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Previous release (v1)
2024-04-29 06:19:38, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001164305 14803 bp mRNA linear ROD 31-DEC-2022
DEFINITION Rattus norvegicus plectin (Plec), transcript variant 9, mRNA.
ACCESSION NM_001164305
VERSION NM_001164305.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 14803)
AUTHORS Ni Y, Wang X, Yin X, Li Y, Liu X, Wang H, Liu X, Zhang J, Gao H,
Shi B and Zhao S.
TITLE Plectin protects podocytes from adriamycin-induced apoptosis and
F-actin cytoskeletal disruption through the integrin
alpha6beta4/FAK/p38 MAPK pathway
JOURNAL J Cell Mol Med 22 (11), 5450-5467 (2018)
PUBMED 30187999
REMARK GeneRIF: these findings indicated that plectin protects podocytes
from ADR-induced apoptosis and F-actin cytoskeletal disruption by
inhibiting integrin alpha6beta4/FAK/p38 pathway activation and that
plectin may be a therapeutic target for podocyte injury-related
glomerular diseases.
REFERENCE 2 (bases 1 to 14803)
AUTHORS Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
TITLE E-cadherin interactome complexity and robustness resolved by
quantitative proteomics
JOURNAL Sci Signal 7 (354), rs7 (2014)
PUBMED 25468996
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 14803)
AUTHORS Zanivan S, Maione F, Hein MY, Hernandez-Fernaud JR, Ostasiewicz P,
Giraudo E and Mann M.
TITLE SILAC-based proteomics of human primary endothelial cell
morphogenesis unveils tumor angiogenic markers
JOURNAL Mol Cell Proteomics 12 (12), 3599-3611 (2013)
PUBMED 23979707
REFERENCE 4 (bases 1 to 14803)
AUTHORS Rezniczek GA, Walko G and Wiche G.
TITLE Plectin gene defects lead to various forms of epidermolysis bullosa
simplex
JOURNAL Dermatol Clin 28 (1), 33-41 (2010)
PUBMED 19945614
REMARK Review article
Erratum:[Dermatol Clin. 2010 Apr;28(2):439-41]
REFERENCE 5 (bases 1 to 14803)
AUTHORS Zhang T, Haws P and Wu Q.
TITLE Multiple variable first exons: a mechanism for cell- and
tissue-specific gene regulation
JOURNAL Genome Res 14 (1), 79-89 (2004)
PUBMED 14672974
REFERENCE 6 (bases 1 to 14803)
AUTHORS Rezniczek GA, Abrahamsberg C, Fuchs P, Spazierer D and Wiche G.
TITLE Plectin 5'-transcript diversity: short alternative sequences
determine stability of gene products, initiation of translation and
subcellular localization of isoforms
JOURNAL Hum Mol Genet 12 (23), 3181-3194 (2003)
PUBMED 14559777
REFERENCE 7 (bases 1 to 14803)
AUTHORS Fuchs P, Zorer M, Rezniczek GA, Spazierer D, Oehler S, Castanon MJ,
Hauptmann R and Wiche G.
TITLE Unusual 5' transcript complexity of plectin isoforms: novel
tissue-specific exons modulate actin binding activity
JOURNAL Hum Mol Genet 8 (13), 2461-2472 (1999)
PUBMED 10556294
REFERENCE 8 (bases 1 to 14803)
AUTHORS Elliott CE, Becker B, Oehler S, Castanon MJ, Hauptmann R and Wiche
G.
TITLE Plectin transcript diversity: identification and tissue
distribution of variants with distinct first coding exons and
rodless isoforms
JOURNAL Genomics 42 (1), 115-125 (1997)
PUBMED 9177781
REFERENCE 9 (bases 1 to 14803)
AUTHORS Liu CG, Maercker C, Castanon MJ, Hauptmann R and Wiche G.
