LOCUS       NM_001415952            3391 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member B5
            (Dnajb5), transcript variant 1, mRNA.
ACCESSION   NM_001415952 XM_039110129
VERSION     NM_001415952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3391)
  AUTHORS   Hageman J, van Waarde MA, Zylicz A, Walerych D and Kampinga HH.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   2  (bases 1 to 3391)
  AUTHORS   Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF and
            Sadoshima J.
  TITLE     A redox-dependent pathway for regulating class II HDACs and cardiac
            hypertrophy
  JOURNAL   Cell 133 (6), 978-993 (2008)
   PUBMED   18555775
REFERENCE   3  (bases 1 to 3391)
  AUTHORS   Chen MS, Roti JR and Laszlo A.
  TITLE     Hsc40, a new member of the hsp40 family, exhibits similar
            expression profile to that of hsc70 in mammalian cells
  JOURNAL   Gene 238 (2), 333-341 (1999)
   PUBMED   10570961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            On Jan 6, 2023 this sequence version replaced XM_039110129.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132292 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JACYVU010000161.1  32601014-32601100
            88-555              JACYVU010000161.1  32601574-32602041
            556-800             JACYVU010000161.1  32604212-32604456
            801-1402            JACYVU010000161.1  32607398-32607999
            1403-3391           JACYVU010000161.1  32608208-32610196
FEATURES             Location/Qualifiers
     source          1..3391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3391
                     /gene="Dnajb5"
                     /note="DnaJ heat shock protein family (Hsp40) member B5"
                     /db_xref="GeneID:313811"
                     /db_xref="RGD:1307453"
     exon            1..87
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            88..555
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    356..358
                     /gene="Dnajb5"
                     /note="upstream in-frame stop codon"
     CDS             374..1636
                     /gene="Dnajb5"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily B member 5; DnaJ (Hsp40) homolog,
                     subfamily B, member 5; heat shock cognate 40"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 5 isoform 1"
                     /protein_id="NP_001402881.1"
                     /db_xref="GeneID:313811"
                     /db_xref="RGD:1307453"
                     /translation="

MFKRTVLSCPPPAAPPLQARGAFRSFPHFWGEDFLASLMFKIQLEPLKLRAWTLNGFVKFRNKEPSTGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGTSGGSGGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS"

