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Previous release (v1)
2026-10-15 05:51:42, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_001169112 4731 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus kinesin family member 11 (Kif11), mRNA.
ACCESSION NM_001169112 XM_001060913 XM_001080591
VERSION NM_001169112.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4731)
AUTHORS Sheng,H., Xu,Y., Chen,Y., Zhang,Y. and Ni,X.
TITLE Corticotropin-releasing hormone stimulates mitotic kinesin-like
protein 1 expression via a PLC/PKC-dependent signaling pathway in
hippocampal neurons
JOURNAL Mol Cell Endocrinol 362 (1-2), 157-164 (2012)
PUBMED 22698524
REMARK GeneRIF: Corticotropin releasing hormone act on CRHR1 to induce
MKLP1 expression via the PLC/PKC signaling pathway.
REFERENCE 2 (bases 1 to 4731)
AUTHORS Courtois,A., Schuh,M., Ellenberg,J. and Hiiragi,T.
TITLE The transition from meiotic to mitotic spindle assembly is gradual
during early mammalian development
JOURNAL J Cell Biol 198 (3), 357-370 (2012)
PUBMED 22851319
REFERENCE 3 (bases 1 to 4731)
AUTHORS Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
and Erdmann,R.
TITLE PEX14 is required for microtubule-based peroxisome motility in
human cells
JOURNAL J Cell Sci 124 (Pt 10), 1759-1768 (2011)
PUBMED 21525035
REFERENCE 4 (bases 1 to 4731)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 5 (bases 1 to 4731)
AUTHORS Nadar,V.C., Ketschek,A., Myers,K.A., Gallo,G. and Baas,P.W.
TITLE Kinesin-5 is essential for growth-cone turning
JOURNAL Curr Biol 18 (24), 1972-1977 (2008)
PUBMED 19084405
REMARK GeneRIF: kinesin-5 works in part by antagonizing cytoplasmic
dynein, and these motor-driven forces function together with the
dynamic properties of the microtubules to determine whether MTs can
enter the P-domain.
REFERENCE 6 (bases 1 to 4731)
AUTHORS Xu,X., He,C., Zhang,Z. and Chen,Y.
TITLE MKLP1 requires specific domains for its dendritic targeting
JOURNAL J Cell Sci 119 (Pt 3), 452-458 (2006)
PUBMED 16418225
REMARK GeneRIF: the motor and tail regions of MKLP1 are important and
significant for its localization to the dendrites
REFERENCE 7 (bases 1 to 4731)
AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
Fan,J.B., Abraham,R.T. and Jiang,W.
TITLE Functional analysis of human microtubule-based motor proteins, the
kinesins and dyneins, in mitosis/cytokinesis using RNA interference
JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005)
PUBMED 15843429
REFERENCE 8 (bases 1 to 4731)
AUTHORS Cassimeris,L. and Morabito,J.
TITLE TOGp, the human homolog of XMAP215/Dis1, is required for centrosome
integrity, spindle pole organization, and bipolar spindle assembly
JOURNAL Mol Biol Cell 15 (4), 1580-1590 (2004)
PUBMED 14718566
REFERENCE 9 (bases 1 to 4731)
AUTHORS Di Fiore,B., Ciciarello,M., Mangiacasale,R., Palena,A.,
Tassin,A.M., Cundari,E. and Lavia,P.
TITLE Mammalian RanBP1 regulates centrosome cohesion during mitosis
JOURNAL J Cell Sci 116 (Pt 16), 3399-3411 (2003)
PUBMED 12840069
REMARK Erratum:[J Cell Sci. 2003 Sep 1;116(Pt 17):3659]
REFERENCE 10 (bases 1 to 4731)
AUTHORS Sperry,A.O. and Zhao,L.P.
TITLE Kinesin-related proteins in the mammalian testes: candidate motors
for meiosis and morphogenesis
JOURNAL Mol Biol Cell 7 (2), 289-305 (1996)
PUBMED 8688559
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000001.1.
