LOCUS       NM_001110793            3400 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus splicing factor 1 (Sf1), transcript variant 1,
            mRNA.
ACCESSION   NM_001110793
VERSION     NM_001110793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Zhou J.
  TITLE     LncRNA MIAT promotes hypoxia-induced H9C2 cell pyroptosis via
            binding to SF1 to inhibit CGRP transcription
  JOURNAL   Exp Physiol 107 (1), 58-67 (2022)
   PUBMED   34713933
  REMARK    GeneRIF: LncRNA MIAT promotes hypoxia-induced H9C2 cell pyroptosis
            via binding to SF1 to inhibit CGRP transcription.
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain JC and
            Kramer A.
  TITLE     Mammalian splicing factor SF1 interacts with SURP domains of U2
            snRNP-associated proteins
  JOURNAL   Nucleic Acids Res 43 (21), 10456-10473 (2015)
   PUBMED   26420826
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Ishizuka A, Hasegawa Y, Ishida K, Yanaka K and Nakagawa S.
  TITLE     Formation of nuclear bodies by the lncRNA Gomafu-associating
            proteins Celf3 and SF1
  JOURNAL   Genes Cells 19 (9), 704-721 (2014)
   PUBMED   25145264
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3400)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3400)
  AUTHORS   Wahl MC, Will CL and Luhrmann R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   7  (bases 1 to 3400)
  AUTHORS   Park SY, Tong M and Jameson JL.
  TITLE     Distinct roles for steroidogenic factor 1 and desert hedgehog
            pathways in fetal and adult Leydig cell development
  JOURNAL   Endocrinology 148 (8), 3704-3710 (2007)
   PUBMED   17495005
REFERENCE   8  (bases 1 to 3400)
  AUTHORS   Cattaruzza M, Schafer K and Hecker M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   9  (bases 1 to 3400)
  AUTHORS   Covini N, Tamburin M, Consalez G, Salvati P and Benatti L.
  TITLE     ZFM1/SF1 mRNA in rat and gerbil brain after global ischaemia
  JOURNAL   Eur J Neurosci 11 (3), 781-787 (1999)
   PUBMED   10103072
REFERENCE   10 (bases 1 to 3400)
  AUTHORS   Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P,
            Sleeman J, Lamond A and Mann M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU671240.1, BC081859.1, CO561066.1 and BQ191177.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               BU671240.1         1-669
            670-1750            BC081859.1         583-1663
            1751-2365           CO561066.1         1-615
            2366-2936           BQ191177.1         57-627
            2937-3400           BC081859.1         2212-2675
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3400
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="splicing factor 1"
                     /db_xref="GeneID:117855"
                     /db_xref="RGD:620645"
     exon            1..418
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    139..141
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="upstream in-frame stop codon"
     CDS             388..2307
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 162"
                     /codon_start=1
                     /product="splicing factor 1 isoform 1"
                     /protein_id="NP_001104263.1"
                     /db_xref="GeneID:117855"
                     /db_xref="RGD:620645"
                     /translation="

MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHTLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPASNPPPPSLMSTTQSRPPWMNSGPSENRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGTPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN"

     misc_feature    436..1158
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="Splicing factor (branch point binding protein) [RNA
                     processing and modification]; Region: MSL5; COG5176"
                     /db_xref="CDD:227503"
     misc_feature    1219..1266
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /note="zinc finger; Region: ZnF_C2HC; smart00343"
                     /db_xref="CDD:197667"
     exon            419..547
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            548..623
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            624..776
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            777..866
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1050
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1166
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1274
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1455
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1729
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1789
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1969
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..3376
                     /gene="Sf1"
                     /gene_synonym="Zfp162"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccgcgcagtaacaagaagtgcgcgctgcgacacctcccagttcactcggccccgccgccatttcgtcgcctggcctaacggttcggccaatcccgacgcgtattgaaaagaactagtgctccgccaatcggaggccgctgactccgacctcacctcgggccggcccaatccaggccgcggccccgccgcccccaacccgcccccgcggcgtcctctctcctccctctttgtgcgtctggcgccgccgccgcccgccgcgtgagaggacgggctccccgcgctcttcgggagcgtagtcgggtcccctccccccaacccgcgaaggttcgtgaaggagaagccgccgcggaggacgaggaaccgctggtgccggtcccctggggcgccatggcgaccggagcgaacgccacgccgctggacttcccaagtaagaagaggaagaggagccgatggaaccaagacacaatggaacagaagacagtgattccaggcatgcctacggttatcccccctggcctgactcgggaacaagaaagagcttatatagtgcaactacagatagaagacctgactcgtaaactgcgcacaggagacctgggcatcccccctaaccctgaggacaggtccccttcccctgagccaatctacaacagcgaggggaagcggcttaatactcgagaattccgtacccgaaaaaagcttgaagaggagcggcataccctcattacggagatggttgctctcaacccagactttaaaccacctgcagattacaagcctccagcaacacgtgtgagcgataaagtaatgatcccccaagacgagtatccagaaatcaattttgtggggctcctaattgggcccagagggaacaccctgaagaacattgagaaggaatgcaacgccaagatcatgatacggggaaagggatcagtaaaagaagggaaagttgggcgtaaagatggtcagatgttgccaggagaagatgaacctcttcatgctctagtcactgccaatacaatggagaatgtcaaaaaggcagtggaacagatcagaaacatcctgaagcagggtattgaaaccccagaggaccagaatgacctaaggaaaatgcagcttcgagagttagctcgcttgaatggcactctacgggaagatgataacaggatcttgagaccctggcagagctcagagacacgaagcattaccaacacgactgtgtgtactaagtgtggaggggctggtcacattgcctctgattgcaaatttcagaggcctggtgaccctcaatcagctcaggataaagcacggatggataaagagtatttgtcccttatggctgagctaggggaagctcctgtccctgcatctgtgggctccacctctggacctgccaccacacccctggccagtgcaccaaggcctgctgctcctgccagcaacccaccaccaccgtctctcatgtctacaactcagagtcgcccaccctggatgaattctggtccttcagagaatcggccctaccatggcatgcatggaggtggtcctggtgggcctggaggtggcccccacagtttcccacacccattacccagcctgacaggtgggcatggtggacatcccatgcagcacaacccaaatggaccaccaccaccttggatgcagccaccaccaccaccgatgaaccagggcccccacccacctgggcaccatggccctcctccaatggatcagtacctgggaagtacgcctgtgggctctggggtctatcgcctgcatcaaggaaaaggtatgatgccgccgccgcctatgggcatgatgccgccgcctccgccacctcccagtgggcagcccccgcctcctccctctggtcctcttcctccatggcagcagcagcagcagcagcctccaccaccccctccgcccagcagcagtatggcttccagcacccccttgccatggcagcaaaatacgacgactaccaccacgagcgctggcacagggtccatcccgccatggcaacagcagcaggcggctgccgcagcttctccaggaacccctcagatgcaaggcaaccccactatggtgcccctgccccccggggtccagccgcctctgccgcccggggcccctccccctccgccgcctccgccacctggttccgccggcatgatgtatgccccaccccctcctcctccgcctcccatggacccttctaactttgtcaccatgatgggcatgggggtggcgggcatgccgcccttcgggatgcctccagctcccccaccgcctccaccacagaactagacttgttttttttttaagaaaatatatattatatacatagagagttggtctcgtttaaacacacgccgaacctcaccatatggagccagacattgggatgcacgcatgtgattgtgtgtgcacgcatgtgtgtgtgtgcacgcactgggctgggccaagtgactggactcgcttgggaaacgggcaagtggtagtaggggcgccagcttgggctctcctggcgccctgtagcatcgagtgtcttctttgtcttctctcctcacccaactccctttgcctctccccaaaccgggccgccaggatccctccccgcagcagcgatggcccgagccatgagagtgaggactttccgcgcccattggtgacccttccaggcagacagcctcaacagcgcccctggtggacaggatggttcggcaaagcagcctgagttatttttgtggacggaatcggaacacgctggctccatatcgtgaaatttttattaatttttatctttttcctttgttatttccttatcttttcctttcttcagactccgtccaaggagatgctctccccgatcttctgctgcagataggatccttccccttgtctccattcctttcctcccataggggagaggggcaaatggtttaggcacaggctttggctagtaatgtcaggcgtggtggtggcggcggggtcctattgttctaatttgttgaagggcctcaaccacactcaaagaagggtggtttatcttcgacatcttaaagagtcttgataatcctgacattgctaaataggggtaatccggcagtgggattcattcatatcttcctgcactcctgccagcagtacatggcacagcccaagccaccctaggccagcctggagtcttttccatgctctgatcacctaagctgcctcagaactcatttgcttctctccttcctggaaagcttccctttatgttttattttgaccccagatgtccagatgttttgcagtgtctggggcttgtgccccttgttgttcgttctgcttctttgcccctttcctctacatggagtgattatgttgacaaaaaaaaaaaaaaaaaaaaaaaaaa

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