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Previous release (v1)
2024-04-26 01:10:11, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001166022 2834 bp mRNA linear ROD 11-NOV-2023
DEFINITION Rattus norvegicus discoidin domain receptor tyrosine kinase 1
(Ddr1), transcript variant 2, mRNA.
ACCESSION NM_001166022
VERSION NM_001166022.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2834)
AUTHORS Wu R, Pan S, Chen Y, Nakano Y, Li M, Balog S and Tsukamoto H.
TITLE Fate and functional roles of Prominin 1+ cells in liver injury and
cancer
JOURNAL Sci Rep 10 (1), 19412 (2020)
PUBMED 33173221
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2834)
AUTHORS Romayor I, Badiola I, Benedicto A, Marquez J, Herrero A, Arteta B
and Olaso E.
TITLE Silencing of sinusoidal DDR1 reduces murine liver metastasis by
colon carcinoma
JOURNAL Sci Rep 10 (1), 18398 (2020)
PUBMED 33110221
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2834)
AUTHORS Lino M, Ngai D, Liu A, Mohabeer A, Harper C, Caruso LL, Schroer SA,
Fu F, McKee T, Giacca A, Woo M and Bendeck MP.
TITLE Discoidin domain receptor 1-deletion ameliorates fibrosis and
promotes adipose tissue beiging, brown fat activity, and increased
metabolic rate in a mouse model of cardiometabolic disease
JOURNAL Mol Metab 39, 101006 (2020)
PUBMED 32360427
REFERENCE 4 (bases 1 to 2834)
AUTHORS Zhong X, Zhang W and Sun T.
TITLE DDR1 promotes breast tumor growth by suppressing antitumor immunity
JOURNAL Oncol Rep 42 (6), 2844-2854 (2019)
PUBMED 31578591
REFERENCE 5 (bases 1 to 2834)
AUTHORS Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk
NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T,
Vanacore RM, Zent R and Pozzi A.
TITLE The Extracellular Matrix Receptor Discoidin Domain Receptor 1
Regulates Collagen Transcription by Translocating to the Nucleus
JOURNAL J Am Soc Nephrol 30 (9), 1605-1624 (2019)
PUBMED 31383731
REFERENCE 6 (bases 1 to 2834)
AUTHORS Vogel WF, Aszodi A, Alves F and Pawson T.
TITLE Discoidin domain receptor 1 tyrosine kinase has an essential role
in mammary gland development
JOURNAL Mol Cell Biol 21 (8), 2906-2917 (2001)
PUBMED 11283268
REFERENCE 7 (bases 1 to 2834)
AUTHORS Chin GS, Lee S, Hsu M, Liu W, Kim WJ, Levinson H and Longaker MT.
TITLE Discoidin domain receptors and their ligand, collagen, are
temporally regulated in fetal rat fibroblasts in vitro
JOURNAL Plast Reconstr Surg 107 (3), 769-776 (2001)
PUBMED 11304604
REFERENCE 8 (bases 1 to 2834)
AUTHORS Bhatt RS, Tomoda T, Fang Y and Hatten ME.
TITLE Discoidin domain receptor 1 functions in axon extension of
cerebellar granule neurons
JOURNAL Genes Dev 14 (17), 2216-2228 (2000)
PUBMED 10970885
REFERENCE 9 (bases 1 to 2834)
AUTHORS Vogel W, Gish GD, Alves F and Pawson T.
TITLE The discoidin domain receptor tyrosine kinases are activated by
collagen
JOURNAL Mol Cell 1 (1), 13-23 (1997)
PUBMED 9659899
REFERENCE 10 (bases 1 to 2834)
AUTHORS Sanchez MP, Tapley P, Saini SS, He B, Pulido D and Barbacid M.
TITLE Multiple tyrosine protein kinases in rat hippocampal neurons:
isolation of Ptk-3, a receptor expressed in proliferative zones of
the developing brain
JOURNAL Proc Natl Acad Sci U S A 91 (5), 1819-1823 (1994)
PUBMED 8127887
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX883047.1, CB613563.1 and BC166604.1.