On or before Dec 18, 2009 this sequence version replaced
XM_001080591.1, XM_001060913.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26643429.5527.1,
SRR26643292.6340.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760389
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-269 JAXUCZ010000001.1 244536867-244537135
270-402 JAXUCZ010000001.1 244545285-244545417
403-500 JAXUCZ010000001.1 244545581-244545678
501-579 JAXUCZ010000001.1 244545767-244545845
580-765 JAXUCZ010000001.1 244548526-244548711
766-890 JAXUCZ010000001.1 244548821-244548945
891-981 JAXUCZ010000001.1 244550801-244550891
982-1224 JAXUCZ010000001.1 244551133-244551375
1225-1320 JAXUCZ010000001.1 244560002-244560097
1321-1409 JAXUCZ010000001.1 244563122-244563210
1410-1497 JAXUCZ010000001.1 244568610-244568697
1498-1686 JAXUCZ010000001.1 244569729-244569917
1687-1894 JAXUCZ010000001.1 244570365-244570572
1895-2067 JAXUCZ010000001.1 244573122-244573294
2068-2193 JAXUCZ010000001.1 244577595-244577720
2194-2352 JAXUCZ010000001.1 244577797-244577955
2353-2459 JAXUCZ010000001.1 244579190-244579296
2460-2739 JAXUCZ010000001.1 244579816-244580095
2740-2962 JAXUCZ010000001.1 244582047-244582269
2963-3111 JAXUCZ010000001.1 244584209-244584357
3112-3228 JAXUCZ010000001.1 244585217-244585333
3229-4731 JAXUCZ010000001.1 244587748-244589250
FEATURES Location/Qualifiers
source 1..4731
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="1"
/map="1q53"
gene 1..4731
/gene="Kif11"
/gene_synonym="Knsl1"
/note="kinesin family member 11"
/db_xref="GeneID:171304"
/db_xref="RGD:621258"
exon 1..269
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
CDS 193..3363
/gene="Kif11"
/gene_synonym="Knsl1"
/note="kinesin-like 1"
/codon_start=1
/product="kinesin-like protein KIF11"
/protein_id="NP_001162583.1"
/db_xref="GeneID:171304"
/db_xref="RGD:621258"
/translation="
MASQPSSSSKKKEEKGKNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEESFRAMNGKVTVQEEQIAELAEKIGVLEEELSKAAELFTDSEKELNQCKSDLQTKTQELETTQKHLQETKLQLVKEEYVSSALERTEKKLHETASKLLNTVKETTRDVSGLHSKLDRKRAIDAHNAEAQESFGRSLSSLFNNMEELIRDGSEKQKAMLDVHKALFGNLMSSSVSALDTISTTALESLMSIPENVLARVSQISDMILEEQSLAAQSKTVLQGSIDELVTNLFTSLKTIIAPGVVSILNINRQLQHIFRASVTMAEKVEDQKREIDSFLSILCNNLHELRENTVSSLVESQKLCGNLTEDLKTIKETHSQELCQLSSSWAERFCALEKKYANIQKPLNSIQENTERKSTDIINKTTVHSKKILADSDGLLQELRHFNEEGTQLVEDSVGHCGSLSSNLETVSQEITQRCGTLNTSTVHFSDQWASCLSKRKEELQNLMEFVNGCCEASSSEITEKIRGHRAAIESQHSSFVVQITSDEEKFKAGSLELDKTIKTGLTKLNCFLQQDLKLDIPTGMTPERKNYLYPSTLVRTEPREQLLDQLQKKQPKPLMMLNCSESSKETSQDMEEDREVLEQSTEELVSQEPCVHTSADCSSSGGVPFFQHKKPHGKDKENRGLNPVEKGKVEEASEHSISKSRLPLRASINLC"
misc_feature 238..1296
/gene="Kif11"
/gene_synonym="Knsl1"
/note="Kinesin motor domain, BimC/Eg5 spindle pole
proteins; Region: KISc_BimC_Eg5; cd01364"
/db_xref="CDD:276815"
misc_feature order(268..270,505..507,514..516,520..531,985..987)
/gene="Kif11"
/gene_synonym="Knsl1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:276815"
misc_feature order(1126..1128,1135..1137,1144..1146)
/gene="Kif11"
/gene_synonym="Knsl1"
/note="microtubule interaction site [polypeptide binding];
other site"
/db_xref="CDD:276815"
misc_feature 1240..>1716
/gene="Kif11"
/gene_synonym="Knsl1"
/note="phosphodiesterase; Provisional; Region: PRK12704"
/db_xref="CDD:237177"
misc_feature 1330..>2547
