LOCUS       NM_001108004            3068 bp    mRNA    linear   ROD 06-JAN-2023
DEFINITION  Rattus norvegicus DnaJ heat shock protein family (Hsp40) member B5
            (Dnajb5), transcript variant 2, mRNA.
ACCESSION   NM_001108004 XM_001061825 XM_233767
VERSION     NM_001108004.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Hageman J, van Waarde MA, Zylicz A, Walerych D and Kampinga HH.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF and
            Sadoshima J.
  TITLE     A redox-dependent pathway for regulating class II HDACs and cardiac
            hypertrophy
  JOURNAL   Cell 133 (6), 978-993 (2008)
   PUBMED   18555775
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Chen MS, Roti JR and Laszlo A.
  TITLE     Hsc40, a new member of the hsp40 family, exhibits similar
            expression profile to that of hsc70 in mammalian cells
  JOURNAL   Gene 238 (2), 333-341 (1999)
   PUBMED   10570961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            On Jan 6, 2023 this sequence version replaced NM_001108004.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132308,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JACYVU010000161.1  32601014-32601100
            88-232              JACYVU010000161.1  32601897-32602041
            233-477             JACYVU010000161.1  32604212-32604456
            478-1079            JACYVU010000161.1  32607398-32607999
            1080-3068           JACYVU010000161.1  32608208-32610196
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3068
                     /gene="Dnajb5"
                     /note="DnaJ heat shock protein family (Hsp40) member B5"
                     /db_xref="GeneID:313811"
                     /db_xref="RGD:1307453"
     exon            1..87
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            88..232
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1313
                     /gene="Dnajb5"
                     /note="isoform 2 is encoded by transcript variant 2; dnaJ
                     homolog subfamily B member 5; DnaJ (Hsp40) homolog,
                     subfamily B, member 5; heat shock cognate 40"
                     /codon_start=1
                     /product="dnaJ homolog subfamily B member 5 isoform 2"
                     /protein_id="NP_001101474.1"
                     /db_xref="GeneID:313811"
                     /db_xref="RGD:1307453"
                     /translation="

MFKIQLEPLKLRAWTLNGFVKFRNKEPSTGPVAVMGKDYYKILGIPSGANEDEIKKAYRKMALKYHPDKNKEPNAEEKFKEIAEAYDVLSDPKKRSLYDQYGEEGLKTGGGTSGGSGGSFHYTFHGDPHATFASFFGGSNPFDIFFASSRSTRPFSGFDPDDMDVDEDEDPFGAFGRFGFNGLSRGPRRAPEPLYPRRKVQDPPVVHELRVSLEEIYHGSTKRMKITRRRLNPDGRTVRTEDKILHIVIKRGWKEGTKITFPKEGDATPDNIPADIVFVLKDKPHAHFRRDGTNVLYSALISLKEALCGCTVNIPTIDGRVIPLPCNDVIKPGTVKRLRGEGLPFPKVPTQRGDLIVEFKVRFPDRLTPQTRQILKQHLPCS"

