2024-05-04 23:13:00, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001416483 3607 bp mRNA linear ROD 23-MAR-2023 DEFINITION Rattus norvegicus ral guanine nucleotide dissociation stimulator (Ralgds), transcript variant 2, mRNA. ACCESSION NM_001416483 XM_006233750 VERSION NM_001416483.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3607) AUTHORS Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H and Bos JL. TITLE Rap2A links intestinal cell polarity to brush border formation JOURNAL Nat Cell Biol 14 (8), 793-801 (2012) PUBMED 22797597 REFERENCE 2 (bases 1 to 3607) AUTHORS Kawai M, Kawashima S, Sakoda T, Toh R, Kikuchi A, Yamauchi-Takihara K, Kunisada K and Yokoyama M. TITLE Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy JOURNAL Hypertension 41 (4), 956-962 (2003) PUBMED 12642511 REMARK GeneRIF: Ral GDP dissociation stimulator is involved in myocardial hypertrophy. REFERENCE 3 (bases 1 to 3607) AUTHORS Huang,L., Weng,X., Hofer,F., Martin,G.S. and Kim,S.H. TITLE Three-dimensional structure of the Ras-interacting domain of RalGDS JOURNAL Nat Struct Biol 4 (8), 609-615 (1997) PUBMED 9253406 REMARK Erratum:[Nat Struct Biol 1997 Oct;4(10):840] REFERENCE 4 (bases 1 to 3607) AUTHORS Hofer F, Fields S, Schneider C and Martin GS. TITLE Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator JOURNAL Proc Natl Acad Sci U S A 91 (23), 11089-11093 (1994) PUBMED 7972015 REFERENCE 5 (bases 1 to 3607) AUTHORS Albright CF, Giddings BW, Liu J, Vito M and Weinberg RA. TITLE Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase JOURNAL EMBO J 12 (1), 339-347 (1993) PUBMED 8094051 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000115.1. On Feb 3, 2023 this sequence version replaced XM_006233750.4. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-282 JACYVU010000115.1 5316351-5316632 283-393 JACYVU010000115.1 5324241-5324351 394-587 JACYVU010000115.1 5325597-5325790 588-683 JACYVU010000115.1 5326248-5326343 684-877 JACYVU010000115.1 5327028-5327221 878-1275 JACYVU010000115.1 5327469-5327866 1276-1491 JACYVU010000115.1 5328568-5328783 1492-1595 JACYVU010000115.1 5328956-5329059 1596-1680 JACYVU010000115.1 5329422-5329506 1681-1749 JACYVU010000115.1 5330670-5330738 1750-1836 JACYVU010000115.1 5331054-5331140 1837-1869 JACYVU010000115.1 5331587-5331619 1870-1991 JACYVU010000115.1 5331888-5332009 1992-2087 JACYVU010000115.1 5332130-5332225 2088-2289 JACYVU010000115.1 5332429-5332630 2290-2532 JACYVU010000115.1 5332740-5332982 2533-2647 JACYVU010000115.1 5334094-5334208 2648-3607 JACYVU010000115.1 5335910-5336869 FEATURES Location/Qualifiers source 1..3607 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="3" /map="3p12" gene 1..3607 /gene="Ralgds" /gene_synonym="Rgds" /note="ral guanine nucleotide dissociation stimulator" /db_xref="GeneID:29622" /db_xref="RGD:3533" exon 1..282 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" CDS 100..2823 /gene="Ralgds" /gene_synonym="Rgds" /note="isoform 2 is encoded by transcript variant 2; ralGEF; ral guanine nucleotide exchange factor" /codon_start=1 /product="ral guanine nucleotide dissociation stimulator isoform 2" /protein_id="NP_001403412.1" /db_xref="GeneID:29622" /db_xref="RGD:3533" /translation="
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLHPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF"