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMD00132261,
SAMD00132262 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-12 BX883047.1 279872-279883 c
13-274 CB613563.1 13-274
275-2620 BC166604.1 362-2707
2621-2693 BX883047.1 260674-260746 c
2694-2834 BX883047.1 260414-260554 c
FEATURES Location/Qualifiers
source 1..2834
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="20"
/map="20p12"
gene 1..2834
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="discoidin domain receptor tyrosine kinase 1"
/db_xref="GeneID:25678"
/db_xref="RGD:2252"
exon 1..59
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 60..189
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
CDS 102..2834
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/EC_number="2.7.10.1"
/note="discoidin domain receptor family, member 1;
epithelial discoidin domain-containing receptor 1; cell
adhesion kinase; tyrosine kinase DDR; tyrosine-protein
kinase CAK; protein-tyrosine kinase PTK-3; CD167
antigen-like family member A; discoidin receptor tyrosine
kinase; epithelial discoidin domain receptor 1;
protein-tyrosine kinase 3; neurotrophic tyrosine kinase
receptor type 4"
/codon_start=1
/product="epithelial discoidin domain-containing receptor
1 precursor"
/protein_id="NP_001159494.1"
/db_xref="GeneID:25678"
/db_xref="RGD:2252"
/translation="
MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEMVYLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNHSFPSGYVEMEFEFDRLRSFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPTHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLENKVTQGLPGDRESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFSQLHRFLADDALNTV"
sig_peptide 102..158
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63474.1)"
mat_peptide 159..2831
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/product="Epithelial discoidin domain-containing receptor
1. /id=PRO_0000016745"
/note="propagated from UniProtKB/Swiss-Prot (Q63474.1)"
misc_feature 273..656
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Coagulation factor 5/8 C-terminal domain, discoidin
domain; Cell surface-attached carbohydrate-binding domain,
present in eukaryotes and assumed to have horizontally
transferred to eubacterial genomes; Region: FA58C;
cd00057"
/db_xref="CDD:238014"
misc_feature order(324..326,417..419,441..443)
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="sugar binding site [chemical binding]; other site"
/db_xref="CDD:238014"
misc_feature 678..1205
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="propagated from UniProtKB/Swiss-Prot (Q63474.1);
Region: DS-like domain. /evidence=ECO:0000250"
misc_feature 735..737
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63474.1); glycosylation site"
misc_feature 882..884
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63474.1); glycosylation site"
misc_feature 1212..1214
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63474.1); glycosylation site"
misc_feature 1272..1274
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q63474.1); glycosylation site"
misc_feature 1344..1406
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="propagated from UniProtKB/Swiss-Prot (Q63474.1);
transmembrane region"
misc_feature 1500..1583
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="propagated from UniProtKB/Swiss-Prot (Q63474.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1533..1544
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="propagated from UniProtKB/Swiss-Prot (Q63474.1);
Region: PPxY motif"
misc_feature 1542..1544
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature 1629..1631
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature 1650..1652
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature 1902..2813
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Discoidin Domain Receptor 1; Region: PTKc_DDR1; cd05096"
/db_xref="CDD:133227"
misc_feature order(1938..1952,1962..1964,2049..2051,2055..2057,
2193..2204,2211..2216,2388..2390,2400..2405,2409..2411,
2442..2444,2496..2510,2535..2537,2640..2642)
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="active site"
/db_xref="CDD:133227"
misc_feature order(1938..1943,1947..1952,1962..1964,2049..2051,
2055..2057,2193..2204,2211..2216,2400..2405,2409..2411,
2442..2444)
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133227"
misc_feature 2310..2312
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature order(2388..2390,2400..2402,2496..2510,2535..2537,
2640..2642)
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:133227"
misc_feature 2439..2516
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133227"
misc_feature 2466..2468
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature 2478..2480
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
misc_feature 2481..2483
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/note="Phosphotyrosine, by autocatalysis.
