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Previous release (v1)
2024-04-20 01:23:32, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_012554 1754 bp mRNA linear ROD 23-MAR-2023
DEFINITION Rattus norvegicus enolase 1 (Eno1), transcript variant 1, mRNA.
ACCESSION NM_012554
VERSION NM_012554.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1754)
AUTHORS Li L, Luo Y, Zhang Y, Wei M, Zhang M, Liu H and Su Z.
TITLE CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in
CCI rat models
JOURNAL Gene 763, 145069 (2020)
PUBMED 32827683
REMARK GeneRIF: CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1
axis in CCI rat models.
REFERENCE 2 (bases 1 to 1754)
AUTHORS El Waly B, Mignon-Ravix C, Cacciagli P, Buhler E, Ben Zeev B and
Villard L.
TITLE Molecular characterization of a 1p36 chromosomal duplication and in
utero interference define ENO1 as a candidate gene for
polymicrogyria
JOURNAL Eur J Hum Genet 28 (12), 1703-1713 (2020)
PUBMED 32488097
REMARK GeneRIF: Molecular characterization of a 1p36 chromosomal
duplication and in utero interference define ENO1 as a candidate
gene for polymicrogyria.
REFERENCE 3 (bases 1 to 1754)
AUTHORS Zhang ZH, Zhang H, Wang YR, Liu XL, Huang H and Xu XH.
TITLE SIRT 1 binding with PKM and NSE and modulate their acetylation and
activities
JOURNAL Biochim Biophys Acta Proteins Proteom 1867 (9), 794-801 (2019)
PUBMED 31202897
REMARK GeneRIF: SIRT1 may regulate acetylation level of NSE and PKM
through deacetylation and further regulate their catalytic
activity.
REFERENCE 4 (bases 1 to 1754)
AUTHORS Dai J, Zhou Q, Chen J, Rexius-Hall ML, Rehman J and Zhou G.
TITLE Alpha-enolase regulates the malignant phenotype of pulmonary artery
smooth muscle cells via the AMPK-Akt pathway
JOURNAL Nat Commun 9 (1), 3850 (2018)
PUBMED 30242159
REMARK GeneRIF: regulates the metabolic reprogramming and malignant
phenotype of pulmonary artery smooth muscle cells in pulmonary
arterial hypertension
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1754)
AUTHORS Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW,
Roeder RG, Zhao Y and Li X.
TITLE p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
JOURNAL Mol Cell 70 (4), 663-678 (2018)
PUBMED 29775581
REMARK Erratum:[Mol Cell. 2018 Jun 7;70(5):984. Title and abstract
corrected. PMID: 29883613]
REFERENCE 6 (bases 1 to 1754)
AUTHORS Ray R and Miller DM.
TITLE Cloning and characterization of a human c-myc promoter-binding
protein
JOURNAL Mol Cell Biol 11 (4), 2154-2161 (1991)
PUBMED 2005901
REFERENCE 7 (bases 1 to 1754)
AUTHORS Berry MN, Gregory RB, Grivell AR, Henly DC, Phillips JW, Wallace PG
and Welch GR.
TITLE Evidence that stimulation of gluconeogenesis by fatty acid is
mediated through thermodynamic mechanisms
JOURNAL FEBS Lett 231 (1), 19-24 (1988)
PUBMED 2966075
REFERENCE 8 (bases 1 to 1754)
AUTHORS Giallongo,A., Feo,S., Moore,R., Croce,C.M. and Showe,L.C.
TITLE Molecular cloning and nucleotide sequence of a full-length cDNA for
human alpha enolase
JOURNAL Proc Natl Acad Sci U S A 83 (18), 6741-6745 (1986)
PUBMED 3529090
REFERENCE 9 (bases 1 to 1754)
AUTHORS Sakimura,K., Kushiya,E., Obinata,M. and Takahashi,Y.
TITLE Molecular cloning and the nucleotide sequence of cDNA to mRNA for
non-neuronal enolase (alpha alpha enolase) of rat brain and liver
JOURNAL Nucleic Acids Res 13 (12), 4365-4378 (1985)
PUBMED 2989793
REFERENCE 10 (bases 1 to 1754)
AUTHORS Jorgensen,O.S. and Centervall,G.
TITLE Alpha gamma-enolase in the rat: ontogeny and tissue distribution
JOURNAL J Neurochem 39 (2), 537-542 (1982)
PUBMED 7086434
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CB809779.1 and BC091572.1.
On Jun 6, 2012 this sequence version replaced NM_012554.2.
