2024-05-04 17:17:54, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_012554 1754 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus enolase 1 (Eno1), transcript variant 1, mRNA. ACCESSION NM_012554 VERSION NM_012554.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1754) AUTHORS Li L, Luo Y, Zhang Y, Wei M, Zhang M, Liu H and Su Z. TITLE CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models JOURNAL Gene 763, 145069 (2020) PUBMED 32827683 REMARK GeneRIF: CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models. REFERENCE 2 (bases 1 to 1754) AUTHORS El Waly B, Mignon-Ravix C, Cacciagli P, Buhler E, Ben Zeev B and Villard L. TITLE Molecular characterization of a 1p36 chromosomal duplication and in utero interference define ENO1 as a candidate gene for polymicrogyria JOURNAL Eur J Hum Genet 28 (12), 1703-1713 (2020) PUBMED 32488097 REMARK GeneRIF: Molecular characterization of a 1p36 chromosomal duplication and in utero interference define ENO1 as a candidate gene for polymicrogyria. REFERENCE 3 (bases 1 to 1754) AUTHORS Zhang ZH, Zhang H, Wang YR, Liu XL, Huang H and Xu XH. TITLE SIRT 1 binding with PKM and NSE and modulate their acetylation and activities JOURNAL Biochim Biophys Acta Proteins Proteom 1867 (9), 794-801 (2019) PUBMED 31202897 REMARK GeneRIF: SIRT1 may regulate acetylation level of NSE and PKM through deacetylation and further regulate their catalytic activity. REFERENCE 4 (bases 1 to 1754) AUTHORS Dai J, Zhou Q, Chen J, Rexius-Hall ML, Rehman J and Zhou G. TITLE Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway JOURNAL Nat Commun 9 (1), 3850 (2018) PUBMED 30242159 REMARK GeneRIF: regulates the metabolic reprogramming and malignant phenotype of pulmonary artery smooth muscle cells in pulmonary arterial hypertension Publication Status: Online-Only REFERENCE 5 (bases 1 to 1754) AUTHORS Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y and Li X. TITLE p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis JOURNAL Mol Cell 70 (4), 663-678 (2018) PUBMED 29775581 REMARK Erratum:[Mol Cell. 2018 Jun 7;70(5):984. Title and abstract corrected. PMID: 29883613] REFERENCE 6 (bases 1 to 1754) AUTHORS Ray R and Miller DM. TITLE Cloning and characterization of a human c-myc promoter-binding protein JOURNAL Mol Cell Biol 11 (4), 2154-2161 (1991) PUBMED 2005901 REFERENCE 7 (bases 1 to 1754) AUTHORS Berry MN, Gregory RB, Grivell AR, Henly DC, Phillips JW, Wallace PG and Welch GR. TITLE Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms JOURNAL FEBS Lett 231 (1), 19-24 (1988) PUBMED 2966075 REFERENCE 8 (bases 1 to 1754) AUTHORS Giallongo,A., Feo,S., Moore,R., Croce,C.M. and Showe,L.C. TITLE Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase JOURNAL Proc Natl Acad Sci U S A 83 (18), 6741-6745 (1986) PUBMED 3529090 REFERENCE 9 (bases 1 to 1754) AUTHORS Sakimura,K., Kushiya,E., Obinata,M. and Takahashi,Y. TITLE Molecular cloning and the nucleotide sequence of cDNA to mRNA for non-neuronal enolase (alpha alpha enolase) of rat brain and liver JOURNAL Nucleic Acids Res 13 (12), 4365-4378 (1985) PUBMED 2989793 REFERENCE 10 (bases 1 to 1754) AUTHORS Jorgensen,O.S. and Centervall,G. TITLE Alpha gamma-enolase in the rat: ontogeny and tissue distribution JOURNAL J Neurochem 39 (2), 537-542 (1982) PUBMED 7086434 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB809779.1 and BC091572.1. On Jun 6, 2012 this sequence version replaced NM_012554.2. Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ225935.1, BC063174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-30 CB809779.1 1-30 31-1754 BC091572.1 1-1724 FEATURES Location/Qualifiers source 1..1754 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="5" /map="5q36" gene 1..1754 /gene="Eno1" /gene_synonym="Nne" /note="enolase 1" /db_xref="GeneID:24333" /db_xref="RGD:2553" exon 1..112 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" misc_feature 11..13 /gene="Eno1" /gene_synonym="Nne" /note="upstream in-frame stop codon" exon 113..206 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" CDS 122..1426 /gene="Eno1" /gene_synonym="Nne" /EC_number="4.2.1.11" /note="non-neural enolase; 2-phospho-D-glycerate hydro-lyase; enolase 1, alpha non-neuron; enolase 1, (alpha)" /codon_start=1 /product="alpha-enolase" /protein_id="NP_036686.2" /db_xref="GeneID:24333" /db_xref="RGD:2553" /translation="
MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK"