     misc_feature    587..1618
                     /gene="Dnajb5"
                     /note="DnaJ-class molecular chaperone with C-terminal Zn
                     finger domain [Posttranslational modification, protein
                     turnover, chaperones]; Region: DnaJ; COG0484"
                     /db_xref="CDD:223560"
     exon            556..800
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1402
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..3391
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtcccgagtggaggcggcggagccggagccgggggagggggcagcggctgatagaaggaccgcggcggcgcccgcagctcctcaccggtacacacgctgccactcaacaactacacacagtcacttccggcctcactgtcacacagccgtccaggcgctcacaccattcagccagacactgctgtacccgagagcaggtggccactggaccctctcactgcactctacacctggggatcaggtccagcttctggggcacgagacaggccttgctgggccacggcctgtgggaatctgaggaggtggcttccagagctacagcgtcccaggcaggctccggtggagcgatcagaggtgaggggcttggctgggcatgtttaagcgcacagtgctgtcctgcccacccccagcagcacccccactgcaggctcgaggagctttccggagcttcccacacttctggggagaagacttcttagccagcttgatgtttaaaattcagctggagcccttaaaacttcgagcgtggacgctgaatgggtttgtaaagtttcgaaacaaggagcccagcaccggtccagtggctgtgatgggaaaagattattacaagattcttggaatcccgtctggggccaacgaagatgagatcaagaaagcctatcgaaagatggccttgaagtaccacccagacaagaacaaagaacccaacgctgaggagaagtttaaggagattgccgaggcctacgacgtgctgagtgaccctaagaaacggagcctgtatgaccagtatggggaggaaggcctcaagaccggcggtggtacctcaggtggctccggtggctcctttcactacacctttcacggggaccctcatgccacctttgcttccttctttggtggctccaaccccttcgatatcttctttgccagcagccgctccactcggcctttcagtggctttgacccagatgacatggatgtggatgaagatgaggacccatttggtgcctttggccgctttggcttcaatgggctgagtaggggtccgaggcgagccccagaaccactgtacccccggcgcaaggtacaggacccccctgtggtgcatgagctgcgggtgtccctggaggagatctaccacggctccaccaagcgcatgaagatcacaaggcgacgccttaaccccgatgggcgaactgtgcgcaccgaggacaaaatcctgcacattgtcatcaaacgtggctggaaggagggcaccaagattaccttccccaaagagggcgatgccacacccgacaacatcccagccgacattgtcttcgtgctcaaagacaagcctcatgcgcactttcgccgagatggcaccaacgtgctctacagtgcactcatcagcctcaaggaggcgctgtgtggctgcaccgtgaacattcccaccattgatggccgagtgatccctttaccctgcaatgatgttattaaaccaggcaccgtgaagagactccgtggggagggacttcccttccccaaggtgcccactcagcggggagacctcattgttgagttcaaagttcgattcccagacagattaaccccacagacacggcagatccttaaacagcacctaccctgctcctaggctctccctagcctgtctggagcccaccacagcaatacccccacactcaccaatctcatgtggacccggctggatgtccaccggacactggcactttcctaaaatgcaagaagccactgattttcaggaaaatgttcctcttcccgacaacccctttcggagctgggctgctttgggggaatgggagggcggtggggagaactagcccagaccaggggtcaatttttttgtcacgtgctttgaatccagttcccactgcagtggctggagagtgacttgagagctactcggagctatagattccttgtcctgcctgtaaatagcatgtcctcccccttctcagccttgctaacacctttcctctcccttcccctcggcttcctcctgtttctggagaaagaagttagaaaggacaccgcttcccaccccacccccaggtctgtagtgtccgaggctattttgcacaagtgttcgtgcacatgaagcactcgccaaaatggtccgtgtctctctgagagacaagaaaggacaggaggtaggaaggtcccttaccgatgaacaaggctgtcatttgagcacgagacacttttcatttggggcagggaggtgagccaacccttaggagccttcccaacagctgccctgcctacaccccacagagttggaggatctgtccccctcagctgctctggggagtgttcaggggtggagagaagaaaggagggcctgaaccatccaccacagctaagaggtggggcaggacccatctcccagccatcaccaggaaggaaaagggctttgggatcaggtggcagctgttccccaccaagagattcaggatcacaggttccttcccatatctctgaactcagggcctagccaccccaaacttccaagccccacttttgcgatatgtgaagctacttatttcttacttttcttggaggctgtgtcggaaatttccagcctctctgcctgtgtgaccctcaccccaccccactcccacagttgtataaaagtcgaatagtgaaggagctgggagaaaactgcttcagttggtcctggggtggggtctttaggttttctcactttgacaagcccctgaatgtttttatagtagttttttgtatttttttgtaatgacagtattatgaaaaaaataaagtattttaaaaatatggcctctgagcagaagcagtaaccctgggtgcaggcaggaataaagtggcactgtcagcctccttcagggccctgatcatccaggaaagccaagcagcctcagcagctgacgctcaccccttctccctgtaagctctgacttcttggaattctggaacatataccccaaacaaacagcaacaccagaagccacagcccagctgtctgcgaagaaagatgggcctttgttgtgagagagagcctggcctcttcagaagcttgtcaacatgagatctagcacacttgtctcggtgttctctttgaattagagacactttattccttggaggagattgaggactctctgactagcgagactaggcacactcccaaaaacagagttgggctaccaagtgggctggagagatggttcagcagttaagagcacttcctgttctcacagagaagccaaattcagttcccaggacacatcaggcagctcgagactgctcaagggaatccaacaagtccagcctcacaaagaatctgcacccatgcacacacacacttacaaaaaataaaaagtttttttaaaaa

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