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Previous release (v1)
2024-04-27 23:00:21, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001113522 4662 bp mRNA linear ROD 23-NOV-2023
DEFINITION Rattus norvegicus Rho guanine nucleotide exchange factor 7
(Arhgef7), transcript variant 2, mRNA.
ACCESSION NM_001113522 XM_039094098
VERSION NM_001113522.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4662)
AUTHORS Liu S, Premont RT, Park KH and Rockey DC.
TITLE beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide
synthase in sinusoidal endothelial cells
JOURNAL Am J Physiol Gastrointest Liver Physiol 323 (5), G511-G522 (2022)
PUBMED 36044673
REMARK GeneRIF: beta-PIX cooperates with GIT1 to regulate endothelial
nitric oxide synthase in sinusoidal endothelial cells.
REFERENCE 2 (bases 1 to 4662)
AUTHORS Shin EY, Lee CS, Kim HB, Park JH, Oh K, Lee GW, Cho EY, Kim HK and
Kim EG.
TITLE Kinesin-1-dependent transport of the betaPIX/GIT complex in
neuronal cells
JOURNAL BMB Rep 54 (7), 380-385 (2021)
PUBMED 34154701
REMARK GeneRIF: Kinesin-1-dependent transport of the betaPIX/GIT complex
in neuronal cells.
REFERENCE 3 (bases 1 to 4662)
AUTHORS Sahin GS, Luis Rodriguez-Llamas J, Dillon C, Medina I, Appleyard
SM, Gaiarsa JL and Wayman GA.
TITLE Leptin increases GABAergic synaptogenesis through the Rho guanine
exchange factor beta-PIX in developing hippocampal neurons
JOURNAL Sci Signal 14 (683) (2021)
PUBMED 34006608
REMARK GeneRIF: Leptin increases GABAergic synaptogenesis through the Rho
guanine exchange factor beta-PIX in developing hippocampal neurons.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4662)
AUTHORS Rathor N, Chung HK, Wang SR, Qian M, Turner DJ, Wang JY and Rao JN.
TITLE beta-PIX plays an important role in regulation of intestinal
epithelial restitution by interacting with GIT1 and Rac1 after
wounding
JOURNAL Am J Physiol Gastrointest Liver Physiol 314 (3), G399-G407 (2018)
PUBMED 29191942
REMARK GeneRIF: Induced association of beta-PIX with GIT1 is essential for
the stimulation of intestinal epithelial restitution by activating
Rac1, and this signaling pathway is tightly regulated by cellular
polyamines.
REFERENCE 5 (bases 1 to 4662)
AUTHORS Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A,
Li Y, Kumaran R, Nalls MA and Cookson MR.
TITLE Phosphorylation of LRRK2 by casein kinase 1alpha regulates
trans-Golgi clustering via differential interaction with ARHGEF7
JOURNAL Nat Commun 5, 5827 (2014)
PUBMED 25500533
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4662)
AUTHORS Shin EY, Shin KS, Lee CS, Woo KN, Quan SH, Soung NK, Kim YG, Cha
CI, Kim SR, Park D, Bokoch GM and Kim EG.
TITLE Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine
nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is
required for basic fibroblast growth factor-induced neurite
outgrowth
JOURNAL J Biol Chem 277 (46), 44417-44430 (2002)
PUBMED 12226077
REMARK GeneRIF: has a role in bFGF-induced neurite outgrowth via the ERK
cascade
REFERENCE 7 (bases 1 to 4662)
AUTHORS Paris S, Za L, Sporchia B and de Curtis I.
TITLE Analysis of the subcellular distribution of avian p95-APP2, an
ARF-GAP orthologous to mammalian paxillin kinase linker
JOURNAL Int J Biochem Cell Biol 34 (7), 826-837 (2002)
PUBMED 11950598
REFERENCE 8 (bases 1 to 4662)
AUTHORS Koh CG, Tan EJ, Manser E and Lim L.
TITLE The p21-activated kinase PAK is negatively regulated by POPX1 and
POPX2, a pair of serine/threonine phosphatases of the PP2C family
JOURNAL Curr Biol 12 (4), 317-321 (2002)
PUBMED 11864573
REFERENCE 9 (bases 1 to 4662)
AUTHORS Premont RT, Claing A, Vitale N, Perry SJ and Lefkowitz RJ.
