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Previous release (v1)
2024-04-29 09:31:15, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001164302 14873 bp mRNA linear ROD 31-DEC-2022
DEFINITION Rattus norvegicus plectin (Plec), transcript variant 5, mRNA.
ACCESSION NM_001164302
VERSION NM_001164302.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 14873)
AUTHORS Ni Y, Wang X, Yin X, Li Y, Liu X, Wang H, Liu X, Zhang J, Gao H,
Shi B and Zhao S.
TITLE Plectin protects podocytes from adriamycin-induced apoptosis and
F-actin cytoskeletal disruption through the integrin
alpha6beta4/FAK/p38 MAPK pathway
JOURNAL J Cell Mol Med 22 (11), 5450-5467 (2018)
PUBMED 30187999
REMARK GeneRIF: these findings indicated that plectin protects podocytes
from ADR-induced apoptosis and F-actin cytoskeletal disruption by
inhibiting integrin alpha6beta4/FAK/p38 pathway activation and that
plectin may be a therapeutic target for podocyte injury-related
glomerular diseases.
REFERENCE 2 (bases 1 to 14873)
AUTHORS Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
TITLE E-cadherin interactome complexity and robustness resolved by
quantitative proteomics
JOURNAL Sci Signal 7 (354), rs7 (2014)
PUBMED 25468996
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 14873)
AUTHORS Zanivan S, Maione F, Hein MY, Hernandez-Fernaud JR, Ostasiewicz P,
Giraudo E and Mann M.
TITLE SILAC-based proteomics of human primary endothelial cell
morphogenesis unveils tumor angiogenic markers
JOURNAL Mol Cell Proteomics 12 (12), 3599-3611 (2013)
PUBMED 23979707
REFERENCE 4 (bases 1 to 14873)
AUTHORS Rezniczek GA, Walko G and Wiche G.
TITLE Plectin gene defects lead to various forms of epidermolysis bullosa
simplex
JOURNAL Dermatol Clin 28 (1), 33-41 (2010)
PUBMED 19945614
REMARK Review article
Erratum:[Dermatol Clin. 2010 Apr;28(2):439-41]
REFERENCE 5 (bases 1 to 14873)
AUTHORS Zhang T, Haws P and Wu Q.
TITLE Multiple variable first exons: a mechanism for cell- and
tissue-specific gene regulation
JOURNAL Genome Res 14 (1), 79-89 (2004)
PUBMED 14672974
REFERENCE 6 (bases 1 to 14873)
AUTHORS Rezniczek GA, Abrahamsberg C, Fuchs P, Spazierer D and Wiche G.
TITLE Plectin 5'-transcript diversity: short alternative sequences
determine stability of gene products, initiation of translation and
subcellular localization of isoforms
JOURNAL Hum Mol Genet 12 (23), 3181-3194 (2003)
PUBMED 14559777
REFERENCE 7 (bases 1 to 14873)
AUTHORS Fuchs P, Zorer M, Rezniczek GA, Spazierer D, Oehler S, Castanon MJ,
Hauptmann R and Wiche G.
TITLE Unusual 5' transcript complexity of plectin isoforms: novel
tissue-specific exons modulate actin binding activity
JOURNAL Hum Mol Genet 8 (13), 2461-2472 (1999)
PUBMED 10556294
REFERENCE 8 (bases 1 to 14873)
AUTHORS Elliott CE, Becker B, Oehler S, Castanon MJ, Hauptmann R and Wiche
G.
TITLE Plectin transcript diversity: identification and tissue
distribution of variants with distinct first coding exons and
rodless isoforms
JOURNAL Genomics 42 (1), 115-125 (1997)
PUBMED 9177781
REFERENCE 9 (bases 1 to 14873)
AUTHORS Liu CG, Maercker C, Castanon MJ, Hauptmann R and Wiche G.