     misc_feature    264..1295
                     /gene="Dnajb5"
                     /note="DnaJ-class molecular chaperone with C-terminal Zn
                     finger domain [Posttranslational modification, protein
                     turnover, chaperones]; Region: DnaJ; COG0484"
                     /db_xref="CDD:223560"
     exon            233..477
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1079
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..3068
                     /gene="Dnajb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtcccgagtggaggcggcggagccggagccgggggagggggcagcggctgatagaaggaccgcggcggcgcccgcagctcctcaccgcagcacccccactgcaggctcgaggagctttccggagcttcccacacttctggggagaagacttcttagccagcttgatgtttaaaattcagctggagcccttaaaacttcgagcgtggacgctgaatgggtttgtaaagtttcgaaacaaggagcccagcaccggtccagtggctgtgatgggaaaagattattacaagattcttggaatcccgtctggggccaacgaagatgagatcaagaaagcctatcgaaagatggccttgaagtaccacccagacaagaacaaagaacccaacgctgaggagaagtttaaggagattgccgaggcctacgacgtgctgagtgaccctaagaaacggagcctgtatgaccagtatggggaggaaggcctcaagaccggcggtggtacctcaggtggctccggtggctcctttcactacacctttcacggggaccctcatgccacctttgcttccttctttggtggctccaaccccttcgatatcttctttgccagcagccgctccactcggcctttcagtggctttgacccagatgacatggatgtggatgaagatgaggacccatttggtgcctttggccgctttggcttcaatgggctgagtaggggtccgaggcgagccccagaaccactgtacccccggcgcaaggtacaggacccccctgtggtgcatgagctgcgggtgtccctggaggagatctaccacggctccaccaagcgcatgaagatcacaaggcgacgccttaaccccgatgggcgaactgtgcgcaccgaggacaaaatcctgcacattgtcatcaaacgtggctggaaggagggcaccaagattaccttccccaaagagggcgatgccacacccgacaacatcccagccgacattgtcttcgtgctcaaagacaagcctcatgcgcactttcgccgagatggcaccaacgtgctctacagtgcactcatcagcctcaaggaggcgctgtgtggctgcaccgtgaacattcccaccattgatggccgagtgatccctttaccctgcaatgatgttattaaaccaggcaccgtgaagagactccgtggggagggacttcccttccccaaggtgcccactcagcggggagacctcattgttgagttcaaagttcgattcccagacagattaaccccacagacacggcagatccttaaacagcacctaccctgctcctaggctctccctagcctgtctggagcccaccacagcaatacccccacactcaccaatctcatgtggacccggctggatgtccaccggacactggcactttcctaaaatgcaagaagccactgattttcaggaaaatgttcctcttcccgacaacccctttcggagctgggctgctttgggggaatgggagggcggtggggagaactagcccagaccaggggtcaatttttttgtcacgtgctttgaatccagttcccactgcagtggctggagagtgacttgagagctactcggagctatagattccttgtcctgcctgtaaatagcatgtcctcccccttctcagccttgctaacacctttcctctcccttcccctcggcttcctcctgtttctggagaaagaagttagaaaggacaccgcttcccaccccacccccaggtctgtagtgtccgaggctattttgcacaagtgttcgtgcacatgaagcactcgccaaaatggtccgtgtctctctgagagacaagaaaggacaggaggtaggaaggtcccttaccgatgaacaaggctgtcatttgagcacgagacacttttcatttggggcagggaggtgagccaacccttaggagccttcccaacagctgccctgcctacaccccacagagttggaggatctgtccccctcagctgctctggggagtgttcaggggtggagagaagaaaggagggcctgaaccatccaccacagctaagaggtggggcaggacccatctcccagccatcaccaggaaggaaaagggctttgggatcaggtggcagctgttccccaccaagagattcaggatcacaggttccttcccatatctctgaactcagggcctagccaccccaaacttccaagccccacttttgcgatatgtgaagctacttatttcttacttttcttggaggctgtgtcggaaatttccagcctctctgcctgtgtgaccctcaccccaccccactcccacagttgtataaaagtcgaatagtgaaggagctgggagaaaactgcttcagttggtcctggggtggggtctttaggttttctcactttgacaagcccctgaatgtttttatagtagttttttgtatttttttgtaatgacagtattatgaaaaaaataaagtattttaaaaatatggcctctgagcagaagcagtaaccctgggtgcaggcaggaataaagtggcactgtcagcctccttcagggccctgatcatccaggaaagccaagcagcctcagcagctgacgctcaccccttctccctgtaagctctgacttcttggaattctggaacatataccccaaacaaacagcaacaccagaagccacagcccagctgtctgcgaagaaagatgggcctttgttgtgagagagagcctggcctcttcagaagcttgtcaacatgagatctagcacacttgtctcggtgttctctttgaattagagacactttattccttggaggagattgaggactctctgactagcgagactaggcacactcccaaaaacagagttgggctaccaagtgggctggagagatggttcagcagttaagagcacttcctgttctcacagagaagccaaattcagttcccaggacacatcaggcagctcgagactgctcaagggaatccaacaagtccagcctcacaaagaatctgcacccatgcacacacacacttacaaaaaataaaaagtttttttaaaaa

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