LOCUS       NM_001416483            3607 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ral guanine nucleotide dissociation stimulator
            (Ralgds), transcript variant 2, mRNA.
ACCESSION   NM_001416483 XM_006233750
VERSION     NM_001416483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ,
            Clevers H and Bos JL.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Kawai M, Kawashima S, Sakoda T, Toh R, Kikuchi A, Yamauchi-Takihara
            K, Kunisada K and Yokoyama M.
  TITLE     Ral GDP dissociation stimulator and Ral GTPase are involved in
            myocardial hypertrophy
  JOURNAL   Hypertension 41 (4), 956-962 (2003)
   PUBMED   12642511
  REMARK    GeneRIF: Ral GDP dissociation stimulator is involved in myocardial
            hypertrophy.
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Huang,L., Weng,X., Hofer,F., Martin,G.S. and Kim,S.H.
  TITLE     Three-dimensional structure of the Ras-interacting domain of RalGDS
  JOURNAL   Nat Struct Biol 4 (8), 609-615 (1997)
   PUBMED   9253406
  REMARK    Erratum:[Nat Struct Biol 1997 Oct;4(10):840]
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Hofer F, Fields S, Schneider C and Martin GS.
  TITLE     Activated Ras interacts with the Ral guanine nucleotide
            dissociation stimulator
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11089-11093 (1994)
   PUBMED   7972015
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA.
  TITLE     Characterization of a guanine nucleotide dissociation stimulator
            for a ras-related GTPase
  JOURNAL   EMBO J 12 (1), 339-347 (1993)
   PUBMED   8094051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000115.1.
            
            On Feb 3, 2023 this sequence version replaced XM_006233750.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JACYVU010000115.1  5316351-5316632
            283-393             JACYVU010000115.1  5324241-5324351
            394-587             JACYVU010000115.1  5325597-5325790
            588-683             JACYVU010000115.1  5326248-5326343
            684-877             JACYVU010000115.1  5327028-5327221
            878-1275            JACYVU010000115.1  5327469-5327866
            1276-1491           JACYVU010000115.1  5328568-5328783
            1492-1595           JACYVU010000115.1  5328956-5329059
            1596-1680           JACYVU010000115.1  5329422-5329506
            1681-1749           JACYVU010000115.1  5330670-5330738
            1750-1836           JACYVU010000115.1  5331054-5331140
            1837-1869           JACYVU010000115.1  5331587-5331619
            1870-1991           JACYVU010000115.1  5331888-5332009
            1992-2087           JACYVU010000115.1  5332130-5332225
            2088-2289           JACYVU010000115.1  5332429-5332630
            2290-2532           JACYVU010000115.1  5332740-5332982
            2533-2647           JACYVU010000115.1  5334094-5334208
            2648-3607           JACYVU010000115.1  5335910-5336869
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3607
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="ral guanine nucleotide dissociation stimulator"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
     exon            1..282
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2823
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ralGEF; ral guanine nucleotide exchange factor"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation stimulator
                     isoform 2"
                     /protein_id="NP_001403412.1"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
                     /translation="

MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLHPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF"

