LOCUS       NM_001111294            5280 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3
            (Hnrnpa3), transcript variant 1, mRNA.
ACCESSION   NM_001111294
VERSION     NM_001111294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A,
            Hanisch F, Kamp F, Nuscher B, Orozco D, Edbauer D and Haass C.
  CONSRTM   German Consortium for Frontotemporal Lobar Degeneration; Bavarian
            Brain Banking Alliance
  TITLE     Reduced hnRNPA3 increases C9orf72 repeat RNA levels and
            dipeptide-repeat protein deposition
  JOURNAL   EMBO Rep 17 (9), 1314-1325 (2016)
   PUBMED   27461252
  REMARK    GeneRIF: Neurons in the hippocampus of C9orf72 patients are
            frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the
            hippocampus of patients with extended C9orf72 repeats correlates
            with increased DPR deposition.
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Todd MA and Picketts DJ.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 5280)
  AUTHORS   Chen JJ, Jiang HY, Liu P, Liu W, Wei MT, Wang SX and Weng YG.
  TITLE     [Differential analysis of two-dimensional gel electrophoresis
            profiles in lung tissue of rats exposed to silica early]
  JOURNAL   Zhonghua Yu Fang Yi Xue Za Zhi 43 (5), 418-422 (2009)
   PUBMED   19534998
REFERENCE   6  (bases 1 to 5280)
  AUTHORS   Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske
            WA, Morin D, Penn SG, Jovanovich SB, Plopper CG and Buckpitt AR.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   7  (bases 1 to 5280)
  AUTHORS   Ma AS, Moran-Jones K, Shan J, Munro TP, Snee MJ, Hoek KS and Smith
            R.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking
            response element-binding protein
  JOURNAL   J Biol Chem 277 (20), 18010-18020 (2002)
   PUBMED   11886857
  REMARK    GeneRIF: has a role in cytoplasmic trafficking of RNA (heterogenous
            nuclear ribonucleoprotein A3)
REFERENCE   8  (bases 1 to 5280)
  AUTHORS   Percipalle P, Jonsson A, Nashchekin D, Karlsson C, Bergman T,
            Guialis A and Daneholt B.
  TITLE     Nuclear actin is associated with a specific subset of hnRNP
            A/B-type proteins
  JOURNAL   Nucleic Acids Res 30 (8), 1725-1734 (2002)
   PUBMED   11937625
REFERENCE   9  (bases 1 to 5280)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 5280)
  AUTHORS   Plomaritoglou A, Choli-Papadopoulou T and Guialis A.
  TITLE     Molecular characterization of a murine, major A/B type hnRNP
            protein: mBx
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 54-62 (2000)
   PUBMED   10786617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB585714.1, BC081878.1, CF110891.1, BI292197.1, AT006305.1,
            AW534817.1, BP488086.1, CV109437.1, CV107265.1 and CF110612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               CB585714.1         13-318
            307-913             BC081878.1         247-853
            914-1927            CF110891.1         80-1093
            1928-2345           BI292197.1         18-435              c
            2346-2472           AT006305.1         130-256
            2473-2644           AW534817.1         186-357             c
            2645-3130           BP488086.1         2-487               c
            3131-3472           CV109437.1         344-685
            3473-4023           CV107265.1         100-650
            4024-4478           CF110612.1         537-991
            4479-5280           BC081878.1         1807-2608
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5280
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="heterogeneous nuclear ribonucleoprotein A3"
                     /db_xref="GeneID:362152"
                     /db_xref="RGD:727807"
     exon            1..152
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    45..47
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="upstream in-frame stop codon"
     CDS             81..1220
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     A3"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A3
                     isoform a"
                     /protein_id="NP_001104764.1"
                     /db_xref="GeneID:362152"
                     /db_xref="RGD:727807"
                     /translation="

MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF"

     misc_feature    81..185
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6URK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    81..83
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); acetylation site"
     misc_feature    120..122
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    186..419
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="RNA recognition motif 1 (RRM1) found in