/evidence=ECO:0000250|UniProtKB:Q08345; propagated from
UniProtKB/Swiss-Prot (Q63474.1); phosphorylation site"
exon 190..292
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 293..521
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 522..669
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 670..769
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 770..956
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 957..1203
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1204..1287
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1288..1439
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1440..1605
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1606..1716
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1717..1961
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 1962..2089
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 2090..2308
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 2309..2543
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 2544..2693
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
exon 2694..2834
/gene="Ddr1"
/gene_synonym="Cak; Drd1; PTK3D"
/inference="alignment:Splign:2.1.0"
ORIGIN
cctccacgccccggccagcctctgcaggacccagatttcccatcgctgtctgcagagggagatgctgtcccctcctccataggccagagggatcaggagcgatggggacagggaccctctcatctctcctgctgctgctactcttggtgacaattggagatgctgacatgaagggacattttgacccagccaagtgccgctatgccctgggcatgcaggaccgcaccattccagacagcgatatctctgtgtccagctcctggtcggactctaccgccgcccgccacagcaggctggaaagcagtgatggagatggggcttggtgccctgcagggcctgtgttccccaaagaagaggagtacctgcaggtggaccttcgtaggctacacctggtggctctggtgggcacccagggccgccatgctgggggtctgggcaaagagttctcccgaagctaccggttgcgttactcccgagatggccgacgatggatggactggaaagacagatggggtcaggaggtgatttcgggtaacgaggatcctgggggagtggtgctgaaggatctcgggccccccatggtggcccggctggtccgtttctaccccagggctgaccgggtcatgagtgtctgtcttcgggtggagctctatggctgcctctggcgggacggactcttgtcctatacagcccccgtggggcagaccatgcaattatctgagatggtgtatctcaatgattccacttacgatggatatactgctggagggctgcagtacggtggtctgggccaactggcagacggcgtggtggggctggatgatttcaggcagagccaggagctgcgggtttggccaggctatgactatgtgggatggagcaaccatagcttccccagcggctacgtggagatggagtttgagtttgaccggctgaggtctttccagaccatgcaggtccactgtaacaacatgcacactctgggagcccgcctcccaggcggggtggaatgccggtttaaaaggggtccggccatggcctgggaaggagagcctgtacgccatgccctggggggtagccttggagaccccagagccagggccatctcggtgcccctgggtggtcacgtgggccgcttcctgcagtgcagattcctctttgcaggaccctggttactcttcagtgagatctctttcatctcggatgtggtgaacgactcgtctgacaccttcccaccagccccctggtggccgcctggcccgcctcccaccaacttcagcagcttggagctggagccccggggtcaacagcctgtggccaaggcggaggggagcccaactgccatcctcattggctgcctggtggccatcatccttctcctcctccttatcattgccctgatgctctggaggctgcactggcgccggctgctcagcaaggcagagcgccgggtgttggaggaggagctgacggttcacctctctgtccctggggacaccatcctcatcaacaaccgcccagggccccgagagccacccccttaccaggaaccccggcctcgggggactccaactcactctgcgccctgcgtccccaatggctctgcgttgctgctctccaatccggcctaccgcctccttctggccacttacgcccgtccccctcgaggcccgggcccccccacacccgcctgggccaaacccaccaacacccaggcctgcagtggggactacatggagcccgagaagccgggcgccccacttctacccccacctccccagaacagcgtcccccattacgccgaggctgacattgtcaccctgcagggcgtcacagggggcaacacctacgctgttcccgcactgcccccaggggcggttggggatgggccccccagagtggatttccctcggtcacggctccgtttcaaggagaagctcggcgagggccaatttggggaggtacatctctgtgaagtagaggaccctcaagatctggtcactagtgacttccctatcagtgtgcaaaagggacaccccttgctggtggcagtgaagatcctccggccagatgccaccaaaaatgccaggaatgacttcctgaaggaggtaaagatcatgtcacggctgaaggacccaaacatcatccggctcctgggtgtgtgtgtgcaggatgaccctctctgcatgattacagactacatggagaacggtgacctgaaccaattcctcagtgcccaccagctggagaacaaggtcactcaggggcttcctggggacagagagtctgaccaggggcccacaatcagctaccctatgctgttacacgtgggggcccagatcgcctctggcatgcgatatctggccacccttaactttgtgcatcgggacctggccacccggaactgcttggttggggaaaatttcaccatcaaaatcgccgactttggcatgagccggaatctctacgctggggattattaccgtgtacagggccgggcagtgctgcccatcaggtggatggcctgggagtgtatcctcatggggaagttcacaacagccagtgatgtgtgggccttcggagtgaccctgtgggaggtgcttatgctctgcaggtcacagcccttcgggcaactcacagacgagcaggtcatcgagaacgccggcgagttcttcagggaccagggccggcaggtatacttatccaggccacccgcctgcccgcagaccttgtatgagctgatgctccggtgttggagccgggagccggagcagcggccgcccttctcccagcttcatcggttcctggcggatgatgcactcaacacagtgtaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]