TITLE The GIT family of ADP-ribosylation factor GTPase-activating
proteins. Functional diversity of GIT2 through alternative splicing
JOURNAL J Biol Chem 275 (29), 22373-22380 (2000)
PUBMED 10896954
REFERENCE 10 (bases 1 to 4662)
AUTHORS Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T
and Lim L.
TITLE PAK kinases are directly coupled to the PIX family of nucleotide
exchange factors
JOURNAL Mol Cell 1 (2), 183-192 (1998)
PUBMED 9659915
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000283.1.
On or before Aug 30, 2022 this sequence version replaced
XM_039094098.1, NM_001113522.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
[ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-359 JACYVU010000283.1 26957941-26958299 c
360-446 JACYVU010000283.1 26925818-26925904 c
447-531 JACYVU010000283.1 26904418-26904502 c
532-662 JACYVU010000283.1 26902940-26903070 c
663-864 JACYVU010000283.1 26899637-26899838 c
865-953 JACYVU010000283.1 26891160-26891248 c
954-1048 JACYVU010000283.1 26883684-26883778 c
1049-1144 JACYVU010000283.1 26883364-26883459 c
1145-1267 JACYVU010000283.1 26878272-26878394 c
1268-1406 JACYVU010000283.1 26874121-26874259 c
1407-1466 JACYVU010000283.1 26873479-26873538 c
1467-1613 JACYVU010000283.1 26872770-26872916 c
1614-1700 JACYVU010000283.1 26870415-26870501 c
1701-1779 JACYVU010000283.1 26867405-26867483 c
1780-1919 JACYVU010000283.1 26867106-26867245 c
1920-2144 JACYVU010000283.1 26864301-26864525 c
2145-2238 JACYVU010000283.1 26862557-26862650 c
2239-2328 JACYVU010000283.1 26859767-26859856 c
2329-2428 JACYVU010000283.1 26850422-26850521 c
2429-2483 JACYVU010000283.1 26850126-26850180 c
2484-4662 JACYVU010000283.1 26847043-26849221 c
FEATURES Location/Qualifiers
source 1..4662
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="16"
/map="16q12.5"
gene 1..4662
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Rho guanine nucleotide exchange factor 7"
/db_xref="GeneID:114559"
/db_xref="RGD:620624"
exon 1..359
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
CDS 195..2606
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="isoform b is encoded by transcript variant 2;
beta-Pix; PAK-interacting exchange factor beta; Rho
guanine nucleotide exchange factor (GEF) 7"
/codon_start=1
/product="rho guanine nucleotide exchange factor 7 isoform
b"
/protein_id="NP_001106994.2"
/db_xref="GeneID:114559"
/db_xref="RGD:620624"
/translation="
MNSAEQTVTWLITLGVLESPKKTISDPEVFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRNESECLSNIREFLRACGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVTKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL"
misc_feature 201..539
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="calponin homology (CH) domain found in beta-Pak
Interactive eXchange factor; Region: CH_betaPIX; cd21266"
/db_xref="CDD:409115"
misc_feature order(201..203,213..215,387..389,393..398,405..410,
414..416,438..464,480..482,486..491,495..500,507..512,
519..521)
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="putative actin binding site [polypeptide binding];
other site"
/db_xref="CDD:409115"
misc_feature 543..683
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Unstructured region one on RhoGEF 6 and 7; Region:
RhoGEF67_u1; pfam16615"
/db_xref="CDD:435465"
misc_feature 693..854
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Src Homology 3 domain of beta-Pak Interactive
eXchange factor; Region: SH3_betaPIX; cd12061"
/db_xref="CDD:212994"
misc_feature order(708..710,714..716,723..725,732..737,780..782,
786..794,825..827,831..833,837..842)
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212994"
misc_feature 945..1478
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Guanine nucleotide exchange factor for
Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
(DH) domain. It appears that PH domains invariably occur
C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160"
/db_xref="CDD:238091"
misc_feature order(963..965,975..977,1257..1259,1329..1334,1341..1346,
1350..1355,1362..1367,1374..1379,1386..1388,1464..1466,
1476..1478)
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:238091"
misc_feature 1569..1865
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Cloned out of library/PAK-interactive exchange
factor pleckstrin homology (PH) domain; Region:
PH_Cool_Pix; cd01225"
/db_xref="CDD:269932"
misc_feature 2040..2315
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="Unstructured region two on RhoGEF 6 and 7; Region:
RhoGEF67_u2; pfam16614"
/db_xref="CDD:435464"
misc_feature 2346..2600
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="betaPIX coiled coil; Region: betaPIX_CC; pfam16523"
/db_xref="CDD:435396"
exon 360..446
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 447..531
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 532..662
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 663..864
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
misc_feature 666..845
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="encodes SH3 domain which binds alpha-PAK
proline-rich sequence"
exon 865..953
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
misc_feature 935..1495
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="encodes DBL homology (DH) domain similar to Tiam-1
(T-lymphoma invasion and metastasis inducing protein 1)"
exon 954..1048
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1049..1144
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1145..1267
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1268..1406
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1407..1466
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1467..1613
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
misc_feature 1565..1865
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/note="encodes a pleckstrin homology (PH) domain"
exon 1614..1700
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1701..1779
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1780..1919
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 1920..2144
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 2145..2238
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 2239..2328
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 2329..2428
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 2429..2483
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
exon 2484..4662
/gene="Arhgef7"
/gene_synonym="P85spr; Pak3bp"
/inference="alignment:Splign:2.1.0"
ORIGIN
acttgacagcgggccagggcgcgcgcgagcccgcggagccgagcgggacctgctgggccggccgggccaatcgccggcgcgcggccgcccatgggcgcggaggcggcgggggcgcgggtggccgcggcccgggccgctccgaggtgatcgcgcgcggcgccccctctgtgcgcgcagcccgagccgccgcagcgatgaattctgccgagcagaccgttacgtggctcatcaccctgggcgtgctggagtcgcccaagaaaaccatttcggacccggaggtcttcttgcaggcgtcgctcaaggacggggtggtcctatgccggctgctggagcgcttgctgcccgggaccatcgagaaagtctacccggagccgcggaacgagagcgagtgcctgagcaacatccgcgagttcctgcgcgcctgcggggcgtccctgcgcctggagacttttgatgcaaatgatttgtatcaggggcagaactttaacaaggtcctcagctccttggtgacactaaataaagtgacagcagacattggactaggaagtgattctgtgtgtgcccggccctcgtcacataggataaagtcttttgattccctgggatcccagtcttcacacagtaggacttcaaaattgctgcagagccagtaccgaagcttggacatgactgataacgccaacagccaactggtagtacgagccaagtttaacttccagcagaccaatgaagatgagctctccttctcgaagggtgacgtcatccatgtcactcgagtggaggaaggaggctggtgggaaggcacacacaatggcaggaccggctggttccccagcaactacgtacgagagatcaagccaagtgagaagcctgtgtcacccaaatcagggaccttgaagagccctcccaaagggttcgatacgactgccatcaacaagagctattacaatgtggtgctacagaacatcctggaaacagagcatgagtattccaaggagctgcagtctgtgctgtcaacctacctgtggccgctgcagaccagcgagaagttgagttcagcaaacacttcatatttaatgggaaatctagaggaaatatcttccttccagcaagtgcttgtacagtccctagaagaatgcacaaagtctcctgaagcccagcagagagtcggtggctgcttcctgagcctgatgccgcagatgaggaccctgtaccttgcctactgtgccaaccacccatctgctgtgagcgtcctcacagagcacagtgaggacctgggagagttcatggagacaaaaggtgccagcagccctgggatcctggtgctgactaccggcctgagcaagcccttcatgcgcctggacaagtaccccacactgctgaaggagctggagagacacatggaggattatcatcctgatagacaagatattcagaaatctatgactgccttcaaaaacctttcagcccagtgtcaagaagtacgaaaaaggaaagagctggagctgcagatcctgacagagcccatcaggagctgggagggggatgacataaagacgttgggcagtgttacatacatgtcccaagtcacaattcagtgtgcaggaagcgaggagaagaatgagaggtacctcctgctcttcccaaaccttctgctcatgttgtctgccagtcccaggatgagcggtttcatctatcagggaaagctgccaacaacaggaatgacaatcacaaaactcgaggacagtgagaaccataggaatgcatttgagatatcagggagcatgatcgagcgcatcctggtgtcctgcaacaaccaacaggacttgcacgaatgggtggagcatctgcagaggcagacgaaggtcacgtctgtgagcaaccccaccatcaagccccactcggtgccatcgcacacacttccttcccatcctctcactccatccagcaaacacgcggacagcaagcctgtggcactgacgcctgcgtaccacacactcccccacccctctcaccatggcaccccacataccaccatcagctggggacccctggagcctccgaagacccccaagccttggagcctgagttgcctgcggcctgcccctcccctccggccctcagctgctctctgctacaaggaggatctcagcaggagtcccaagaccatgaaaaagctgctgccaaaacgcaagcccgagcgcaagccttcagacgaggagttcgctgtgaccaagagcacagccgctctggaggaagacgctcagatcctgaaggttattgaagcttactgcacaagtgcaaagacgaggcagaccctgaactcaagttcacgcaaagagtctgctccacaagtgttgcttccagaagaagagaaaattatagtcgaagaaaccaaaagcaacgggcagacagtgatagaggaaaagagcctcgtggataccgtgtacgcactaaaggatgaagtccaagagttacgacaggataacaagaagatgaagaaatccttagaggaggaacagagggcccgcaaggacctagagaagctggtgaggaaggttctaaagaacatgaacgaccctgcttgggatgagaccaatctataggctgacttcattctcataggctgaagaccagcagctcctggacaaggctggggcccttggtccccagcacagtgacattcaggactaaggaggtggtcttcaaaaggcaagcagcagtgatgagctgttgctgaagtagctacatgtgagttctagacaccgaggcctgggctgagtgagcacctcgctgtacacctctccctgcagtgactgaccagagtcctcggctttgggacttgagttgaatctataaatagcttacctgtgtactccttgtaaatactgagatctgaatgaacatgtacctgagaggtgactaggctaaccctcttgctaggatttccttctcagcctttctggccacagggatctgaagttgtgttcctaaagtgttggaagcagagaggtgaagggatgcccgggcagcatctgactcgtgtgcagtgtaggctccttggtgccatcaggagcaggcactcaggcacagtggatttgtgtgtctcttttaactgcagtattccagtcccgagctacggcagtacccagggcaccatgggttctaggagggtgagactggtgcccgcctctgctgcgctgtcctgcctgggccctgggtcacagtgtggagtagtgggctagcctggtgtatcttggccctgtacatagttgtgttatttattccatattctttagccggtgctgccgggcagggtttggctgcaggccgttttcatccacaacctctgctctgcctttggctgcagccagcgttgtccaggccactgagagccctcttaaccctgagcaagactaaagcaatacacaccgcactggagcagcgcggagagcctcagtgctgtgcccccgccctcccttgctgcctccccaggcccagatgggccctggaaggctggtggcttccaagaggccctgcttctgttgggccaggcttgcccttgatttggcaacagtgacagtgacctcaggagcttagctgtccccttcctttctccaaagaggttgttttgaagtcagagatacttccccatagaaaggtgtttgtctttaaacactgaggagcagtgtggctggggcctcagcatagcctaggttgtgacccagctcctggccgctcgtcctccgtgcaggtttctgagtgggtgtgtggaggccctttgtgctctccttcctccacactctggctgggtgcagcgtctgtcaggatccaccagagcctcccgctcctgttagcattttaccagcccagtctgtgccgggtgagaaaagctgaggtgttctttctctttggtaagccctgcttcccaagcactctccgacccaaaagacactacagcagaggacagtgtgttcgctgtcacagtggacctcacctcaggaacaacgctccttgcaactccactgctggcgactggtgcctggggttgctggacagctcctccgccaagagcaagcgaagaccatctctgacgcggtcctcaccccgccgaggtggctgtgcaggccccaaggacagtttttacagacctgccttaatgattcgcttggagacttccatgagtatccctaccctggacagggtggtagcgttgtgtcagcacgccaccctgtccttctgagatccagtgtcttccaggctctcagggagcgagaatctgcacccggagcagtcctttttaaagctggcacacaccccgttctcctcctgcatctctgcggtggagctctgacacccacagcacagggtgcctctcaccaactccaactcctccgcgctctgtgagggatgagggggattaagccatttcctgtcctctagtgaagcactttccgttctgaaccatgctgctgcgtgcagcctctgaagctccactcttccctcccagttgttgcccacgctccctgtgcacctcatgccaacccctccttccctgcgacactgcaggagccggtgctggcagaccgcaccggtgtgactgctgcagtgtgtgtgctgccccctccaattattaaactccttattttcctatctcaccaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]