misc_feature 433..843 /gene="Ralgds" /gene_synonym="Rgds" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; Region: RasGEFN; smart00229" /db_xref="CDD:214571" misc_feature order(490..492,670..672,682..687,694..696,703..708, 817..822,829..831,850..852) /gene="Ralgds" /gene_synonym="Rgds" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:100121" misc_feature <856..>1179 /gene="Ralgds" /gene_synonym="Rgds" /note="DNA polymerase III subunit gamma/tau; Region: PRK07003" /db_xref="CDD:235906" misc_feature 1036..1107 /gene="Ralgds" /gene_synonym="Rgds" /note="propagated from UniProtKB/Swiss-Prot (Q03386.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1222..2010 /gene="Ralgds" /gene_synonym="Rgds" /note="Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cd00155" /db_xref="CDD:238087" misc_feature order(1321..1329,1366..1371,1375..1383,1387..1392, 1399..1404,1411..1413,1516..1518,1525..1530,1534..1542, 1546..1557,1561..1566,1624..1626,1633..1635,1648..1656, 1663..1665,1774..1782,1789..1797,1801..1809,1813..1824, 1867..1869,1879..1881,1984..1986,1993..1998) /gene="Ralgds" /gene_synonym="Rgds" /note="Ras interaction site [polypeptide binding]; other site" /db_xref="CDD:238087" misc_feature 2257..2397 /gene="Ralgds" /gene_synonym="Rgds" /note="propagated from UniProtKB/Swiss-Prot (Q03386.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2470..2727 /gene="Ralgds" /gene_synonym="Rgds" /note="Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins; Region: RA_RalGDS; cd17209" /db_xref="CDD:340729" misc_feature order(2470..2481,2485..2487,2506..2532,2542..2547, 2569..2571,2578..2583,2587..2589) /gene="Ralgds" /gene_synonym="Rgds" /note="RA-Ras interaction site [polypeptide binding]; other site" /db_xref="CDD:340729" misc_feature 2518..2520 /gene="Ralgds" /gene_synonym="Rgds" /note="Phosphotyrosine. /evidence=ECO:0000250|UniProtKB:Q12967; propagated from UniProtKB/Swiss-Prot (Q03386.1); phosphorylation site" exon 283..393 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 394..587 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 588..683 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 684..877 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 878..1275 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1276..1491 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1492..1595 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1596..1680 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1681..1749 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1750..1836 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1837..1869 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1870..1991 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 1992..2087 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2088..2289 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2290..2532 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2533..2647 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" exon 2648..3607 /gene="Ralgds" /gene_synonym="Rgds" /inference="alignment:Splign:2.1.0" ORIGIN
