagattcccaattgtggtctgccgtctgcacgtctggccgctcctaacctcacggtggaggaagggaagtctgtgaccatttcctgcagcgtcgggggtgacccgctccccaccttgtactgggacgttgggaatttggtttccaaacacatgaatgaaacaagccacacacagggctccttaaggataacaaacatttcatcggatgacagtgggaaacaaatctcttgtgtggcagaaaacctcgttggagaagatcaagactctgtgaacctcactgtgcattttgcaccaaccatcacatttctcgaatctccaacctcagaccaccactggtgcatcccattcactgtgagaggcaaccccaagccagcacttcagtggttctacaacggagccatactgaatgaatccaagtacatctgtaccaaaatacacgtcaccaatcacacggagtaccacggctgcctccagctggataaccccactcatatgaataatggagactacaccctaatggccaagaatgaatatgggaaggacgagagacagatttctgctcacttcatgggccggcctggagttgactatgagacaaacccaaattaccctgaagtcctctatgaagactggaccacgccaactgacatcggggatactacaaacaaaagtaatgagatcccctccacggatgttgctgaccaaaccaatcgggagcatctctcggtctatgccgtggtggtgattgcctctgtggtaggattctgcctgctggtgatgctgcttctgctcaagttggcgagacattccaagtttggcatgaaaggcccagcttccgtcatcagcaacgacgatgactctgccagccctctccaccacatctccaacgggagcaacactccgtcttcttcggagggcgggcccgatgctgtcatcattgggatgaccaagatccctgtcattgaaaacccccagtacttcggtatcaccaacagccagctcaagccggacacatttgttcagcacatcaagagacacaacatcgttctgaagagggagcttggagaaggagcctttgggaaagttttcctagcggagtgctataacctctgccccgagcaggataagatcctggtggccgtgaagacgctgaaggacgccagcgacaatgctcgcaaggactttcatcgcgaagccgagctgctgaccaacctccagcacgagcacattgtcaagttctacggtgtctgtgtggagggcgacccactcatcatggtctttgagtacatgaagcacggggacctcaacaagttccttagggcacacgggccagatgcagtgctgatggcagagggtaacccgcccaccgagctgacgcagtcgcagatgctgcacatcgctcagcaaatcgcagcaggcatggtctacctggcatcccaacacttcgtgcaccgagacctggccacccggaactgcttggtaggagagaacctgctggtgaaaattggggacttcgggatgtcccgggatgtatacagcaccgactactaccgggttggtggccacacaatgttgcccatccgatggatgcctccagagagcatcatgtacaggaaattcaccaccgagagtgacgtctggagcctgggagttgtgttgtgggagatcttcacctacggcaagcagccctggtatcagctatcaaacaacgaggtgatagaatgcatcacccagggcagagtccttcagcggcctcgcacgtgtccccaggaggtgtacgagctgatgctgggatgctggcagcgggaaccacacacaaggaagaacatcaagaacatccacacactccttcagaacttggcgaaggcgtcgcccgtctacctggacatcctaggctagactccctcttctcccagacggcccttcccaaggcacccctcagacctcttaactgccgctgatgtcaccaccttgctgtccttcgctctgacagtgttaacaagacaaggagcggctctccggggtgaggcagtgcgcacttccccatccacagacagtatcgactcgcttctggctttgtcgctttctctccctttggtttgtttctttcttttgcccattctccatttatttatttatttatttatttatttatttatttatttatctatctatctatctatctatctatctatttatttatttattggtcttcactgcttcatggtcctcggcctctctccttgaccgatctggcttctgtactcctattcactgtacatagacaaaggccttaacaaacctgatttgttatatcagcagacactccagtttgcccaccacaactaacaatgccttgttgtattcctgcctttgatgtggatgaaaaaaagggaaaaaaaaataatcaaacatctgacttaaaccgtcacttccgatgtacagacacggggcgtttctatggattcacttctatctatctatttatttatttatctatttatttatttctcttctttgttgttttccggtggttttagcctgtgtatgagaagggaaagtcatgtacagtctgggaaaactttatctgtgggaaatggaaaccagaaagggaaagaagctttaccataaagcacagcaggagtgagacacagaaaagccattggatcagccagagtccgtcctgcataggaaaacccagcagccatcaggctggaggatcatgttcggcactgacccccgaggacctttctgaggaggacacagaatgttaaactctgcatcatggacacagtttccgatcacagatactggccttcaatggaaaaaaaaaaaaacccagatagttcttgtgagacctggacagcacgtccaacatccagacattgtggtcgggcacagtgacagagttgatgcatttctcacgggttattctacagagcttttgtcaagtccaatggaaggaggtagattcttgttcagatatgatttcgggaaaaaccgagtccttgacaaagacaggagacaccctcagttgggaggcaagtttctcttaccttggactttctcacacagcaattctcacccccaccccctccactctcacctgtcttgtaactgtgcaaacaaaagtgtgcatggtctttgtcagttgatacctttgtgcacctctgtgcagaaactgctgtctgtcccggctgtggtacccgatcagtggggtagatccacgaaaggtctcattttaggccgctttgggaaggtaaccagatcggtagctggaagcactctccagtaggtggcgaagggtgagtgggtctgctgaagcctgcatatcttcacccacctcaaacccaccgggctgcacaggggacaggcacaggccacccctgagggacagggaagctctcttgggataccacctgagtttacattcagtgtgctcaggtcaagtctctcgctcggggctctgtttcggggagaatggtttcattccaacgcactcattatcaggattctgttttc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]