/gene="Kif11"
/gene_synonym="Knsl1"
/note="Uncharacterized conserved protein YhaN, contains
AAA domain [Function unknown]; Region: YhaN; COG4717"
/db_xref="CDD:443752"
misc_feature 2938..3348
/gene="Kif11"
/gene_synonym="Knsl1"
/note="Kinesin-associated microtubule-binding; Region:
Microtub_bind; pfam13931"
/db_xref="CDD:464048"
exon 270..402
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 403..500
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 501..579
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 580..765
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 766..890
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 891..981
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 982..1224
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1225..1320
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1321..1409
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1410..1497
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1498..1686
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1687..1894
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 1895..2067
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2068..2193
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2194..2352
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2353..2459
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2460..2739
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2740..2962
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 2963..3111
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 3112..3228
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
exon 3229..4731
/gene="Kif11"
/gene_synonym="Knsl1"
/inference="alignment:Splign:2.1.0"
ORIGIN
agcagaggaggtttgtcctctccggctcttgcggggcggtggccacggccaaaaggtctgcgtggacctcggggacgcggagctgcaagtcttggtccttcttccctggtcagcaccgggcgagaagaggcggcgcccggttcttactgtgtcggagtcaccgccaggccggcaggttttggctcgaccgtcatggcgtcccagccgagttcttcttcgaagaagaaagaggaaaagggcaagaacattcaggtggtggtgagatgcagaccatttaatttggcagagcggaaagctaacgcccactctgtagtagaatgtgatcacgcacggaaggaagtcagtgtacgaactgcagggctgactgacaagacctcaaggaaaacatacacgtttgacatggtgtttggagcatctacaaaacaaattgatgtttaccgaagtgttgtttgtccaattctagatgaagttattatgggctataattgtaccatcttcgcatatggccagactggcactggaaaaacttttacaatggaaggtgaaaggtcacctaatgaagtatatacctgggaggaggatcctctggctggtataattccacgtactcttcatcagatttttgagaaacttactgataatggcactgagttttcagtgaaagtatccctattggaaatctataatgaggagctttttgatcttctgagtccgtcttctgatgtttctgaaaggctgcagatgtttgatgatccccggaacaagagaggagtgataatcaaaggcttagaggaaatcacagtacacaacaaagatgaagtctaccaaatcttagagaagggggcagccaaaaggacaactgcagcaaccttgatgaatgcttactccagtcgttcacactcagttttttctgtcacgatacacatgaaagaaacgacaattgatggagaagagcttgttaaaattggcaagttgaatttggttgatcttgcaggaagtgaaaatattgggcgttctggagctgttgacaagagggcccgggaagctggaaatatcaaccagtccctgctgactctggggagagttatcactgctcttgtggaaagaacacctcatattccttatcgagaatctaaactaacaagaatcctgcaagattctcttggggggcgtacaaggacatctataattgcaaccatttcccctgcgtctctcaatcttgaggaaactctgagtacattggaatatgctcacagagcaaagaacataatgaataagcctgaagttaatcagaaactcaccaaaaaggcacttattaaggagtatacagaagagatagagcgtttgaagcgagatcttgcagcagctcgtgagaaaaatggagtgtacatctctgaagaaagtttcagagccatgaatggaaaagtaactgttcaggaggaacaaattgctgagttggctgaaaaaattggtgtccttgaggaggagctcagtaaggctgcagagttatttacggatagtgaaaaggaacttaatcagtgtaaatctgacctgcaaaccaagacacaggaacttgaaaccactcagaaacatttgcaagaaacaaaattacaacttgttaaagaggagtatgtctcttcagctttggaaagaactgagaagaagcttcatgaaacggccagcaagttgcttaacacagttaaagaaaccaccagggacgtatctggtctgcattctaaactggaccggaagagagcaatcgatgcgcacaacgctgaggctcaggagagctttggcaggagcctcagcagtctgtttaataatatggaagagttgatcagggacggcagtgagaaacagaaggccatgctggacgttcacaaagcactgttcggtaacctgatgtcttctagtgtctctgcattagacactatttccacgacagcacttgaatctctcatgtctattccagaaaacgtgttagctcgtgtttctcagatttctgatatgatattggaagagcagtcgttagcagcccagagtaaaactgtgctgcaaggatcgattgatgaacttgtgaccaaccttttcacgtccctgaagaccatcatagctcctggtgtggtgtccatcttaaacataaataggcaactacagcatattttcagggcttcggtgacaatggctgaaaaggtagaagatcaaaaaagagaaatagacagttttctcagcatattgtgtaacaatttacatgaactccgagaaaacactgtttcttccttggttgaatcacaaaagctttgtggaaacctaactgaagacctgaagacaataaaggaaacccattcacaggaactttgccagttaagcagtagttgggcagagagattctgtgctttggagaagaagtatgcaaacatccagaaaccactgaacagtattcaagaaaacacagagcggaagtctactgatataatcaataaaacaacagttcacagtaagaaaattcttgcagactctgatggattattacaagaactcagacactttaacgaagaaggtacacagttggttgaagactctgtaggacactgtggttcactcagcagcaacctggagactgtatcccaagagatcacacagaggtgtgggaccctgaacacaagcacagttcatttttctgatcagtgggcatcctgcttaagcaagaggaaggaagagcttcagaacttaatggagtttgtaaatggatgttgtgaagcttcaagttcagagatcactgaaaaaataagaggacacagagcagctattgagagccagcacagctcctttgttgttcagataacttctgatgaagaaaaatttaaagctggaagcctagagcttgataaaactataaaaactggtttaacaaagcttaattgctttctgcaacaggatctgaaactagatatcccaacaggtatgacaccagagaggaaaaattatttatatccatcaacacttgtgagaactgaaccacgggagcaactccttgatcagctgcaaaagaaacagcccaagccactgatgatgctaaattgctcagaaagcagcaaagagaccagtcaggacatggaggaggacagggaggttctggagcagagtactgaagaactcgtaagtcaagagccgtgtgtacataccagtgcggattgctcttccagtggaggtgttccattttttcagcataaaaagccacatggaaaagacaaagaaaacagaggccttaaccccgtggagaagggtaaagtggaggaggcctcggagcactccatctccaagagcagactgccgctgcgcgcctccatcaacctctgctgatctgagggttaggggttgccttcagaatacagcctgaaactccagtctgaagctatgtacagatgacagtgggacagactatatgagggccccacagtaaatgtagttgaattgaacgtccttctttataatccctgtagttcaagtatgtagtaagttgggttccatttgggatttacactgaatatgtatgtgtgtttctagctttttatatgaagaagctcttctgtaacaagtaagtatttttcttgtatataattaaataccaaatatatggaaatggttattccaggcttagacttgtattggcgaatactatctcctttgcagtccggctaaggctgagttcagtgtgtgtttccctacctctgaccagccttttctatttgtcttcagctcacttctcccttttcctgtcacttaaccctttgtaggcccacagaaaggtttccttattatgagaagtccagggttttacctagaaatcttatgtttcactgattacctctacaatcattgtcaaaaataaactgaccctggaagtcccttccttctgtgctcttcgtttgttctcccctcatatgcatgcatctcatgccttcctgaggtctgacacctggcaccagcctccctgcactgtcagctgctgctgcaggagacctgtctagagctctaactcattctttgaggccacaagctaaggcctgtatctcttagaaataacaagacttttttcagactaccaattatgactataacttctgttttgtttatcttttaaaactttattctttgtatataataaaaatgtatatatacattctttctgttgaaatattaacccttactctttctatctgacaactctatttctggaagttggtccatctcaagatgaaccagagcacctacctaaaagacatgtaagcagagagtaaatgggtcacatcaggttcagtgtatatggttcagagtgatgtggctatatttttgtcactgtctcactatgtagctcaggcttactgtgcagacttactgtgcagtaggacagtcctttgtcatccttccaaggcctgggttccaggcatcatcactatgcctggctctagagagatgactttgtaaccacgaacgaaccgttaatagaaaattagaaaagatgctactttaagaaattgattttcttgtgccatttctccagctcactgtagaaatagaaatgttattttaataaaaataatggataaatttccctgcaaacagatgtcaacctaatctgtgggtattctctaatatgcttttggtaaatctctaatcagtaattggtaattgtttttaaatttttttaattaaattattttaattttt
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]