LOCUS       NM_001100885            1099 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus myosin light chain 9 (Myl9), mRNA.
ACCESSION   NM_001100885 XM_001067182 XM_006235401 XM_215905
VERSION     NM_001100885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1099)
  AUTHORS   Lu Z, Ma XN, Zhang HM, Ji HH, Ding H, Zhang J, Luo D, Sun Y and Li
            XD.
  TITLE     Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular
            motor
  JOURNAL   J Biol Chem 289 (26), 18535-18548 (2014)
   PUBMED   24825904
REFERENCE   2  (bases 1 to 1099)
  AUTHORS   Frobel J, Cadeddu RP, Hartwig S, Bruns I, Wilk CM, Kundgen A,
            Fischer JC, Schroeder T, Steidl UG, Germing U, Lehr S, Haas R and
            Czibere A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   3  (bases 1 to 1099)
  AUTHORS   Park I, Han C, Jin S, Lee B, Choi H, Kwon JT, Kim D, Kim J, Lifirsu
            E, Park WJ, Park ZY, Kim DH and Cho C.
  TITLE     Myosin regulatory light chains are required to maintain the
            stability of myosin II and cellular integrity
  JOURNAL   Biochem J 434 (1), 171-180 (2011)
   PUBMED   21126233
REFERENCE   4  (bases 1 to 1099)
  AUTHORS   Shehadeh LA, Webster KA, Hare JM and Vazquez-Padron RI.
  TITLE     Dynamic regulation of vascular myosin light chain (MYL9) with
            injury and aging
  JOURNAL   PLoS One 6 (10), e25855 (2011)
   PUBMED   22003410
  REMARK    GeneRIF: consistent upregulation of the myosin light chain protein
            (Myl9) with age and injury
REFERENCE   5  (bases 1 to 1099)
  AUTHORS   Szczesna-Cordary D, Guzman G, Zhao J, Hernandez O, Wei J and
            Diaz-Perez Z.
  TITLE     The E22K mutation of myosin RLC that causes familial hypertrophic
            cardiomyopathy increases calcium sensitivity of force and ATPase in
            transgenic mice
  JOURNAL   J Cell Sci 118 (Pt 16), 3675-3683 (2005)
   PUBMED   16076902
REFERENCE   6  (bases 1 to 1099)
  AUTHORS   Iwai N, Shimoike H and Kinoshita M.
  TITLE     Genes up-regulated in hypertrophied ventricle
  JOURNAL   Biochem Biophys Res Commun 209 (2), 527-534 (1995)
   PUBMED   7733921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000119.1.
            
            On or before Dec 7, 2020 this sequence version replaced
            XM_006235401.2, NM_001100885.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229855.1, BC158548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132279, SAMD00132285
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JACYVU010000119.1  18937085-18937167
            84-292              JACYVU010000119.1  18939822-18940030
            293-454             JACYVU010000119.1  18942217-18942378
            455-1099            JACYVU010000119.1  18942804-18943448
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1099
                     /gene="Myl9"
                     /note="myosin light chain 9"
                     /db_xref="GeneID:296313"
                     /db_xref="RGD:1311235"
     exon            1..83
                     /gene="Myl9"
                     /inference="alignment:Splign:2.1.0"
     exon            84..292
                     /gene="Myl9"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..627
                     /gene="Myl9"
                     /note="myosin regulatory light chain 9; myosin, light
                     polypeptide 9, regulatory; myosin, light chain 9,
                     regulatory"
                     /codon_start=1
                     /product="myosin regulatory light polypeptide 9"
                     /protein_id="NP_001094355.2"
                     /db_xref="GeneID:296313"
                     /db_xref="RGD:1311235"
                     /translation="

MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD"

     misc_feature    163..615
                     /gene="Myl9"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; Region: FRQ1; COG5126"
                     /db_xref="CDD:227455"
     exon            293..454
                     /gene="Myl9"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1099
                     /gene="Myl9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gagctccggagagcgggcgagctgctgcaagccagctttcgaagcaccgcagcaacgccaaggacttttcttctctgcagcagggaacccccaacacccaaagccaagatgtccagcaagagagccaaggccaagaccaccaagaagaggccccagagggctacgtccaatgtcttcgctatgtttgaccagtcccagatccaggagtttaaggaggccttcaacatgattgatcagaaccgtgatggcttcattgacaaggaggacctacatgacatgctggcctccctggggaagaaccccacggatgagtacctggagggtatgatgaacgaggccccgggacctatcaacttcaccatgttcctcactatgtttggggagaagctgaacggcacagaccccgaggacgtgatccgcaatgcctttgcctgctttgatgaggaagcctcagggttcatccacgaggaccacctgcgggagctgctcaccaccatgggcgaccgattcacggatgaggaggtggacgagatgtaccgtgaggcgcccattgataagaagggcaacttcaactatgtggagttcactcgcatcctcaagcacggcgccaaggacaaagacgactaggctcttcttagctgtcccaatgcctacaccccatcccagtcacctcctcaacacatacactctaccctccccatgaggagttagggtcccggctcccagggcaggaaatgagccattaagacgcacagggtgaggcaggggttccaccacggacccaggcactagaggaagggccacagtggggaggtgagccaagggtggggccagctagcaccaaagtgaaggaagccactgaagatggccaccctcagccatgccctcccattccagggctaccctgaggaagaaaacacccatgttctggtgttggacactaattcccagcatccccacaaaggtacacacccattcaccatgtcccttcagaggatgacagtctgcacttacacctatggagttgtcccagcacacccagaatgcatagagggacgctgcctgagggacaaattctctaatacaaggctgagcacca

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