misc_feature 125..1417 /gene="Eno1" /gene_synonym="Nne" /note="enolase; Region: PLN00191" /db_xref="CDD:215095" misc_feature 125..127 /gene="Eno1" /gene_synonym="Nne" /note="N-acetylserine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 134..136 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 251..253 /gene="Eno1" /gene_synonym="Nne" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); phosphorylation site" misc_feature 299..301 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P17182; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 311..313 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 332..334 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 386..388 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 497..499 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 698..700 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 716..718 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 725..727 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P17182; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 803..805 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 818..820 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 887..889 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 908..910 /gene="Eno1" /gene_synonym="Nne" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); phosphorylation site" misc_feature 962..964 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 974..976 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 980..982 /gene="Eno1" /gene_synonym="Nne" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); phosphorylation site" misc_feature 992..994 /gene="Eno1" /gene_synonym="Nne" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); phosphorylation site" misc_feature 1124..1126 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P17182; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 1148..1150 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P17182; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 1334..1423 /gene="Eno1" /gene_synonym="Nne" /note="propagated from UniProtKB/Swiss-Prot (P04764.4); Region: Required for interaction with PLG. /evidence=ECO:0000269|PubMed:7964722" misc_feature 1337..1339 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P17182; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" misc_feature 1379..1381 /gene="Eno1" /gene_synonym="Nne" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P06733; propagated from UniProtKB/Swiss-Prot (P04764.4); acetylation site" exon 207..302 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 303..361 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 362..431 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 432..565 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 566..788 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 789..986 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 987..1188 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 1189..1297 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 1298..1356 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" exon 1357..1731 /gene="Eno1" /gene_synonym="Nne" /inference="alignment:Splign:2.1.0" ORIGIN
gggaggcgcttagtgctgctccggtaccgagtcgcgctcacgtttgtccttaagactcccttcggtgtctccaggaccctctttccttcctccgcagcgatcctactgccagaacttcaccatgtccattctcaagatccatgccagagagatctttgactcccgcgggaatcccaccgttgaggtggatctctacaccgcaaaaggtctcttccgtgctgcggtgcccagcggtgcgtccactggcatctacgaggccctagaactccgagacaatgataagacccgcttcatggggaagggtgtctcaaaggctgttgagcacatcaataaaactattgcacctgctctggttagcaagaaactgaatgttgtggagcaggagaagattgaccagctgatgatcgagatggacggcacagagaataaatctaagtttggtgcaaatgccatcctgggagtgtccctggctgtctgcaaggctggtgccgtggagaagggggtgcccctttaccgtcacattgccgacttggccggcaaccctgaagtcatcctgccggtcccagctttcaatgtgatcaacggcggttctcatgctggcaacaagttggccatgcaagagttcatgatcctgcctgtgggggcatcctctttccgggaagccatgcgcattggagcagaggtttaccacaacctgaagaacgtcatcaaggagaagtacgggaaagacgccaccaatgtgggtgatgagggtggattcgcacctaacatcctggagaacaaagaagcactggagctgctcaagtctgccattgcaaaggccggctacactgaccaggttgtcatcggcatggatgtggctgcctccgagttctacagggctggcaagtatgacctggacttcaagtctccagatgatgccagccggtacatcacacccgaccagctggccgacctgtacaagtccttcatcaaggactacccagtggtgtccattgaagatccctttgaccaggacgactgggatgcttggcagaagttcacagctactgcaggcatccaggtggtgggggatgacctcacagtgaccaaccctaagcggatcgccaaggctgcaggcgaaaagtcctgcaactgcctcctgctcaaagtgaaccagattggctctgtgaccgagtctctgcaggcgtgtaagctggcccagtccaatggctggggtgtcatggtgtcccatcgatctggggagactgaggacactttcattgccgacctggtggtggggctctgcactgggcagatcaagactggtgccccctgccgatctgagcgcctggccaagtacaatcagatccttagaatcgaggaggagctgggcagcaaagccaagtttgccggcaggtccttcaggaaccccctggccaagtaaggcatggaccggagatccctggagctaccagatcctctgtctctgtcatccaggcggctcaaggctggcccagtgcttgcccctcccatgtcactgcttccttagatgtccaccccgaccacctggagccctgctggagcccccagctttgtaatcatgtgatcagtctgaatcattgtttctgtcacctgactttccagctagtgtctggagccctctgaactccagcgtaatctctagggtgcccacaccatcaagactccccccagtggtttacttgcaaaaataaaagctgcagaagcccaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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