TITLE Human plectin: organization of the gene, sequence analysis, and
chromosome localization (8q24)
JOURNAL Proc Natl Acad Sci U S A 93 (9), 4278-4283 (1996)
PUBMED 8633055
REFERENCE 10 (bases 1 to 14873)
AUTHORS Wiche G, Becker B, Luber K, Weitzer G, Castanon MJ, Hauptmann R,
Stratowa C and Stewart M.
TITLE Cloning and sequencing of rat plectin indicates a 466-kD
polypeptide chain with a three-domain structure based on a central
alpha-helical coiled coil
JOURNAL J Cell Biol 114 (1), 83-99 (1991)
PUBMED 2050743
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Gunther Rezniczek, Gerhard Wiche. The reference
sequence was derived from JACYVU010000186.1.
On Feb 10, 2021 this sequence version replaced NM_001164302.1.
Summary: Plectin is a prominent member of an important family of
structurally and in part functionally related proteins, termed
plakins or cytolinkers, that are capable of interlinking different
elements of the cytoskeleton. Plakins, with their multi-domain
structure and enormous size, not only play crucial roles in
maintaining cell and tissue integrity and orchestrating dynamic
changes in cytoarchitecture and cell shape, but also serve as
scaffolding platforms for the assembly, positioning, and regulation
of signaling complexes (for reviews see PMID: 9701547, 11854008,
and 17499243). Plectin is expressed as several protein isoforms in
a wide range of cell types and tissues from a single gene located
on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010,
this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in
mouse and rat) and the gene product had been referred to as
'hemidesmosomal protein 1' or 'plectin 1, intermediate filament
binding 500kDa'. These names were replaced by plectin. The plectin
gene locus in mouse on chromosome 15 has been analyzed in detail
(PMID: 10556294, 14559777), revealing a genomic exon-intron
organization with well over 40 exons spanning over 62 kb and an
unusual 5' transcript complexity of plectin isoforms. Eleven exons
(1-1j) have been identified that alternatively splice directly into
a common exon 2 which is the first exon to encode plectin's highly
conserved actin binding domain (ABD). Three additional exons (-1,
0a, and 0) splice into an alternative first coding exon (1c), and
two additional exons (2alpha and 3alpha) are optionally spliced
within the exons encoding the acting binding domain (exons 2-8).
Analysis of the human locus has identified eight of the eleven
alternative 5' exons found in mouse and rat (PMID: 14672974); exons
1i, 1j and 1h have not been confirmed in human. Furthermore,
isoforms lacking the central rod domain encoded by exon 31 have
been detected in mouse (PMID:10556294), rat (PMID: 9177781), and
human (PMID: 11441066, 10780662, 20052759). The short alternative
amino-terminal sequences encoded by the different first exons
direct the targeting of the various isoforms to distinct
subcellular locations (PMID: 14559777). As the expression of
specific plectin isoforms was found to be dependent on cell type
(tissue) and stage of development (PMID: 10556294, 12542521,
17389230) it appears that each cell type (tissue) contains a unique
set (proportion and composition) of plectin isoforms, as if
custom-made for specific requirements of the particular cells.
Concordantly, individual isoforms were found to carry out distinct
and specific functions (PMID: 14559777, 12542521, 18541706). In
1996, a number of groups reported that patients suffering from
epidermolysis bullosa simplex with muscular dystrophy (EBS-MD)
lacked plectin expression in skin and muscle tissues due to defects
in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687,
8696340). Two other subtypes of plectin-related EBS have been
described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of
plectin-related diseases see PMID: 15810881, 19945614. Mutations in
the plectin gene related to human diseases should be named based on
the position in NM_000445 (human variant 1, isoform 1c), unless the
mutation is located within one of the other alternative first
exons, in which case the position in the respective Reference
Sequence should be used. [provided by RefSeq, Aug 2011].
