2024-05-03 10:59:19, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001270859 1345 bp mRNA linear ROD 24-DEC-2022 DEFINITION Rattus norvegicus stathmin 4 (Stmn4), transcript variant 6, mRNA. ACCESSION NM_001270859 VERSION NM_001270859.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1345) AUTHORS Nakazawa T, Morii H, Tamai M and Mori N. TITLE Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy JOURNAL Brain Res 1061 (2), 97-106 (2005) PUBMED 16256088 REMARK GeneRIF: RB3 is the unique response protein in the stathmin-related proteins following optic nerve axotomy and the induced RB3 may play a critical role in the CNTF-induced response on the axotomized retinal ganglion cells REFERENCE 2 (bases 1 to 1345) AUTHORS Nakao C, Itoh TJ, Hotani H and Mori N. TITLE Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain JOURNAL J Biol Chem 279 (22), 23014-23021 (2004) PUBMED 15039434 REMARK GeneRIF: regulatory role of the unique N-terminal domain of RB3 in microtubule dynamics would contribute to the physiological regulation of neuronal morphogenesis REFERENCE 3 (bases 1 to 1345) AUTHORS Ozon S, El Mestikawy S and Sobel A. TITLE Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain JOURNAL J Neurosci Res 56 (5), 553-564 (1999) PUBMED 10369222 REFERENCE 4 (bases 1 to 1345) AUTHORS Gavet O, Ozon S, Manceau V, Lawler S, Curmi P and Sobel A. TITLE The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network JOURNAL J Cell Sci 111 (Pt 22), 3333-3346 (1998) PUBMED 9788875 REFERENCE 5 (bases 1 to 1345) AUTHORS Ozon S, Byk T and Sobel A. TITLE SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system JOURNAL J Neurochem 70 (6), 2386-2396 (1998) PUBMED 9603203 REFERENCE 6 (bases 1 to 1345) AUTHORS Ozon S, Maucuer A and Sobel A. TITLE The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system JOURNAL Eur J Biochem 248 (3), 794-806 (1997) PUBMED 9342231 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB580507.1 and BC092646.1. Transcript Variant: This variant (6) differs in the 5' UTR and has an alternate exon in the 3' end compared to variant 1. This exon has an in-frame stop codon, resulting in an isoform (b) with a shorter and distinct C-terminus compared to isoform a. Variants 2 and 6 both encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## CDS exon combination :: BC092646.1, CO398144.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA5760389, SAMEA5760393 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-32 CB580507.1 1-32 33-1345 BC092646.1 39-1351 FEATURES Location/Qualifiers source 1..1345 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="15" /map="15p12" gene 1..1345 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /note="stathmin 4" /db_xref="GeneID:79423" /db_xref="RGD:69349" exon 1..32 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 33..123 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" misc_feature 60..62 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /note="upstream in-frame stop codon" CDS 111..722 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /note="isoform b is encoded by transcript variant 6; stathmin-like protein B3; stathmin-like-protein RB3; stathmin-like 4" /codon_start=1 /product="stathmin-4 isoform b" /protein_id="NP_001257788.1" /db_xref="GeneID:79423" /db_xref="RGD:69349" /translation="
MTLAAYKEKMKELPLVSLFCSCFLSDPLNKSSYKYEGWCGRQCRRKGQSQRKGSADWRERREQADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKEPPAAR"
misc_feature 336..704 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /note="Stathmin family; Region: Stathmin; pfam00836" /db_xref="CDD:425897" exon 124..219 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 220..300 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 301..509 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 510..701 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 702..754 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" exon 755..1344 /gene="Stmn4" /gene_synonym="Lagl; Rb3" /inference="alignment:Splign:2.1.0" ORIGIN
gagaacagctcgctttggaaaccggactgcaggattgtgatccagttctgagctggtgataaacactccttgtgacttttggtcaattcagctaccagattccagccaacatgaccctcgcagcctataaggagaagatgaaggaactcccactagtgtctctgttctgctcctgttttctgtctgatcccctgaataaatcatcctacaaatatgaaggctggtgtgggagacagtgtaggaggaaaggtcaaagccagcggaaaggcagtgctgactggagagaaagaagagaacaggcagatacggtagacctgaactggtgtgtcatctctgatatggaagtcatcgagctgaataagtgtacctcgggccagtcctttgaagtcatcctgaagccaccttcctttgacggggtgcctgagtttaatgcctccctcccaagacgtcgagacccatcgctagaagagatacagaagaagctagaagcagcagaggagcgaaggaagtaccaggaagctgagctcctaaaacaccttgcagagaaacgagagcatgagcgtgaggtaatccagaaagctatcgaggaaaacaacaacttcatcaagatggcgaaagagaagctggcccagaagatggagtccaataaggaaaaccgggaggcccatctggctgccatgttggagcggctgcaagagaaggagccgcctgctgcgcggtgactcccgggaccgatcggtggcctcgtcccatggacaagcacgcagaggaggtgcggaaaaacaaggagctgaaggaagaggcctccaggtaaagcccagaggccaaggaagtttccaggacagccggacagctcccgcagcaacctggttccagcagcatcggccgctggctgctctcccagcactggggttcggggggaggggggtggccaaaggggcgtttcctctgcttttggtgtttgtacatgtaaaagattgaccagtgaagccatcctatttgtttctggggaacaatgatggggtgggagaggggacagagagtgtgtggaaaaggaggtgaagatgagcccgaggactttgtgacactgtccactgactgcagacttgggccaaggcccccgcttttcacggctctgcctggacattcggcctccaggttcctagtggagagaagatgtgacagaagttcagagtgaagggccgagtcctggtggggtggtgtgcagggccagcaggacgagcccgtctggatggagtgaaacctaccctgagcgggtgggataaggtctgtgtgcgtctgttcattgtcatcttttgatcatcatgaccaacgaaacatttaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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