TITLE Human plectin: organization of the gene, sequence analysis, and
chromosome localization (8q24)
JOURNAL Proc Natl Acad Sci U S A 93 (9), 4278-4283 (1996)
PUBMED 8633055
REFERENCE 10 (bases 1 to 14803)
AUTHORS Wiche G, Becker B, Luber K, Weitzer G, Castanon MJ, Hauptmann R,
Stratowa C and Stewart M.
TITLE Cloning and sequencing of rat plectin indicates a 466-kD
polypeptide chain with a three-domain structure based on a central
alpha-helical coiled coil
JOURNAL J Cell Biol 114 (1), 83-99 (1991)
PUBMED 2050743
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Gunther Rezniczek, Gerhard Wiche. The reference
sequence was derived from JACYVU010000186.1.
On Feb 10, 2021 this sequence version replaced NM_001164305.1.
Summary: Plectin is a prominent member of an important family of
structurally and in part functionally related proteins, termed
plakins or cytolinkers, that are capable of interlinking different
elements of the cytoskeleton. Plakins, with their multi-domain
structure and enormous size, not only play crucial roles in
maintaining cell and tissue integrity and orchestrating dynamic
changes in cytoarchitecture and cell shape, but also serve as
scaffolding platforms for the assembly, positioning, and regulation
of signaling complexes (for reviews see PMID: 9701547, 11854008,
and 17499243). Plectin is expressed as several protein isoforms in
a wide range of cell types and tissues from a single gene located
on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010,
this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in
mouse and rat) and the gene product had been referred to as
'hemidesmosomal protein 1' or 'plectin 1, intermediate filament
binding 500kDa'. These names were replaced by plectin. The plectin
gene locus in mouse on chromosome 15 has been analyzed in detail
(PMID: 10556294, 14559777), revealing a genomic exon-intron
organization with well over 40 exons spanning over 62 kb and an
unusual 5' transcript complexity of plectin isoforms. Eleven exons
(1-1j) have been identified that alternatively splice directly into
a common exon 2 which is the first exon to encode plectin's highly
conserved actin binding domain (ABD). Three additional exons (-1,
0a, and 0) splice into an alternative first coding exon (1c), and
two additional exons (2alpha and 3alpha) are optionally spliced
within the exons encoding the acting binding domain (exons 2-8).
Analysis of the human locus has identified eight of the eleven
alternative 5' exons found in mouse and rat (PMID: 14672974); exons
1i, 1j and 1h have not been confirmed in human. Furthermore,
isoforms lacking the central rod domain encoded by exon 31 have
been detected in mouse (PMID:10556294), rat (PMID: 9177781), and
human (PMID: 11441066, 10780662, 20052759). The short alternative
amino-terminal sequences encoded by the different first exons
direct the targeting of the various isoforms to distinct
subcellular locations (PMID: 14559777). As the expression of
specific plectin isoforms was found to be dependent on cell type
(tissue) and stage of development (PMID: 10556294, 12542521,
17389230) it appears that each cell type (tissue) contains a unique
set (proportion and composition) of plectin isoforms, as if
custom-made for specific requirements of the particular cells.
Concordantly, individual isoforms were found to carry out distinct
and specific functions (PMID: 14559777, 12542521, 18541706). In
1996, a number of groups reported that patients suffering from
epidermolysis bullosa simplex with muscular dystrophy (EBS-MD)
lacked plectin expression in skin and muscle tissues due to defects
in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687,
8696340). Two other subtypes of plectin-related EBS have been
described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of
plectin-related diseases see PMID: 15810881, 19945614. Mutations in
the plectin gene related to human diseases should be named based on
the position in NM_000445 (human variant 1, isoform 1c), unless the
mutation is located within one of the other alternative first
exons, in which case the position in the respective Reference
Sequence should be used. [provided by RefSeq, Aug 2011].