Transcript Variant: This variant (1) represents the shorter
transcript. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FQ225935.1, BC063174.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00132261, SAMD00132262
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-30 CB809779.1 1-30
31-1754 BC091572.1 1-1724
FEATURES Location/Qualifiers
source 1..1754
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..1754
/gene="Eno1"
/gene_synonym="Nne"
/note="enolase 1"
/db_xref="GeneID:24333"
/db_xref="RGD:2553"
exon 1..112
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
misc_feature 11..13
/gene="Eno1"
/gene_synonym="Nne"
/note="upstream in-frame stop codon"
exon 113..206
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
CDS 122..1426
/gene="Eno1"
/gene_synonym="Nne"
/EC_number="4.2.1.11"
/note="non-neural enolase; 2-phospho-D-glycerate
hydro-lyase; enolase 1, alpha non-neuron; enolase 1,
(alpha)"
/codon_start=1
/product="alpha-enolase"
/protein_id="NP_036686.2"
/db_xref="GeneID:24333"
/db_xref="RGD:2553"
/translation="
MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK"
misc_feature 125..1417
/gene="Eno1"
/gene_synonym="Nne"
/note="enolase; Region: PLN00191"
/db_xref="CDD:215095"
misc_feature 125..127
/gene="Eno1"
/gene_synonym="Nne"
/note="N-acetylserine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 134..136
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 251..253
/gene="Eno1"
/gene_synonym="Nne"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); phosphorylation site"
misc_feature 299..301
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P17182; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 311..313
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 332..334
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 386..388
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 497..499
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 698..700
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 716..718
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 725..727
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P17182; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 803..805
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 818..820
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 887..889
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 908..910
/gene="Eno1"
/gene_synonym="Nne"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); phosphorylation site"
misc_feature 962..964
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 974..976
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 980..982
/gene="Eno1"
/gene_synonym="Nne"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); phosphorylation site"
misc_feature 992..994
/gene="Eno1"
/gene_synonym="Nne"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); phosphorylation site"
misc_feature 1124..1126
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P17182; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 1148..1150
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P17182; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 1334..1423
/gene="Eno1"
/gene_synonym="Nne"
/note="propagated from UniProtKB/Swiss-Prot (P04764.4);
Region: Required for interaction with PLG.
/evidence=ECO:0000269|PubMed:7964722"
misc_feature 1337..1339
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P17182; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
misc_feature 1379..1381
/gene="Eno1"
/gene_synonym="Nne"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P06733; propagated from
UniProtKB/Swiss-Prot (P04764.4); acetylation site"
exon 207..302
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 303..361
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 362..431
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 432..565
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 566..788
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 789..986
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 987..1188
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 1189..1297
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 1298..1356
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
exon 1357..1731
/gene="Eno1"
/gene_synonym="Nne"
/inference="alignment:Splign:2.1.0"
ORIGIN
gggaggcgcttagtgctgctccggtaccgagtcgcgctcacgtttgtccttaagactcccttcggtgtctccaggaccctctttccttcctccgcagcgatcctactgccagaacttcaccatgtccattctcaagatccatgccagagagatctttgactcccgcgggaatcccaccgttgaggtggatctctacaccgcaaaaggtctcttccgtgctgcggtgcccagcggtgcgtccactggcatctacgaggccctagaactccgagacaatgataagacccgcttcatggggaagggtgtctcaaaggctgttgagcacatcaataaaactattgcacctgctctggttagcaagaaactgaatgttgtggagcaggagaagattgaccagctgatgatcgagatggacggcacagagaataaatctaagtttggtgcaaatgccatcctgggagtgtccctggctgtctgcaaggctggtgccgtggagaagggggtgcccctttaccgtcacattgccgacttggccggcaaccctgaagtcatcctgccggtcccagctttcaatgtgatcaacggcggttctcatgctggcaacaagttggccatgcaagagttcatgatcctgcctgtgggggcatcctctttccgggaagccatgcgcattggagcagaggtttaccacaacctgaagaacgtcatcaaggagaagtacgggaaagacgccaccaatgtgggtgatgagggtggattcgcacctaacatcctggagaacaaagaagcactggagctgctcaagtctgccattgcaaaggccggctacactgaccaggttgtcatcggcatggatgtggctgcctccgagttctacagggctggcaagtatgacctggacttcaagtctccagatgatgccagccggtacatcacacccgaccagctggccgacctgtacaagtccttcatcaaggactacccagtggtgtccattgaagatccctttgaccaggacgactgggatgcttggcagaagttcacagctactgcaggcatccaggtggtgggggatgacctcacagtgaccaaccctaagcggatcgccaaggctgcaggcgaaaagtcctgcaactgcctcctgctcaaagtgaaccagattggctctgtgaccgagtctctgcaggcgtgtaagctggcccagtccaatggctggggtgtcatggtgtcccatcgatctggggagactgaggacactttcattgccgacctggtggtggggctctgcactgggcagatcaagactggtgccccctgccgatctgagcgcctggccaagtacaatcagatccttagaatcgaggaggagctgggcagcaaagccaagtttgccggcaggtccttcaggaaccccctggccaagtaaggcatggaccggagatccctggagctaccagatcctctgtctctgtcatccaggcggctcaaggctggcccagtgcttgcccctcccatgtcactgcttccttagatgtccaccccgaccacctggagccctgctggagcccccagctttgtaatcatgtgatcagtctgaatcattgtttctgtcacctgactttccagctagtgtctggagccctctgaactccagcgtaatctctagggtgcccacaccatcaagactccccccagtggtttacttgcaaaaataaaagctgcagaagcccaaaaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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