gcagagcgcaggcagcgcggagccgcgccggccggccctgcgcccacgccgccccgggtctcgcggcccgccggccacccgcgccaccgggagtcgtccatggtgcagcgcatgtgggccgaggcgtccgggcccatagggggcgccgagccgttgtttcccggctcccggcgcagccgcagcgtgtgggacgccgtgcgtctggaggtgggcgtccctgacagctgtccagtggtgctgcacagcttcacgcagctcgaccccgatctgccgcgcctggagagctctacgcaggagattggggaggagctgatcaacggggtcatctactccatctccctgcgcaaggttcagctacacccaggagccaccaagggccagcgctggctagggtgcgagaatgagtcagctctgaacctctacgagacttgcaaggtgcgcacggtgaaggccggtactctggagaagctggtggaacacctggtgcctgccttccagggcagtgacctttcctacgtcaccgtattcctgtgcacctacagagccttcacaaccactcagcaggtgctagacctgctgttcaaaaggtacggtagatgtgacgccctcacggcctcctctagatatggctgcatccttccctactccagtgaggacggcggaccacaggaccaactcaaaaatgccatctcttccatcctgggcacctggctggaccaatactccgaggacttctgtcaacccccggactttccctgcctcaagcagctggtggcttatgtgcagctcaacatgcctggctcagacctggagcgccgtgctcaccttctcctggcccagctggaggacctggagcccagtgaggttgagcctgaggccctgtccccagctccagtgctgtctctgaaaccagcttcacagctagaaccagctcccgccctgcttctgacgcccagccgagctgtggcatccactccagtccgagagccagccccggtgccagtactggcatccagcccggtggtggcgccagcctctgagctagaaccagctctggagccgcccctagaccctgagccaaccctcgcacctgctccagagctggaccccactgtctcacagagcctccacctcgagcccgctcccgtgcccgctcctgcattagagccttcctggcctctgcctgaaaccacggagaacggactgtgtgcaaagcctcacctactgctgttccctccagacttggtggctgaacagtttacgctgatggacgcagagctattcaagaaagttgtgccctaccactgcctgggctccatctggtcccagcgggacaagaagggcaaggagcacctcgcgcccaccatccgtgccactgtcgcccagttcaacaacgtggccaactgtgtcatcaccacctgccttggggaccagagtatgaaagcttcggacagggcccgggtggtggaacactggatcgaggtggccagggagtgcagggtgctcaagaatttctcctccctctacgccatcctctctgccctacagagcaatgccatccaccgcctaaagaagacatgggaagaggtctccaggggcagctttcgagtgttccagaaactgtcagaaatcttctctgatgagaacaactactccttgagcagagagctgctcatcaaggaaggaacctccaagtttgccacgctggagatgaaccctaggagaacccagaggcggcagaaggagacaggtgtcatccagggcactgtcccctacctgggcacattcctcactgacctggtgatgctggacacagccatgaaggactatctatatgggagactgatcaactttgaaaagaggaggaaggagttcgaagtcatcgcccagatcaagttgctccagtcggcctgcaacaactacagcattgttcccgaggagcactttggagcctggttccgagccatgggacggctcagcgaggctgagagctacaacctgtcgtgtgagctggagcccccgtctgagtcagccagcaacaccctgaggagcaagaaaagcacagctatcgtcaagcgctggagcgaccgccaggctcccagcacggagctcagcaccagtagcagtgcacactccaagtcatgtgaccagctccggtgcagcccctacctcagcagcggggacatcacggacgcactcagtgtgcactcagctggttcatccagctctgacgtggaggagatcaacatgagctttgttccagagtctcctgatggccaggaaaagaagttctgggagtcagcctcccagtcgtccccagagacctctggcatcagctcggcctccagcagcacctcctcttcgtcagcctctaccacaccggtgtctaccacacgcacccacaagcgctctgtctcaggggtctgcagctacagctcctcactgccactctacaaccagcaggtgggcgactgctgcatcatcagggtcagcctggatgtggacaacggcaacatgtacaagagcatcctggtgaccagccaggataaggctccgactgtcatccggaaagccatggacaaacacaacctagatgaggacgagcccgaggactatgagctgctgcagatcatctcagaggaccacaagctgaaaattccagagaacgccaatgtgttctatgccatgaactctgccgccaactatgacttcatcctaaagaagcgggccttcactaagggggctaaagtcaagcatggagccagctccactctccctcgaatgaagcagaagggactcaggattgccagaggcatcttctaaggacgtctcccaggggctggctggctggctggggactaagcacttacagactagagtggcccaggccacacaggtacctctgccctcctgccagcccaggctactcccagactccactttcaccccgaacctgtcctgctgccgggattgacacctgccactgacaggctgacctggcctccggggaccgctcaccgccttaggtgccttctgctctctgcaaccagaggactagctgactttgccaaggggtgctgccagctgggcatggagcctcgcctgccctggacaatgtccaccacactttcctgtcacctccccaagtgcagatcactgccacccatgctcccagatgctccaggacacccacacacccagcggggctgccaactgcgttctctccttgtgcccataggcactggcctgggaccttcatggaggtcctagcctttcttaggctgcaccaaagattccaccttcagggcctacagagtgagggagtctcgcccaccacgagcccaagccctcccatggatcagagagagaagccctctcatggaccgcctggttggcattgaaccccataccactgaaagtgccattcaccaccgctgcgtcccgggtgtacaagactacatgcaatgggaggtttgtggggagggggaagacgactggatatttgtataaaacgtaaaaagtttactgattggggtggggcaatatttatttgttgtaaatagaaaatgctagacttgaatattatattaaaatcccgtttctacta
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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