Transcript Variant: This variant (9), also known as 1h, contains an
alternate 5' terminal exon which results in a distinct 5' UTR and
causes translation initiation at a downstream start codon compared
to variant 1. The resulting protein (isoform 1hij) has a shorter
N-terminus compared to isoform 1c. Variants 4, 5 and 9 encode the
same protein. Support for the use of the alternate downstream start
codon can be found in PMID:14559777.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMD00132261,
SAMD00132262 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: community standard
(PMID:14559777)
gene product(s) localized to mito. :: PMID: 18541706, 17389230
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-115 JACYVU010000186.1 1158674-1158788 c
116-177 JACYVU010000186.1 1154007-1154068 c
178-267 JACYVU010000186.1 1153608-1153697 c
268-345 JACYVU010000186.1 1152740-1152817 c
346-438 JACYVU010000186.1 1152541-1152633 c
439-605 JACYVU010000186.1 1151539-1151705 c
606-721 JACYVU010000186.1 1150779-1150894 c
722-828 JACYVU010000186.1 1150601-1150707 c
829-948 JACYVU010000186.1 1150388-1150507 c
949-1044 JACYVU010000186.1 1150220-1150315 c
1045-1172 JACYVU010000186.1 1149844-1149971 c
1173-1266 JACYVU010000186.1 1149483-1149576 c
1267-1421 JACYVU010000186.1 1148624-1148778 c
1422-1731 JACYVU010000186.1 1148207-1148516 c
1732-1809 JACYVU010000186.1 1148046-1148123 c
1810-1971 JACYVU010000186.1 1147811-1147972 c
1972-2076 JACYVU010000186.1 1147533-1147637 c
2077-2172 JACYVU010000186.1 1147327-1147422 c
2173-2298 JACYVU010000186.1 1146987-1147112 c
2299-2451 JACYVU010000186.1 1145996-1146148 c
2452-2606 JACYVU010000186.1 1145747-1145901 c
2607-2733 JACYVU010000186.1 1145528-1145654 c
2734-2917 JACYVU010000186.1 1145241-1145424 c
2918-3075 JACYVU010000186.1 1145003-1145160 c
3076-3254 JACYVU010000186.1 1144733-1144911 c
3255-3393 JACYVU010000186.1 1143473-1143611 c
3394-3750 JACYVU010000186.1 1143029-1143385 c
3751-3834 JACYVU010000186.1 1142873-1142956 c
3835-3939 JACYVU010000186.1 1142597-1142701 c
3940-4038 JACYVU010000186.1 1142407-1142505 c
4039-7419 JACYVU010000186.1 1138026-1141406 c
7420-14803 JACYVU010000186.1 1130507-1137890 c
FEATURES Location/Qualifiers
source 1..14803
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q34"
gene 1..14803
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="plectin"
/db_xref="GeneID:64204"
/db_xref="RGD:621649"
exon 1..115
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
misc_feature 61..63
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="upstream in-frame stop codon"
exon 116..177
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 178..267
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 268..345
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
misc_feature 286..288
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="upstream_AUG_codon; putative N-terminal extension:
MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVS
GQSED"
exon 346..438
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 439..605
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
CDS 475..13638
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="isoform 1hij is encoded by transcript variant 9;
plectin 1"
/codon_start=1
/product="plectin isoform 1hij"
/protein_id="NP_001157777.1"
/db_xref="GeneID:64204"
/db_xref="RGD:621649"
/translation="
MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKIPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLNQADSLLQSDIRLLASGKAAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLHDLLAWVEENQRRIDGAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRSITVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLLAVCDYKQVEVTVHKGDQCQLVGPAQPFHWKVLGGSSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQSLNRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEHLKEAQAVPATLQELEVTKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSSWLQDAKSRQEQIQAVPIANSQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEARELQRRMQEEVTRREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEDELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELKLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKASFEKAAAGKAELELELGRIRSNAEDTMRSKELAEQEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDQDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLQEEQQRQQQQMEQEKQELVASMEEARRRQREAEEGVRRKQEELQRLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEEIATSQAAATKALPNGRDALDGPSMEAEPEYTFEGLRQKVPAQQLQEAGILSMEELQRLTQGHTTVAELTQREDVHRYLKGGSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIVITVVEEHERKGQLCFEGLRALVPAAELLDSGVISHEVYQQLQRGERSVREVAEADEVRQALRGTSVIAGVWLEEAGQKLSIYEALRRDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEMHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRALTSPRDDARVYLDPSTREPVTYSQLQQRCRSDQLTGLSLLPLSEKAVRARQEEVYSELQARETLEKAKVEVPVGGFKGRALTVWELISSEYFTEEQRQELLRQFRTGKVTVEKVIKILITIVEEVETQRQERLSFSGLRAPVPASELLASKILSRTQFEQLKDGKTSVKDLSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVLRDHAIRLLEAQIATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLRGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSDMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKSLREVLEMESAWRYLYGTGSVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQPISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDNSGQMLLPLSDARKLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISSAVPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPESAVA"
misc_feature <475..>1113
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Ca2+-binding actin-bundling protein fimbrin/plastin
(EF-Hand superfamily) [Cytoskeleton]; Region: SAC6;
COG5069"
/db_xref="CDD:227401"
misc_feature 475..792
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="second calponin homology (CH) domain found in
plectin and similar proteins; Region: CH_PLEC_rpt2;
cd21238"
/db_xref="CDD:409087"
misc_feature order(481..483,493..495,643..645,649..654,661..666,
670..672,697..723,742..744,748..753,757..762,769..774,
781..783)
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="putative actin binding site [polypeptide binding];
other site"
/db_xref="CDD:409087"
misc_feature order(565..567,574..576,634..645,649..654)
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409087"
misc_feature 1846..2382
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:238103"
misc_feature 2155..2172
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="linker region [active]"
/db_xref="CDD:238103"
misc_feature 2371..2571
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="SH3 domain; Region: SH3_10; pfam17902"
/db_xref="CDD:407754"
misc_feature 2674..2907
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Spectrin like domain; Region: Spectrin_like;
pfam18373"
/db_xref="CDD:436447"
misc_feature <3070..4680
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="DNA repair exonuclease SbcCD ATPase subunit
[Replication, recombination and repair]; Region: SbcC;
COG0419"
/db_xref="CDD:223496"
misc_feature <4027..6147
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="MAEBL; Provisional; Region: PTZ00121"
/db_xref="CDD:173412"
misc_feature <5158..7701
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="MAEBL; Provisional; Region: PTZ00121"
/db_xref="CDD:173412"
misc_feature 8065..8181
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 8179..8295
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 8290..8400
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 8407..8523
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 9043..9156
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 9163..9279
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 9274..9384
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 9391..9507
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10042..10158
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10156..10272