Transcript Variant: This variant (5), also known as 1j, contains an
alternate 5' terminal exon which results in a distinct 5' UTR and
causes translation initiation at a downstream start codon compared
to variant 1. The resulting protein (isoform 1hij) has a shorter
N-terminus compared to isoform 1c. Variants 4, 5 and 9 encode the
same protein. Support for the use of the alternate downstream start
codon can be found in PMID:14559777.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMEA5760383,
SAMEA5760389 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: community standard
(PMID:14559777)
gene product(s) localized to mito. :: PMID: 18541706, 17389230
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-185 JACYVU010000186.1 1167407-1167591 c
186-247 JACYVU010000186.1 1154007-1154068 c
248-337 JACYVU010000186.1 1153608-1153697 c
338-415 JACYVU010000186.1 1152740-1152817 c
416-508 JACYVU010000186.1 1152541-1152633 c
509-675 JACYVU010000186.1 1151539-1151705 c
676-791 JACYVU010000186.1 1150779-1150894 c
792-898 JACYVU010000186.1 1150601-1150707 c
899-1018 JACYVU010000186.1 1150388-1150507 c
1019-1114 JACYVU010000186.1 1150220-1150315 c
1115-1242 JACYVU010000186.1 1149844-1149971 c
1243-1336 JACYVU010000186.1 1149483-1149576 c
1337-1491 JACYVU010000186.1 1148624-1148778 c
1492-1801 JACYVU010000186.1 1148207-1148516 c
1802-1879 JACYVU010000186.1 1148046-1148123 c
1880-2041 JACYVU010000186.1 1147811-1147972 c
2042-2146 JACYVU010000186.1 1147533-1147637 c
2147-2242 JACYVU010000186.1 1147327-1147422 c
2243-2368 JACYVU010000186.1 1146987-1147112 c
2369-2521 JACYVU010000186.1 1145996-1146148 c
2522-2676 JACYVU010000186.1 1145747-1145901 c
2677-2803 JACYVU010000186.1 1145528-1145654 c
2804-2987 JACYVU010000186.1 1145241-1145424 c
2988-3145 JACYVU010000186.1 1145003-1145160 c
3146-3324 JACYVU010000186.1 1144733-1144911 c
3325-3463 JACYVU010000186.1 1143473-1143611 c
3464-3820 JACYVU010000186.1 1143029-1143385 c
3821-3904 JACYVU010000186.1 1142873-1142956 c
3905-4009 JACYVU010000186.1 1142597-1142701 c
4010-4108 JACYVU010000186.1 1142407-1142505 c
4109-7489 JACYVU010000186.1 1138026-1141406 c
7490-14873 JACYVU010000186.1 1130507-1137890 c
FEATURES Location/Qualifiers
source 1..14873
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q34"
gene 1..14873
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="plectin"
/db_xref="GeneID:64204"
/db_xref="RGD:621649"
exon 1..185
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
misc_feature 59..61
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="upstream in-frame stop codon"
exon 186..247
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 248..337
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 338..415
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
misc_feature 356..358
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="upstream_AUG_codon; putative N-terminal extension:
MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVS
GQSED"
exon 416..508
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 509..675
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
CDS 545..13708
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="isoform 1hij is encoded by transcript variant 5;
plectin 1"
/codon_start=1
/product="plectin isoform 1hij"
/protein_id="NP_001157774.1"
/db_xref="GeneID:64204"
/db_xref="RGD:621649"
/translation="
MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKIPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLNQADSLLQSDIRLLASGKAAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLHDLLAWVEENQRRIDGAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRSITVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLLAVCDYKQVEVTVHKGDQCQLVGPAQPFHWKVLGGSSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQSLNRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEHLKEAQAVPATLQELEVTKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSSWLQDAKSRQEQIQAVPIANSQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEARELQRRMQEEVTRREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEDELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELKLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKASFEKAAAGKAELELELGRIRSNAEDTMRSKELAEQEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDQDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLQEEQQRQQQQMEQEKQELVASMEEARRRQREAEEGVRRKQEELQRLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEEIATSQAAATKALPNGRDALDGPSMEAEPEYTFEGLRQKVPAQQLQEAGILSMEELQRLTQGHTTVAELTQREDVHRYLKGGSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIVITVVEEHERKGQLCFEGLRALVPAAELLDSGVISHEVYQQLQRGERSVREVAEADEVRQALRGTSVIAGVWLEEAGQKLSIYEALRRDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEMHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRALTSPRDDARVYLDPSTREPVTYSQLQQRCRSDQLTGLSLLPLSEKAVRARQEEVYSELQARETLEKAKVEVPVGGFKGRALTVWELISSEYFTEEQRQELLRQFRTGKVTVEKVIKILITIVEEVETQRQERLSFSGLRAPVPASELLASKILSRTQFEQLKDGKTSVKDLSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGSTISLFQAMKKGLVLRDHAIRLLEAQIATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLRGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSDMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKSLREVLEMESAWRYLYGTGSVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQPISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDNSGQMLLPLSDARKLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISSAVPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPESAVA"
misc_feature <545..>1183
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Ca2+-binding actin-bundling protein fimbrin/plastin
(EF-Hand superfamily) [Cytoskeleton]; Region: SAC6;
COG5069"
/db_xref="CDD:227401"
misc_feature 545..862
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="second calponin homology (CH) domain found in
plectin and similar proteins; Region: CH_PLEC_rpt2;
cd21238"
/db_xref="CDD:409087"
misc_feature order(551..553,563..565,713..715,719..724,731..736,
740..742,767..793,812..814,818..823,827..832,839..844,
851..853)
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="putative actin binding site [polypeptide binding];
other site"
/db_xref="CDD:409087"
misc_feature order(635..637,644..646,704..715,719..724)
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409087"
misc_feature 1916..2452
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:238103"
misc_feature 2225..2242
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="linker region [active]"
/db_xref="CDD:238103"
misc_feature 2441..2641
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="SH3 domain; Region: SH3_10; pfam17902"
/db_xref="CDD:407754"
misc_feature 2744..2977
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Spectrin like domain; Region: Spectrin_like;
pfam18373"
/db_xref="CDD:436447"
misc_feature <3140..4750
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="DNA repair exonuclease SbcCD ATPase subunit
[Replication, recombination and repair]; Region: SbcC;
COG0419"
/db_xref="CDD:223496"
misc_feature <4097..6217
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="MAEBL; Provisional; Region: PTZ00121"
/db_xref="CDD:173412"
misc_feature <5228..7771
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="MAEBL; Provisional; Region: PTZ00121"
/db_xref="CDD:173412"
misc_feature 8135..8251
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 8249..8365
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 8360..8470
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 8477..8593
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 9113..9226
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 9233..9349
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 9344..9454
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 9461..9577
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10112..10228
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10226..10342
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 10337..10432