     misc_feature    433..843
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(490..492,670..672,682..687,694..696,703..708,
                     817..822,829..831,850..852)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    <856..>1179
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="DNA polymerase III subunit gamma/tau; Region:
                     PRK07003"
                     /db_xref="CDD:235906"
     misc_feature    1036..1107
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03386.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1222..2010
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(1321..1329,1366..1371,1375..1383,1387..1392,
                     1399..1404,1411..1413,1516..1518,1525..1530,1534..1542,
                     1546..1557,1561..1566,1624..1626,1633..1635,1648..1656,
                     1663..1665,1774..1782,1789..1797,1801..1809,1813..1824,
                     1867..1869,1879..1881,1984..1986,1993..1998)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
     misc_feature    2257..2397
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03386.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2470..2727
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Ras-associating (RA) domain found in Ral guanine
                     nucleotide dissociation stimulator (RalGDS) and similar
                     proteins; Region: RA_RalGDS; cd17209"
                     /db_xref="CDD:340729"
     misc_feature    order(2470..2481,2485..2487,2506..2532,2542..2547,
                     2569..2571,2578..2583,2587..2589)
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="RA-Ras interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:340729"
     misc_feature    2518..2520
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q12967; propagated from
                     UniProtKB/Swiss-Prot (Q03386.1); phosphorylation site"
     exon            283..393
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            394..587
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            588..683
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            684..877
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1275
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1491
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1595
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1680
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1749
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1836
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1869
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1991
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2087
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2289
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2532
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2647
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..3607
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcagagcgcaggcagcgcggagccgcgccggccggccctgcgcccacgccgccccgggtctcgcggcccgccggccacccgcgccaccgggagtcgtccatggtgcagcgcatgtgggccgaggcgtccgggcccatagggggcgccgagccgttgtttcccggctcccggcgcagccgcagcgtgtgggacgccgtgcgtctggaggtgggcgtccctgacagctgtccagtggtgctgcacagcttcacgcagctcgaccccgatctgccgcgcctggagagctctacgcaggagattggggaggagctgatcaacggggtcatctactccatctccctgcgcaaggttcagctacacccaggagccaccaagggccagcgctggctagggtgcgagaatgagtcagctctgaacctctacgagacttgcaaggtgcgcacggtgaaggccggtactctggagaagctggtggaacacctggtgcctgccttccagggcagtgacctttcctacgtcaccgtattcctgtgcacctacagagccttcacaaccactcagcaggtgctagacctgctgttcaaaaggtacggtagatgtgacgccctcacggcctcctctagatatggctgcatccttccctactccagtgaggacggcggaccacaggaccaactcaaaaatgccatctcttccatcctgggcacctggctggaccaatactccgaggacttctgtcaacccccggactttccctgcctcaagcagctggtggcttatgtgcagctcaacatgcctggctcagacctggagcgccgtgctcaccttctcctggcccagctggaggacctggagcccagtgaggttgagcctgaggccctgtccccagctccagtgctgtctctgaaaccagcttcacagctagaaccagctcccgccctgcttctgacgcccagccgagctgtggcatccactccagtccgagagccagccccggtgccagtactggcatccagcccggtggtggcgccagcctctgagctagaaccagctctggagccgcccctagaccctgagccaaccctcgcacctgctccagagctggaccccactgtctcacagagcctccacctcgagcccgctcccgtgcccgctcctgcattagagccttcctggcctctgcctgaaaccacggagaacggactgtgtgcaaagcctcacctactgctgttccctccagacttggtggctgaacagtttacgctgatggacgcagagctattcaagaaagttgtgccctaccactgcctgggctccatctggtcccagcgggacaagaagggcaaggagcacctcgcgcccaccatccgtgccactgtcgcccagttcaacaacgtggccaactgtgtcatcaccacctgccttggggaccagagtatgaaagcttcggacagggcccgggtggtggaacactggatcgaggtggccagggagtgcagggtgctcaagaatttctcctccctctacgccatcctctctgccctacagagcaatgccatccaccgcctaaagaagacatgggaagaggtctccaggggcagctttcgagtgttccagaaactgtcagaaatcttctctgatgagaacaactactccttgagcagagagctgctcatcaaggaaggaacctccaagtttgccacgctggagatgaaccctaggagaacccagaggcggcagaaggagacaggtgtcatccagggcactgtcccctacctgggcacattcctcactgacctggtgatgctggacacagccatgaaggactatctatatgggagactgatcaactttgaaaagaggaggaaggagttcgaagtcatcgcccagatcaagttgctccagtcggcctgcaacaactacagcattgttcccgaggagcactttggagcctggttccgagccatgggacggctcagcgaggctgagagctacaacctgtcgtgtgagctggagcccccgtctgagtcagccagcaacaccctgaggagcaagaaaagcacagctatcgtcaagcgctggagcgaccgccaggctcccagcacggagctcagcaccagtagcagtgcacactccaagtcatgtgaccagctccggtgcagcccctacctcagcagcggggacatcacggacgcactcagtgtgcactcagctggttcatccagctctgacgtggaggagatcaacatgagctttgttccagagtctcctgatggccaggaaaagaagttctgggagtcagcctcccagtcgtccccagagacctctggcatcagctcggcctccagcagcacctcctcttcgtcagcctctaccacaccggtgtctaccacacgcacccacaagcgctctgtctcaggggtctgcagctacagctcctcactgccactctacaaccagcaggtgggcgactgctgcatcatcagggtcagcctggatgtggacaacggcaacatgtacaagagcatcctggtgaccagccaggataaggctccgactgtcatccggaaagccatggacaaacacaacctagatgaggacgagcccgaggactatgagctgctgcagatcatctcagaggaccacaagctgaaaattccagagaacgccaatgtgttctatgccatgaactctgccgccaactatgacttcatcctaaagaagcgggccttcactaagggggctaaagtcaagcatggagccagctccactctccctcgaatgaagcagaagggactcaggattgccagaggcatcttctaaggacgtctcccaggggctggctggctggctggggactaagcacttacagactagagtggcccaggccacacaggtacctctgccctcctgccagcccaggctactcccagactccactttcaccccgaacctgtcctgctgccgggattgacacctgccactgacaggctgacctggcctccggggaccgctcaccgccttaggtgccttctgctctctgcaaccagaggactagctgactttgccaaggggtgctgccagctgggcatggagcctcgcctgccctggacaatgtccaccacactttcctgtcacctccccaagtgcagatcactgccacccatgctcccagatgctccaggacacccacacacccagcggggctgccaactgcgttctctccttgtgcccataggcactggcctgggaccttcatggaggtcctagcctttcttaggctgcaccaaagattccaccttcagggcctacagagtgagggagtctcgcccaccacgagcccaagccctcccatggatcagagagagaagccctctcatggaccgcctggttggcattgaaccccataccactgaaagtgccattcaccaccgctgcgtcccgggtgtacaagactacatgcaatgggaggtttgtggggagggggaagacgactggatatttgtataaaacgtaaaaagtttactgattggggtggggcaatatttatttgttgtaaatagaaaatgctagacttgaatattatattaaaatcccgtttctacta

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