                     heterogeneous nuclear ribonucleoprotein A subfamily;
                     Region: RRM1_hnRNPA_like; cd12578"
                     /db_xref="CDD:409992"
     misc_feature    order(186..188,192..194,198..203,267..269,273..275,
                     279..281,306..314,318..320,387..389,396..398,402..419)
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:409992"
     misc_feature    207..209
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    234..236
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Dimethylated arginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    306..308
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    414..416
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    426..428
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    450..452
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    456..695
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="RNA recognition motif 2 (RRM2) found in
                     heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and
                     similar proteins; Region: RRM2_hnRNPA3; cd12582"
                     /db_xref="CDD:409996"
     misc_feature    480..482
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); acetylation site"
     misc_feature    690..755
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6URK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    720..722
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000269|PubMed:24098712;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    726..728
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000269|PubMed:24098712;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    756..758
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000269|PubMed:24098712;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    795..797
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000269|PubMed:24098712;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q8BG05; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    816..818
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000269|PubMed:24098712;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    849..851
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8BG05; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    936..938
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000269|PubMed:24098712; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    1074..>1124
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Nuclear factor hnRNPA1; Region: HnRNPA1; pfam11627"
                     /db_xref="CDD:431967"
     misc_feature    1083..1217
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6URK4.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1131..1133
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1143..1145
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); methylation site"
     misc_feature    1155..1157
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1161..1163
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1173..1175
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1179..1181
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1191..1193
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1200..1202
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     misc_feature    1206..1208
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51991; propagated from
                     UniProtKB/Swiss-Prot (Q6URK4.1); phosphorylation site"
     exon            153..275
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            276..422
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            423..633
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            634..723
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            724..819
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            820..900
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1044
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1167
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1233
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..5256
                     /gene="Hnrnpa3"
                     /gene_synonym="Hnrpa3; mBx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