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10267..10362
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 10384..10500
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11044..11154
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11161..11277
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11272..11382
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11389..11505
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11770..11883
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11890..12006
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 12118..12234
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature <12421..12507
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 12817..12918
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 12925..13041
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 13153..13269
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
exon 606..721
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 722..828
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 829..948
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 949..1044
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1045..1172
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1173..1266
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1267..1421
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1422..1731
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1732..1809
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1810..1971
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1972..2076
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2077..2172
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2173..2298
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2299..2451
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2452..2606
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2607..2733
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2734..2917
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2918..3075
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3076..3254
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3255..3393
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3394..3750
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3751..3834
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3835..3939
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3940..4038
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 4039..7419
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 7420..14803
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
ORIGIN
gagtgtgaaagcccgttgtctcccttgtgcctattctgcattgaaggccctgccacttcctaggatgtgctgggggtagaacttctgtggctgcttagcttgcatcaggtcctggatgaacgagaccgtgtgcagaagaaaactttcaccaagtgggtcaataaacaccttatcaaggctcaaaggcacatcagtgacctgtatgaagacctccgtgatggccacaacctcatctccctgctggaagtcctctcaggagacagcctgccccgagagaaggggaggatgcgtttccacaagctgcaaaacgttcagattgccctggactatctccgacatcggcaggtgaagttggtgaacatcagaaatgatgacatcgccgatggcaaccccaagctgaccctgggcctgatctggacaatcatcctgcacttccagatctcagacattcaggtgagcggccagtccgaggacatgacagccaaggagaagctgctgctgtggtctcagcgtatggtagagggctaccaaggcctgcgctgtgacaacttcaccaccagctggcgcgacggccggctcttcaatgctatcatccacaggcacaagcccatgctcatagacatgaataaagtgtaccgacagaccaacctggagaacctagaccaggccttctccgtggcagagcgggacctgggagttaccaggctcctggacccagaagatgtggatgtccctcagcctgatgagaagtccatcatcacctacgtttcatccctgtatgatgccatgccccgtgtgccgggcgcacaggatggagtgagggccaatgagctgcagcttcgttggcaagagtaccgggagcttgtgctgctgctgctacagtggatccggcaccacaccgctgcttttgaggagcgcaagttcccctccagctttgaggagattgagatcctatggtgccagtttctgaagttcaaggagacagaacttcctgccaaggaggcagacaagaaccggtccaaaggcatctaccagtctttggagggagcagtacaagcaggccagctcaagattccccctggctaccacccgctagacgtggaaaaggagtggggcaagctgcacgtggccatcctggagcgggagaagcaactccggagcgagtttgagaggctggagtgtcttcagcgcattgtgagcaagctacagatggaggctgggctatgtgaggagcagctgaaccaggccgattccctactgcagtcggatattcggctgctggcctcaggcaaggcggcacagcgggctggggaagtggagagagacctggacaaggctgatggtatgatccggctgttgttcaatgatgtgcagacccttaaagatgggcggcatccacagggtgaacagatgtaccggagggtgtatcgtctgcatgagcgcctggtagccatccgcactgaatacaacctccggctgaaggcaggggtgggtgcccctgtgacccaggtgaccctgcagagcacacagaggcgcccagagctagaggactccacactgcgttacctgcacgacctgctggcatgggtggaggagaaccagcgtcgaatagacggtgctgagtggggcgtggacttgcccagtgtagaggcacagctgggcagccaccgaggcatgcatcagtctattgaggaattccgggccaagatcgagcgggctcggaatgatgagagccagctctcccctgccacccgaggtgcctaccgagactgcctgggccgcctggacctgcagtatgcaaagctgctgaactcctccaaggcccgcctccggtccctggagagcttgcatgggtttgtggcggcagctaccaaggagctgatgtggctgaatgagaaggaagaggaagaagtgggctttgattggagtgaccgcaacaccaacatggctgccaagaaagaaagttactcggccctgatgcgtgagctggagatgaaggaaaagaaaattaaggagatccagaacacgggggacaggttgctgcgggaagaccatcctgcccggcccacagtggagtccttccaggctgccctgcagacacagtggagctggatgctgcagctgtgttgctgcattgaagcgcacttgaaagagaacacagcctacttccagttcttctcagatgttcgggaggctgaggaacagttgcagaaactacaggagacgttacgcaggaagtacagctgtgaccgctccatcactgtcacaaggcttgaggacctgctgcaggatgcccaggatgagaaggagcaactgaatgagtacaaagggcacctctcaggcctggccaagcgggccaaggctattgtgcagctgaagccacgcaaccctgcccaccctgtgcggggtcacgtgcccctgctagctgtgtgtgactacaagcaggtggaggtgactgtgcacaagggtgaccaatgccagctggtgggccctgcccagccgttccactggaaggtgctcggtggttccagcagtgaggctgccgtgccttctgtgtgctttcttgtgccgccacccaaccaggaggcccaggaagctgttgctaggctggaggcccagcatcaggccctggttactctgtggcaccagcttcacgtggacatgaagagtcttctggcatggcagagcctcaatcgtgacatacagctcatccggtcctggtccctagtcacgttccgcacgctgaagcccgaggagcagcggcaagctctgcgcaacctggagttgcactaccaggccttccttcgagacagccaggacgctggtggctttgggcccgaggaccggctggtggcagagcgcgaatatggatcttgtagtcgccactaccagcagctgctacaaagcctggagcagggtgagcaggaggagtctcgctgtcagcgatgcatctcggagctcaaggacattcggctgcaactggaggcctgtgagactcggactgtgcaccgtctgcggctgccactggataaagaccccgcacgggagtgtgcccagcgcatcgctgagcaacagaaagcacaggctgaggtggaggggctgggcaagggagttgcccggctgtctgctgaggctgagaaagttctggccttgccagagccgtcacctgctgcaccaactctgcgctcggagttggaattgaccctgggcaagctggaacaggtcagaagcctgtctgccatctacttggagaaactcaagaccatcagcttggtaattcgcagtacccagggggctgaggaggtgcttaaaacacacgaggagcacctgaaggaggcccaggccgtgcctgccacactccaagagctcgaagtcaccaaggcttcactaaagaagctgcgggcccaggcggaggcacagcagcctgtattcaacaccctacgagatgagctgaggggggcacaggaagttggtgaacggctacagcagcggcatggtgagcgggacgtggaagtagagcgctggcgagaacgtgtcactcagttgctggagcgctggcaggctgtgctagcccagactgatgtgcggcagcgggagcttgaacagctgggccgccaacttcgctactaccgtgaaagtgcggatccgctgagctcctggctgcaggatgccaagagccggcaagagcagatccaggctgtgccaatagccaacagtcaggctgcacgagaacagctgcgccaggagaaggccctgctggaggagattgagcgccatggtgagaaggttgaggagtgccagaagtttgctaagcagtacatcaatgcaatcaaggactatgagctccagctgatcacctacaaggctcagcttgaacctgtggcctcccccgccaagaagcccaaggttcagtctggatcggagagcgtcatccaggagtacgtggatctgcgtacacgctacagtgagctgaccacactcacgagtcagtacatcaagttcatcagtgagacactgcgccgcatggaagaggaagagcggctggctgagcaacagcgggcagaggagcgggagcgcctggccgaggtggaggccgcgctggagaagcagcggcagctggctgaggcccatgcccaggccaaggcacaggccgagctggaggcacgagaactgcagcggcgcatgcaggaggaggtgacgcggcgcgaggaggcggcggtggacgcacagcaacagaagcgcagcatccaagaggagctgcagcatctgcggcaaagctcagaggcagagatccaggccaaggcccagcaggtggaggctgcagagcgcagccgcatgcgcattgaggaagagatccgcgtagtccgtctgcagctagagacaactgagcgtcagcgtggaggggcggaggatgagctgcaggctctgcgtgcacgggctgaggaggcagaagcacagaagcggcaggctcaggaggaagccgagcgcttgcggaggcaggtgcaggatgagagccaacgcaaacggcaggcggaggccgagctggccctgcgtgtgaaggcagaagcggaggcagcgcgagagaagcagcgggccctgcaggctctggatgaactgaaactgcaggccgaggaggccgaacggcggctgcgccaagccgaggcagagagggctcgccaagtgcaggtagccctggagacagcgcagcgtagtgcagaagtggagctgcagagcaagcgtgcgtcctttgcagagaagaccgcacagttggagcgcacgctgcaggaagagcacgtgacagtgacacagctgcgggaggaggcggaacggcgggcacagcagcaggctgaagccgagcgagcccgtgaggaagccgagcgggagctggagcgctggcagctgaaggccaatgaggcgctgcggctgcggctgcaggcagaggaggtggcacagcagaagagcctggcccaggccgatgcagagaagcagaaggaagaggc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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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