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 10454..10570
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11114..11224
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11231..11347
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11342..11452
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11459..11575
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 11840..11953
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 11960..12076
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 12188..12304
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature <12491..12577
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 12887..12988
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: PLEC; smart00250"
/db_xref="CDD:197605"
misc_feature 12995..13111
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
misc_feature 13223..13339
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/note="Plectin repeat; Region: Plectin; pfam00681"
/db_xref="CDD:425816"
exon 676..791
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 792..898
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 899..1018
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1019..1114
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1115..1242
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1243..1336
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1337..1491
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1492..1801
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1802..1879
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 1880..2041
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2042..2146
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2147..2242
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2243..2368
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2369..2521
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2522..2676
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2677..2803
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2804..2987
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 2988..3145
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3146..3324
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3325..3463
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3464..3820
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3821..3904
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 3905..4009
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 4010..4108
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 4109..7489
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
exon 7490..14873
/gene="Plec"
/gene_synonym="Pcn; Plec1; Pltn"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggaggagagattccctacacactggttctgctgctgggagctactgccctctcctgcctaaaggtgggatagggacgatggctgggttgacttagttactgtaagggcacccatatgggactgggcagaagcgtcttcaggtccaagggctcaggggactttggaagtggctgggatcatttgggatgaacgagaccgtgtgcagaagaaaactttcaccaagtgggtcaataaacaccttatcaaggctcaaaggcacatcagtgacctgtatgaagacctccgtgatggccacaacctcatctccctgctggaagtcctctcaggagacagcctgccccgagagaaggggaggatgcgtttccacaagctgcaaaacgttcagattgccctggactatctccgacatcggcaggtgaagttggtgaacatcagaaatgatgacatcgccgatggcaaccccaagctgaccctgggcctgatctggacaatcatcctgcacttccagatctcagacattcaggtgagcggccagtccgaggacatgacagccaaggagaagctgctgctgtggtctcagcgtatggtagagggctaccaaggcctgcgctgtgacaacttcaccaccagctggcgcgacggccggctcttcaatgctatcatccacaggcacaagcccatgctcatagacatgaataaagtgtaccgacagaccaacctggagaacctagaccaggccttctccgtggcagagcgggacctgggagttaccaggctcctggacccagaagatgtggatgtccctcagcctgatgagaagtccatcatcacctacgtttcatccctgtatgatgccatgccccgtgtgccgggcgcacaggatggagtgagggccaatgagctgcagcttcgttggcaagagtaccgggagcttgtgctgctgctgctacagtggatccggcaccacaccgctgcttttgaggagcgcaagttcccctccagctttgaggagattgagatcctatggtgccagtttctgaagttcaaggagacagaacttcctgccaaggaggcagacaagaaccggtccaaaggcatctaccagtctttggagggagcagtacaagcaggccagctcaagattccccctggctaccacccgctagacgtggaaaaggagtggggcaagctgcacgtggccatcctggagcgggagaagcaactccggagcgagtttgagaggctggagtgtcttcagcgcattgtgagcaagctacagatggaggctgggctatgtgaggagcagctgaaccaggccgattccctactgcagtcggatattcggctgctggcctcaggcaaggcggcacagcgggctggggaagtggagagagacctggacaaggctgatggtatgatccggctgttgttcaatgatgtgcagacccttaaagatgggcggcatccacagggtgaacagatgtaccggagggtgtatcgtctgcatgagcgcctggtagccatccgcactgaatacaacctccggctgaaggcaggggtgggtgcccctgtgacccaggtgaccctgcagagcacacagaggcgcccagagctagaggactccacactgcgttacctgcacgacctgctggcatgggtggaggagaaccagcgtcgaatagacggtgctgagtggggcgtggacttgcccagtgtagaggcacagctgggcagccaccgaggcatgcatcagtctattgaggaattccgggccaagatcgagcgggctcggaatgatgagagccagctctcccctgccacccgaggtgcctaccgagactgcctgggccgcctggacctgcagtatgcaaagctgctgaactcctccaaggcccgcctccggtccctggagagcttgcatgggtttgtggcggcagctaccaaggagctgatgtggctgaatgagaaggaagaggaagaagtgggctttgattggagtgaccgcaacaccaacatggctgccaagaaagaaagttactcggccctgatgcgtgagctggagatgaaggaaaagaaaattaaggagatccagaacacgggggacaggttgctgcgggaagaccatcctgcccggcccacagtggagtccttccaggctgccctgcagacacagtggagctggatgctgcagctgtgttgctgcattgaagcgcacttgaaagagaacacagcctacttccagttcttctcagatgttcgggaggctgaggaacagttgcagaaactacaggagacgttacgcaggaagtacagctgtgaccgctccatcactgtcacaaggcttgaggacctgctgcaggatgcccaggatgagaaggagcaactgaatgagtacaaagggcacctctcaggcctggccaagcgggccaaggctattgtgcagctgaagccacgcaaccctgcccaccctgtgcggggtcacgtgcccctgctagctgtgtgtgactacaagcaggtggaggtgactgtgcacaagggtgaccaatgccagctggtgggccctgcccagccgttccactggaaggtgctcggtggttccagcagtgaggctgccgtgccttctgtgtgctttcttgtgccgccacccaaccaggaggcccaggaagctgttgctaggctggaggcccagcatcaggccctggttactctgtggcaccagcttcacgtggacatgaagagtcttctggcatggcagagcctcaatcgtgacatacagctcatccggtcctggtccctagtcacgttccgcacgctgaagcccgaggagcagcggcaagctctgcgcaacctggagttgcactaccaggccttccttcgagacagccaggacgctggtggctttgggcccgaggaccggctggtggcagagcgcgaatatggatcttgtagtcgccactaccagcagctgctacaaagcctggagcagggtgagcaggaggagtctcgctgtcagcgatgcatctcggagctcaaggacattcggctgcaactggaggcctgtgagactcggactgtgcaccgtctgcggctgccactggataaagaccccgcacgggagtgtgcccagcgcatcgctgagcaacagaaagcacaggctgaggtggaggggctgggcaagggagttgcccggctgtctgctgaggctgagaaagttctggccttgccagagccgtcacctgctgcaccaactctgcgctcggagttggaattgaccctgggcaagctggaacaggtcagaagcctgtctgccatctacttggagaaactcaagaccatcagcttggtaattcgcagtacccagggggctgaggaggtgcttaaaacacacgaggagcacctgaaggaggcccaggccgtgcctgccacactccaagagctcgaagtcaccaaggcttcactaaagaagctgcgggcccaggcggaggcacagcagcctgtattcaacaccctacgagatgagctgaggggggcacaggaagttggtgaacggctacagcagcggcatggtgagcgggacgtggaagtagagcgctggcgagaacgtgtcactcagttgctggagcgctggcaggctgtgctagcccagactgatgtgcggcagcgggagcttgaacagctgggccgccaacttcgctactaccgtgaaagtgcggatccgctgagctcctggctgcaggatgccaagagccggcaagagcagatccaggctgtgccaatagccaacagtcaggctgcacgagaacagctgcgccaggagaaggccctgctggaggagattgagcgccatggtgagaaggttgaggagtgccagaagtttgctaagcagtacatcaatgcaatcaaggactatgagctccagctgatcacctacaaggctcagcttgaacctgtggcctcccccgccaagaagcccaaggttcagtctggatcggagagcgtcatccaggagtacgtggatctgcgtacacgctacagtgagctgaccacactcacgagtcagtacatcaagttcatcagtgagacactgcgccgcatggaagaggaagagcggctggctgagcaacagcgggcagaggagcgggagcgcctggccgaggtggaggccgcgctggagaagcagcggcagctggctgaggcccatgcccaggccaaggcacaggccgagctggaggcacgagaactgcagcggcgcatgcaggaggaggtgacgcggcgcgaggaggcggcggtggacgcacagcaacagaagcgcagcatccaagaggagctgcagcatctgcggcaaagctcagaggcagagatccaggccaaggcccagcaggtggaggctgcagagcgcagccgcatgcgcattgaggaagagatccgcgtagtccgtctgcagctagagacaactgagcgtcagcgtggaggggcggaggatgagctgcaggctctgcgtgcacgggctgaggaggcagaagcacagaagcggcaggctcaggaggaagccgagcgcttgcggaggcaggtgcaggatgagagccaacgcaaacggcaggcggaggccgagctggccctgcgtgtgaaggcagaagcggaggcagcgcgagagaagcagcgggccctgcaggctctggatgaactgaaactgcaggccgaggaggccgaacggcggctgcgccaagccgaggcagagagggctcgccaagtgcaggtagccctggagacagcgcagcgtagtgcagaagtggagctgcagagcaagcgtgcgtcctttgcagagaagaccgcacagttggagcgcacgctgcaggaagagcacgtgacagtgacacagctgcgggaggaggcggaacggcgggcacagcagcaggctgaagccgagcgagcccgtgaggaagccgagcgggagctggagcgctggcagctgaaggccaatgaggcgctgcggctgcggc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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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