catcacgtggttactagccccgcctcttcctctcggtcccatattgaactcgagttggaagaggcgagtccggtctcaaaatggaggtaaaaccgccgcccggtcgcccccagcctgactccggccgtcgccgccgccgccggggggaggagggccacgatccaaaggaaccagagcagctgaggaagctgtttattggtggtctgagctttgaaaccacagatgatagcttaagagaacattttgagaaatggggcacacttacagattgtgtggtaatgagagatcctcaaacaaaacgttccagaggctttggttttgtgacctactcttgtgtcgaagaggtggatgctgcaatgtgtgctcggccacacaaggttgatggacgtgtggtggaaccaaagagagctgtttctagagaggattctgtaaagcctggtgcccatttaacagtgaagaagatttttgttggtggtattaaagaggatacagaagaatataatctgagagactactttgaaaagtatggcaagattgaaaccatagaagttatggaagataggcagagtgggaaaaagagaggatttgcttttgtaacttttgatgatcatgacacagttgataaaattgttgttcagaaataccacactattaatgggcataattgtgaagtgaaaaaggccctttctaaacaagagatgcagtctgctggatcacagagaggtcgtggaggtggatctggcaactttatgggacgtggaggaaactttggtggcggcggaggaaactttgggcgtggaggaaactttggtggaagaggaggctatggtggtggaggtggtggcagcagaggcagttatggaggtggtgatggtggatataatggatttggaggtgatggtggcaactatggtggtggtcctggttacagtagtagaggaggttatggaggtggtggaccaggatatggaaaccaaggtggtggatatggtggtggaggaggaggatatgatggttacaatgaaggaggaaattttggtggaggtaactatggtggtggtgggaactataatgactttggaaattatagtggacagcaacaatctaattatggacccatgaaggggggcagttttggtggaagaagctcaggcagtccctatggtggtggctatggatctggaggtggaagtggtggatatggtagcagaaggttttaaaataaaacaaacggctacagttcttagcaggagagagagcgaggagttgtcaggaaagctgcaggttactttgagacagtcgtcctaaatgcattagaggaactgtaaaaatctgccacagaaggaacgatgatccatagtcagaaaagttactgcagcttaaacaggaagcccttcttgttcaggactgtcatagccacagtttgcaaaagtgcagctatcgattaatgcaatgtagtgtcaattagatgtacattcctgaggtcttttatctgttgtagctttgtctttttctttttcttttcattacatcaggtatattgccctgtaaattgtggtagtggtaccaggaataaaaaattaaggaatttttaacttttcaatatttgtgtagttcagtttttctacattttagtacagaaactttaacaaaatgcagttttgaaggtgtttccttgtgagttaacaagtaaagaagatcattgttaatcactattttgtatgaattttgctaaagttaactgtaaagaaacacctactgacttgcagtttaaggggaatctattctcccatttccaaaaccatgatgactgggcgctgacatgtggagagaatagatacttgtatgtttgcaaatgtgtgttttagataattaggattgggtaataaaaaatagcatatttgtgaatttaatagcattaagattacattcaaatgaaaaagatctcaaaatttgctgtttggttttgtgcattttctttcaaaatgtaatcatgattttagtgtggtagacttaagtcctaaccatgtttaagaacatctccattccacatttaccttgataacattgaaactgctgccaatagtttggggtatgaagtgtttatactgccctctacttcccaagggcggtagatgaatgccatctccctatttaacagccttttaatatagaaccaccaagtctgctgtgtctgagcagactgtggtgggtacctggtttgtttctgcttttaagatttaaggtctcaaagccccattggtctagtcaactttccttggttacgttccccacacacagcttttcagagcaaaggaataaaaatcactggtttgaacccctgactggctggcatgctttcctgttcatattctagccattttgctggatggtgaagcaaagtatagtaaggtgtcgtctaaaccaagcagcagaagatgtagcacacacagttgctcagtgcaagcacctcacttcccaaatatctcaattcaaattcagaacgtcttgagtccttaaatccccaaagaacacatggttattcttgtatatatatcattctaaaacatgttgggtgtgacaatttggagaacctgtttgaggagctttagatactaaggtggtcatatacatgaaaaaaaaatgtctgctgttgcgccagctagtgcttaacaatttcattcaagtcctaagtatgtgccctgctgttactttctttggcagttgaccgttgaattcagatttttacttggtttttaaagtataagctaaacaagcaataaaaaggggaatggggtgtgctagtatttcaatatgctctcttgttgctctactgtgcctctgtgcattaatatttggatgcatgcaatgctagcatggaactttggtcttcacaaatactgcagtttttccagaaaacactcacaaaccaataaatgtaacagacaacattccatttgttaatgggcatatgtgcataagcagtgtagaaaataggctcatgttagaaactggttacatccttcataactaaaagtgtggttatttgaatggacactgtcaatgttcatagcttaaacctgggtacctggtcaaaatgcttaggaaacattaaaattgagctaaattgtctcaagtccttttattcatataataaagatggaagaaatgggatgggggaggctggcagttcctgctttgtttgtgaaattgttgggcacaaccttgacagtatccttaaatgtaatgaggtcaattgtattaaccaactttttatgttctggaactagtatcatagtgaaacctttttcagtaagttgatgtttacaacctataatcaggtgaaacctgtatgtggcctgtttataagttgtactaagttagtttttgtgaacagtgtggaagagtaagccatgagagcgatttaaccagctttaaaggacctaagttgtgctttttaagcactggatcaaaggaaaacccactaagacaggacttcagcagccaattgagtatggacaagtcagcataaataaagaatgagaaggcagcagcaagagcttcaacaacagagaagtggaggcataagatactatggtgatagtgagcaacttcccaaaagctagttaaagctgcttattacaactgaatgtcgaagaaagtagcaggaaggagctccgccatttggaacatcaatgagctagttgccacaggcactaggtctagcgtttagacctgcaaggaagggcaataagcattaggtaaggcttgaatttgatttttttttcactaattaaagaatactttttgtaaagcaaggtaagagtaatctttttgatttgcaggtgaatgagaaccctacctgcctaactgaggaatgtctttcccaccaccttaaatacgaaggtttctggctgggtaaggtttgtagctcacagtaaaaaccgatgaccgttggtttccctacaaattaatgggacagtttgagacattacccctcaagctcagttttatttggtaccccatagaacaagttctaagccttaggcagttataccatgccaagggtatttgtcatgagccagatgtgttctcttcatatgtacaacttgctgttccaagggaaaggcagctttccataacggaaagtcatgttggcttttcagaaagtaatttttggtgtatgactttataatgagctgctagtttccctagttccaccctaggaaagcaaggaactttcacaattgtcaaaatgtcttcctcaaagttctctagcttaaaagtttactattgcatggaccagcagggacagtcagtttagttatgtgtttttagtcttccccaaaacccatcacaccaacagtctggtctcactgttgtcctagcttggaactcagtccaccagccttctgtcacccaagtgctgggattaaagggtggtgcctatatgacaactcattcctttaaaaaaaaaaatccaaagaacggctgggttactattaaaatgtgttgctgattgtccaaaagggctatttctgctgccctgaaagggcttctttgaaaattgcttaattcaggttactttttaatagaatattttcaggggacaaatctgcaaaatgtttccttcacagggataccctgcattgcatcaacaagtttgtgtggcatttaagtcaggatgaattcacagaaataggtagcaatctttcagtggtggttacttaatagatttagaaaaataaatacgttatcttaaaaggcatttacagttcatttcctttctgaaataaaattattttacttaatatggttccactgtcatttctgcaaaaatcgttggtagcaacggtgaacaagaaaacaaacgaaggctgactttggttttgttggacttgtgggatactgcttccagtttatgtctgaaagctgtgttcacattcatgttgaaattagggaacacatggagaaaaagttctggtaggggactacagcgagttcaacttggtttttatgagttctgtcacgatttaaaacgcctgacaacggtacggtgattggcatggtagcaagcatgcagatatgcaaggtgctgtgaggatcggtagcctgtccaagtattcagttttgaagctaacatgttttcagatctttatgacagcagaggtggtctgtaattcaattgtttcatttgtagcataatgaaatgttacagaaagatgaccttttcattaaaatatttttagaaatgtgaaaaaaaaaaaaaaaaaaaaaaaa

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